SG11201902945SA - Compositions and methods for protein expression and delivery - Google Patents
Compositions and methods for protein expression and deliveryInfo
- Publication number
- SG11201902945SA SG11201902945SA SG11201902945SA SG11201902945SA SG11201902945SA SG 11201902945S A SG11201902945S A SG 11201902945SA SG 11201902945S A SG11201902945S A SG 11201902945SA SG 11201902945S A SG11201902945S A SG 11201902945SA SG 11201902945S A SG11201902945S A SG 11201902945SA
- Authority
- SG
- Singapore
- Prior art keywords
- singapore
- medicine
- international
- ferritin
- school
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 abstract 7
- 239000003814 drug Substances 0.000 abstract 7
- 108050000784 Ferritin Proteins 0.000 abstract 4
- 102000008857 Ferritin Human genes 0.000 abstract 4
- 238000008416 Ferritin Methods 0.000 abstract 4
- 101710157275 Ferritin subunit Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241000205042 Archaeoglobus fulgidus Species 0.000 abstract 1
- 230000000712 assembly Effects 0.000 abstract 1
- 238000000429 assembly Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
NO N O GC O r•i C () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) WIP0 I PCT olimion °nolo III oiloo moninno oimIE (10) International Publication Number WO 2018/067075 Al (51) International Patent Classification: C07K 14/47 (2006.01) A61K 9/51 (2006.01) (21) International Application Number: PCT/SG2017/050505 (22) International Filing Date: 06 October 2017 (06.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/405,613 07 October 2016 (07.10.2016) US (71) Applicant: NATIONAL UNIVERSITY OF SINGA- PORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: DRUM, Chester Lee; c/o National Universi- ty of Singapore, Yong Loo Lin School of Medicine / De- partment of Medicine, 21 Lower Kent Ridge Road, Sin- gapore 119077 (SG). MASURKAR, Nihar; c/o National University of Singapore, Yong Loo Lin School of Medi- cine / Department of Medicine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). DESHPANDE, Siddharth; c/o National University of Singapore, NUS Graduate School for Integrative Science and Engineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). CHAKRABORTY, Goutam; c/o National University of Singapore, Yong Loo Lin School of Medicine / Department of Medicine, 21 Low- er Kent Ridge Road, Singapore 119077 (SG). VALLERIN- TEAVIDE MAVELLI, Girish; c/o National University of Singapore, Yong Loo Lin School of Medicine / Department of Medicine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). (74) Agent: MATTEUCCI, Gianfranco; Marks & Clerk Sin- gapore LLP, Tanjong Pagar, P 0 Box 636, Singapore 910816 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (54) Title: COMPOSITIONS AND METHODS FOR PROTEIN EXPRESSION AND DELIVERY FIG. 1A 12nm 8nm (57) : The present invention relates to methods and compositions that provide an environment that promotes enhanced protein expressing and/or folding. More particularly, the present invention provides engineered thermostable ferritin assemblies comprising at least one modified ferritin subunit, wherein the least at least one modified ferritin subunit lacks an unstructured carboxy-terminal sequence that is present in a wildtype ferritin subunit and wherein the engineered assembly is stable at lower salt concentrations that a wildtype ferritin assembly. The invention is exemplified by a ferritin assembly derived from hyperthermophilic Archaeoglobus fulgidus. Also claimed are nucleic acids, compositions, kits and methods of encapsulating a polypeptide, delivering and administering the said engineered ferritin assembly to a subject. [Continued on next page] WO 2018/067075 Al MIDEDIMOMMIDIREIEHMOHNEDIRMOUVON Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662405613P | 2016-10-07 | 2016-10-07 | |
| PCT/SG2017/050505 WO2018067075A1 (en) | 2016-10-07 | 2017-10-06 | Compositions and methods for protein expression and delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201902945SA true SG11201902945SA (en) | 2019-05-30 |
Family
ID=61831159
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201911421VA SG10201911421VA (en) | 2016-10-07 | 2017-10-06 | Compositions and methods for protein expression and delivery |
| SG11201902945SA SG11201902945SA (en) | 2016-10-07 | 2017-10-06 | Compositions and methods for protein expression and delivery |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201911421VA SG10201911421VA (en) | 2016-10-07 | 2017-10-06 | Compositions and methods for protein expression and delivery |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11510881B2 (en) |
| EP (1) | EP3523321A4 (en) |
| JP (1) | JP7096239B2 (en) |
| KR (1) | KR102579209B1 (en) |
| CN (1) | CN110023328B (en) |
| IL (1) | IL265831A (en) |
| SG (2) | SG10201911421VA (en) |
| WO (1) | WO2018067075A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019092481A (en) * | 2017-11-27 | 2019-06-20 | 国立大学法人東京工業大学 | Hetero protein cage |
| JP2019193594A (en) * | 2018-05-01 | 2019-11-07 | 国立大学法人東京工業大学 | Fusion proteins and uses thereof |
| CN112094861B (en) * | 2020-10-26 | 2022-11-22 | 南京林业大学 | Expression and purification method of green alga plant ferritin and application thereof |
| WO2024043836A1 (en) * | 2022-08-25 | 2024-02-29 | National University Of Singapore | Gastrointestinal tract stabilized protein delivery using disulfide tes system |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1262489A1 (en) * | 2001-05-14 | 2002-12-04 | Matsushita Electric Industrial Co., Ltd. | Complex comprising recombinant ferritin and a precious metal and DNA encoding said ferritin |
| US11202820B2 (en) * | 2014-09-25 | 2021-12-21 | Nanyang Technological University | Targeting of melanocytes for delivering therapeutic or diagnostic agents using protein nanocages |
| EP3250233A4 (en) * | 2015-01-29 | 2018-07-25 | Agency for Science, Technology and Research | Nanocapsules carrying chikungunya-associated peptides |
-
2017
- 2017-10-06 KR KR1020197012269A patent/KR102579209B1/en active IP Right Grant
- 2017-10-06 SG SG10201911421VA patent/SG10201911421VA/en unknown
- 2017-10-06 WO PCT/SG2017/050505 patent/WO2018067075A1/en unknown
- 2017-10-06 CN CN201780073646.4A patent/CN110023328B/en active Active
- 2017-10-06 US US16/340,089 patent/US11510881B2/en active Active
- 2017-10-06 JP JP2019518924A patent/JP7096239B2/en active Active
- 2017-10-06 EP EP17858829.9A patent/EP3523321A4/en active Pending
- 2017-10-06 SG SG11201902945SA patent/SG11201902945SA/en unknown
-
2019
- 2019-04-04 IL IL265831A patent/IL265831A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018067075A1 (en) | 2018-04-12 |
| US11510881B2 (en) | 2022-11-29 |
| US20210113484A1 (en) | 2021-04-22 |
| KR102579209B1 (en) | 2023-09-15 |
| JP2019534700A (en) | 2019-12-05 |
| CN110023328B (en) | 2024-03-05 |
| IL265831A (en) | 2019-06-30 |
| KR20190062483A (en) | 2019-06-05 |
| EP3523321A4 (en) | 2020-07-08 |
| SG10201911421VA (en) | 2020-02-27 |
| JP7096239B2 (en) | 2022-07-05 |
| CN110023328A (en) | 2019-07-16 |
| EP3523321A1 (en) | 2019-08-14 |
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