SG11201902465TA - Inhibitors of mtor-deptor interactions and methods of use thereof - Google Patents
Inhibitors of mtor-deptor interactions and methods of use thereofInfo
- Publication number
- SG11201902465TA SG11201902465TA SG11201902465TA SG11201902465TA SG11201902465TA SG 11201902465T A SG11201902465T A SG 11201902465TA SG 11201902465T A SG11201902465T A SG 11201902465TA SG 11201902465T A SG11201902465T A SG 11201902465TA SG 11201902465T A SG11201902465T A SG 11201902465TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- deptor
- inhibitors
- pct
- rule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/84—Hydrazones having doubly-bound carbon atoms of hydrazone groups being part of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
- C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Al 11111111 0 1111111111111111 011001 0 0111111111111001H1111111011111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/085753 Al 11 May 2018 (11.05.2018) WIPO I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7C 251/84 (2006.01) A61K 31/15 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7C 281/04 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: Declarations under Rule 4.17: PCT/US2017/060116 — of inventorship (Rule 4.17(iv)) (22) International Filing Date: Published: 06 November 2017 (06.11.2017) — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the (25) Filing Language: English claims and to be republished in the event of receipt of (26) Publication Language: English amendments (Rule 48.2(h)) (30) Priority Data: 62/418,362 07 November 2016 (07.11.2016) US (71) Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, CA 94607-5200 (US). THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS [US/US]; Office of the General Counsel, Washington, DC 20420 (US). Inventors: LICHTENSTEIN, Alan; 5002 Valjean Ave., Encino, CA 91436 (US). JUNG, Michael E.; 2335 Man- = (72) ning Avenue, Los Angeles, CA 90064 (US). GERA, Joseph F.; 42349 Sunnyslope Drive, Lancaster, CA 93536 =_ (US). LEE, Jihye; 2440 S. Barrington Ave. #307, Los An- geles, CA 90064 (US). SHI, Yijiang; 1334 19th Street, San- - to Monica, CA 90404 (US). Agent: HALSTEAD, David P. et al.; Foley Hoag LLP, 155 (74) — Seaport Boulevard, Boston, MA 02210-2600 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (81) = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = — SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — 1-1 M 4.) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 1 1 i n MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, IN 1 1 i n 00 © CO (54) Title: INHIBITORS OF MTOR-DEPTOR INTERACTIONS AND METHODS OF USE THEREOF 1-1 0 (57) : Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides ei pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hydrazone C: compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662418362P | 2016-11-07 | 2016-11-07 | |
PCT/US2017/060116 WO2018085753A1 (en) | 2016-11-07 | 2017-11-06 | Inhibitors of mtor-deptor interactions and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201902465TA true SG11201902465TA (en) | 2019-05-30 |
Family
ID=62076420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201902465TA SG11201902465TA (en) | 2016-11-07 | 2017-11-06 | Inhibitors of mtor-deptor interactions and methods of use thereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US20190330142A1 (en) |
EP (1) | EP3535239A1 (en) |
JP (1) | JP2019535815A (en) |
KR (1) | KR20190114955A (en) |
CN (1) | CN109952287A (en) |
AU (1) | AU2017355566A1 (en) |
BR (1) | BR112019008606A2 (en) |
CA (1) | CA3039070A1 (en) |
IL (1) | IL266344A (en) |
MX (1) | MX2019005294A (en) |
RU (1) | RU2019112671A (en) |
SG (1) | SG11201902465TA (en) |
WO (1) | WO2018085753A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102114899B1 (en) * | 2020-02-26 | 2020-05-26 | 가천대학교 산학협력단 | Pharmaceutical composition for preventing or treating infertility or abortion comprising inhibitors of mSIN1 protein as an active ingredient |
KR102147491B1 (en) * | 2020-05-29 | 2020-08-25 | 가천대학교 산학협력단 | Pharmaceutical composition for preventing or treating infertility or abortion comprising inhibitors of DEPTOR protein or mSIN1 protein as an active ingredient |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3882152A (en) * | 1970-09-09 | 1975-05-06 | Air Prod & Chem | Beta cyclopentadienyl hydrazides and carbazates |
-
2017
- 2017-11-06 RU RU2019112671A patent/RU2019112671A/en not_active Application Discontinuation
- 2017-11-06 AU AU2017355566A patent/AU2017355566A1/en not_active Abandoned
- 2017-11-06 WO PCT/US2017/060116 patent/WO2018085753A1/en active Application Filing
- 2017-11-06 KR KR1020197013668A patent/KR20190114955A/en unknown
- 2017-11-06 SG SG11201902465TA patent/SG11201902465TA/en unknown
- 2017-11-06 BR BR112019008606A patent/BR112019008606A2/en not_active Application Discontinuation
- 2017-11-06 CA CA3039070A patent/CA3039070A1/en not_active Abandoned
- 2017-11-06 JP JP2019545716A patent/JP2019535815A/en active Pending
- 2017-11-06 US US16/347,295 patent/US20190330142A1/en not_active Abandoned
- 2017-11-06 CN CN201780068696.3A patent/CN109952287A/en active Pending
- 2017-11-06 MX MX2019005294A patent/MX2019005294A/en unknown
- 2017-11-06 EP EP17867401.6A patent/EP3535239A1/en not_active Withdrawn
-
2019
- 2019-04-30 IL IL266344A patent/IL266344A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2019005294A (en) | 2019-10-14 |
CN109952287A (en) | 2019-06-28 |
KR20190114955A (en) | 2019-10-10 |
WO2018085753A1 (en) | 2018-05-11 |
AU2017355566A1 (en) | 2019-04-04 |
US20190330142A1 (en) | 2019-10-31 |
CA3039070A1 (en) | 2018-05-11 |
JP2019535815A (en) | 2019-12-12 |
RU2019112671A (en) | 2020-12-07 |
BR112019008606A2 (en) | 2019-07-09 |
IL266344A (en) | 2019-06-30 |
EP3535239A1 (en) | 2019-09-11 |
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