SG11201901648YA - Cell culture device and cell culture method - Google Patents

Cell culture device and cell culture method

Info

Publication number
SG11201901648YA
SG11201901648YA SG11201901648YA SG11201901648YA SG11201901648YA SG 11201901648Y A SG11201901648Y A SG 11201901648YA SG 11201901648Y A SG11201901648Y A SG 11201901648YA SG 11201901648Y A SG11201901648Y A SG 11201901648YA SG 11201901648Y A SG11201901648Y A SG 11201901648YA
Authority
SG
Singapore
Prior art keywords
culture
culture solution
cell culture
tank
cell
Prior art date
Application number
SG11201901648YA
Inventor
Kousuke Ishii
Akihiko Yoshimura
Makiko Saito
Michinori Shida
Masayo Nakagawa
Shin-Ichi Sakai
Original Assignee
Ihi Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ihi Corp filed Critical Ihi Corp
Publication of SG11201901648YA publication Critical patent/SG11201901648YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A cell culture device includes: a culture tank of culturing a cell in a culture solution, the culture tank being in a shape in which a horizontal sectional area upwardly increases; a pump and a culture solution supply pipe, as a supply unit supplying the culture solution to 5 the culture tank; and a control unit controlling the supply of the culture solution of the supply unit, in which the culture solution is intermittently supplied to the culture tank from the supply unit, according to the control of the control unit, and a circulation upward flow is formed in the culture solution, and thus, a plug flow of the culture solution is 10 formed in a culture region in which the cell is retained in the culture tank. Fig. 1
SG11201901648YA 2016-08-26 2017-08-24 Cell culture device and cell culture method SG11201901648YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016166068 2016-08-26
PCT/JP2017/030410 WO2018038228A1 (en) 2016-08-26 2017-08-24 Cell culture device and cell culture method

Publications (1)

Publication Number Publication Date
SG11201901648YA true SG11201901648YA (en) 2019-03-28

Family

ID=61244950

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201901648YA SG11201901648YA (en) 2016-08-26 2017-08-24 Cell culture device and cell culture method

Country Status (6)

Country Link
US (1) US20190185807A1 (en)
EP (1) EP3505610A4 (en)
JP (1) JP6690718B2 (en)
CN (1) CN109642193A (en)
SG (1) SG11201901648YA (en)
WO (1) WO2018038228A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7127335B2 (en) * 2017-06-12 2022-08-30 株式会社Ihi Cell culture tank and cell culture equipment
JPWO2019022067A1 (en) * 2017-07-27 2019-11-07 株式会社Ｉｈｉ Cell culture equipment
JP7106944B2 (en) * 2018-04-02 2022-07-27 株式会社Ihi cell culture tank
JP2020188691A (en) * 2019-05-20 2020-11-26 株式会社Ihi Cell culture device
JPWO2021039416A1 (en) * 2019-08-30 2021-03-04
CN112210504B (en) * 2020-10-15 2021-05-18 新疆天润生物科技股份有限公司 Culture method of Kluyveromyces marxianus strain

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6274283A (en) * 1985-09-26 1987-04-06 Nitto Electric Ind Co Ltd Continuous cultivation of cell or the like and apparatus therefor
CN1045602A (en) * 1989-03-08 1990-09-26 三井石油化学工业株式会社 The production method of tissue culture method of plant and device thereof and meta-bolites
JP2507523Y2 (en) * 1991-04-16 1996-08-14 株式会社フジタ Floating algae culture device
JP2001178445A (en) * 1999-12-27 2001-07-03 Able Corp Carrier for culturing three-dimensional animal cell and three-dimensional animal cell
JP4061149B2 (en) * 2002-07-24 2008-03-12 株式会社ティッシュエンジニアリングイニシアティブ Cell culture device and cell culture method
JP4316225B2 (en) * 2002-11-25 2009-08-19 新日鐵化学株式会社 Method and apparatus for removing nitrate nitrogen in water and denitrification treatment material
JP4561192B2 (en) * 2004-06-11 2010-10-13 株式会社Ｉｈｉ Cell culture device and cell culture method
JP4270082B2 (en) * 2004-09-08 2009-05-27 株式会社Ｉｈｉ Cell culture apparatus and method
CN101033449A (en) * 2006-12-12 2007-09-12 北京航空航天大学 Optical bioreactor for spacing regenerative oxygen
GB2505638B (en) * 2012-07-23 2016-01-06 Green Biologics Ltd Continuous culture
WO2015003012A2 (en) * 2013-07-01 2015-01-08 Olivier Berteau Distributed perfusion bioreactor system for continuous culture of biological cells
JP6492449B2 (en) * 2013-12-26 2019-04-03 株式会社Ihi Cell culture equipment
JP6247932B2 (en) * 2013-12-27 2017-12-13 株式会社Ihi Cell culture equipment
JP6492561B2 (en) * 2014-11-11 2019-04-03 株式会社Ihi Cell culture equipment

Also Published As

Publication number Publication date
CN109642193A (en) 2019-04-16
JPWO2018038228A1 (en) 2019-06-24
EP3505610A1 (en) 2019-07-03
US20190185807A1 (en) 2019-06-20
JP6690718B2 (en) 2020-04-28
EP3505610A4 (en) 2020-04-22
WO2018038228A1 (en) 2018-03-01

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