SG11201811328PA - Predictive focus tracking apparatus and methods - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property :::` , MD HIM 0 11101 HOE HI 1 0 I 0111 010 HO 11111 RHO 11110 MAMIE Organization International Bureau (10) International Publication Number 03 (43) International Publication Date ......°' WO 2018/127769 Al 12 July 2018 (12.07.2018) WIP0 1 PCT (51) International Patent Classification: (72) Inventors: ARIANPOUR, Ashkan; 5200 Illumina Way, G02B 21/00 (2006.01) San Diego, California 92122 (US). BAILEY, John; 5200 (21) International Application Number: Illumina Way, San Diego, California 92122 (US). BLAIR, PCT/IB2017/058383 Dustin; 5200 Illumina Way, San Diego, California 92122 (US). CHEN, Xiangling (Steve); 5200 Illumina Way, San (22) International Filing Date: Diego, California 92122 (US). HONG, Stanley S.; 5200 Il- 22 December 2017 (22.12.2017) lumina Way, San Diego, California 92122 (US). PRINCE, (25) Filing Language: English Simon; 5200 Illumina Way, San Diego, California 92122 (US). SIU, Merek C.; 5200 Illumina Way, San Diego, Cal- (26) Publication Language: English ifornia 92122 (US). ZHOU, Chunhong (Allen); 5200 Illu- mina Way, San Diego, California 92122 (US). CONDEL- (30) Priority Data: LO, Danilo; 5200 Illumina Way, San Diego, California 62/442,947 05 January 2017 (05.01.2017) US 92122 (US). 1704770.5 24 March 2017 (24.03.2017) GB (74) Agent: YANNUZZI, Daniel N. et al.; c/o Sheppard Mullin (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Richter & Hampton LLP, 12275 El Camino Real, Suite 200, Way, San Diego, California 92122 (US). San Diego, California 92130 (US). (54) Title: PREDICTIVE FOCUS TRACKING APPARATUS AND METHODS = = - = • 1 .Q 4 145 I 141 / = = 130 = _ - = - _ 1 'a 120 110 175 -----------________----- = I = 100 \ t' = = 170 160 = = Fig. 1 ,-1 (57) : An imaging system may include a sample stage comprising a surface to support a sample container, the sample container CN having a plurality of sample locations; an optical stage having an objective lens, the optical stage being positionable relative to the r..., sample stage to image samples at the sample locations; an actuator physically coupled to at least one of the sample stage and the optical IN stage to move the sample stage relative to the optical stage to focus the optical stage onto a current sample location; and a drive circuit to el determine a focus setting for a next sample location and to provide a drive signal to the actuator before the optical stage is positioned to 1-1 —. image a sample at the next sample location, wherein at least one parameter of the drive signal is determined using a difference between c)1: 1-1 a focus setting for the current sample location and the determined focus setting for the next sample location. 0 N O [Continued on next page] WO 2018/127769 Al IMEDIMOMMIDIREEMOMOHMEMEHOMEMOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE