SG11201810887UA - Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof - Google Patents

Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

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Publication number
SG11201810887UA
SG11201810887UA SG11201810887UA SG11201810887UA SG11201810887UA SG 11201810887U A SG11201810887U A SG 11201810887UA SG 11201810887U A SG11201810887U A SG 11201810887UA SG 11201810887U A SG11201810887U A SG 11201810887UA SG 11201810887U A SG11201810887U A SG 11201810887UA
Authority
SG
Singapore
Prior art keywords
baff
international
duarte
car
targeted
Prior art date
Application number
SG11201810887UA
Other languages
English (en)
Inventor
Hong Qin
Larry W Kwak
Original Assignee
Hope City
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hope City, Univ Texas filed Critical Hope City
Publication of SG11201810887UA publication Critical patent/SG11201810887UA/en

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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SG11201810887UA 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof SG11201810887UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662346324P 2016-06-06 2016-06-06
US201662396767P 2016-09-19 2016-09-19
PCT/US2017/036178 WO2017214167A1 (fr) 2016-06-06 2017-06-06 Cellules t modifiées par un récepteur d'antigène chimérique ciblant baff-r et leurs utilisations

Publications (1)

Publication Number Publication Date
SG11201810887UA true SG11201810887UA (en) 2019-01-30

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SG11201810887UA SG11201810887UA (en) 2016-06-06 2017-06-06 Baff-r targeted chimeric antigen receptor-modified t-cells and uses thereof

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US (2) US11161908B2 (fr)
EP (1) EP3464371A1 (fr)
JP (1) JP7070932B2 (fr)
KR (5) KR20230146094A (fr)
CN (2) CN109311991B (fr)
AU (1) AU2017277269B2 (fr)
CA (1) CA3026640A1 (fr)
IL (3) IL297925B1 (fr)
SG (1) SG11201810887UA (fr)
WO (1) WO2017214167A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230146094A (ko) * 2016-06-06 2023-10-18 시티 오브 호프 Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도
EP3589295A4 (fr) 2017-02-28 2020-11-04 Endocyte, Inc. Compositions et méthodes de thérapie par lymphocytes t car
JP7417542B2 (ja) 2018-01-22 2024-01-18 シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) Car t細胞の使用方法
KR20210104816A (ko) * 2018-12-19 2021-08-25 시티 오브 호프 Baff-r 이중특이적 t 세포 인게이저 항체
WO2020172440A1 (fr) * 2019-02-20 2020-08-27 Qin Hong Lymphocytes t modifiés par des récepteur d'antigènes chimériques ciblant baff-r/cd19 et leur utilisation
WO2021064718A1 (fr) * 2019-10-01 2021-04-08 Case Western Reserve University Ciblage du récepteur du facteur d'activation des lymphocytes b (baff-r) à l'aide de lymphocytes t récepteurs d'antigènes chimériques (car) à base de ligands
WO2021163989A1 (fr) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anticorps anti-récepteur baff et leurs utilisations
CN111499723B (zh) * 2020-05-28 2021-04-09 广州百暨基因科技有限公司 一种嵌合抗原受体及其应用
IL310434A (en) 2021-07-29 2024-03-01 Sonoma Biotherapeutics Inc A chimeric extracellular matrix-specific antigen receptor from a destroyer to target regulatory T cells for the treatment of autoimmune diseases
WO2023235819A1 (fr) * 2022-06-01 2023-12-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Récepteurs recombinants se liant au récepteur du facteur d'activation des cellules b et leurs utilisations
CN116143943B (zh) * 2022-10-31 2023-09-01 邦恩泰(山东)生物医药科技集团股份有限公司 一种靶向baffr嵌合抗原受体、car-t细胞及应用
CN117050195B (zh) * 2023-10-13 2023-12-19 旭和(天津)医药科技有限公司 一种靶向baffr嵌合抗原受体、car-t细胞和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1690934A3 (fr) 1990-01-12 2008-07-30 Abgenix, Inc. Génération d'anticorps xenogéniques
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
EP0746609A4 (fr) 1991-12-17 1997-12-17 Genpharm Int Animaux transgeniques non humains capables de produire des anticorps heterologues
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6066718A (en) 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
IL166244A0 (en) 2001-07-12 2006-01-15 Jefferson Foote Super humanized antibodies
EA200701211A1 (ru) * 2004-12-31 2007-12-28 Дженентек, Инк. Полипептиды, которые связываются с br3, и их применение
EP3134437A1 (fr) * 2014-04-23 2017-03-01 Board of Regents, The University of Texas System Récepteurs d'antigènes chimères (car) utilisés dans un traitement et méthodes de fabrication associées
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
KR20230146094A (ko) * 2016-06-06 2023-10-18 시티 오브 호프 Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도

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