CN109311991B - Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 - Google Patents

Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 Download PDF

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CN109311991B
CN109311991B CN201780035645.0A CN201780035645A CN109311991B CN 109311991 B CN109311991 B CN 109311991B CN 201780035645 A CN201780035645 A CN 201780035645A CN 109311991 B CN109311991 B CN 109311991B
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chain variable
cells
seq
baff
variable region
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CN109311991A (zh
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秦宏
拉里·W·夸克
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University of Texas System
City of Hope
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City of Hope
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CN201780035645.0A 2016-06-06 2017-06-06 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途 Active CN109311991B (zh)

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US201662346324P 2016-06-06 2016-06-06
US62/346,324 2016-06-06
US201662396767P 2016-09-19 2016-09-19
US62/396,767 2016-09-19
PCT/US2017/036178 WO2017214167A1 (fr) 2016-06-06 2017-06-06 Cellules t modifiées par un récepteur d'antigène chimérique ciblant baff-r et leurs utilisations

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Publication number Priority date Publication date Assignee Title
KR20230146094A (ko) * 2016-06-06 2023-10-18 시티 오브 호프 Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도
EP3589295A4 (fr) 2017-02-28 2020-11-04 Endocyte, Inc. Compositions et méthodes de thérapie par lymphocytes t car
JP7417542B2 (ja) 2018-01-22 2024-01-18 シアトル チルドレンズ ホスピタル （ディービーエイ シアトル チルドレンズ リサーチ インスティテュート） Ｃａｒ ｔ細胞の使用方法
KR20210104816A (ko) * 2018-12-19 2021-08-25 시티 오브 호프 Baff-r 이중특이적 t 세포 인게이저 항체
WO2020172440A1 (fr) * 2019-02-20 2020-08-27 Qin Hong Lymphocytes t modifiés par des récepteur d'antigènes chimériques ciblant baff-r/cd19 et leur utilisation
WO2021064718A1 (fr) * 2019-10-01 2021-04-08 Case Western Reserve University Ciblage du récepteur du facteur d'activation des lymphocytes b (baff-r) à l'aide de lymphocytes t récepteurs d'antigènes chimériques (car) à base de ligands
WO2021163989A1 (fr) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anticorps anti-récepteur baff et leurs utilisations
CN111499723B (zh) * 2020-05-28 2021-04-09 广州百暨基因科技有限公司 一种嵌合抗原受体及其应用
IL310434A (en) 2021-07-29 2024-03-01 Sonoma Biotherapeutics Inc A chimeric extracellular matrix-specific antigen receptor from a destroyer to target regulatory T cells for the treatment of autoimmune diseases
WO2023235819A1 (fr) * 2022-06-01 2023-12-07 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Récepteurs recombinants se liant au récepteur du facteur d'activation des cellules b et leurs utilisations
CN116143943B (zh) * 2022-10-31 2023-09-01 邦恩泰(山东)生物医药科技集团股份有限公司 一种靶向baffr嵌合抗原受体、car-t细胞及应用
CN117050195B (zh) * 2023-10-13 2023-12-19 旭和（天津）医药科技有限公司 一种靶向baffr嵌合抗原受体、car-t细胞和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015164594A1 (fr) * 2014-04-23 2015-10-29 Board Of Regents, The University Of Texas System Récepteurs d'antigènes chimères (car) utilisés dans un traitement et méthodes de fabrication associées

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP1690934A3 (fr) 1990-01-12 2008-07-30 Abgenix, Inc. Génération d'anticorps xenogéniques
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
EP0746609A4 (fr) 1991-12-17 1997-12-17 Genpharm Int Animaux transgeniques non humains capables de produire des anticorps heterologues
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6066718A (en) 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
IL166244A0 (en) 2001-07-12 2006-01-15 Jefferson Foote Super humanized antibodies
EA200701211A1 (ru) * 2004-12-31 2007-12-28 Дженентек, Инк. Полипептиды, которые связываются с br3, и их применение
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
KR20230146094A (ko) * 2016-06-06 2023-10-18 시티 오브 호프 Baff-r 표적 키메라 항원 수용체-변형된 t 세포 및 그 용도

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015164594A1 (fr) * 2014-04-23 2015-10-29 Board Of Regents, The University Of Texas System Récepteurs d'antigènes chimères (car) utilisés dans un traitement et méthodes de fabrication associées

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IL308798A (en) 2024-01-01
KR20230054739A (ko) 2023-04-25
US11161908B2 (en) 2021-11-02
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CN109311991A (zh) 2019-02-05
CA3026640A1 (fr) 2017-12-14
IL263385B (en) 2022-12-01
KR20230146094A (ko) 2023-10-18
IL263385A (en) 2018-12-31
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IL297925A (en) 2023-01-01
US20220010023A1 (en) 2022-01-13
KR102584944B1 (ko) 2023-10-05
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KR102356864B1 (ko) 2022-02-04
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