SG11201810264TA - Method and apparatus for spatial compression and increased mobility resolution of ions - Google Patents
Method and apparatus for spatial compression and increased mobility resolution of ionsInfo
- Publication number
- SG11201810264TA SG11201810264TA SG11201810264TA SG11201810264TA SG11201810264TA SG 11201810264T A SG11201810264T A SG 11201810264TA SG 11201810264T A SG11201810264T A SG 11201810264TA SG 11201810264T A SG11201810264T A SG 11201810264TA SG 11201810264T A SG11201810264T A SG 11201810264TA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- ions
- richland
- packets
- battelle
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 11111111111111111111111111111111111111111111111111111111111111111111111111110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/200695 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (US). D.; c/o Battelle Memorial Insti- SMITH, Richard, BOW 59/44 (2006.01) HOLI 49/00 (2006.01) tute, P.O. Box 999, M/S K1-53, Richland, WA 99352 (US). (21) International Application Number: (74) Agent: GEARY, William et al.; Mintz, Levin, Cohn, Fer- PCT/US2017/028626 ris, Glovsky and Popeo, P.C., One Financial Center, Boston, (22) MA International Filing Date: 02111 (US). 20 April 2017 (20.04.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 15/157,217 17 May 2016 (17.05.2016) US HR, KW, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (71) Applicant: BATTELLE MEMORIAL INSTITUTE MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, [US/US]; 902 Battelle Boulevard, Richland, WA 99354 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (US). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: IBRAHIM, Yehia, M.; c/o Battelle Memorial Institute, P.O. Box 999, M/S K1-53, Richland, WA 99352 (84) Designated States (unless otherwise indicated, for every (US). GARIMELLA, Sandilya; c/o Battelle Memorial In- kind of regional protection available): ARIPO (BW, GH, — stitute, P.O. Box 999, M/S K1-53, Richland, WA 99352 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = (54) Title: METHOD AND APPARATUS FOR SPATIAL COMPRESSION AND INCREASED MOBILITY RESOLUTION OF IONS = tea ., e ,;,... ,:... .le -e\" o. _ = = N\ „,.... 1A •.::.. a- ' k , , • . ~ = = = = = k „ = . - , . = 4if . 11 ki) 01 v; ,:::, ,:::, Fig. I ei ---- (57) IN : Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions ,—I are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their 0 mobilities A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number \" of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of C: the intermittent traveling wave. [Continued on next page] WO 2017/200695 Al MIDEDIMOMOIDEIRMEM0010101110111MOMOVOIMIE TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, SK, SM, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/157,217 US10018592B2 (en) | 2016-05-17 | 2016-05-17 | Method and apparatus for spatial compression and increased mobility resolution of ions |
| PCT/US2017/028626 WO2017200695A1 (en) | 2016-05-17 | 2017-04-20 | Method and apparatus for spatial compression and increased mobility resolution of ions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810264TA true SG11201810264TA (en) | 2018-12-28 |
Family
ID=60326603
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810264TA SG11201810264TA (en) | 2016-05-17 | 2017-04-20 | Method and apparatus for spatial compression and increased mobility resolution of ions |
| SG10201908002W SG10201908002WA (en) | 2016-05-17 | 2017-04-20 | Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions |
| SG10202100140PA SG10202100140PA (en) | 2016-05-17 | 2017-04-20 | Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201908002W SG10201908002WA (en) | 2016-05-17 | 2017-04-20 | Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions |
| SG10202100140PA SG10202100140PA (en) | 2016-05-17 | 2017-04-20 | Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10018592B2 (en) |
| EP (1) | EP3458181A4 (en) |
| JP (2) | JP6677826B2 (en) |
| CN (2) | CN113049666B (en) |
| AU (2) | AU2017267392B2 (en) |
| CA (1) | CA3024420C (en) |
| SG (3) | SG11201810264TA (en) |
| WO (1) | WO2017200695A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10018592B2 (en) | 2016-05-17 | 2018-07-10 | Battelle Memorial Institute | Method and apparatus for spatial compression and increased mobility resolution of ions |
| EP3794630A4 (en) | 2018-05-14 | 2022-01-26 | Mobilion Systems, Inc. | Coupling of ion mobility spectrometer with mass spectrometer |
| WO2020237037A1 (en) | 2019-05-21 | 2020-11-26 | MOBILion Systems, Inc. | Voltage control for ion mobility separation |
| US11119069B2 (en) | 2019-05-28 | 2021-09-14 | Battelle Memorial Institute | Device and method to manipulate ions in multi level system |
| US11543384B2 (en) | 2019-11-22 | 2023-01-03 | MOBILion Systems, Inc. | Mobility based filtering of ions |
| GB202003890D0 (en) * | 2020-03-18 | 2020-05-06 | Micromass Ltd | ION peak compression or expansion |
| WO2021207235A1 (en) | 2020-04-06 | 2021-10-14 | MOBILion Systems, Inc. | Systems and methods for two-dimensional mobility based filtering of ions |
| CN115885176A (en) | 2020-05-22 | 2023-03-31 | 莫比莱昂系统有限公司 | Method and apparatus for trapping and accumulating ions |
| US11874252B2 (en) | 2020-06-05 | 2024-01-16 | MOBILion Systems, Inc. | Apparatus and methods for ion manipulation having improved duty cycle |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19523859C2 (en) | 1995-06-30 | 2000-04-27 | Bruker Daltonik Gmbh | Device for reflecting charged particles |
| GB9519033D0 (en) | 1995-09-18 | 1995-11-15 | Smithkline Beecham Plc | Treatment |
| CA2391140C (en) | 2001-06-25 | 2008-10-07 | Micromass Limited | Mass spectrometer |
| US7095013B2 (en) | 2002-05-30 | 2006-08-22 | Micromass Uk Limited | Mass spectrometer |
| US6791078B2 (en) * | 2002-06-27 | 2004-09-14 | Micromass Uk Limited | Mass spectrometer |
| US20040195503A1 (en) | 2003-04-04 | 2004-10-07 | Taeman Kim | Ion guide for mass spectrometers |
| CA2567466C (en) | 2004-05-21 | 2012-05-01 | Craig M. Whitehouse | Rf surfaces and rf ion guides |
| DE102004048496B4 (en) | 2004-10-05 | 2008-04-30 | Bruker Daltonik Gmbh | Ion guide with RF diaphragm stacks |
| GB0427634D0 (en) | 2004-12-17 | 2005-01-19 | Micromass Ltd | Mass spectrometer |
| JP4621744B2 (en) | 2005-11-28 | 2011-01-26 | 株式会社日立製作所 | Ion guide device, ion reaction device, and mass spectrometer |
| GB0524972D0 (en) | 2005-12-07 | 2006-01-18 | Micromass Ltd | Mass spectrometer |
| US7548818B2 (en) | 2005-12-07 | 2009-06-16 | Mds Analytical Technologies | Automated analysis of complex matrices using mass spectrometer |
| GB0708391D0 (en) * | 2007-05-01 | 2007-06-06 | Smiths Detection Watford Ltd | Detection and spectrometers |
| GB0718468D0 (en) | 2007-09-21 | 2007-10-31 | Micromass Ltd | Mass spectrometer |
| US7888635B2 (en) | 2008-05-30 | 2011-02-15 | Battelle Memorial Institute | Ion funnel ion trap and process |
| US8373120B2 (en) | 2008-07-28 | 2013-02-12 | Leco Corporation | Method and apparatus for ion manipulation using mesh in a radio frequency field |
| US7838826B1 (en) | 2008-08-07 | 2010-11-23 | Bruker Daltonics, Inc. | Apparatus and method for parallel flow ion mobility spectrometry combined with mass spectrometry |
| WO2010051518A1 (en) * | 2008-10-31 | 2010-05-06 | Excellims Corporation | Ion mobility based separation methods and apparatus |
| EP2237307B1 (en) * | 2009-03-30 | 2014-05-14 | Vidal de Miguel, Guillermo | Method and apparatus to produce steady beams of mobility selected ions via time-dependent electric fields |
| WO2010120895A1 (en) * | 2009-04-14 | 2010-10-21 | Northeastern University | Rapid gas-phase isotopic labeling for enhanced detection of protein conformations |
| DE112012004563T5 (en) * | 2011-11-02 | 2014-08-21 | Leco Corporation | Ion-mobility spectrometer |
| GB2509412B (en) * | 2012-02-21 | 2016-06-01 | Thermo Fisher Scient (Bremen) Gmbh | Apparatus and methods for ion mobility spectrometry |
| WO2013184995A1 (en) * | 2012-06-07 | 2013-12-12 | Waters Technologies Corporation | Methods and apparatus for performing mass spectrometry |
| US8835839B1 (en) | 2013-04-08 | 2014-09-16 | Battelle Memorial Institute | Ion manipulation device |
| CN104112642B (en) * | 2013-04-18 | 2017-05-24 | 岛津分析技术研发（上海）有限公司 | Ion guide device and ion guide method |
| US9063086B1 (en) * | 2014-02-12 | 2015-06-23 | Battelle Memorial Institute | Method and apparatus for compressing ions |
| GB201410247D0 (en) | 2014-06-10 | 2014-07-23 | Micromass Ltd | Separation for space charge reduction |
| US9147565B1 (en) * | 2014-12-30 | 2015-09-29 | Morpho Detection, Llc | Ion mobility spectrometer and method of using the same |
| US9304106B1 (en) * | 2015-02-05 | 2016-04-05 | Bruker Daltonik Gmbh | High duty cycle trapping ion mobility spectrometer |
| CN106373854B (en) * | 2015-07-23 | 2018-12-21 | 株式会社岛津制作所 | A kind of ion guide device |
| US10018592B2 (en) * | 2016-05-17 | 2018-07-10 | Battelle Memorial Institute | Method and apparatus for spatial compression and increased mobility resolution of ions |
-
2016
- 2016-05-17 US US15/157,217 patent/US10018592B2/en active Active
-
2017
- 2017-04-20 WO PCT/US2017/028626 patent/WO2017200695A1/en unknown
- 2017-04-20 CN CN202110400094.1A patent/CN113049666B/en active Active
- 2017-04-20 CN CN201780041489.9A patent/CN109414651B/en active Active
- 2017-04-20 CA CA3024420A patent/CA3024420C/en active Active
- 2017-04-20 SG SG11201810264TA patent/SG11201810264TA/en unknown
- 2017-04-20 SG SG10201908002W patent/SG10201908002WA/en unknown
- 2017-04-20 SG SG10202100140PA patent/SG10202100140PA/en unknown
- 2017-04-20 EP EP17799838.2A patent/EP3458181A4/en active Pending
- 2017-04-20 JP JP2018560583A patent/JP6677826B2/en active Active
- 2017-04-20 AU AU2017267392A patent/AU2017267392B2/en active Active
-
2018
- 2018-07-03 US US16/027,092 patent/US10466202B2/en active Active
-
2019
- 2019-11-04 US US16/672,690 patent/US10976283B2/en active Active
-
2020
- 2020-02-19 AU AU2020201199A patent/AU2020201199B2/en active Active
- 2020-03-12 JP JP2020042533A patent/JP7171638B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10466202B2 (en) | 2019-11-05 |
| US10976283B2 (en) | 2021-04-13 |
| JP7171638B2 (en) | 2022-11-15 |
| SG10202100140PA (en) | 2021-02-25 |
| JP6677826B2 (en) | 2020-04-08 |
| AU2020201199A1 (en) | 2020-03-05 |
| CN109414651A (en) | 2019-03-01 |
| CA3024420A1 (en) | 2017-11-23 |
| JP2020109415A (en) | 2020-07-16 |
| SG10201908002WA (en) | 2019-10-30 |
| EP3458181A4 (en) | 2020-05-13 |
| JP2019519766A (en) | 2019-07-11 |
| AU2017267392A1 (en) | 2018-12-06 |
| CN109414651B (en) | 2021-05-11 |
| US20170336355A1 (en) | 2017-11-23 |
| US10018592B2 (en) | 2018-07-10 |
| AU2020201199B2 (en) | 2021-09-09 |
| US20190056352A1 (en) | 2019-02-21 |
| US20200200708A1 (en) | 2020-06-25 |
| WO2017200695A1 (en) | 2017-11-23 |
| CN113049666A (en) | 2021-06-29 |
| AU2017267392B2 (en) | 2019-12-05 |
| EP3458181A1 (en) | 2019-03-27 |
| CA3024420C (en) | 2023-06-13 |
| CN113049666B (en) | 2024-06-18 |
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