SG10201908002WA - Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions - Google Patents

Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions

Info

Publication number
SG10201908002WA
SG10201908002WA SG10201908002WA SG10201908002WA SG 10201908002W A SG10201908002W A SG 10201908002WA SG 10201908002W A SG10201908002W A SG 10201908002WA SG 10201908002W A SG10201908002W A SG 10201908002WA
Authority
SG
Singapore
Prior art keywords
ions
packets
increased mobility
spatial compression
mobility resolution
Prior art date
Application number
Inventor
Yehia Ibrahim
Sandilya Garimella
Richard Smith
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Publication of SG10201908002WA publication Critical patent/SG10201908002WA/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/022—Circuit arrangements, e.g. for generating deviation currents or voltages ; Components associated with high voltage supply

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METHOD AND APPARATUS FOR SPATIAL COMPRESSION AND INCREASED MOBILITY RESOLUTION OF IONS Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for 5 dispersing the ion packets temporally or spatially according to their mobilities A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave. Figure 1 10
SG10201908002W 2016-05-17 2017-04-20 Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions SG10201908002WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15/157,217 US10018592B2 (en) 2016-05-17 2016-05-17 Method and apparatus for spatial compression and increased mobility resolution of ions

Publications (1)

Publication Number Publication Date
SG10201908002WA true SG10201908002WA (en) 2019-10-30

Family

ID=60326603

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201810264TA SG11201810264TA (en) 2016-05-17 2017-04-20 Method and apparatus for spatial compression and increased mobility resolution of ions
SG10202100140PA SG10202100140PA (en) 2016-05-17 2017-04-20 Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions
SG10201908002W SG10201908002WA (en) 2016-05-17 2017-04-20 Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG11201810264TA SG11201810264TA (en) 2016-05-17 2017-04-20 Method and apparatus for spatial compression and increased mobility resolution of ions
SG10202100140PA SG10202100140PA (en) 2016-05-17 2017-04-20 Method and Apparatus for Spatial Compression and Increased Mobility Resolution of Ions

Country Status (8)

Country Link
US (3) US10018592B2 (en)
EP (1) EP3458181A4 (en)
JP (2) JP6677826B2 (en)
CN (2) CN113049666B (en)
AU (2) AU2017267392B2 (en)
CA (1) CA3024420C (en)
SG (3) SG11201810264TA (en)
WO (1) WO2017200695A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10018592B2 (en) 2016-05-17 2018-07-10 Battelle Memorial Institute Method and apparatus for spatial compression and increased mobility resolution of ions
EP3794630A4 (en) 2018-05-14 2022-01-26 Mobilion Systems, Inc. Coupling of ion mobility spectrometer with mass spectrometer
EP3972726A4 (en) 2019-05-21 2023-05-10 Mobilion Systems, Inc. Voltage control for ion mobility separation
US11119069B2 (en) 2019-05-28 2021-09-14 Battelle Memorial Institute Device and method to manipulate ions in multi level system
CN114616463A (en) * 2019-09-16 2022-06-10 莫比莱昂系统有限公司 Voltage control for travelling wave characteristic changes
WO2021102406A1 (en) 2019-11-22 2021-05-27 MOBILion Systems, Inc. Mobility based filtering of ions
GB202003890D0 (en) * 2020-03-18 2020-05-06 Micromass Ltd ION peak compression or expansion
WO2021207235A1 (en) 2020-04-06 2021-10-14 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions
CA3178943A1 (en) 2020-05-22 2021-11-25 MOBILion Systems, Inc. Methods and apparatus for trapping and accumulation of ions
EP4161683A4 (en) * 2020-06-05 2024-07-03 Mobilion Systems Inc Apparatus and methods for ion manipulation having improved duty cycle

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19523859C2 (en) 1995-06-30 2000-04-27 Bruker Daltonik Gmbh Device for reflecting charged particles
GB9519033D0 (en) 1995-09-18 1995-11-15 Smithkline Beecham Plc Treatment
CA2391140C (en) 2001-06-25 2008-10-07 Micromass Limited Mass spectrometer
US7095013B2 (en) 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
US6791078B2 (en) * 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US20040195503A1 (en) 2003-04-04 2004-10-07 Taeman Kim Ion guide for mass spectrometers
EP1759402B1 (en) 2004-05-21 2015-07-08 Craig M. Whitehouse Rf surfaces and rf ion guides
DE102004048496B4 (en) 2004-10-05 2008-04-30 Bruker Daltonik Gmbh Ion guide with RF diaphragm stacks
GB0427634D0 (en) 2004-12-17 2005-01-19 Micromass Ltd Mass spectrometer
EP1956635B1 (en) 2005-11-28 2013-05-15 Hitachi, Ltd. Ion guide device, ion reactor, and mass analyzer
US7548818B2 (en) 2005-12-07 2009-06-16 Mds Analytical Technologies Automated analysis of complex matrices using mass spectrometer
GB0524972D0 (en) 2005-12-07 2006-01-18 Micromass Ltd Mass spectrometer
US8063361B2 (en) * 2008-02-05 2011-11-22 Excellims Corporation Ion mobility based separation methods and apparatus
GB0708391D0 (en) * 2007-05-01 2007-06-06 Smiths Detection Watford Ltd Detection and spectrometers
GB0718468D0 (en) 2007-09-21 2007-10-31 Micromass Ltd Mass spectrometer
US7888635B2 (en) 2008-05-30 2011-02-15 Battelle Memorial Institute Ion funnel ion trap and process
DE112008003955B4 (en) 2008-07-28 2018-02-08 Leco Corp. Ion guide, use of such an ion guide, interface, pulsed ion converter for the ion guide and methods for ion manipulation
US7838826B1 (en) 2008-08-07 2010-11-23 Bruker Daltonics, Inc. Apparatus and method for parallel flow ion mobility spectrometry combined with mass spectrometry
EP2237307B1 (en) * 2009-03-30 2014-05-14 Vidal de Miguel, Guillermo Method and apparatus to produce steady beams of mobility selected ions via time-dependent electric fields
US9093254B2 (en) * 2009-04-14 2015-07-28 Northeastern University Rapid gas-phase isotopic labeling for enhanced detection of protein conformations
DE112012004563T5 (en) * 2011-11-02 2014-08-21 Leco Corporation Ion-mobility spectrometer
GB2499587B (en) 2012-02-21 2016-06-01 Thermo Fisher Scient (Bremen) Gmbh Apparatus and methods for ion mobility spectrometry
US9653271B2 (en) * 2012-06-07 2017-05-16 Waters Technologies Corporation Methods and apparatus for performing mass spectrometry
US8835839B1 (en) 2013-04-08 2014-09-16 Battelle Memorial Institute Ion manipulation device
CN104112642B (en) * 2013-04-18 2017-05-24 岛津分析技术研发（上海）有限公司 Ion guide device and ion guide method
US9063086B1 (en) * 2014-02-12 2015-06-23 Battelle Memorial Institute Method and apparatus for compressing ions
GB201410247D0 (en) 2014-06-10 2014-07-23 Micromass Ltd Separation for space charge reduction
US9147565B1 (en) * 2014-12-30 2015-09-29 Morpho Detection, Llc Ion mobility spectrometer and method of using the same
US9304106B1 (en) * 2015-02-05 2016-04-05 Bruker Daltonik Gmbh High duty cycle trapping ion mobility spectrometer
CN106373854B (en) * 2015-07-23 2018-12-21 株式会社岛津制作所 A kind of ion guide device
US10018592B2 (en) 2016-05-17 2018-07-10 Battelle Memorial Institute Method and apparatus for spatial compression and increased mobility resolution of ions

Also Published As

Publication number Publication date
CN113049666B (en) 2024-06-18
US20170336355A1 (en) 2017-11-23
WO2017200695A1 (en) 2017-11-23
US10018592B2 (en) 2018-07-10
JP6677826B2 (en) 2020-04-08
JP7171638B2 (en) 2022-11-15
CN109414651B (en) 2021-05-11
CA3024420C (en) 2023-06-13
US10976283B2 (en) 2021-04-13
AU2017267392B2 (en) 2019-12-05
AU2020201199A1 (en) 2020-03-05
SG11201810264TA (en) 2018-12-28
CN109414651A (en) 2019-03-01
CA3024420A1 (en) 2017-11-23
EP3458181A4 (en) 2020-05-13
AU2017267392A1 (en) 2018-12-06
SG10202100140PA (en) 2021-02-25
JP2019519766A (en) 2019-07-11
EP3458181A1 (en) 2019-03-27
AU2020201199B2 (en) 2021-09-09
JP2020109415A (en) 2020-07-16
US20200200708A1 (en) 2020-06-25
US20190056352A1 (en) 2019-02-21
CN113049666A (en) 2021-06-29
US10466202B2 (en) 2019-11-05

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