SG11201809456UA - Interferon beta antibodies and uses thereof - Google Patents

Interferon beta antibodies and uses thereof

Info

Publication number
SG11201809456UA
SG11201809456UA SG11201809456UA SG11201809456UA SG11201809456UA SG 11201809456U A SG11201809456U A SG 11201809456UA SG 11201809456U A SG11201809456U A SG 11201809456UA SG 11201809456U A SG11201809456U A SG 11201809456UA SG 11201809456U A SG11201809456U A SG 11201809456UA
Authority
SG
Singapore
Prior art keywords
international
avenue
street
antibodies
boston
Prior art date
Application number
SG11201809456UA
Inventor
Stefano Gulla
Christine Huard
Janet Buhlmann
Juan Almagro
Sreekumar Kodangattil
Steven Greenberg
Edward Lavallie
Eric Bennett
Lidia Mosyak
James Hall
Anthony Coyle
Original Assignee
Pfizer
Brigham & Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Brigham & Womens Hospital Inc filed Critical Pfizer
Publication of SG11201809456UA publication Critical patent/SG11201809456UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 November 2017 (02.11.2017) ill Hu omits Holm o 101101MIR HMV 011 (10) International Publication Number WO 2017/189983 Al WIPO I PCT (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/24 (2006.01) (21) International Application Number: PCT/US2017/030089 (22) International Filing Date: 28 April 2017 (28.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/329,327 29 April 2016 (29.04.2016) US 62/339,709 20 May 2016 (20.05.2016) US 62/483,669 10 April 2017 (10.04.2017) US (71) Applicants: PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/US]; 75 Francis Street, Boston, MA 02115 (US). (72) Inventors: GULLA, Stefano, V.; 345 D. Street, Unit 13, Boston, MA 02127 (US). HUARD, Christine; 58 Cherry Street, #14, Somerville, MA 02144 (US). BUHLMANN, Janet, Elizabeth; 30 Gardner Rd., Apt. 4b, Brookline, MA 02445 (US). ALMAGRO, Juan, Carlos; 320 Con- cord Avenue, Cambridge, MA 02138 (US). KODANGAT- TIL, Sreekumar, R.; 517 Concord Avenue, Lexington, MA 02421 (US). GREENBERG, Steven, A.; 46 New- tonville Avenue, Newton, MA 02458 (US). LAVALLIE, Edward, Roland; 113 Ann Lee Road, Harvard, MA 01451 (US). BENNETT, Eric, M.; 45 Morningside Drive, Ar- lington, MA 02474 (US). MOSYAK, Lidia; 92 Littefield Road, Newton, MA 02469 (US). HALL, James, Perry; 19 Lanes End Road, Stow, MA 01775 (US). COYLE, Antho- ny, John; 12 Union Park, Boston, MA 02118 (US). (74) Agent: MANGASARIAN, Karen et al.; Ropes & Gray Llp, 1211 Avenue Of The Americas, New York, NY 10036 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 00 00 1-1 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) N (54) Title: INTERFERON BETA ANTIBODIES AND USES THEREOF 1-1 0 (57) : The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta \" (IFNp). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes. C
SG11201809456UA 2016-04-29 2017-04-28 Interferon beta antibodies and uses thereof SG11201809456UA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662329327P 2016-04-29 2016-04-29
US201662339709P 2016-05-20 2016-05-20
US201762483669P 2017-04-10 2017-04-10
PCT/US2017/030089 WO2017189983A1 (en) 2016-04-29 2017-04-28 Interferon beta antibodies and uses thereof

Publications (1)

Publication Number Publication Date
SG11201809456UA true SG11201809456UA (en) 2018-11-29

Family

ID=59215947

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201809456UA SG11201809456UA (en) 2016-04-29 2017-04-28 Interferon beta antibodies and uses thereof

Country Status (29)

Country Link
US (3) US10829553B2 (en)
EP (2) EP4273165A3 (en)
JP (2) JP6799076B2 (en)
KR (1) KR102527840B1 (en)
CN (1) CN109069606B (en)
AU (1) AU2017258492B2 (en)
BR (1) BR112018072118A2 (en)
CA (1) CA2965652A1 (en)
CO (1) CO2018012497A2 (en)
DK (1) DK3448419T5 (en)
ES (1) ES2950288T3 (en)
FI (1) FI3448419T3 (en)
HR (1) HRP20230605T1 (en)
HU (1) HUE063621T2 (en)
IL (1) IL262244B2 (en)
MX (1) MX2018013222A (en)
MY (1) MY194084A (en)
NZ (1) NZ747225A (en)
PE (1) PE20190371A1 (en)
PH (1) PH12018502275A1 (en)
PL (1) PL3448419T3 (en)
PT (1) PT3448419T (en)
RU (1) RU2750454C2 (en)
SA (1) SA518400327B1 (en)
SG (1) SG11201809456UA (en)
SI (1) SI3448419T1 (en)
TW (1) TWI776808B (en)
WO (1) WO2017189983A1 (en)
ZA (1) ZA201806682B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201809456UA (en) 2016-04-29 2018-11-29 Pfizer Interferon beta antibodies and uses thereof
EP4410378A3 (en) 2016-07-01 2024-10-09 Resolve Therapeutics, LLC Optimized binuclease fusions and methods
JP7374091B2 (en) 2017-08-22 2023-11-06 サナバイオ, エルエルシー Soluble interferon receptors and their uses
EP3784699A4 (en) 2018-04-25 2022-04-13 Prometheus Biosciences, Inc. Optimized anti-tl1a antibodies
CN115925950A (en) * 2019-01-31 2023-04-07 广东旋玉健康生物科技有限公司 Novel anti-IFNAR 1 antibodies
KR20220103721A (en) 2019-10-24 2022-07-22 프로메테우스 바이오사이언시즈, 인크. Humanized Antibodies to TNF-Like Ligand 1A (TL1A) and Uses Thereof
CN114733455B (en) * 2022-04-15 2023-02-14 北京田园奥瑞生物科技有限公司 Method for rapidly parting mammal sperms by utilizing biologically modified beta-cyclodextrin nano magnetic particles
TW202426493A (en) * 2022-09-22 2024-07-01 美商輝瑞大藥廠 METHODS OF TREATMENT WITH IFNß ANTIBODIES

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US6682896B1 (en) * 1988-10-14 2004-01-27 Schering Aktiengesellschaft Peptides representing epitopic sites on r-IFN-β, antibodies thereto and uses thereof
WO1990003982A1 (en) * 1988-10-14 1990-04-19 Triton Biosciences, Inc. Peptides representing epitopic sites on r-ifn-beta, antibodies thereto, and uses thereof
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL108584A (en) * 1994-02-07 2008-03-20 Yeda Res & Dev Cloning of interferon -alpha/beta binding protein
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US7771951B2 (en) 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
KR100708398B1 (en) 2002-03-22 2007-04-18 (주) 에이프로젠 Humanized antibody and process for preparing same
EP1575517B1 (en) 2002-12-24 2012-04-11 Rinat Neuroscience Corp. Anti-ngf antibodies and methods using same
CN103596983B (en) * 2011-04-07 2016-10-26 霍夫曼-拉罗奇有限公司 Anti-FGFR4 antibody and using method
CN102898521A (en) * 2011-07-26 2013-01-30 上海市免疫学研究所 Anti-beta-interferon monoclonal antibody and its application
US10647756B2 (en) 2015-05-18 2020-05-12 Pfizer Inc. Humanized antibodies
KR20180020296A (en) * 2015-06-26 2018-02-27 바이오버라티브 유에스에이 인코포레이티드 How to treat autoimmune and allogeneic immune disorders
SG11201809456UA (en) 2016-04-29 2018-11-29 Pfizer Interferon beta antibodies and uses thereof

Also Published As

Publication number Publication date
EP3448419B1 (en) 2023-06-07
US11858986B2 (en) 2024-01-02
SA518400327B1 (en) 2022-12-03
TW201739764A (en) 2017-11-16
RU2018141839A (en) 2020-05-29
JP2021040642A (en) 2021-03-18
CA2965652A1 (en) 2017-10-29
IL262244B1 (en) 2023-09-01
CO2018012497A2 (en) 2018-12-14
IL262244A (en) 2018-11-29
DK3448419T3 (en) 2023-06-26
EP4273165A3 (en) 2023-12-20
ES2950288T3 (en) 2023-10-06
TWI776808B (en) 2022-09-11
US20210163588A1 (en) 2021-06-03
SI3448419T1 (en) 2023-10-30
PL3448419T3 (en) 2023-09-04
CN109069606B (en) 2022-07-01
EP4273165A2 (en) 2023-11-08
US20170313769A1 (en) 2017-11-02
EP3448419A1 (en) 2019-03-06
JP7102489B2 (en) 2022-07-19
PH12018502275A1 (en) 2019-09-09
AU2017258492A1 (en) 2018-10-25
JP2019516366A (en) 2019-06-20
US10829553B2 (en) 2020-11-10
NZ747225A (en) 2022-07-29
HUE063621T2 (en) 2024-01-28
PE20190371A1 (en) 2019-03-08
RU2750454C2 (en) 2021-06-28
CN109069606A (en) 2018-12-21
MY194084A (en) 2022-11-11
US20240174742A1 (en) 2024-05-30
HRP20230605T1 (en) 2023-09-29
FI3448419T3 (en) 2023-08-02
MX2018013222A (en) 2019-04-22
ZA201806682B (en) 2022-05-25
AU2017258492B2 (en) 2023-12-07
DK3448419T5 (en) 2024-09-09
WO2017189983A1 (en) 2017-11-02
KR102527840B1 (en) 2023-05-03
RU2018141839A3 (en) 2020-10-16
JP6799076B2 (en) 2020-12-09
KR20190003625A (en) 2019-01-09
IL262244B2 (en) 2024-01-01
PT3448419T (en) 2023-07-26
BR112018072118A2 (en) 2019-03-19

Similar Documents

Publication Publication Date Title
SG11201809456UA (en) Interferon beta antibodies and uses thereof
SG11201808693WA (en) Anti-il-33 antibodies, compositions, methods and uses thereof
SG11201805709RA (en) Anti-pro/latent myostatin antibodies and methods of use thereof
SG11201909941QA (en) Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof
SG11201806496SA (en) Antigen binding proteins that bind pd-l1
SG11201908740VA (en) Sustained release delivery systems comprising traceless linkers
SG11201805579SA (en) Recombinant igg fc multimers
SG11201803679TA (en) Antibodies and antibody fragments for site-specific conjugation
SG11201811193TA (en) Anti-b7-h3 antibodies and antibody drug conjugates
SG11201902938TA (en) Compounds, devices, and uses thereof
SG11201809082WA (en) Nlrp3 modulators
SG11201900154VA (en) Compounds, compositions, and methods for the treatment of disease
SG11201810970WA (en) Anti-egfr antibody drug conjugates
SG11201809764XA (en) Humanized anti-il-1r3 antibodies
SG11201907673YA (en) Pharmaceutical compositions for combination therapy
SG11201906853QA (en) Anti-rsv monoclonal antibody formulation
SG11201907889YA (en) Glycan-interacting compounds and methods of use
SG11201803676PA (en) Site specific her2 antibody drug conjugates
SG11201408228QA (en) Dual receptor antagonistic antigen-binding proteins and uses thereof
SG11201807809XA (en) A transient commensal microorganism for improving gut health
SG11201809499UA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201408318RA (en) Compositions and methods for transmucosal absorption
SG11201908092RA (en) Anti-tigit antigen-binding proteins and methods of use thereof
SG11201906961UA (en) Polypeptide variants and uses thereof
SG11201909466RA (en) Human anti-semaphorin 4d antibody