SG11201809396SA - A specific trifluoroethyl quinoline analogue for use in the treatment of apds - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 November 2017 (23.11.2017) WIPO I PCT omit IIl Hot 0 mu im iflo Hs (10) International Publication Number WO 2017/198590 Al (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/519 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/EP2017/061567 (22) International Filing Date: 15 May 2017 (15.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1608797.5 19 May 2016 (19.05.2016) GB (71) Applicant: UCB BIOPHARMA SPRL [BE/BE]; 60, Al- lee de la Recherche, 1070 Brussels (BE). (72) Inventors: ALLEN, Rodger Anthony; c/o IPD, UCB Cell- tech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). ARMSTRONG, Martin John; c/o IP Department, UCB Biopharma SPRL, 60, Allee de la Recherche, 1070 Brussels (BE). CAVAZZANA, Marina; Institut Imagine - INSERM U1163, Laboratoire de lympho-hematopoiese humaine, 24, Boulevard du Montparnasse, 75015 PARIS (FR). KRACK- ER, Sven; Institut Imagine - INSERM U1163, Laboratoire de lympho-hematopoiese humaine, 24, Boulevard du Mont- parnasse, 75015 Paris (FR). MCHALE, Duncan Philip; c/ o IPD, UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). PAYNE, Andrew Charles; c/o IPD, UCB Cell- tech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). (74) Agent: UCB INTELLECTUAL PROPERTY; c/o UCB Celltech, 208 Bath Road, Slough Berkshire SL1 3WE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1-1 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, O EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 00 1-1 KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) N (54) Title: A SPECIFIC TRIFLUOROETHYL QUINOLINE ANALOGUE FOR USE IN THE TREATMENT OF APDS 0 (57) : N- {(R)-1-[8-Chloro-2-(1-oxypyridin-3-y1)-quinolin-3-y1]-2,2,2-trifluoroethyll -pyrido[3,2-d]pyrimidin-4-ylamine is ef- \" fective in the treatment and/or prevention of activated phosphoinositide 3-kinase delta syndrome (APDS).