SG11201809315YA - Therapeutic sall4 peptide - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111 11111111 1 1111 11111 11111 111 11111 1 11 111 1111111111111 1111 1111111 1111 1111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/190032 A3 02 November 2017 (02.11.2017) WIP0 I PCT (51) International Patent Classification: SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 38/04 (2006.01) C07K 7/02 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 38/10 (2006.01) CO7K 7/04 (2006.01) A61K 38/17 (2006.01) CO7K 7/06 (2006.01) (84) Designated States (unless otherwise indicated, for every CO7K 7/00 (2006.01) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (21) International Application Number: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, PCT/US2017/030164 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 28 April 2017 (28.04.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Declarations under Rule 4.17: (30) Priority Data: — of inventorship (Rule 4.17(iv)) 62/329,010 28 April 2016 (28.04.2016) US Published: (71) Applicants: NATIONAL UNIVERSITY OF SINGA- — with international search report (Art. 21(3)) PORE [SG/SG]; 21 Lower Kent Ridge Road, Singa- — before the expiration of the time limit for amending the pore 119077 (SG). THE BRIGHAM AND WOMEN'S claims and to be republished in the event of receipt of _ HOSPITAL, INC. [US/US]; Harvard Medical School, amendments (Rule 48.2(h)) 75 Francis Street, Boston, MA 02115 (US). AGENCY — with sequence listing part of description (Rule 5.2(a)) = = FOR SCIENCE, TECHNOLOGY AND RESEARCH (88) Date of publication of the international search report: [SG/SG]; 1 Fusionopolis Way, #9-10 Connexis North Tow- er, Singapore 138632 (SG). 21 December 2017 (21.12.2017) _ = Inventors: LIU, Bee, Hui; C/o National University Of Sin- gapore, Cancer Science Institute Of Singapore, 21 Low- (72) — = er Kent Ridge Road, Singapore 119077 (SG). TENEN, Daniel, Geoffrey; C/o National University Of Singapore, Cancer Science Institute Of Singapore, 21 Lower Kent = Ridge Road, Singapore 119077 (SG). CHAI, Li; C/o The Brigham And Women's Hospital, Inc., Harvard Medical _ School, 75 Francis Street, Boston, MA 02115 (US). CHIA, = Cheng San, Brian; C/o Experimental Therapeutics Cen- tre, _ 31 Biopolis Way, #03-01 The Nanos, Singapore 138669 = (SG). POULSEN, Anders; C/o Experimental Therapeutics = Centre, 31 Biopolis Way, #03-01 The Nanos, Singapore = 138669 (SG). Agent: CARROLL, Alice, 0. et al.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Rd, P.O. Box 9133, (74) = = Concord, MA 01742-9133 (US). = Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = _ M N 0 en PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 0 0\ 1-1 (54) Title: THERAPEUTIC SALL4 PEPTIDE IN (57) : The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising 0 isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. \" Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation 0 of SALL4 are also provided.