SG11201809184VA - Crystal polymorphism of kcnq2-5 channel activator - Google Patents
Crystal polymorphism of kcnq2-5 channel activatorInfo
- Publication number
- SG11201809184VA SG11201809184VA SG11201809184VA SG11201809184VA SG11201809184VA SG 11201809184V A SG11201809184V A SG 11201809184VA SG 11201809184V A SG11201809184V A SG 11201809184VA SG 11201809184V A SG11201809184V A SG 11201809184VA SG 11201809184V A SG11201809184V A SG 11201809184VA
- Authority
- SG
- Singapore
- Prior art keywords
- crystal
- kcnq2
- polymorphism
- crystal polymorphism
- channel activator
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016086239 | 2016-04-22 | ||
| PCT/JP2017/016109 WO2017183725A1 (ja) | 2016-04-22 | 2017-04-21 | Ｋｃｎｑ２～５チャネル活性化剤の結晶多形 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201809184VA true SG11201809184VA (en) | 2018-11-29 |
Family
ID=60116201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201809184VA SG11201809184VA (en) | 2016-04-22 | 2017-04-21 | Crystal polymorphism of kcnq2-5 channel activator |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20190135755A1 (ja) |
| EP (1) | EP3447047A1 (ja) |
| JP (1) | JP6265313B1 (ja) |
| KR (1) | KR20180135448A (ja) |
| CN (1) | CN109071441A (ja) |
| AU (1) | AU2017254257A1 (ja) |
| BR (1) | BR112018071654A2 (ja) |
| CA (1) | CA3021624A1 (ja) |
| IL (1) | IL262439A (ja) |
| MX (1) | MX2018012898A (ja) |
| PH (1) | PH12018502228A1 (ja) |
| RU (1) | RU2018136892A (ja) |
| SG (1) | SG11201809184VA (ja) |
| WO (1) | WO2017183725A1 (ja) |
| ZA (1) | ZA201807006B (ja) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| WO2013156154A1 (en) * | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Substituted 6-amino-nicotinamides bearing an oh-containing group as kcnq2/3 modulators |
| BR112015012418A2 (pt) * | 2012-11-28 | 2017-07-11 | Gruenenthal Gmbh | carboxamidas específicas como moduladores de kcnq2/3 |
| RU2712163C2 (ru) * | 2014-10-24 | 2020-01-24 | Оно Фармасьютикал Ко., Лтд. | Активатор kcnq2-5 каналов |
-
2017
- 2017-04-21 KR KR1020187030081A patent/KR20180135448A/ko unknown
- 2017-04-21 US US16/095,370 patent/US20190135755A1/en not_active Abandoned
- 2017-04-21 SG SG11201809184VA patent/SG11201809184VA/en unknown
- 2017-04-21 EP EP17786062.4A patent/EP3447047A1/en not_active Withdrawn
- 2017-04-21 MX MX2018012898A patent/MX2018012898A/es unknown
- 2017-04-21 RU RU2018136892A patent/RU2018136892A/ru not_active Application Discontinuation
- 2017-04-21 WO PCT/JP2017/016109 patent/WO2017183725A1/ja active Application Filing
- 2017-04-21 JP JP2017546923A patent/JP6265313B1/ja not_active Expired - Fee Related
- 2017-04-21 CN CN201780025011.7A patent/CN109071441A/zh active Pending
- 2017-04-21 AU AU2017254257A patent/AU2017254257A1/en not_active Abandoned
- 2017-04-21 BR BR112018071654-5A patent/BR112018071654A2/pt not_active Application Discontinuation
- 2017-04-21 CA CA3021624A patent/CA3021624A1/en not_active Abandoned
-
2018
- 2018-10-17 IL IL262439A patent/IL262439A/en unknown
- 2018-10-18 PH PH12018502228A patent/PH12018502228A1/en unknown
- 2018-10-19 ZA ZA2018/07006A patent/ZA201807006B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3021624A1 (en) | 2017-10-26 |
| ZA201807006B (en) | 2019-07-31 |
| EP3447047A4 (en) | 2019-02-27 |
| IL262439A (en) | 2018-12-31 |
| CN109071441A (zh) | 2018-12-21 |
| PH12018502228A1 (en) | 2019-07-08 |
| JP6265313B1 (ja) | 2018-01-24 |
| US20190135755A1 (en) | 2019-05-09 |
| AU2017254257A1 (en) | 2018-11-15 |
| EP3447047A1 (en) | 2019-02-27 |
| MX2018012898A (es) | 2019-01-30 |
| BR112018071654A2 (pt) | 2019-02-19 |
| WO2017183725A1 (ja) | 2017-10-26 |
| RU2018136892A (ru) | 2020-05-22 |
| JPWO2017183725A1 (ja) | 2018-04-26 |
| KR20180135448A (ko) | 2018-12-20 |
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