SG11201808169RA - Medical delivery device with axially expandable drive member - Google Patents

Medical delivery device with axially expandable drive member

Info

Publication number
SG11201808169RA
SG11201808169RA SG11201808169RA SG11201808169RA SG11201808169RA SG 11201808169R A SG11201808169R A SG 11201808169RA SG 11201808169R A SG11201808169R A SG 11201808169RA SG 11201808169R A SG11201808169R A SG 11201808169RA SG 11201808169R A SG11201808169R A SG 11201808169RA
Authority
SG
Singapore
Prior art keywords
ribbon
drive
international
indiana
indianapolis
Prior art date
Application number
SG11201808169RA
Inventor
Jared Alden Judson
Timothy Lee Moulton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SG11201808169RA publication Critical patent/SG11201808169RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization IIIM141101110101011111 HO 11111011101111011101101 100 HIM III International Bureau ... ..... ..Yi j ..... ...,/ (10) International Publication Number (43) International Publication Date WO 2017/165154 Al 28 September 2017 (28.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agents: EBERSOLE, Ted et al.; ELI LILLY AND COM- A61M 5/315 (2006.01) A61111 5/24 (2006.01) PANY, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (21) International Application Number: PCT/US2017/022259 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 14 March 2017 (14.03.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/310,961 21 March 2016 (21.03.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicant: ELI LILLY AND COMPANY [US/US]; TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Lilly Corporate Center, Indianapolis, Indiana 46285 (US). ZA, ZM, ZW. (72) Inventors: JUDSON, Jared Alden; c/o ELI LILLY AND (84) Designated States (unless otherwise indicated, for every COMPANY, P.O. Box 6288, Indianapolis, Indiana 46206- kind of regional protection available): ARIPO (BW, GH, 6288 (US). MOULTON, Timothy Lee; c/o ELI LILLY GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, AND COMPANY, P.O. Box 6288, Indianapolis, Indiana TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 46206-6288 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [Continued on next page] = (54) Title: MEDICAL - = _ = 34 = = — = DELIVERY = DEVICE WITH AXIALLY EXPANDABLE DRIVE MEMBER (57) : A medical delivery device for advancing a pis- ton in a medicament container to expel a medicament. A sup - port structure supports the container and a drive assembly that advances the piston. The drive assembly includes a drive rib- bon that can be retracted and extended. The retracted ribbon defines a spiral and the extended ribbon defines a helix. The drive ribbon is incrementally moveable between the retracted 40 spiral configuration and extended helical configuration. A mechanical drive rotates the drive ribbon to selectively extend and retract the ribbon. A thrust member having a helical ramp = 116 ( = 118 _ _ 120 . !tri0 0 1 ( [1 ' 4111110,%-j II 11 I engages a proximal edge of the drive ribbon where it trans - 1 1 78 itions between a spiral and helix. A bearing member at the il y distal end of the drive ribbon exerts an axial force on the pis ton when the ribbon is extended. 78 - 122 • ' 118 38 114 _ 122 = 11 .4 II II tr 11 II 1 78 iv kr) Ili 88 Il kr) 91 1-1 Fig. 15 IN 1-1 © el 0 WO 2017/165154 Al MIDEDIMOMOIDIONOIDEMOMOHEMMONIMMEMOIMIE LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — as to the applicant's entitlement to claim the priority of SM, TR), OAPI (BF, BJ, CF, GW, KM, ML, MR, NE, SN, CG, CI, TD, TG). CM, GA, GN, GQ, the earlier application (Rule 4.17(iii)) Published: Declarations under Rule 4.17: — as to applicant's entitlement a patent (Rule 4.17(ii)) to apply for and be granted with international 21(3)) search report (Art.
SG11201808169RA 2016-03-21 2017-03-14 Medical delivery device with axially expandable drive member SG11201808169RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662310961P 2016-03-21 2016-03-21
PCT/US2017/022259 WO2017165154A1 (en) 2016-03-21 2017-03-14 Medical delivery device with axially expandable drive member

Publications (1)

Publication Number Publication Date
SG11201808169RA true SG11201808169RA (en) 2018-10-30

Family

ID=58428383

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808169RA SG11201808169RA (en) 2016-03-21 2017-03-14 Medical delivery device with axially expandable drive member

Country Status (27)

Country Link
US (3) US10898652B2 (en)
EP (3) EP3730173B1 (en)
JP (4) JP6694527B2 (en)
KR (1) KR102234682B1 (en)
CN (2) CN108778378B (en)
AU (2) AU2017237899B2 (en)
CA (1) CA3018068C (en)
CY (1) CY1123559T1 (en)
DK (2) DK3432948T3 (en)
EA (1) EA035398B1 (en)
ES (1) ES2820831T3 (en)
FI (1) FI3730173T3 (en)
HK (1) HK1259416A1 (en)
HR (1) HRP20201514T1 (en)
HU (1) HUE051554T2 (en)
IL (1) IL261755B (en)
LT (2) LT3730173T (en)
MA (1) MA43750B1 (en)
MD (1) MD3432948T2 (en)
MX (1) MX2018011456A (en)
PL (2) PL3432948T3 (en)
PT (2) PT3432948T (en)
RS (2) RS60905B1 (en)
SA (1) SA518400054B1 (en)
SG (1) SG11201808169RA (en)
SI (2) SI3730173T1 (en)
WO (1) WO2017165154A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018011456A (en) * 2016-03-21 2019-01-10 Lilly Co Eli Medical delivery device with axially expandable drive member.
JP1631211S (en) * 2017-11-06 2019-05-13
CA3083278A1 (en) * 2017-12-08 2019-06-13 Eli Lilly And Company Medical delivery device with axially expandable drive ribbon
KR20230126438A (en) * 2022-02-23 2023-08-30 주식회사 페라자 Vascular intervention device and drum assembly for vascular intervention device
WO2023249928A1 (en) 2022-06-22 2023-12-28 Eli Lilly And Company Fluid delivery cassette

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4875660A (en) 1988-02-02 1989-10-24 Pierre Gagnon Push actuator
JPH0451966A (en) 1990-06-19 1992-02-20 Toichi Ishikawa Medical fluid continuous injector
US5478316A (en) * 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
DE19717107B4 (en) 1997-04-23 2005-06-23 Disetronic Licensing Ag System of container and drive device for a piston, which is held in the container containing a drug fluid
EP1171374B1 (en) 1999-04-16 2003-08-27 Gestion Laforest Inc. Multiple balls supported push actuator
TW523415B (en) 2000-03-24 2003-03-11 Novo Nordisk As A flexible piston rod
US6537251B2 (en) * 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
US7073505B2 (en) 2002-09-06 2006-07-11 Apneon, Inc. Systems and methods for moving and/or restraining tissue in the oral cavity
CN1732027A (en) 2002-12-23 2006-02-08 M2医药有限公司 Flexible piston rod
GB0304822D0 (en) * 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
CN100531813C (en) * 2003-08-12 2009-08-26 伊莱利利公司 Medication dispensing apparatus with triple screw threads for mechanical advantage
UA89950C2 (en) 2004-02-18 2010-03-25 Арес Трейдинг С.А. Hand-held injection device
US7213796B2 (en) 2004-07-01 2007-05-08 Gestion Laforest Inc. Linear actuator with releasably interlocking bands
WO2006066963A1 (en) 2004-12-23 2006-06-29 Novo Nordisk A/S Segmented piston rod
DK1728529T3 (en) * 2005-06-01 2008-11-24 Shl Group Ab Device for drug delivery
EP1923084A1 (en) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Dosing and drive mechanism for drug delivery device
JP5324656B2 (en) * 2008-10-01 2013-10-23 エス・ホー・エル・グループ・アクチボラゲット Drug delivery device driven by spiral spring
EP2349140B1 (en) 2008-11-25 2016-06-22 Lumen Devices LLC Medical device for a patient
EP2196232A1 (en) * 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Drive mechanism for a medication delivery device and medication delivery device
NZ594318A (en) 2009-02-05 2012-12-21 Sanofi Aventis Deutschland Medicament delivery devices with a telescopic piston rod assembly
EP2393534B1 (en) 2009-02-05 2015-03-25 Sanofi-Aventis Deutschland GmbH Medicament delivery devices
CA2698027C (en) * 2009-03-31 2017-07-11 Animas Corporation Novel drive system for use with an insulin delivery device
EP2512564A4 (en) * 2009-12-14 2017-11-01 SHL Group AB Medicament delivery device
CA2799784C (en) 2010-06-09 2018-08-28 Valeritas, Inc. Fluid delivery device needle retraction mechanisms, cartridges and expandable hydraulic fluid seals
CN102971237B (en) * 2010-07-12 2015-09-16 莱特拉姆有限责任公司 Force to drive screw type conveyer and band
EP2698180A1 (en) * 2012-08-15 2014-02-19 Sanofi-Aventis Deutschland GmbH Autoinjector
US20140214001A1 (en) 2013-01-31 2014-07-31 Alpimed Sarl Fluid dispensing device
US9849260B2 (en) 2013-03-06 2017-12-26 Jed Eric Black Adhesive devices and methods for improving breathing and/or sleep using such devices
CN105102018B (en) * 2013-04-10 2019-07-05 赛诺菲 The driving mechanism of medicine delivery device
WO2014166904A1 (en) * 2013-04-10 2014-10-16 Sanofi Hand-held drug injection device and dose setting limiter mechanism therefor
WO2015007811A1 (en) * 2013-07-17 2015-01-22 Sanofi Drive mechanism
AR102195A1 (en) 2014-10-09 2017-02-08 Sanofi Sa ACCOMMODATION AND DEVICE FOR ADMINISTRATION OF DRUGS WITH THE SAME
US10406282B2 (en) 2015-12-10 2019-09-10 Repro-Med Systems, Inc. System and method for a syringe micro pump with volute spring
JOP20170042B1 (en) 2016-02-12 2022-09-15 Amgen Inc Drug Delivery Device, Method of Manufacture and Method of Use
MX2018011456A (en) * 2016-03-21 2019-01-10 Lilly Co Eli Medical delivery device with axially expandable drive member.

Also Published As

Publication number Publication date
AU2020201233B2 (en) 2022-07-28
US20190046733A1 (en) 2019-02-14
CN113069642B (en) 2023-08-29
SI3432948T1 (en) 2020-11-30
KR102234682B1 (en) 2021-04-02
JP2020121161A (en) 2020-08-13
IL261755A (en) 2018-10-31
EP4279103A2 (en) 2023-11-22
MX2018011456A (en) 2019-01-10
US20210100958A1 (en) 2021-04-08
PT3432948T (en) 2020-09-24
AU2020201233A1 (en) 2020-03-12
EP3730173A1 (en) 2020-10-28
PL3730173T3 (en) 2024-04-02
ES2820831T3 (en) 2021-04-22
LT3432948T (en) 2020-10-12
MA43750B1 (en) 2020-11-30
CA3018068C (en) 2021-02-09
EP4279103A3 (en) 2024-01-24
RS65082B1 (en) 2024-02-29
AU2017237899A1 (en) 2018-08-30
JP7268126B2 (en) 2023-05-02
PL3432948T3 (en) 2021-01-25
BR112018067428A2 (en) 2019-01-22
WO2017165154A1 (en) 2017-09-28
SI3730173T1 (en) 2024-02-29
JP2022046620A (en) 2022-03-23
EP3730173B1 (en) 2023-11-08
EP3432948A1 (en) 2019-01-30
RS60905B1 (en) 2020-11-30
MD3432948T2 (en) 2020-12-31
JP6694527B2 (en) 2020-05-13
CA3018068A1 (en) 2017-09-28
KR20180118700A (en) 2018-10-31
US11642467B2 (en) 2023-05-09
JP2019506282A (en) 2019-03-07
EA201891728A1 (en) 2019-02-28
SA518400054B1 (en) 2021-03-29
IL261755B (en) 2021-12-01
JP2023100714A (en) 2023-07-19
EP3432948B1 (en) 2020-07-29
DK3730173T3 (en) 2024-01-08
CN113069642A (en) 2021-07-06
HK1259416A1 (en) 2019-11-29
MA43750A (en) 2018-11-28
CN108778378A (en) 2018-11-09
CN108778378B (en) 2021-03-30
US20230256173A1 (en) 2023-08-17
HRP20201514T1 (en) 2020-12-11
JP7000492B2 (en) 2022-01-19
LT3730173T (en) 2023-12-27
AU2017237899B2 (en) 2019-11-21
CY1123559T1 (en) 2022-03-24
HUE051554T2 (en) 2021-03-01
PT3730173T (en) 2024-02-07
DK3432948T3 (en) 2020-09-28
EA035398B1 (en) 2020-06-08
US10898652B2 (en) 2021-01-26
FI3730173T3 (en) 2024-01-11

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