SG11201803913RA - Abuse resistant transdermal delivery devices and compositions comprising an opioid agonist and a non-transdermally delivered n-oxide derivative of an opioid antagonist for the treatment of pain - Google Patents

Abstract

12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, -, Organization IIIM1411011101010111110101111 1010111111111110111001101011111110111011# International Bureau ... ...... .Y1 j ..... ...,/ (10) International Publication Number International Publication Date WO 2017/085502 Al 26 May 2017(26.05.2017) WIPO I PCT (51) (21) (22) (25) (26) (30) (71) (71) (72) (74) International Patent Classification: A61K 9/70 (2006.01) A61P A61K 31/485 (2006.01) International Application Number: International Filing Date: Filing Language: Publication Language: Priority Data: 1520390.4 19 November 2015 Applicant: EURO-CELTIQUE Jean Piret, L-2350 Luxembourg (LU). Applicant (for SD only): GORDON, C/O Marks & Clerk LLP, 62-68 Cambridgeshire CB2 1LA (GB). 18 November (81) Designated States (unless otherwise indicated, for every 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/GB2016/053600 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 2016 (18.11.2016) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (19.11.2015) GB (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, S.A. [LU/LU]; 1, me GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Kirsteen [GB/GB]; DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Hills Road, Cambridge LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Mundipharma Research GW, KM, ML, MR, NE, SN, TD, TG). Park, Milton Road, Cam- (GB). Published: with international search report (Art. 21(3)) LLP; 62-68 Hills Road, 1LA (GB). Inventor: WHITELOCK, Steve; Limited, 191 Cambridge Science bridge Cambridgeshire CB4 OGW Agent: MARKS & CLERK Cambridge Cambridgeshire CB2 = Title: ABUSE RESISTANT TRANSDERMAL NON-TRANSDERMALLY DELIVERED 32 ----)2i : The present invention provides a transdermal delivery device comprising comprises a N-oxide derivative (54) N composition DELIVERY DEVICES AND COMPOSITIONS N-OXIDE DERIVATIVE OF AN OPIOID ANTAGONIST 34 32 31 33 COMPRISING AN OPIOID AGONIST AND FOR THE TREATMENT OF PAIN 30 / 35 a pharmaceutical composition, wherein said an opioid agonist or salt thereof. - A V' eek( 1) 1 V i)' az, co 'D V (> el ° a V J . . g a ',' a 1 7 a ‘) to O ci- (.•_, 0 el. 0 1-1 ei © ir) ir) ot 0 IN Il 0 (57) C ,////// Z/Z/Z/Z. - \ Figure 4 of an opioid antagonist, or a salt thereof, and