SG11201705350XA - Methods for tagging dna-encoded libraries - Google Patents

Methods for tagging dna-encoded libraries

Info

Publication number
SG11201705350XA
SG11201705350XA SG11201705350XA SG11201705350XA SG11201705350XA SG 11201705350X A SG11201705350X A SG 11201705350XA SG 11201705350X A SG11201705350X A SG 11201705350XA SG 11201705350X A SG11201705350X A SG 11201705350XA SG 11201705350X A SG11201705350X A SG 11201705350XA
Authority
SG
Singapore
Prior art keywords
methods
encoded libraries
tagging dna
tagging
dna
Prior art date
Application number
SG11201705350XA
Other languages
English (en)
Inventor
Anthony D Keefe
Alexander Litovchick
Matthew Clark
Richard W Wagner
Original Assignee
X-Chem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X-Chem Inc filed Critical X-Chem Inc
Publication of SG11201705350XA publication Critical patent/SG11201705350XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201705350XA 2014-12-30 2015-12-28 Methods for tagging dna-encoded libraries SG11201705350XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098037P 2014-12-30 2014-12-30
PCT/US2015/067667 WO2016109423A1 (en) 2014-12-30 2015-12-28 Methods for tagging dna-encoded libraries

Publications (1)

Publication Number Publication Date
SG11201705350XA true SG11201705350XA (en) 2017-08-30

Family

ID=56284965

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201705350XA SG11201705350XA (en) 2014-12-30 2015-12-28 Methods for tagging dna-encoded libraries

Country Status (15)

Country Link
US (1) US20180002688A1 (ja)
EP (1) EP3240795A4 (ja)
JP (1) JP6864621B2 (ja)
KR (1) KR20170094445A (ja)
CN (1) CN107428795B (ja)
AU (2) AU2015374309B2 (ja)
BR (1) BR112017013904A2 (ja)
CA (1) CA2972275A1 (ja)
EA (1) EA201791312A1 (ja)
HK (1) HK1246301A1 (ja)
IL (2) IL253154B (ja)
MA (1) MA41298A (ja)
MX (1) MX2017008772A (ja)
SG (1) SG11201705350XA (ja)
WO (1) WO2016109423A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115820806A (zh) 2016-06-16 2023-03-21 哈斯达克科学公司 寡核苷酸指导和记录的编码探针分子的组合合成
WO2018195134A1 (en) * 2017-04-18 2018-10-25 X-Chem, Inc. Methods for identifying compounds
EP3619340A4 (en) 2017-05-02 2021-01-20 Haystack Sciences Corporation MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF
US11384376B2 (en) * 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
WO2020001560A1 (zh) * 2018-06-29 2020-01-02 成都先导药物开发股份有限公司 一种合成dna编码化合物中的反应监测方法
CN109468310B (zh) * 2018-10-25 2020-12-01 深圳劲宇生物科技有限公司 Dna编码碎片分子库的合成方法和连接基团的筛选方法
CN113677836A (zh) * 2019-03-14 2021-11-19 海斯塔克科学公司 用于处理或分析寡核苷酸编码分子的方法和系统
CN112941634B (zh) * 2019-12-10 2023-09-26 成都先导药物开发股份有限公司 通过dna编码化合物库筛选同时结合多个生物靶标的化合物的方法
CA3197283A1 (en) * 2020-11-06 2022-05-12 The University Of Chicago Hairpin oligonucleotides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038726A1 (en) * 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
ES2640279T3 (es) * 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
MXPA06006863A (es) * 2003-12-17 2006-09-04 Praecis Pharm Inc Metodo para la sintesis de bibliotecas codificadas.
US8846883B2 (en) * 2011-08-16 2014-09-30 University Of Southhampton Oligonucleotide ligation
US10865409B2 (en) * 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
AU2013289993B2 (en) * 2012-07-13 2018-05-10 X-Chem, Inc. DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases

Also Published As

Publication number Publication date
US20180002688A1 (en) 2018-01-04
EA201791312A1 (ru) 2017-10-31
AU2020230345A1 (en) 2020-10-01
KR20170094445A (ko) 2017-08-17
EP3240795A1 (en) 2017-11-08
CA2972275A1 (en) 2016-07-07
CN107428795A (zh) 2017-12-01
JP6864621B2 (ja) 2021-04-28
AU2015374309A1 (en) 2017-07-27
WO2016109423A1 (en) 2016-07-07
CN107428795B (zh) 2021-06-18
IL253154B (en) 2020-10-29
HK1246301A1 (zh) 2018-09-07
IL253154A0 (en) 2017-08-31
BR112017013904A2 (pt) 2018-01-02
AU2015374309B2 (en) 2020-06-11
WO2016109423A8 (en) 2017-07-20
JP2018501796A (ja) 2018-01-25
MA41298A (fr) 2017-11-07
EP3240795A4 (en) 2019-02-13
MX2017008772A (es) 2018-03-15
IL278117A (en) 2020-11-30

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