SG11201704106VA - Envenomation therapies and related pharmaceutical compositions, systems and kits - Google Patents

Envenomation therapies and related pharmaceutical compositions, systems and kits

Info

Publication number
SG11201704106VA
SG11201704106VA SG11201704106VA SG11201704106VA SG11201704106VA SG 11201704106V A SG11201704106V A SG 11201704106VA SG 11201704106V A SG11201704106V A SG 11201704106VA SG 11201704106V A SG11201704106V A SG 11201704106VA SG 11201704106V A SG11201704106V A SG 11201704106VA
Authority
SG
Singapore
Prior art keywords
envenomation
therapies
kits
systems
pharmaceutical compositions
Prior art date
Application number
SG11201704106VA
Other languages
English (en)
Inventor
Matthew R Lewin
Original Assignee
Ophirex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ophirex Inc filed Critical Ophirex Inc
Publication of SG11201704106VA publication Critical patent/SG11201704106VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201704106VA 2014-11-21 2015-11-20 Envenomation therapies and related pharmaceutical compositions, systems and kits SG11201704106VA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462082895P 2014-11-21 2014-11-21
US201562131441P 2015-03-11 2015-03-11
US201562243374P 2015-10-19 2015-10-19
PCT/US2015/061834 WO2016081826A2 (en) 2014-11-21 2015-11-20 Envenomation therapies and related pharmaceutical compositions, systems and kits

Publications (1)

Publication Number Publication Date
SG11201704106VA true SG11201704106VA (en) 2017-06-29

Family

ID=56014685

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201704106VA SG11201704106VA (en) 2014-11-21 2015-11-20 Envenomation therapies and related pharmaceutical compositions, systems and kits

Country Status (18)

Country Link
US (2) US11000506B2 (pt)
EP (1) EP3220902A4 (pt)
JP (1) JP6883515B2 (pt)
KR (1) KR20170086089A (pt)
CN (1) CN107249578B (pt)
AU (1) AU2015349774B2 (pt)
BR (1) BR112017010495B1 (pt)
CA (1) CA2968383C (pt)
CR (1) CR20170259A (pt)
EA (1) EA037262B1 (pt)
IL (1) IL252418B (pt)
MA (1) MA40998A (pt)
MX (1) MX2017006551A (pt)
MY (1) MY187053A (pt)
PH (1) PH12017500927A1 (pt)
SG (1) SG11201704106VA (pt)
TW (1) TWI745280B (pt)
WO (1) WO2016081826A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10786483B2 (en) * 2016-03-04 2020-09-29 Hk Pharma Tumescent contravenom drug delivery
IL307232A (en) 2016-04-29 2023-11-01 Ophirex Inc PLA2 and HMG-COA suppressors for the treatment of pathological diseases that cause hemolysis, brain edema and acute kidney injury
US20200009071A1 (en) * 2016-12-16 2020-01-09 The Regents Of The University Of California Neutralizing venomous biomacromolecules
CN110662548A (zh) * 2017-02-17 2020-01-07 卡姆瑞斯国际公司 通用抗毒液素
CN108703975A (zh) * 2018-08-30 2018-10-26 黄汝怡 一种治疗毒虫叮咬的涂抹剂
CN109260196A (zh) * 2018-11-08 2019-01-25 中国科学院海洋研究所 巴马司他作为制备水母皮炎药物的应用
EP4045026A4 (en) * 2019-10-15 2023-11-08 Ophirex, Inc. EARLY MANAGEMENT, MITIGATION AND PREVENTION OF SEPTICEMIA AND SEPTICEMIA-LIKE SYNDROMES, INCLUDING SYNDROMES OF ACUTE RESPIRATORY DISTRESS OF THE NEWBORN DUE TO INFECTION, INJURY OR IATROGENESIS
CN112494498A (zh) * 2020-12-11 2021-03-16 中国人民解放军海军军医大学 四环素在制备预防或缓解水母蜇伤药物中的应用
WO2022216953A1 (en) * 2021-04-08 2022-10-13 Believe In A Cure, Inc. Compounds for use in increasing foxg1 expression
US20230054792A1 (en) * 2021-05-14 2023-02-23 Liverpool School Of Tropical Medicine Methods and compositions for the treatment of snake bite
CN113817738B (zh) * 2021-10-20 2023-06-16 湖南科技学院 银杏长链非编码rna及其在银杏内酯生物合成中的应用
WO2023086343A1 (en) * 2021-11-09 2023-05-19 Ophirex, Inc. Compositions and dosage forms for topical and transdermal delivery of actives and methods of use
KR20230131139A (ko) 2022-03-04 2023-09-12 한국원자력의학원 다라플라딥 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 방사선 조사에 의한 피부질환 예방 또는 치료용 약학 조성물

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US5196193A (en) 1989-10-31 1993-03-23 Ophidian Pharmaceuticals, Inc. Antivenoms and methods for making antivenoms
CN1067054C (zh) 1994-04-01 2001-06-13 伊莱利利公司 1H-吲哚-3-乙醛酰胺sPLA2抑制剂
AUPP076797A0 (en) 1997-12-05 1998-01-08 Active (Pla) R&D Pty Ltd Phospholipase inhibitor
AU2003298514A1 (en) 2002-05-17 2004-05-04 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
US20030225031A1 (en) 2002-05-21 2003-12-04 Quay Steven C. Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid
US20040254146A1 (en) 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
DK1613297T3 (da) 2003-04-14 2007-09-24 Lohmann Therapie Syst Lts Terapeutisk plaster med polysiloxanmatrix indeholdende capsaicin
US20070093518A1 (en) 2003-09-19 2007-04-26 Wetherell Janet R Pharmaceutical compositions for the treatment of organophosphate poisoning
WO2005041960A2 (en) 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US20090012067A1 (en) 2005-02-14 2009-01-08 Luciano Rossetti Modulation of Hypothalamic Atp-Sensitive Potassium Channels
ES2413056T3 (es) 2005-10-12 2013-07-15 Advanced Accelerator Applications Antagonista del péptido receptor Alfavbeta3 selectivo para aplicaciones terapéuticas y de diagnóstico
EP2069377A4 (en) 2006-09-27 2009-11-11 Univ California METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS
US20090062369A1 (en) * 2007-08-31 2009-03-05 Joaquim Trias Use of secretory phospholipase a2 (spla2) inhibitors to decrease spla2 levels
WO2009047762A1 (en) * 2007-10-09 2009-04-16 Yeda Research And Development Co. Ltd Compositions and peptides for treatment of envenomation by pla2 containing venoms like bungarus multicinct venom
CN101977626A (zh) 2008-01-21 2011-02-16 德莫迪斯公司 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途
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US20130253060A1 (en) * 2011-09-21 2013-09-26 Harihara M. Mehendale Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS)
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US20140087003A1 (en) * 2012-09-21 2014-03-27 Ignacio Cisneros Method for treating venomous bites and stings

Also Published As

Publication number Publication date
BR112017010495B1 (pt) 2023-12-05
US20170354642A1 (en) 2017-12-14
EA037262B1 (ru) 2021-03-01
WO2016081826A3 (en) 2016-07-14
PH12017500927A1 (en) 2017-11-20
CR20170259A (es) 2017-10-02
EP3220902A2 (en) 2017-09-27
MA40998A (fr) 2017-09-26
AU2015349774B2 (en) 2020-07-02
CA2968383C (en) 2024-03-12
EA201791122A1 (ru) 2018-04-30
MX2017006551A (es) 2018-01-15
IL252418B (en) 2021-01-31
US20210260029A1 (en) 2021-08-26
TWI745280B (zh) 2021-11-11
CN107249578B (zh) 2021-01-26
CA2968383A1 (en) 2016-05-26
IL252418A0 (en) 2017-07-31
CN107249578A (zh) 2017-10-13
JP2017536372A (ja) 2017-12-07
MY187053A (en) 2021-08-27
US11000506B2 (en) 2021-05-11
AU2015349774A1 (en) 2017-06-01
EP3220902A4 (en) 2018-11-07
TW201632204A (zh) 2016-09-16
WO2016081826A2 (en) 2016-05-26
KR20170086089A (ko) 2017-07-25
JP6883515B2 (ja) 2021-06-09
BR112017010495A2 (pt) 2018-04-03

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