SG11201703950PA - Anti-pd-1 antibodies and methods of use thereof - Google Patents
Anti-pd-1 antibodies and methods of use thereofInfo
- Publication number
- SG11201703950PA SG11201703950PA SG11201703950PA SG11201703950PA SG11201703950PA SG 11201703950P A SG11201703950P A SG 11201703950PA SG 11201703950P A SG11201703950P A SG 11201703950PA SG 11201703950P A SG11201703950P A SG 11201703950PA SG 11201703950P A SG11201703950P A SG 11201703950PA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462089658P | 2014-12-09 | 2014-12-09 | |
US201562242750P | 2015-10-16 | 2015-10-16 | |
US201562251973P | 2015-11-06 | 2015-11-06 | |
PCT/IB2015/059268 WO2016092419A1 (en) | 2014-12-09 | 2015-12-02 | Anti-pd-1 antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201703950PA true SG11201703950PA (en) | 2017-06-29 |
Family
ID=54849669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201703950PA SG11201703950PA (en) | 2014-12-09 | 2015-12-02 | Anti-pd-1 antibodies and methods of use thereof |
Country Status (27)
Country | Link |
---|---|
US (4) | US10155037B2 (en) |
EP (2) | EP3230319B8 (en) |
JP (1) | JP6552621B2 (en) |
KR (1) | KR102012113B1 (en) |
CN (1) | CN107207593B (en) |
AU (2) | AU2015359003B2 (en) |
BR (1) | BR112017010762A2 (en) |
CA (1) | CA2914087A1 (en) |
CO (1) | CO2017005738A2 (en) |
DK (1) | DK3230319T3 (en) |
ES (1) | ES2929721T3 (en) |
HK (1) | HK1244492A1 (en) |
HR (1) | HRP20221226T1 (en) |
HU (1) | HUE060165T2 (en) |
IL (1) | IL252280B2 (en) |
MX (1) | MX2017007537A (en) |
MY (1) | MY193404A (en) |
NZ (1) | NZ731735A (en) |
PE (1) | PE20171180A1 (en) |
PH (1) | PH12017500994A1 (en) |
PL (1) | PL3230319T3 (en) |
PT (1) | PT3230319T (en) |
RU (1) | RU2701797C2 (en) |
SA (1) | SA517381676B1 (en) |
SG (1) | SG11201703950PA (en) |
TW (1) | TWI595006B (en) |
WO (1) | WO2016092419A1 (en) |
Families Citing this family (243)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011153514A2 (en) | 2010-06-03 | 2011-12-08 | Pharmacyclics, Inc. | The use of inhibitors of bruton's tyrosine kinase (btk) |
ES2671748T3 (en) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
JP6575950B2 (en) | 2012-07-24 | 2019-09-18 | ファーマサイクリックス エルエルシー | Mutations with resistance to Bruton tyrosine kinase (Btk) inhibitors |
WO2014079886A1 (en) | 2012-11-20 | 2014-05-30 | Sanofi | Anti-ceacam5 antibodies and uses thereof |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
RS59480B1 (en) | 2013-12-12 | 2019-12-31 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
EP3971209A1 (en) | 2014-02-04 | 2022-03-23 | Pfizer Inc. | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer |
US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
WO2015153514A1 (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
MA47849A (en) | 2014-05-28 | 2020-01-29 | Agenus Inc | ANTI-GITR ANTIBODIES AND THEIR METHODS OF USE |
TWI693232B (en) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
US9993551B2 (en) | 2014-09-13 | 2018-06-12 | Novartis Ag | Combination therapies of EGFR inhibitors |
TWI595006B (en) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | Anti-pd-1 antibodies and methods of use thereof |
EP3242940B1 (en) | 2015-01-09 | 2023-03-29 | Etubics Corporation | Methods and compositions for combination immunotherapy |
MA41414A (en) * | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | ICOS AGONIST BINDING PROTEINS |
WO2016137985A1 (en) | 2015-02-26 | 2016-09-01 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
MA41866A (en) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | SELF-ASSEMBLING MOLECULES FOR TARGETED DRUG DELIVERY |
EP3286213B1 (en) * | 2015-04-20 | 2021-08-04 | Etubics Corporation | Methods and compositions for combination immunotherapy |
EP3563684A1 (en) | 2015-05-06 | 2019-11-06 | Snipr Technologies Limited | Altering microbial populations & modifying microbiota |
SG11201708804WA (en) | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
TWI773646B (en) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | Lag-3-binding molecules and methods of use thereof |
MX2017016324A (en) | 2015-06-16 | 2018-03-02 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments. |
KR20180040138A (en) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of using them |
EP3322448A4 (en) | 2015-07-16 | 2019-03-06 | Bioxcel Therapeutics, Inc. | A novel approach for treatment of cancer using immunomodulation |
KR20180034588A (en) | 2015-07-30 | 2018-04-04 | 마크로제닉스, 인크. | PD-1-binding molecules and methods for their use |
EA201890630A1 (en) | 2015-09-01 | 2018-10-31 | Эйдженус Инк. | ANTIBODIES AGAINST PD-1 AND METHODS OF THEIR APPLICATION |
EA201890790A1 (en) | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | CONNECTING PD-1 PROTEINS AND METHODS OF THEIR APPLICATION |
KR102146319B1 (en) | 2015-10-02 | 2020-08-25 | 에프. 호프만-라 로슈 아게 | Bispecific antibodies specific for PD1 and TIM3 |
AU2016329251B2 (en) * | 2015-10-02 | 2023-02-02 | F. Hoffmann-La Roche Ag | Anti-PD1 antibodies and methods of use |
BR112018002570A2 (en) | 2015-10-02 | 2018-10-16 | Hoffmann La Roche | bispecific antigen binding molecule, bispecific antibody, polynucleotides, ox40-specific binding antibody, pharmaceutical composition and method for inhibiting tumor cell growth in an individual |
BR112018008904A2 (en) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | antibodies specifically binding to tim-3 and their uses |
CN108883173B (en) | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | Antibodies and methods of use thereof |
CR20180318A (en) | 2015-12-14 | 2018-09-19 | Macrogenics Inc | BISPECIFIC MOLECULES THAT HAVE IMMUNORREACTIVITY WITH PD-1 AND CTLA-4, AND METHODS OF USE OF THE SAME |
RU2018131123A (en) | 2016-02-17 | 2020-03-17 | Новартис Аг | ANTIBODIES TO TGF-BETA2 |
WO2017165125A1 (en) * | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Use of a pd-1 antagonist and an anti-ccr2 antibody in the treatment of cancer |
AR108516A1 (en) | 2016-05-18 | 2018-08-29 | Boehringer Ingelheim Int | ANTI-PD1 AND ANTI-LAG3 ANTIBODY MOLECULES FOR CANCER TREATMENT |
MX2018014387A (en) | 2016-05-27 | 2019-03-14 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof. |
GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
JP7185530B2 (en) | 2016-06-13 | 2022-12-07 | トルク セラピューティクス, インコーポレイテッド | Methods and compositions for promoting immune cell function |
TWI784957B (en) | 2016-06-20 | 2022-12-01 | 英商克馬伯有限公司 | Immunocytokines |
RU2656181C1 (en) * | 2016-07-13 | 2018-05-31 | Закрытое Акционерное Общество "Биокад" | Anti-pd-1 antibodies, method for their production, and method of application |
JP2019528251A (en) * | 2016-07-20 | 2019-10-10 | エスティーキューブ,インコーポレイテッド | Methods of treating and treating cancer using a combination of antibodies that bind to glycosylated PD-L1 |
WO2018027524A1 (en) | 2016-08-09 | 2018-02-15 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibody formulation |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
EP3512885B1 (en) * | 2016-09-16 | 2024-02-21 | Shanghai Henlius Biotech, Inc. | Anti-pd-1 antibodies |
CN109789206A (en) * | 2016-09-16 | 2019-05-21 | 生态有限公司 | The combination treatment of antibody and checkpoint inhibitor |
US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
CA3037407C (en) | 2016-09-21 | 2022-10-18 | Cstone Pharmaceuticals | The novel monoclonal antibodies to programmed death 1 (pd-1) |
AU2017339856A1 (en) | 2016-10-06 | 2019-05-23 | Merck Patent Gmbh | Dosing regimen of avelumab for the treatment of cancer |
TW202246349A (en) | 2016-10-11 | 2022-12-01 | 美商艾吉納斯公司 | Anti-lag-3 antibodies and methods of use thereof |
CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
US11359018B2 (en) | 2016-11-18 | 2022-06-14 | Symphogen A/S | Anti-PD-1 antibodies and compositions |
CN110248668B (en) * | 2016-12-15 | 2023-05-30 | 杜克大学 | Antibodies and methods for depleting regulatory B10 cells and combination with immune checkpoint inhibitors |
JP7122758B2 (en) * | 2016-12-23 | 2022-08-22 | アールイーエムディー バイオセラピューティクス,インコーポレイテッド | Immunotherapy using antibodies that bind programmed death-1 (PD-1) |
CN113480530A (en) | 2016-12-26 | 2021-10-08 | 阿里根公司 | Aromatic hydrocarbon receptor modulators |
EP3570870A1 (en) | 2017-01-20 | 2019-11-27 | Novartis AG | Combination therapy for the treatment of cancer |
WO2018134681A1 (en) | 2017-01-20 | 2018-07-26 | Sanofi | Anti-tgf-beta antibodies and their use |
TW202313678A (en) | 2017-01-20 | 2023-04-01 | 法商賽諾菲公司 | Anti-tgf-beta antibodies and their use |
AR110755A1 (en) | 2017-01-20 | 2019-05-02 | Genzyme Corp | BONE DIRECTED ANTIBODIES |
BR112019013238A2 (en) | 2017-01-20 | 2020-02-11 | Tayu Huaxia Biotech Medical Group Co., Ltd. | ANTI-PD-1 ANTIBODIES AND USES OF THE SAME |
JP7161481B2 (en) | 2017-02-10 | 2022-10-26 | ノバルティス アーゲー | 1-(4-amino-5-bromo-6-(1H-pyrazol-1-yl)pyrimidin-2-yl)-1H-pyrazol-4-ol and its use in treating cancer |
US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
UY37621A (en) | 2017-02-28 | 2018-09-28 | Sanofi Sa | THERAPEUTIC ARN THAT CODIFIES CYTOKINS |
WO2018162944A1 (en) * | 2017-03-04 | 2018-09-13 | Shenzhen Runshin Bioscience | Recombinant antibodies to programmed death 1 (pd-1) and uses therefor |
BR112019019077A2 (en) * | 2017-03-27 | 2020-04-22 | Fuso Pharmaceutical Ind | anti-pd-l1 antibody for detection of pd-l1 |
WO2018181425A1 (en) | 2017-03-29 | 2018-10-04 | 塩野義製薬株式会社 | Medicinal composition for treating cancer |
SG11201907948TA (en) * | 2017-03-29 | 2019-09-27 | Celgene Corp | Formulations comprising pd-1 binding proteins and methods of making thereof |
LT3606946T (en) | 2017-04-03 | 2022-10-25 | F. Hoffmann-La Roche Ag | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
JP2020513009A (en) | 2017-04-05 | 2020-04-30 | シムフォゲン・アクティーゼルスカブSymphogen A/S | Combination therapy targeting PD-1, TIM-3, and LAG-3 |
KR102346336B1 (en) | 2017-04-05 | 2022-01-04 | 에프. 호프만-라 로슈 아게 | Bispecific antibodies that specifically bind to PD1 and LAG3 |
JOP20190222A1 (en) * | 2017-04-11 | 2019-09-24 | Zymeworks Inc | Anti-pd-l1-anti-tim-3 bispecific antibodies |
US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
AR111651A1 (en) | 2017-04-28 | 2019-08-07 | Novartis Ag | CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES |
WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
AR111760A1 (en) | 2017-05-19 | 2019-08-14 | Novartis Ag | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS THROUGH INTRATUMORAL ADMINISTRATION |
JOP20190279A1 (en) | 2017-05-31 | 2019-11-28 | Novartis Ag | Crystalline forms of 5-bromo-2,6-di(1 h-pyrazol-1-yl)pyrimidin-4-amine and new salts |
EP3634995A4 (en) * | 2017-06-05 | 2021-06-09 | Janssen Biotech, Inc. | Antibodies that specifically bind pd-1 and methods of use |
WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
JP7433910B2 (en) | 2017-06-22 | 2024-02-20 | ノバルティス アーゲー | Antibody molecules against CD73 and uses thereof |
WO2018235056A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
WO2018234879A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
WO2019006007A1 (en) | 2017-06-27 | 2019-01-03 | Novartis Ag | Dosage regimens for anti-tim-3 antibodies and uses thereof |
EP3421494A1 (en) | 2017-06-29 | 2019-01-02 | Sanofi | Use of isatuximab in combination with an anti-pd-1 antibody |
SG11202000197PA (en) | 2017-07-11 | 2020-02-27 | Pfizer | Immunogenic compositions comprising cea muc1 and tert |
JP2020527572A (en) | 2017-07-20 | 2020-09-10 | ノバルティス アーゲー | Anti-LAG-3 antibody dosage regimen and its use |
US11498966B2 (en) | 2017-08-09 | 2022-11-15 | Orionis Biosciences Inc. | PD-1 and PD-L1 binding agents |
EP3679070A1 (en) * | 2017-09-07 | 2020-07-15 | Augusta University Research Institute, Inc. | Antibodies to programmed cell death protein 1 |
WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | Treatment regimen for cancers that are insensitive to bcl-2 inhibitors using the mcl-1 inhibitor alvocidib |
BR112020006371A2 (en) | 2017-10-13 | 2020-09-29 | Merck Patent Gmbh | combination of a parp inhibitor and a pd-1 axis binding antagonist |
ES2938652T3 (en) * | 2017-10-18 | 2023-04-13 | Forty Seven Inc | Treatment of ovarian cancer with anti-CD47 and anti-PD-L1 |
EP3697817B1 (en) | 2017-10-18 | 2022-10-05 | Forty Seven, Inc. | Anti-cd47 agent-based ovarian cancer therapy |
WO2019081983A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
WO2019094326A1 (en) * | 2017-11-08 | 2019-05-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating cancer using rhoa dominant negative forms |
WO2019094265A1 (en) * | 2017-11-10 | 2019-05-16 | Armo Biosciences, Inc. | Pd1 polypeptide binding molecules |
US11529344B2 (en) | 2017-11-14 | 2022-12-20 | Pfizer Inc. | EZH2 inhibitor combination therapies |
CN109793892B (en) * | 2017-11-16 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | Application of anti-PD-1 antibody in preparation of medicine for treating esophageal cancer |
JP2021503478A (en) | 2017-11-16 | 2021-02-12 | ノバルティス アーゲー | Combination treatment |
US11459322B2 (en) | 2017-11-20 | 2022-10-04 | Ariagen, Inc. | Indole compounds and their use |
KR20200096253A (en) | 2017-11-30 | 2020-08-11 | 노파르티스 아게 | BCMA-targeting chimeric antigen receptor, and uses thereof |
WO2019109238A1 (en) * | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
TW201938165A (en) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | Methods and combination therapy to treat cancer |
CN112218651A (en) | 2018-01-08 | 2021-01-12 | 诺华公司 | Immunopotentiating RNA for combination with chimeric antigen receptor therapy |
US20210038659A1 (en) | 2018-01-31 | 2021-02-11 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
JP7110369B2 (en) | 2018-02-23 | 2022-08-01 | ユーキュア・(ベイジン)・バイオファーマ・カンパニー・リミテッド | Anti-PD-1 antibody and use thereof |
CA3085467A1 (en) | 2018-02-28 | 2019-09-06 | Ap Biosciences, Inc. | Bifunctional proteins combining checkpoint blockade for targeted therapy |
CA3034912A1 (en) | 2018-02-28 | 2019-08-28 | Pfizer Inc. | Il-15 variants and uses thereof |
AU2019232625A1 (en) * | 2018-03-07 | 2020-09-17 | Pfizer Inc. | Anti-PD-1 antibody compositions |
CN108434452A (en) * | 2018-03-13 | 2018-08-24 | 安徽瀚海博兴生物技术有限公司 | It is a kind of that PD-1 antibody and JMJD6 are combined to the application for being used to prepare anticancer drug |
US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
AU2019255515B2 (en) * | 2018-04-15 | 2023-04-06 | Immvira Co., Limited | Antibodies binding PD-1 and uses thereof |
BR112020022145A2 (en) | 2018-05-04 | 2021-01-26 | Merck Patent Gmbh | combined inhibition of pd-1 / pd-l1, tgfbeta and dna-pk for the treatment of cancer |
TWI793325B (en) | 2018-05-23 | 2023-02-21 | 美商輝瑞大藥廠 | Antibodies specific for cd3 and uses thereof |
EP3796983A2 (en) | 2018-05-23 | 2021-03-31 | Pfizer Inc. | Antibodies specific for gucy2c and uses thereof |
TW202015726A (en) | 2018-05-30 | 2020-05-01 | 瑞士商諾華公司 | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
AU2019277029C1 (en) | 2018-06-01 | 2024-01-04 | Novartis Ag | Binding molecules against BCMA and uses thereof |
US20210221908A1 (en) * | 2018-06-03 | 2021-07-22 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
RS64759B1 (en) | 2018-07-10 | 2023-11-30 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases |
AR116109A1 (en) | 2018-07-10 | 2021-03-31 | Novartis Ag | DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME |
EP3823991A4 (en) * | 2018-07-19 | 2022-08-03 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-1 antibodies, dosages and uses thereof |
WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
AU2019323790A1 (en) | 2018-08-20 | 2021-03-11 | Pfizer Inc. | Anti-GDF15 antibodies, compositions and methods of use |
US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
WO2020041655A1 (en) | 2018-08-24 | 2020-02-27 | Sanofi | Therapeutic rna for solid tumor cancers |
WO2020044252A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Dosage regimes for anti-m-csf antibodies and uses thereof |
CN112823167A (en) | 2018-09-07 | 2021-05-18 | 辉瑞大药厂 | Anti-alphavbeta 8 antibodies and compositions and uses thereof |
WO2020049534A1 (en) | 2018-09-07 | 2020-03-12 | Novartis Ag | Sting agonist and combination therapy thereof for the treatment of cancer |
AU2019346012A1 (en) | 2018-09-26 | 2021-04-15 | Merck Patent Gmbh | Combination of a PD-1 antagonist, an ATR inhibitor and a platinating agent for the treatment of cancer |
EP3867409A1 (en) | 2018-10-16 | 2021-08-25 | Novartis AG | Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy |
EP3873532A1 (en) | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
EP3873612A2 (en) * | 2018-11-01 | 2021-09-08 | Merck Patent GmbH | Methods of administering anti-tim-3 antibodies |
EP3876929A1 (en) | 2018-11-05 | 2021-09-15 | Pfizer Inc. | Combination for treating cancer |
EP3876940A1 (en) | 2018-11-05 | 2021-09-15 | Pfizer Inc. | Combinations for treating cancer |
WO2020103885A1 (en) | 2018-11-19 | 2020-05-28 | Beijing Biocytogen Co., Ltd | Anti-pd-1 antibodies and uses thereof |
EP3883605A1 (en) | 2018-11-19 | 2021-09-29 | Ariagen, Inc. | Methods of treating cancer |
MX2021006544A (en) | 2018-12-04 | 2021-07-07 | Sumitomo Pharma Oncology Inc | Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer. |
EP3666905A1 (en) | 2018-12-11 | 2020-06-17 | Sanofi | E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer |
WO2020119719A1 (en) * | 2018-12-12 | 2020-06-18 | Wuxi Biologics (Shanghai) Co. Ltd. | Anti-tim-3 antibodies and uses thereof |
AU2019402189B2 (en) | 2018-12-20 | 2023-04-13 | Novartis Ag | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
WO2020128637A1 (en) | 2018-12-21 | 2020-06-25 | Novartis Ag | Use of il-1 binding antibodies in the treatment of a msi-h cancer |
CN111349162A (en) * | 2018-12-21 | 2020-06-30 | 神州细胞工程有限公司 | Humanized anti-PD-1 antibodies and uses thereof |
US20220054524A1 (en) | 2018-12-21 | 2022-02-24 | Onxeo | New conjugated nucleic acid molecules and their uses |
KR20210108422A (en) | 2018-12-21 | 2021-09-02 | 노파르티스 아게 | Uses of IL-1β Binding Antibodies |
US20220025036A1 (en) | 2018-12-21 | 2022-01-27 | Novartis Ag | Use of il-1beta binding antibodies |
KR20210107730A (en) | 2018-12-21 | 2021-09-01 | 노파르티스 아게 | Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome |
WO2020135415A1 (en) * | 2018-12-24 | 2020-07-02 | 正大天晴药业集团股份有限公司 | Use of anti-pd-l1 monoclonal antibody for treatment of cancer |
CN113544146A (en) * | 2018-12-27 | 2021-10-22 | 吉加根公司 | anti-PD-1 binding proteins and methods of use thereof |
WO2020148612A1 (en) | 2019-01-14 | 2020-07-23 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
BR112021013965A2 (en) | 2019-01-21 | 2021-09-21 | Sanofi | THERAPEUTIC RNA AND ANTI-PD1 ANTIBODIES FOR ADVANCED STAGE SOLID TUMOR CANCER |
MX2021009562A (en) | 2019-02-12 | 2021-09-08 | Novartis Ag | Pharmaceutical combination comprising tno155 and a pd-1 inhibitor. |
EP3924351A4 (en) | 2019-02-12 | 2022-12-21 | Sumitomo Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
US11685904B2 (en) | 2019-02-14 | 2023-06-27 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
AU2020222346B2 (en) | 2019-02-15 | 2021-12-09 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
EA202192019A1 (en) | 2019-02-15 | 2021-11-02 | Новартис Аг | DERIVATIVES OF 3- (1-OXO-5- (PIPERIDIN-4-YL) ISOINDOLIN-2-YL) PIPERIDINE-2,6-DIONE AND ROUTES OF THEIR APPLICATION |
WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
AU2020245437A1 (en) | 2019-03-22 | 2021-09-30 | Sumitomo Pharma Oncology, Inc. | Compositions comprising PKM2 modulators and methods of treatment using the same |
MX2021012543A (en) | 2019-04-15 | 2021-12-10 | Ariagen Inc | Chiral indole compounds and their use. |
CN111973739B (en) * | 2019-05-23 | 2024-02-13 | 正大天晴药业集团股份有限公司 | Use of anti-PD-L1 monoclonal antibodies for the treatment of cancer |
EP3976090A1 (en) | 2019-05-24 | 2022-04-06 | Pfizer Inc. | Combination therapies using cdk inhibitors |
WO2021003417A1 (en) | 2019-07-03 | 2021-01-07 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
US20220372137A1 (en) * | 2019-07-03 | 2022-11-24 | Oxford Biotherapeutics Ltd | Antibodies and methods of use |
KR20220030956A (en) | 2019-07-05 | 2022-03-11 | 오노 야꾸힝 고교 가부시키가이샤 | Hematological cancer treatment by PD-1/CD3 bispecific protein |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
WO2021025140A1 (en) | 2019-08-08 | 2021-02-11 | 小野薬品工業株式会社 | Dual-specific protein |
JP2022548881A (en) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | ENTPD2 Antibodies, Combination Therapy and Methods of Using Antibodies and Combination Therapy |
TW202124446A (en) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | Combination therapies with entpd2 antibodies |
WO2021055994A1 (en) | 2019-09-22 | 2021-03-25 | Bristol-Myers Squibb Company | Quantitative spatial profiling for lag-3 antagonist therapy |
BR112022005463A2 (en) | 2019-09-25 | 2022-06-14 | Pfizer | Polyheterocyclic sting modulators (interferon gene stimulator) |
MX2022004769A (en) | 2019-10-21 | 2022-05-16 | Novartis Ag | Tim-3 inhibitors and uses thereof. |
CN114786679A (en) | 2019-10-21 | 2022-07-22 | 诺华股份有限公司 | Combination therapy with Vernetork and TIM-3 inhibitors |
JP2022553851A (en) | 2019-11-08 | 2022-12-26 | ブリストル-マイヤーズ スクイブ カンパニー | LAG-3 antagonists for the treatment of melanoma |
US20230000864A1 (en) | 2019-11-22 | 2023-01-05 | Sumitomo Pharma Oncology, Inc. | Solid dose pharmaceutical composition |
US20230002740A1 (en) | 2019-12-12 | 2023-01-05 | Ignite Immunotherapy, Inc | Variant oncolytic vaccinia virus and methods of use thereof |
IL293926A (en) | 2019-12-17 | 2022-08-01 | Pfizer | Antibodies specific for cd47, pd-l1, and uses thereof |
TW202128176A (en) | 2019-12-18 | 2021-08-01 | 美商輝瑞股份有限公司 | Once daily cancer treatment regimen with a prmt5 inhibitor |
WO2021123996A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
US20230201283A1 (en) | 2020-01-09 | 2023-06-29 | Pfizer Inc. | Recombinant vaccinia virus |
CN114980902A (en) | 2020-01-17 | 2022-08-30 | 诺华股份有限公司 | Combination comprising a TIM-3 inhibitor and a hypomethylated drug for the treatment of myelodysplastic syndrome or chronic myelomonocytic leukemia |
KR20220148846A (en) | 2020-02-28 | 2022-11-07 | 노파르티스 아게 | Triple Pharmaceutical Combination Comprising Dabrafenib, ERK Inhibitor, and RAF Inhibitor |
JP7181325B2 (en) | 2020-03-03 | 2022-11-30 | アレイ バイオファーマ インコーポレイテッド | Methods for treating cancer |
WO2021181233A2 (en) | 2020-03-09 | 2021-09-16 | Pfizer Inc. | Fusion proteins and uses thereof |
EP4138819A1 (en) | 2020-04-21 | 2023-03-01 | Novartis AG | Dosing regimen for treating a disease modulated by csf-1r |
KR20230008197A (en) | 2020-05-13 | 2023-01-13 | 화이자 인코포레이티드 | Methods, therapies and uses for treating cancer |
CN111607565A (en) * | 2020-06-04 | 2020-09-01 | 河南大学 | In-vitro amplification method of T cells of northern Pingting monkeys |
TW202214857A (en) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | New conjugated nucleic acid molecules and their uses |
WO2021260528A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
WO2022003554A1 (en) | 2020-07-01 | 2022-01-06 | Pfizer Inc. | Biomarkers for pd-1 axis binding antagonist therapy |
CA3182579A1 (en) | 2020-07-07 | 2022-01-13 | Ugur Sahin | Therapeutic rna for hpv-positive cancer |
WO2022009157A1 (en) | 2020-07-10 | 2022-01-13 | Novartis Ag | Lhc165 and spartalizumab combinations for treating solid tumors |
US20220033784A1 (en) | 2020-07-14 | 2022-02-03 | Pfizer Inc. | Recombinant vaccinia virus |
TW202216779A (en) | 2020-07-17 | 2022-05-01 | 美商輝瑞股份有限公司 | Therapeutic antibodies and their uses |
CN116134027A (en) | 2020-08-03 | 2023-05-16 | 诺华股份有限公司 | Heteroaryl-substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof |
BR112023003427A2 (en) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | LAG-3 ANTAGONIST THERAPY FOR HEPATOCELLULAR CARCINOMA |
WO2022043557A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
WO2022043558A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
US20230340137A1 (en) | 2020-09-14 | 2023-10-26 | Pfizer Inc. | Methods, therapies and uses for treating cancer |
EP4232019A1 (en) | 2020-10-23 | 2023-08-30 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
WO2022097060A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
WO2022118197A1 (en) | 2020-12-02 | 2022-06-09 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
TW202237119A (en) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk-5 inhibitors and uses thereof |
WO2022130206A1 (en) | 2020-12-16 | 2022-06-23 | Pfizer Inc. | TGFβr1 INHIBITOR COMBINATION THERAPIES |
US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
TW202245808A (en) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | Therapeutic rna for treating cancer |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
WO2022153161A1 (en) | 2021-01-14 | 2022-07-21 | Pfizer Inc. | Treatment of cancer using a prmt5 inhibitor |
JP2024505049A (en) | 2021-01-29 | 2024-02-02 | ノバルティス アーゲー | Administration modes for anti-CD73 and anti-ENTPD2 antibodies and their uses |
US11964978B2 (en) | 2021-03-18 | 2024-04-23 | Pfizer Inc. | Modulators of STING (stimulator of interferon genes) |
CN117321418A (en) | 2021-03-18 | 2023-12-29 | 诺华股份有限公司 | Cancer biomarkers and methods of use thereof |
TW202304506A (en) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
WO2022212400A1 (en) | 2021-03-29 | 2022-10-06 | Juno Therapeutics, Inc. | Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy |
TW202304979A (en) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
TW202309022A (en) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | Amino-substituted heterocycles for treating cancers with egfr mutations |
WO2022219080A1 (en) | 2021-04-14 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method to improve nk cells cytotoxicity |
AR125874A1 (en) | 2021-05-18 | 2023-08-23 | Novartis Ag | COMBINATION THERAPIES |
WO2022242757A1 (en) * | 2021-05-21 | 2022-11-24 | 百奥泰生物制药股份有限公司 | Application of anti-pd-1 antibody |
GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
IL309310A (en) | 2021-06-18 | 2024-02-01 | Genzyme Corp | Anti-tgf-beta antibody formulations and their use |
CN117881419A (en) * | 2021-07-01 | 2024-04-12 | 天津立博美华基因科技有限责任公司 | Pharmaceutical combination and use thereof |
AU2022312698A1 (en) | 2021-07-13 | 2024-01-25 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
TW202327595A (en) | 2021-10-05 | 2023-07-16 | 美商輝瑞大藥廠 | Combinations of azalactam compounds for the treatment of cancer |
TW202333802A (en) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | Therapeutic rna for lung cancer |
WO2023077090A1 (en) | 2021-10-29 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023079430A1 (en) | 2021-11-02 | 2023-05-11 | Pfizer Inc. | Methods of treating mitochondrial myopathies using anti-gdf15 antibodies |
WO2023079428A1 (en) | 2021-11-03 | 2023-05-11 | Pfizer Inc. | Combination therapies using tlr7/8 agonist |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
TW202319073A (en) | 2021-11-12 | 2023-05-16 | 瑞士商諾華公司 | Combination therapy for treating lung cancer |
WO2023111203A1 (en) | 2021-12-16 | 2023-06-22 | Onxeo | New conjugated nucleic acid molecules and their uses |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
WO2023166420A1 (en) | 2022-03-03 | 2023-09-07 | Pfizer Inc. | Multispecific antibodies and uses thereof |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
WO2023218320A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Anti-lymphotoxin beta receptor antibodies and methods of use thereof |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2023242769A1 (en) | 2022-06-17 | 2023-12-21 | Pfizer Inc. | Il-12 variants, anti-pd1 antibodies, fusion proteins, and uses thereof |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
FR2413974A1 (en) | 1978-01-06 | 1979-08-03 | David Bernard | DRYER FOR SCREEN-PRINTED SHEETS |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
ES2200016T3 (en) | 1989-03-21 | 2004-03-01 | Vical Incorporated | EXPRESSION OF EXECUTIVE POLINUCLEOTIDIC SEQUENCES IN A VERTEBRATE. |
DE69029036T2 (en) | 1989-06-29 | 1997-05-22 | Medarex Inc | SPECIFIC REAGENTS FOR AIDS THERAPY |
EP1001032A3 (en) | 1989-08-18 | 2005-02-23 | Chiron Corporation | Recombinant retroviruses delivering vector constructs to target cells |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
NZ237464A (en) | 1990-03-21 | 1995-02-24 | Depotech Corp | Liposomes with at least two separate chambers encapsulating two separate biologically active substances |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
JPH06500011A (en) | 1990-06-29 | 1994-01-06 | ラージ スケール バイオロジー コーポレイション | Production of melanin by transformed microorganisms |
US5278299A (en) | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
EP0586505A1 (en) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
JP3534749B2 (en) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | Adenovirus-mediated gene transfer into the gastrointestinal tract |
CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
DK0605522T3 (en) | 1991-09-23 | 2000-01-17 | Medical Res Council | Process for producing humanized antibodies |
ES2136092T3 (en) | 1991-09-23 | 1999-11-16 | Medical Res Council | PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES. |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
WO1993010260A1 (en) | 1991-11-21 | 1993-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases |
GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
FR2688514A1 (en) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
JPH07507689A (en) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Specific tissue targeting methods and compositions |
WO1993025698A1 (en) | 1992-06-10 | 1993-12-23 | The United States Government As Represented By The | Vector particles resistant to inactivation by human serum |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
ATE149570T1 (en) | 1992-08-17 | 1997-03-15 | Genentech Inc | BISPECIFIC IMMUNOADHESINS |
AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
WO1994023697A1 (en) | 1993-04-22 | 1994-10-27 | Depotech Corporation | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
ES2249761T3 (en) | 1993-06-24 | 2006-04-01 | Advec Inc. | ADENOVIRUS VECTORS FOR GENE THERAPY. |
CA2523216C (en) | 1993-09-15 | 2010-11-16 | Chiron Corporation | Recombinant alphavirus vectors |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
DK0797676T3 (en) | 1993-10-25 | 2006-04-18 | Canji Inc | Recombinant adenoviral vector and methods for its use |
CA2176712C (en) | 1993-11-16 | 2000-05-23 | Mantripragada Sankaram | Synthetic membrane vesicles with controlled release of encapsulated biologically active substances |
CA2143491C (en) | 1994-03-01 | 2011-02-22 | Yasumasa Ishida | A novel peptide related to human programmed cell death and dna encoding it |
US6436908B1 (en) | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
DE69535669T2 (en) | 1994-05-09 | 2008-12-04 | Oxford Biomedica (Uk) Ltd. | RETROVIRAL VECTORS WITH REDUCED RECOMBINATION RATE |
WO1996017072A2 (en) | 1994-11-30 | 1996-06-06 | Chiron Viagene, Inc. | Recombinant alphavirus vectors |
US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
ATE424463T1 (en) | 1996-05-06 | 2009-03-15 | Oxford Biomedica Ltd | RECOMBINATION-INCAPABLE RETROVIRAL VECTORS |
US6376471B1 (en) | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
AU3734900A (en) | 1999-03-09 | 2000-09-28 | University Of Southern California | Method of promoting myocyte proliferation and myocardial tissue repair |
US6808710B1 (en) | 1999-08-23 | 2004-10-26 | Genetics Institute, Inc. | Downmodulating an immune response with multivalent antibodies to PD-1 |
EP2829609A1 (en) | 1999-08-24 | 2015-01-28 | E. R. Squibb & Sons, L.L.C. | Human CTLA-4 antibodies and their uses |
CA2399358C (en) | 2000-02-15 | 2006-03-21 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
AR039067A1 (en) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | ANTIBODIES FOR CD40 |
FI2206517T3 (en) | 2002-07-03 | 2023-10-19 | Ono Pharmaceutical Co | Immunopotentiating compositions comprising anti-PD-L1 antibodies |
JP4511943B2 (en) | 2002-12-23 | 2010-07-28 | ワイス エルエルシー | Antibody against PD-1 and use thereof |
PT1575517E (en) | 2002-12-24 | 2012-05-28 | Rinat Neuroscience Corp | Anti-ngf antibodies and methods using same |
ES2729974T3 (en) | 2003-01-23 | 2019-11-07 | Ono Pharmaceutical Co | Specific antibody of human PD-1 and CD3 |
EP1871417B1 (en) | 2005-04-15 | 2013-09-11 | Precision Biologics, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
LT2439273T (en) | 2005-05-09 | 2019-05-10 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
AU2006321593B2 (en) | 2005-12-07 | 2012-10-04 | E. R. Squibb & Sons, L.L.C. | CTLA-4 antibody dosage escalation regimens |
BRPI0620601A2 (en) * | 2005-12-08 | 2011-11-16 | Medarex Inc | isolated human monoclonal antibody or antigen-binding portion thereof, composition, immunoconjugate, isolated nucleic acid molecule, expression vector, host cell, method for preparing an anti-o8e antibody and method for treating or preventing a disease defined by the growth of o8e expressing tumor cells |
CN101663323A (en) * | 2006-12-27 | 2010-03-03 | 埃默里大学 | The composition and the method that are used for the treatment of transmissible disease and tumour |
DK2170959T3 (en) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | ANTIBODIES AGAINST HUMAN PROGRAMMED DEATH RECEPTOR PD-1 |
EP2203051A4 (en) * | 2007-09-25 | 2011-09-07 | Abbott Lab | Octahydropentalene compounds as chemokine receptor antagonists |
NZ591130A (en) | 2008-08-25 | 2012-09-28 | Amplimmune Inc | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof |
ES2592216T3 (en) * | 2008-09-26 | 2016-11-28 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1 and PD-L2 antibodies and their uses |
JP5920929B2 (en) * | 2010-03-11 | 2016-05-18 | ユセベ ファルマ ソシエテ アノニム | PD-1 antibody |
HUE038788T2 (en) * | 2010-03-31 | 2018-11-28 | Boehringer Ingelheim Int | Anti-CD40 antibodies |
AR081434A1 (en) * | 2010-06-10 | 2012-08-29 | Lilly Co Eli | ANTIBODY OF THE PEPTIDE RELATED TO THE CALCITONINE GENE (CGRP), PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, USE OF THE ANTIBODY TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT PAIN OR MIGRANE PAIN AND ANOGEN ANOGEN FRAGMENT |
EP2910572B1 (en) * | 2010-11-11 | 2017-09-06 | Versitech Limited | Soluble pd-1 variants, fusion constructs, and uses thereof |
CN103429264A (en) | 2011-03-31 | 2013-12-04 | 默沙东公司 | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments |
LT2699264T (en) | 2011-04-20 | 2018-07-10 | Medimmune, Llc | Antibodies and other molecules that bind b7-h1 and pd-1 |
DK2844282T3 (en) | 2012-05-04 | 2019-07-15 | Pfizer | PROSTATA ASSOCIATED ANTIGENES AND VACCINE-BASED IMMUNTERAPIREGIMENES |
PL2970473T3 (en) * | 2013-03-14 | 2018-01-31 | Bristol Myers Squibb Co | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
RS61400B1 (en) * | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antibodies directed against programmed death-1 (pd-1) |
AR097306A1 (en) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | MODULATION OF TUMOR IMMUNITY |
AU2014331728A1 (en) | 2013-10-11 | 2016-05-05 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for regulatory T-cell ablation |
BR112016008806A2 (en) | 2013-11-01 | 2017-10-03 | Pfizer | VECTORS FOR EXPRESSION OF PROSTATE-ASSOCIATED ANTIGENS |
CA2934028A1 (en) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
TWI681969B (en) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | Human antibodies to pd-1 |
JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
TWI595006B (en) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | Anti-pd-1 antibodies and methods of use thereof |
KR20180040138A (en) * | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of using them |
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