SG11201700955SA - Mutants of the bacteriophage lambda integrase - Google Patents
Mutants of the bacteriophage lambda integraseInfo
- Publication number
- SG11201700955SA SG11201700955SA SG11201700955SA SG11201700955SA SG11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA
- Authority
- SG
- Singapore
- Prior art keywords
- mutants
- bacteriophage lambda
- lambda integrase
- integrase
- bacteriophage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1414130.3A GB201414130D0 (en) | 2014-08-08 | 2014-08-08 | Mutants of the bacteriophage lambda integrase |
| PCT/SG2015/050255 WO2016022075A1 (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201700955SA true SG11201700955SA (en) | 2017-03-30 |
Family
ID=51629549
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201700955SA SG11201700955SA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
| SG10202005089XA SG10202005089XA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202005089XA SG10202005089XA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Country Status (7)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
| GB201603577D0 (en) * | 2016-03-01 | 2016-04-13 | Oxford Genetics Ltd | Promoter |
| US11078493B2 (en) | 2016-06-21 | 2021-08-03 | Nanyang Technological University | Site-specific DNA recombination |
| JP7402503B2 (ja) | 2017-06-14 | 2023-12-21 | テクニスチェ ユニベルシタト ドレスデン | デザイナーｄｎａ組換え酵素を利用したゲノムを遺伝的に改変するための方法及び手段 |
| CN114450309A (zh) * | 2019-07-29 | 2022-05-06 | 印第安纳大学理事会 | 治疗弗里德里希共济失调的材料和方法 |
| US11988675B2 (en) | 2019-11-25 | 2024-05-21 | Larimar Therapeutics, Inc. | Methods for quantifying frataxin activity |
| US11976100B2 (en) | 2020-04-30 | 2024-05-07 | Larimar Therapeutics, Inc. | Methods for treating myelin associated diseases and mitochondria associated diseases |
| CA3201847A1 (en) | 2020-12-12 | 2022-06-16 | Denis Boyle | Pharmaceutical composition comprising frataxin fusion protein and methods of use thereof |
| CN117178056A (zh) * | 2021-03-12 | 2023-12-05 | 南洋理工大学 | 用于生产无缝dna载体的方法 |
| WO2023234866A1 (en) * | 2022-05-31 | 2023-12-07 | Nanyang Technological University | Method for production of a eukaryotic host cell or cell line for lambda-integrase-mediated recombination |
| CN118546903A (zh) * | 2023-02-24 | 2024-08-27 | 尧唐(上海)生物科技有限公司 | 能介导大片段dna整合到哺乳动物基因组的酶及其应用 |
| WO2024181932A1 (en) * | 2023-03-02 | 2024-09-06 | Nanyang Technological University | Lambda integrase mutants and methods of their use |
| WO2025006468A2 (en) | 2023-06-26 | 2025-01-02 | University Of Hawaii | Evolved integrases and methods of using the same for genome editing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2522166C (en) | 2001-05-30 | 2011-05-03 | Chromos Molecular Systems, Inc. | Lambda integrase mutein for use in recombination |
| JP4489424B2 (ja) * | 2001-05-30 | 2010-06-23 | グラクソ グループ リミテッド | 染色体に基くプラットホーム |
| CN104293751B (zh) * | 2008-11-11 | 2018-11-27 | 丹尼斯科美国公司 | 包含丝氨酸蛋白酶变体的组合物和方法 |
| SG170652A1 (en) * | 2009-11-06 | 2011-05-30 | Agency Science Tech & Res | Muteins of the bacteriophage lambda integrases |
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
-
2014
- 2014-08-08 GB GBGB1414130.3A patent/GB201414130D0/en not_active Ceased
-
2015
- 2015-08-11 EP EP15829802.6A patent/EP3177717A4/en active Pending
- 2015-08-11 WO PCT/SG2015/050255 patent/WO2016022075A1/en active Application Filing
- 2015-08-11 SG SG11201700955SA patent/SG11201700955SA/en unknown
- 2015-08-11 CN CN201580054345.8A patent/CN108064279B/zh active Active
- 2015-08-11 US US15/502,783 patent/US10344301B2/en active Active
- 2015-08-11 SG SG10202005089XA patent/SG10202005089XA/en unknown
- 2015-08-11 JP JP2017506963A patent/JP6616822B2/ja active Active
-
2019
- 2019-06-03 US US16/430,410 patent/US11414681B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3177717A1 (en) | 2017-06-14 |
| SG10202005089XA (en) | 2020-07-29 |
| US20200063165A1 (en) | 2020-02-27 |
| US20170327847A1 (en) | 2017-11-16 |
| US10344301B2 (en) | 2019-07-09 |
| GB201414130D0 (en) | 2014-09-24 |
| CN108064279A (zh) | 2018-05-22 |
| JP2017525355A (ja) | 2017-09-07 |
| CN108064279B (zh) | 2022-03-11 |
| US11414681B2 (en) | 2022-08-16 |
| EP3177717A4 (en) | 2017-12-27 |
| WO2016022075A1 (en) | 2016-02-11 |
| JP6616822B2 (ja) | 2019-12-04 |
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