SG11201605055SA - N-substituted imidazole carboxylic ester chiral compound containing ether side chain, preparation method and application - Google Patents
N-substituted imidazole carboxylic ester chiral compound containing ether side chain, preparation method and applicationInfo
- Publication number
- SG11201605055SA SG11201605055SA SG11201605055SA SG11201605055SA SG11201605055SA SG 11201605055S A SG11201605055S A SG 11201605055SA SG 11201605055S A SG11201605055S A SG 11201605055SA SG 11201605055S A SG11201605055S A SG 11201605055SA SG 11201605055S A SG11201605055S A SG 11201605055SA
- Authority
- SG
- Singapore
- Prior art keywords
- preparation
- application
- side chain
- compound containing
- carboxylic ester
- Prior art date
Links
- -1 N-substituted imidazole carboxylic Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000001033 ether group Chemical group 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310716377.2A CN103739553B (zh) | 2013-12-23 | 2013-12-23 | 含有醚侧链的n-取代咪唑羧酸酯手性化合物、制备方法和用途 |
| PCT/CN2014/089898 WO2015096551A1 (zh) | 2013-12-23 | 2014-10-30 | 含有醚侧链的n-取代咪唑羧酸酯手性化合物、制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201605055SA true SG11201605055SA (en) | 2016-09-29 |
Family
ID=50496641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201605055SA SG11201605055SA (en) | 2013-12-23 | 2014-10-30 | N-substituted imidazole carboxylic ester chiral compound containing ether side chain, preparation method and application |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9969695B2 (zh) |
| EP (1) | EP3088394B1 (zh) |
| JP (1) | JP2016540795A (zh) |
| KR (1) | KR20160089516A (zh) |
| CN (1) | CN103739553B (zh) |
| AU (1) | AU2014373186B2 (zh) |
| CA (1) | CA2933098A1 (zh) |
| PH (1) | PH12016501246A1 (zh) |
| RU (1) | RU2659784C2 (zh) |
| SG (1) | SG11201605055SA (zh) |
| WO (1) | WO2015096551A1 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103739553B (zh) * | 2013-12-23 | 2014-11-12 | 四川大学华西医院 | 含有醚侧链的n-取代咪唑羧酸酯手性化合物、制备方法和用途 |
| CA3001431C (en) * | 2015-10-10 | 2023-09-26 | Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd. | Etomidate derivative and intermediate, preparation method and use thereof |
| CN107382870A (zh) * | 2016-05-17 | 2017-11-24 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107445898A (zh) * | 2016-05-30 | 2017-12-08 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107522662A (zh) * | 2016-06-16 | 2017-12-29 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN107641105A (zh) * | 2016-07-22 | 2018-01-30 | 四川海思科制药有限公司 | N‑取代咪唑羧酸酯类化合物及其制备方法和在医药上的用途 |
| CN109776512A (zh) * | 2018-01-30 | 2019-05-21 | 成都安诺晨创医药科技有限公司 | 一种n-取代咪唑甲酸酯类衍生物及其用途 |
| CN112174890B (zh) * | 2020-10-09 | 2022-05-27 | 成都麻沸散医药科技有限公司 | 酮取代杂环化合物及其麻醉作用 |
| CN110922361B (zh) * | 2019-11-21 | 2021-01-08 | 武汉大安制药有限公司 | 一种依托咪酯氧化杂质及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354173A (en) * | 1964-04-16 | 1967-11-21 | Janssen Pharmaceutica Nv | Imidazole carboxylates |
| US4770689A (en) * | 1986-03-10 | 1988-09-13 | Janssen Pharmaceutica N.V. | Herbicidal imidazole-5-carboxylic acid derivatives |
| US8557856B2 (en) * | 2008-03-31 | 2013-10-15 | The General Hospital Corporation | Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties |
| CN103588757B (zh) * | 2013-01-04 | 2014-11-12 | 四川大学华西医院 | 超短效麻醉效应的n-取代咪唑羧酸酯类化合物、制备方法和用途 |
| CN103739553B (zh) * | 2013-12-23 | 2014-11-12 | 四川大学华西医院 | 含有醚侧链的n-取代咪唑羧酸酯手性化合物、制备方法和用途 |
-
2013
- 2013-12-23 CN CN201310716377.2A patent/CN103739553B/zh active Active
-
2014
- 2014-10-30 EP EP14873468.4A patent/EP3088394B1/en active Active
- 2014-10-30 KR KR1020167017220A patent/KR20160089516A/ko not_active Application Discontinuation
- 2014-10-30 JP JP2016539968A patent/JP2016540795A/ja active Pending
- 2014-10-30 WO PCT/CN2014/089898 patent/WO2015096551A1/zh active Application Filing
- 2014-10-30 US US15/107,415 patent/US9969695B2/en active Active
- 2014-10-30 AU AU2014373186A patent/AU2014373186B2/en active Active
- 2014-10-30 CA CA2933098A patent/CA2933098A1/en not_active Abandoned
- 2014-10-30 RU RU2016123144A patent/RU2659784C2/ru active
- 2014-10-30 SG SG11201605055SA patent/SG11201605055SA/en unknown
-
2016
- 2016-06-23 PH PH12016501246A patent/PH12016501246A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103739553A (zh) | 2014-04-23 |
| WO2015096551A1 (zh) | 2015-07-02 |
| US9969695B2 (en) | 2018-05-15 |
| RU2016123144A (ru) | 2018-01-30 |
| EP3088394B1 (en) | 2018-12-05 |
| RU2659784C2 (ru) | 2018-07-04 |
| JP2016540795A (ja) | 2016-12-28 |
| AU2014373186B2 (en) | 2017-11-23 |
| CN103739553B (zh) | 2014-11-12 |
| AU2014373186A1 (en) | 2016-07-14 |
| PH12016501246A1 (en) | 2016-08-15 |
| RU2016123144A3 (zh) | 2018-04-27 |
| EP3088394A1 (en) | 2016-11-02 |
| CA2933098A1 (en) | 2015-07-02 |
| US20170001963A1 (en) | 2017-01-05 |
| EP3088394A4 (en) | 2017-05-10 |
| KR20160089516A (ko) | 2016-07-27 |
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