SG11201602570WA - Amphotericin b derivatives with improved therapeutic index - Google Patents
Amphotericin b derivatives with improved therapeutic indexInfo
- Publication number
- SG11201602570WA SG11201602570WA SG11201602570WA SG11201602570WA SG11201602570WA SG 11201602570W A SG11201602570W A SG 11201602570WA SG 11201602570W A SG11201602570W A SG 11201602570WA SG 11201602570W A SG11201602570W A SG 11201602570WA SG 11201602570W A SG11201602570W A SG 11201602570WA
- Authority
- SG
- Singapore
- Prior art keywords
- amphotericin
- derivatives
- therapeutic index
- improved therapeutic
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887729P | 2013-10-07 | 2013-10-07 | |
| US201462045956P | 2014-09-04 | 2014-09-04 | |
| PCT/US2014/059334 WO2015054148A1 (en) | 2013-10-07 | 2014-10-06 | Amphotericin b derivatives with improved therapeutic index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201602570WA true SG11201602570WA (en) | 2016-04-28 |
Family
ID=52813555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201602570WA SG11201602570WA (en) | 2013-10-07 | 2014-10-06 | Amphotericin b derivatives with improved therapeutic index |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10323057B2 (de) |
| EP (1) | EP3055030B1 (de) |
| JP (2) | JP6600303B2 (de) |
| KR (2) | KR102548341B1 (de) |
| CN (2) | CN105848721B (de) |
| AU (2) | AU2014332214B2 (de) |
| CA (1) | CA2925904C (de) |
| DK (1) | DK3055030T3 (de) |
| ES (1) | ES2682328T3 (de) |
| SG (1) | SG11201602570WA (de) |
| WO (1) | WO2015054148A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2925904C (en) | 2013-10-07 | 2021-11-23 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivatives with improved therapeutic index |
| SG11201610162XA (en) * | 2014-06-12 | 2017-01-27 | Shionogi & Co | Polyene macrolide derivative |
| AU2016205187B2 (en) | 2015-01-08 | 2020-02-27 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin B |
| US9957290B2 (en) | 2015-04-15 | 2018-05-01 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin B |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| JP7041961B2 (ja) * | 2016-04-08 | 2022-03-25 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復 |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| AU2019335409A1 (en) | 2018-09-07 | 2021-05-06 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin B derivatives with reduced toxicity |
| EP4009984A4 (de) * | 2019-08-08 | 2023-09-06 | The Board Of Trustees Of The University Of Illinois | Hybride amphotericin-b-derivate mit verringerter toxizität |
| CN111909226A (zh) * | 2020-08-11 | 2020-11-10 | 深圳市儿童医院 | 一种葡萄糖酸修饰的两性霉素b衍生物及其用途 |
| WO2024010968A2 (en) * | 2022-07-08 | 2024-01-11 | The Board Of Trustees Of The University Of Illinois | Transfer of c2'-epimerized sugars to the amphotericin b aglycone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0431870A1 (de) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin-B-Derivate |
| WO1993016090A1 (en) * | 1992-02-12 | 1993-08-19 | Smithkline Beecham Plc | Amphotericin b derivative |
| JP5129485B2 (ja) | 2005-01-24 | 2013-01-30 | 公益財団法人微生物化学研究会 | 抗ペニシリン耐性肺炎球菌剤及び新規１６員環マクロライド誘導体 |
| US20090221520A1 (en) | 2005-03-23 | 2009-09-03 | Francisco Malpartida Romero | Polyene Antibiotics, Compositions Containing Said Antibiotics, Method and Micro-Organisms Used to Obtain Same and Applications Thereof |
| EP1987049A1 (de) * | 2006-02-23 | 2008-11-05 | ETH Zürich | Amphotericinderivative |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| DE102006060008A1 (de) | 2006-12-19 | 2008-06-26 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Lampe mit verbesserter Quetschungsgeometrie |
| GB0712881D0 (en) * | 2007-07-03 | 2007-08-15 | Biosergen As | Compounds |
| MX365184B (es) | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| CA2925904C (en) | 2013-10-07 | 2021-11-23 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivatives with improved therapeutic index |
| US9957290B2 (en) | 2015-04-15 | 2018-05-01 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin B |
-
2014
- 2014-10-06 CA CA2925904A patent/CA2925904C/en active Active
- 2014-10-06 SG SG11201602570WA patent/SG11201602570WA/en unknown
- 2014-10-06 ES ES14853012.4T patent/ES2682328T3/es active Active
- 2014-10-06 JP JP2016519955A patent/JP6600303B2/ja active Active
- 2014-10-06 KR KR1020217035284A patent/KR102548341B1/ko active IP Right Grant
- 2014-10-06 CN CN201480065533.6A patent/CN105848721B/zh active Active
- 2014-10-06 EP EP14853012.4A patent/EP3055030B1/de active Active
- 2014-10-06 CN CN201910693627.2A patent/CN110407898B/zh active Active
- 2014-10-06 WO PCT/US2014/059334 patent/WO2015054148A1/en active Application Filing
- 2014-10-06 US US15/026,520 patent/US10323057B2/en active Active
- 2014-10-06 KR KR1020167011985A patent/KR102321482B1/ko active IP Right Grant
- 2014-10-06 AU AU2014332214A patent/AU2014332214B2/en active Active
- 2014-10-06 DK DK14853012.4T patent/DK3055030T3/en active
-
2019
- 2019-06-17 US US16/443,728 patent/US11117920B2/en active Active
- 2019-08-02 US US16/530,109 patent/US11028114B2/en active Active
- 2019-10-04 JP JP2019183577A patent/JP7469862B2/ja active Active
- 2019-12-09 AU AU2019279928A patent/AU2019279928B2/en active Active
-
2021
- 2021-09-02 US US17/464,916 patent/US11970512B2/en active Active
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