SG11201509899PA - Novel antibody frameworks - Google Patents
Novel antibody frameworksInfo
- Publication number
- SG11201509899PA SG11201509899PA SG11201509899PA SG11201509899PA SG11201509899PA SG 11201509899P A SG11201509899P A SG 11201509899PA SG 11201509899P A SG11201509899P A SG 11201509899PA SG 11201509899P A SG11201509899P A SG 11201509899PA SG 11201509899P A SG11201509899P A SG 11201509899PA
- Authority
- SG
- Singapore
- Prior art keywords
- novel antibody
- antibody frameworks
- frameworks
- novel
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003264 | 2013-06-26 | ||
| PCT/EP2014/001730 WO2014206561A1 (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201509899PA true SG11201509899PA (en) | 2016-01-28 |
Family
ID=48699516
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201811017QA SG10201811017QA (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
| SG11201509899PA SG11201509899PA (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201811017QA SG10201811017QA (en) | 2013-06-26 | 2014-06-26 | Novel antibody frameworks |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10174102B2 (zh) |
| EP (1) | EP3013864A1 (zh) |
| JP (4) | JP6708544B2 (zh) |
| KR (4) | KR20210097829A (zh) |
| CN (2) | CN113943366A (zh) |
| AU (2) | AU2014301629B2 (zh) |
| CA (1) | CA2914829A1 (zh) |
| HK (1) | HK1218549A1 (zh) |
| IL (3) | IL293477B1 (zh) |
| NZ (1) | NZ714320A (zh) |
| SG (2) | SG10201811017QA (zh) |
| WO (1) | WO2014206561A1 (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210097829A (ko) | 2013-06-26 | 2021-08-09 | 누맙 세러퓨틱스 아게 | 신규한 항체 기본구조 |
| AU2016278586B2 (en) | 2015-06-15 | 2022-05-19 | Numab Therapeutics AG | Hetero-dimeric multi-specific antibody format |
| EP3420001B1 (en) | 2016-02-25 | 2021-12-01 | Cell Medica Switzerland AG | Binding members to pd-l1 |
| CN108884156B (zh) | 2016-03-17 | 2021-10-01 | 努玛创新有限公司 | 抗TNFα抗体及其功能片段 |
| JP6978427B2 (ja) | 2016-03-17 | 2021-12-08 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | 抗ＴＮＦα抗体とその機能性フラグメント |
| LT3219726T (lt) | 2016-03-17 | 2021-01-25 | Tillotts Pharma Ag | Anti-tnf alfa antikūnai ir jų funkciniai fragmentai |
| SI3219727T1 (sl) | 2016-03-17 | 2021-04-30 | Tillotts Pharma Ag | Anti-TNF alfa protitelesa in njihovi funkcionalni fragmenti |
| WO2017158084A1 (en) | 2016-03-17 | 2017-09-21 | Numab Innovation Ag | ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF |
| GB201621591D0 (en) * | 2016-12-19 | 2017-02-01 | Ucb Biopharma Sprl | Antibody molecules and method |
| WO2018224441A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| WO2018224439A1 (en) | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-hsa antibodies |
| CA3065868C (en) | 2017-06-05 | 2024-06-04 | Numab Therapeutics AG | Novel hetero-dimeric multi-specific antibody format |
| JP7130678B2 (ja) | 2017-06-05 | 2022-09-05 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | 新規抗ｈｓａ抗体 |
| EP3645048A4 (en) * | 2017-06-25 | 2021-06-16 | Systimmune, Inc. | MULTISPECIFIC ANTIBODIES AND THE METHOD OF MANUFACTURING AND USING THEREOF |
| CN116948035A (zh) * | 2017-06-25 | 2023-10-27 | 西雅图免疫公司 | 多特异性抗体及其制备和使用方法 |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
| WO2020157305A1 (en) | 2019-01-31 | 2020-08-06 | Numab Therapeutics AG | Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof |
| EP3689907A1 (en) | 2019-01-31 | 2020-08-05 | Numab Therapeutics AG | Antibodies targeting il-17a and methods of use thereof |
| KR20230140448A (ko) * | 2020-12-30 | 2023-10-06 | 아센도 바이오테크놀로지, 인코퍼레이티드 | 인간 Mac-1에 대한 단일 클론항체 및 이의 용도 |
| CN116848136A (zh) | 2021-02-12 | 2023-10-03 | 勃林格殷格翰国际有限公司 | 补体c3抗原结合蛋白 |
| WO2024098026A2 (en) * | 2022-11-04 | 2024-05-10 | Mink Therapeutics, Inc. | B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| EP1651659A4 (en) | 2003-08-07 | 2008-09-17 | Epitomics Inc | METHOD FOR HUMANIZATION OF MONOCLONAL RABBIT ANTIBODIES |
| WO2008004834A1 (en) | 2006-07-06 | 2008-01-10 | Isu Abxis Co., Ltd | Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor |
| FR2910896B1 (fr) * | 2006-12-29 | 2012-11-16 | Lab Francais Du Fractionnement | Anticorps monoclonal dirige contre le recepteur humain des ldl |
| MX2009012493A (es) | 2007-05-21 | 2010-01-20 | Alder Biopharmaceuticals Inc | Metodos de humanizacion de anticuerpo de conejo novedosos y anticuerpos de conejo humanizados. |
| CN106366192B (zh) | 2007-06-25 | 2020-03-27 | 艾斯巴技术-诺华有限责任公司 | 修饰抗体的方法和具有改善的功能性质的修饰抗体 |
| CN102076716A (zh) * | 2008-06-25 | 2011-05-25 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 抑制TNFα的稳定和可溶的抗体 |
| LT3216803T (lt) * | 2008-06-25 | 2020-06-10 | Novartis Ag | Stabilūs ir tirpūs antikūnai, slopinantys vegf |
| SI2307458T1 (en) * | 2008-06-25 | 2018-08-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanization of rabbit antibodies using a universal antibody framework |
| WO2010144780A1 (en) | 2009-06-12 | 2010-12-16 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
| MX2012012689A (es) * | 2010-04-30 | 2013-12-16 | Alexion Pharma Inc | Anticuerpos que tienen inmunogenicidad reducida en un ser humano. |
| US20140213459A1 (en) * | 2011-05-27 | 2014-07-31 | Roland Beckmann | Antibodies with improved folding stability |
| KR20210097829A (ko) | 2013-06-26 | 2021-08-09 | 누맙 세러퓨틱스 아게 | 신규한 항체 기본구조 |
| EP3459968A1 (en) | 2017-09-20 | 2019-03-27 | Numab Innovation AG | Novel stable antibody variable domain framework combinations |
-
2014
- 2014-06-26 KR KR1020217024096A patent/KR20210097829A/ko not_active Application Discontinuation
- 2014-06-26 KR KR1020227006072A patent/KR20220029763A/ko not_active IP Right Cessation
- 2014-06-26 AU AU2014301629A patent/AU2014301629B2/en active Active
- 2014-06-26 SG SG10201811017QA patent/SG10201811017QA/en unknown
- 2014-06-26 IL IL293477A patent/IL293477B1/en unknown
- 2014-06-26 SG SG11201509899PA patent/SG11201509899PA/en unknown
- 2014-06-26 IL IL313351A patent/IL313351A/en unknown
- 2014-06-26 CN CN202111136784.7A patent/CN113943366A/zh active Pending
- 2014-06-26 EP EP14737144.7A patent/EP3013864A1/en active Pending
- 2014-06-26 CA CA2914829A patent/CA2914829A1/en active Pending
- 2014-06-26 IL IL243311A patent/IL243311B/en unknown
- 2014-06-26 KR KR1020167001339A patent/KR102286053B1/ko active IP Right Grant
- 2014-06-26 KR KR1020237043185A patent/KR20240000622A/ko active Search and Examination
- 2014-06-26 JP JP2016522319A patent/JP6708544B2/ja active Active
- 2014-06-26 WO PCT/EP2014/001730 patent/WO2014206561A1/en active Application Filing
- 2014-06-26 CN CN201480036689.1A patent/CN105579472B/zh active Active
- 2014-06-26 US US14/900,550 patent/US10174102B2/en active Active
- 2014-06-26 NZ NZ714320A patent/NZ714320A/en unknown
-
2016
- 2016-05-27 HK HK16106054.2A patent/HK1218549A1/zh unknown
-
2018
- 2018-10-10 US US16/156,036 patent/US11427628B2/en active Active
-
2019
- 2019-06-17 JP JP2019111990A patent/JP2019201643A/ja not_active Withdrawn
-
2020
- 2020-04-27 AU AU2020202770A patent/AU2020202770B2/en active Active
-
2021
- 2021-10-14 JP JP2021169020A patent/JP2022028659A/ja active Pending
-
2022
- 2022-08-29 US US17/822,959 patent/US20230212265A1/en active Pending
-
2023
- 2023-11-27 JP JP2023199881A patent/JP2024026176A/ja active Pending
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