SG11201507521UA - Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(msc) - Google Patents
Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(msc)Info
- Publication number
- SG11201507521UA SG11201507521UA SG11201507521UA SG11201507521UA SG11201507521UA SG 11201507521U A SG11201507521U A SG 11201507521UA SG 11201507521U A SG11201507521U A SG 11201507521UA SG 11201507521U A SG11201507521U A SG 11201507521UA SG 11201507521U A SG11201507521U A SG 11201507521UA
- Authority
- SG
- Singapore
- Prior art keywords
- mesenschymal
- msc
- therapy
- determining
- stromal cells
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 210000002536 stromal cell Anatomy 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70517—CD8
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13382091 | 2013-03-15 | ||
| PCT/EP2014/055282 WO2014140362A2 (en) | 2013-03-15 | 2014-03-17 | Lymphocyte biomarkers for determining the clinical response to cell therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507521UA true SG11201507521UA (en) | 2015-10-29 |
Family
ID=48044710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507521UA SG11201507521UA (en) | 2013-03-15 | 2014-03-17 | Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(msc) |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10660920B2 (https=) |
| EP (2) | EP3581932A1 (https=) |
| JP (2) | JP6567430B2 (https=) |
| AU (2) | AU2014230014B2 (https=) |
| CA (2) | CA3188652A1 (https=) |
| DK (1) | DK2972368T3 (https=) |
| ES (1) | ES2748825T3 (https=) |
| HU (1) | HUE046531T2 (https=) |
| IL (1) | IL241586B (https=) |
| PL (1) | PL2972368T3 (https=) |
| PT (1) | PT2972368T (https=) |
| SG (1) | SG11201507521UA (https=) |
| WO (1) | WO2014140362A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| KR101536239B1 (ko) | 2005-09-23 | 2015-07-13 | 셀레릭스, 에스.엘. | 면역조절활성을 갖는 세포 개체군, 분리 방법 및 용도 |
| US10660920B2 (en) | 2013-03-15 | 2020-05-26 | Tigenix Nv | Lymphocyte biomarkers for determining the clinical response to cell therapy |
| US10746729B2 (en) | 2015-04-24 | 2020-08-18 | Tigenix, S.A.U. | Biomarkers for determining the clinical response to cell therapy |
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| JP7276664B2 (ja) | 2016-11-11 | 2023-05-18 | ロングエバーオン インコーポレイテッド | 細胞性及び体液性免疫を達成するためのヒト間葉系幹細胞を使用する方法 |
| JP7628499B2 (ja) * | 2019-02-27 | 2025-02-10 | 武田薬品工業株式会社 | 同種異系療法のための改良された幹細胞集団 |
| US20240000850A1 (en) * | 2020-04-08 | 2024-01-04 | Figene, Llc | Methods and compositions for allergy and asthma treatment using fibroblasts |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001028581A1 (fr) * | 1999-10-20 | 2001-04-26 | Chugai Seiyaku Kabushiki Kaisha | Compositions medicinales pouvant inhiber gvhd |
| EP3461884B1 (en) * | 2004-03-22 | 2025-05-28 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| EP1871419A4 (en) * | 2005-04-22 | 2009-01-14 | Univ Maryland | METHODS OF TREATING REJECTION OF GRAFT AGAINST HOST |
| CA2832356C (en) * | 2011-04-06 | 2017-12-19 | Sanbio, Inc. | Methods and compositions for modulating peripheral immune function |
| US10660920B2 (en) | 2013-03-15 | 2020-05-26 | Tigenix Nv | Lymphocyte biomarkers for determining the clinical response to cell therapy |
-
2014
- 2014-03-17 US US14/776,233 patent/US10660920B2/en active Active
- 2014-03-17 JP JP2015562256A patent/JP6567430B2/ja active Active
- 2014-03-17 WO PCT/EP2014/055282 patent/WO2014140362A2/en not_active Ceased
- 2014-03-17 HU HUE14712628A patent/HUE046531T2/hu unknown
- 2014-03-17 AU AU2014230014A patent/AU2014230014B2/en active Active
- 2014-03-17 PT PT147126288T patent/PT2972368T/pt unknown
- 2014-03-17 CA CA3188652A patent/CA3188652A1/en active Pending
- 2014-03-17 EP EP19187915.4A patent/EP3581932A1/en not_active Withdrawn
- 2014-03-17 PL PL14712628T patent/PL2972368T3/pl unknown
- 2014-03-17 SG SG11201507521UA patent/SG11201507521UA/en unknown
- 2014-03-17 DK DK14712628.8T patent/DK2972368T3/da active
- 2014-03-17 CA CA2906299A patent/CA2906299C/en active Active
- 2014-03-17 ES ES14712628T patent/ES2748825T3/es active Active
- 2014-03-17 EP EP14712628.8A patent/EP2972368B1/en active Active
-
2015
- 2015-09-16 IL IL241586A patent/IL241586B/en active IP Right Grant
-
2019
- 2019-07-31 JP JP2019140842A patent/JP6883070B2/ja not_active Expired - Fee Related
-
2020
- 2020-02-05 AU AU2020200807A patent/AU2020200807B2/en active Active
- 2020-04-21 US US16/854,294 patent/US11478511B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT2972368T (pt) | 2019-10-18 |
| AU2014230014B2 (en) | 2019-11-14 |
| CA3188652A1 (en) | 2014-09-18 |
| EP2972368B1 (en) | 2019-07-24 |
| JP2016516985A (ja) | 2016-06-09 |
| IL241586B (en) | 2019-02-28 |
| AU2020200807B2 (en) | 2021-10-28 |
| US10660920B2 (en) | 2020-05-26 |
| WO2014140362A3 (en) | 2015-04-16 |
| JP2019215359A (ja) | 2019-12-19 |
| HK1219775A1 (en) | 2017-04-13 |
| AU2014230014A1 (en) | 2015-10-29 |
| DK2972368T3 (da) | 2019-10-07 |
| EP2972368A2 (en) | 2016-01-20 |
| PL2972368T3 (pl) | 2020-03-31 |
| HUE046531T2 (hu) | 2020-03-30 |
| EP3581932A1 (en) | 2019-12-18 |
| JP6883070B2 (ja) | 2021-06-09 |
| US20160067285A1 (en) | 2016-03-10 |
| AU2020200807A1 (en) | 2020-02-20 |
| ES2748825T3 (es) | 2020-03-18 |
| US20200261511A1 (en) | 2020-08-20 |
| CA2906299A1 (en) | 2014-09-18 |
| JP6567430B2 (ja) | 2019-08-28 |
| CA2906299C (en) | 2023-04-04 |
| WO2014140362A2 (en) | 2014-09-18 |
| US11478511B2 (en) | 2022-10-25 |
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