SG11201507367PA - Cell culture compositions with antioxidants and methods for polypeptide production - Google Patents

Cell culture compositions with antioxidants and methods for polypeptide production

Info

Publication number
SG11201507367PA
SG11201507367PA SG11201507367PA SG11201507367PA SG11201507367PA SG 11201507367P A SG11201507367P A SG 11201507367PA SG 11201507367P A SG11201507367P A SG 11201507367PA SG 11201507367P A SG11201507367P A SG 11201507367PA SG 11201507367P A SG11201507367P A SG 11201507367PA
Authority
SG
Singapore
Prior art keywords
antioxidants
methods
cell culture
polypeptide production
culture compositions
Prior art date
Application number
SG11201507367PA
Inventor
Natarajan Vijayasankaran
Steven J Meier
Sharat Varma
Yi Yang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50639996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201507367P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG11201507367PA publication Critical patent/SG11201507367PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • C12N2500/33Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/44Thiols, e.g. mercaptoethanol
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/46Amines, e.g. putrescine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
SG11201507367PA 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production SG11201507367PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361799602P 2013-03-15 2013-03-15
PCT/US2014/029772 WO2014145098A1 (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production

Publications (1)

Publication Number Publication Date
SG11201507367PA true SG11201507367PA (en) 2015-10-29

Family

ID=50639996

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201809452RA SG10201809452RA (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production
SG10201912621TA SG10201912621TA (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production
SG11201507367PA SG11201507367PA (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201809452RA SG10201809452RA (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production
SG10201912621TA SG10201912621TA (en) 2013-03-15 2014-03-14 Cell culture compositions with antioxidants and methods for polypeptide production

Country Status (19)

Country Link
US (5) US10017732B2 (en)
EP (2) EP2970875B1 (en)
JP (2) JP6591395B2 (en)
KR (2) KR20210037745A (en)
CN (2) CN105121628B (en)
AU (3) AU2014233393B2 (en)
BR (1) BR112015021993A8 (en)
CA (1) CA2903596C (en)
ES (1) ES2798307T3 (en)
HK (1) HK1218141A1 (en)
HR (1) HRP20200893T1 (en)
IL (2) IL240644B (en)
MX (2) MX360779B (en)
PL (1) PL2970875T3 (en)
RU (2) RU2718986C2 (en)
SG (3) SG10201809452RA (en)
SI (1) SI2970875T1 (en)
WO (1) WO2014145098A1 (en)
ZA (2) ZA201506155B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903596C (en) 2013-03-15 2023-10-03 Genentech, Inc. Cell culture compositions with antioxidants and methods for polypeptide production
TW201446961A (en) * 2013-05-06 2014-12-16 Abbvie Inc Compositions for cell culture and methods of using the same
MA40864A (en) * 2014-10-31 2017-09-05 Biogen Ma Inc HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES
TW202330904A (en) 2015-08-04 2023-08-01 美商再生元醫藥公司 Taurine supplemented cell culture medium and methods of use
US11254964B1 (en) * 2016-03-15 2022-02-22 Fresenius Kabi Deutschland Gmbh Cell culture methods for increased cell viability
US11186858B1 (en) 2016-03-15 2021-11-30 Fresenius Kabi Deutschland Gmbh Methods for increasing biosimilarity
AU2017264754A1 (en) * 2016-05-10 2018-12-13 Genentech, Inc. Methods of decreasing trisulfide bonds during recombinant production of polypeptides
CN106070537A (en) * 2016-07-08 2016-11-09 广东海洋大学 A kind of antioxidant suppressing the black change of shrimp and preparation method and application
CN112424339A (en) * 2018-07-13 2021-02-26 隆萨有限公司 Methods for improving production of biological products by reducing endogenous protein levels
JP7453151B2 (en) * 2018-11-02 2024-03-19 協和キリン株式会社 How to prepare liquid culture medium
HU231514B1 (en) * 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture
IL302538A (en) 2019-12-06 2023-07-01 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
MX2022013812A (en) 2020-05-08 2022-12-15 Regeneron Pharma Vegf traps and mini-traps and methods for treating ocular disorders and cancer.
WO2023194946A1 (en) * 2022-04-06 2023-10-12 Kashiv Biosciences, Llc An improved cell culture process for production of protein

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE266710C (en)
US3883511A (en) 1974-03-07 1975-05-13 Rit Rech Ind Therapeut New 6-aminopenicillanic acid derivative
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (en) 1978-01-06 1979-08-03 David Bernard DRYER FOR SCREEN-PRINTED SHEETS
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (en) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Process for the biotechnical production of alkaline phosphatase
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
CA1338518C (en) 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
ATE135397T1 (en) 1988-09-23 1996-03-15 Cetus Oncology Corp CELL CULTIVATION MEDIUM FOR INCREASED CELL GROWTH, TO INCREASE THE LONGEVITY AND EXPRESSION OF THE PRODUCTS
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
ATE144793T1 (en) 1989-06-29 1996-11-15 Medarex Inc BISPECIFIC REAGENTS FOR AIDS THERAPY
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
DE69120146T2 (en) 1990-01-12 1996-12-12 Cell Genesys Inc GENERATION OF XENOGENIC ANTIBODIES
JP3230091B2 (en) 1990-06-25 2001-11-19 ウェルファイド株式会社 Method for suppressing coloration of human serum albumin
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DK0814159T3 (en) 1990-08-29 2005-10-24 Genpharm Int Transgenic, non-human animals capable of forming heterologous antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
EP0571390B1 (en) * 1990-11-23 2000-03-08 Peptech Limited The delay, prevention and/or reversal of cell senescence
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
DE69229477T2 (en) 1991-09-23 1999-12-09 Cambridge Antibody Technology Ltd., Melbourn Methods for the production of humanized antibodies
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
CA2372813A1 (en) 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
AU691469B2 (en) * 1992-03-04 1998-05-21 Synaptic Pharmaceutical Corporation DNA encoding taurine and gaba transporters and uses thereof
JPH07102147B2 (en) * 1992-03-16 1995-11-08 株式会社ミドリ十字 Method for suppressing coloration of human serum albumin
EP0656064B1 (en) 1992-08-17 1997-03-05 Genentech, Inc. Bispecific immunoadhesins
ATE196606T1 (en) 1992-11-13 2000-10-15 Idec Pharma Corp THERAPEUTIC USE OF CHIMERIC AND LABELED ANTIBODIES DIRECTED AGAINST A DIFFERENTIATION ANTIGEN WHICH EXPRESSION IS RESTRICTED TO HUMAN B LYMPHOCYTES, FOR THE TREATMENT OF B-CELL LYMPHOMA
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
EP1709970A1 (en) 1995-04-27 2006-10-11 Abgenix, Inc. Human antibodies against EGFR, derived from immunized xenomice
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
CA2273194C (en) 1996-12-03 2011-02-01 Abgenix, Inc. Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
US20080318254A9 (en) 1997-03-10 2008-12-25 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
US20020012991A1 (en) * 1997-04-07 2002-01-31 Florence Chua Nee Ho Kit Fong Cell culture media for enhanced protein production
US20020173629A1 (en) 1997-05-05 2002-11-21 Aya Jakobovits Human monoclonal antibodies to epidermal growth factor receptor
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AU7984498A (en) * 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Serum-free cell growth medium
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
AU754808B2 (en) 1999-03-30 2002-11-28 Amgen Fremont Inc. Method for preparing Monoclonal Antibody
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
NZ517906A (en) 1999-10-04 2003-01-31 Medicago Inc Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants
RU2192884C2 (en) * 2000-11-09 2002-11-20 Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН Vaccine for antitumor immunity stimulation
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
JP2005519580A (en) 2001-05-16 2005-07-07 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ Human anti-pneumococcal antibody derived from non-human animals
CA2447791A1 (en) 2001-06-13 2002-12-19 Neslihan Delacruz Methods of culturing animal cells and polypeptide production in animal cells
HU229776B1 (en) 2001-08-23 2014-07-28 Genmab As Human antibodies specific for interleukin 15 (il-15)
US7371922B2 (en) * 2002-07-31 2008-05-13 The Board Of Trustees Of The University Of Illinois Nuclear transfer with porcine embryonic stem cells
EP2301966A1 (en) * 2002-12-16 2011-03-30 Genentech, Inc. Immunoglobulin variants and uses thereof
ES2373947T3 (en) * 2002-12-16 2012-02-10 Genmab A/S HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUCINE 8 (IL-8).
JP2007525410A (en) 2003-01-17 2007-09-06 ザ リサーチ ファンデーション オブ ステイト ユニバーシティ オブ ニューヨーク Antigen related to pancreatic cancer, antibody against them, diagnostic method and treatment method
WO2004069172A2 (en) * 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
WO2005023177A2 (en) 2003-05-21 2005-03-17 Medarex, Inc. Human monoclonal antibodies against bacillusanthracis protective antigen
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
US20060115901A1 (en) 2004-10-22 2006-06-01 Bahram Valamehr Method and media for single cell serum-free culture of CHO cells
EP1812557A4 (en) 2004-10-29 2009-11-04 Centocor Ortho Biotech Inc Chemically defined media compositions
BRPI0607203A2 (en) * 2005-02-18 2009-08-25 Medarex Inc isolated anti-cd30 antibody, host cell, methods for inhibiting cd30 + cell growth, and use of a defucosylated anti-cd30 antibody
KR20080005563A (en) * 2005-04-21 2008-01-14 글렌 에이. 골드스타인 N-acetylcysteine amide(nac amide) for treatment of oxidative stress associated with infertility
KR20070122497A (en) * 2005-04-22 2007-12-31 제넨테크, 인크. Method for treating dementia or alzheimer's disease with a cd20 antibody
CA2607663C (en) * 2005-05-19 2014-08-12 Amgen Inc. Compositions and methods for increasing the stability of antibodies
AR058140A1 (en) * 2005-10-24 2008-01-23 Wyeth Corp PROTEIN PRODUCTION METHOD USING ANTI-SENESCENCE COMPOUNDS
EP2035552A2 (en) 2006-06-09 2009-03-18 Anthrogenesis Corporation Placental niche and use thereof to culture stem cells
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
MX2010001319A (en) 2007-08-07 2010-06-01 Chugai Pharmaceutical Co Ltd Method of producing heterogeneous protein.
BRPI0818165B8 (en) 2007-10-12 2021-05-25 Hoffmann La Roche method of recombinant production of a heterologous immunoglobulin in cho cells that is secreted into the culture medium
CN101418330B (en) * 2008-06-20 2012-01-04 华东理工大学 Non protein culture medium adapted to large-scale culture of NSO cell and production of antibody
CN102224239A (en) * 2008-09-26 2011-10-19 先灵公司 High titer antibody production
CN101603026B (en) * 2009-06-19 2011-01-19 华东理工大学 Animal origin-free low-protein culture medium suitable for animal cell product production
US20120183531A1 (en) 2009-07-14 2012-07-19 Biogen Idee Ma Inc Methods for Inhibiting Yellow Color Formation in a Composition
LT2464725T (en) 2009-08-11 2020-06-10 F. Hoffmann-La Roche Ag Production of proteins in glutamine-free cell culture media
CN107254499B (en) 2010-04-26 2021-09-17 诺华股份有限公司 Improved cell culture process
CN103270416A (en) * 2010-11-05 2013-08-28 Abbvie公司 Efficient and effective supplement screening for the development of chemically defined media in cell culture
CN102093978A (en) * 2010-12-17 2011-06-15 上海市农业科学院 Prophase culture solution and anaphase culture solution for porcine early embryonic development
US20120171161A1 (en) * 2010-12-30 2012-07-05 Sascha Abramson Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
US20150267237A1 (en) * 2012-04-24 2015-09-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
AU2013305063A1 (en) 2012-08-20 2015-03-19 Schreder Method of and system for isolating LED luminaires from electrical surges
CA2903596C (en) 2013-03-15 2023-10-03 Genentech, Inc. Cell culture compositions with antioxidants and methods for polypeptide production

Also Published As

Publication number Publication date
IL240644B (en) 2020-04-30
NZ751400A (en) 2021-10-29
JP2019141053A (en) 2019-08-29
US10017732B2 (en) 2018-07-10
CA2903596A1 (en) 2014-09-18
US20160002593A1 (en) 2016-01-07
CN105121628B (en) 2020-03-24
CN110951670A (en) 2020-04-03
US20190144817A1 (en) 2019-05-16
RU2015144172A (en) 2017-04-24
EP3712252A1 (en) 2020-09-23
NZ712315A (en) 2021-07-30
AU2022231703A1 (en) 2022-10-06
US10131873B2 (en) 2018-11-20
IL273504A (en) 2020-05-31
AU2020223634A1 (en) 2020-09-10
CN105121628A (en) 2015-12-02
RU2015144172A3 (en) 2018-03-12
MX2018014043A (en) 2020-11-12
ZA201805630B (en) 2019-11-27
US20210017488A1 (en) 2021-01-21
RU2718986C2 (en) 2020-04-15
KR20150131172A (en) 2015-11-24
JP6591395B2 (en) 2019-10-16
AU2014233393A1 (en) 2015-09-10
HK1218141A1 (en) 2017-02-03
KR20210037745A (en) 2021-04-06
JP6843911B2 (en) 2021-03-17
ES2798307T3 (en) 2020-12-10
SG10201809452RA (en) 2018-11-29
US10829732B2 (en) 2020-11-10
EP2970875B1 (en) 2020-04-15
PL2970875T3 (en) 2020-08-10
KR102235452B1 (en) 2021-04-02
SI2970875T1 (en) 2020-08-31
US20190002822A1 (en) 2019-01-03
IL240644A0 (en) 2015-10-29
SG10201912621TA (en) 2020-02-27
EP2970875A1 (en) 2016-01-20
RU2020111947A (en) 2020-09-02
US10676710B2 (en) 2020-06-09
HRP20200893T1 (en) 2020-09-18
BR112015021993A8 (en) 2019-12-03
AU2014233393B2 (en) 2020-05-28
CA2903596C (en) 2023-10-03
ZA201506155B (en) 2018-11-28
JP2016514461A (en) 2016-05-23
US20140314779A1 (en) 2014-10-23
MX2015012875A (en) 2016-02-03
BR112015021993A2 (en) 2017-07-18
WO2014145098A1 (en) 2014-09-18
MX360779B (en) 2018-11-16

Similar Documents

Publication Publication Date Title
IL273504A (en) Cell culture compositions with antioxidants and methods for polypeptide production
HRP20190484T1 (en) Cell culture compositions and methods for polypeptide production
IL281515A (en) Serum-free cell culture medium
IL246262A0 (en) Media for cell culture
EP2968549A4 (en) Methods of cell culture
EP2971040A4 (en) Methods of cell culture
EP2971014A4 (en) Methods of cell culture
HK1221250A1 (en) Structure for culturing cells
IL245392B (en) Cell culture method
EP3026743A4 (en) Fuel cell production method and fuel cell
GB201420277D0 (en) Cell culture system
SG11201507828VA (en) Method for culturing hepatoblast-like cells and culture product thereof
EP2964746A4 (en) Fuel cell fermentation monitor
PL2978839T3 (en) Method for cell culture
EP3003325A4 (en) Methods of evaluating cell culture additives
SG11201507338PA (en) Method for culturing cells
GB201308905D0 (en) Cell culture
GB201306488D0 (en) Cell culture
AU2013904257A0 (en) Cell culture method
AU2013900676A0 (en) Structure for culturing cells
GB201308949D0 (en) Compositions and methods for reducing methane production