SG11201506487YA - Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor - Google Patents
Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptorInfo
- Publication number
- SG11201506487YA SG11201506487YA SG11201506487YA SG11201506487YA SG11201506487YA SG 11201506487Y A SG11201506487Y A SG 11201506487YA SG 11201506487Y A SG11201506487Y A SG 11201506487YA SG 11201506487Y A SG11201506487Y A SG 11201506487YA SG 11201506487Y A SG11201506487Y A SG 11201506487YA
- Authority
- SG
- Singapore
- Prior art keywords
- growth factor
- factor receptor
- epidermal growth
- mutant forms
- activating mutant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013072250 | 2013-03-06 | ||
PCT/GB2014/050655 WO2014135876A1 (en) | 2013-03-06 | 2014-03-05 | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201506487YA true SG11201506487YA (en) | 2015-09-29 |
Family
ID=50288181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201506487YA SG11201506487YA (en) | 2013-03-06 | 2014-03-05 | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
Country Status (42)
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2901269C (en) * | 2013-03-06 | 2022-01-18 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
EP3508204A1 (en) | 2013-08-23 | 2019-07-10 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2016051380A1 (en) * | 2014-10-01 | 2016-04-07 | Sun Pharmaceutical Industries Limited | Crystalline form of afatinib dimaleate |
CN107613769A (en) | 2015-02-17 | 2018-01-19 | 润新生物公司 | Some chemical entities, composition and method |
CN105859641B (en) | 2015-05-05 | 2018-11-16 | 杭州华东医药集团新药研究院有限公司 | The crystal and its preparation method and application of quinazoline crotonyl compounds 2-maleate |
CN105503906B (en) * | 2015-12-09 | 2018-09-11 | 上海宣创生物科技有限公司 | A kind of Triazolopyridine oxazine derivatives A crystal forms and preparation method thereof |
CN105503905B (en) * | 2015-12-09 | 2018-09-11 | 上海宣创生物科技有限公司 | A kind of Triazolopyridine oxazine derivatives B crystal form and preparation method thereof |
US10544106B2 (en) | 2016-08-15 | 2020-01-28 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN108658946B (en) * | 2017-03-28 | 2020-06-16 | 焦玉奇 | Novel quinazoline inhibitors |
CN107400094B (en) * | 2017-09-08 | 2020-04-03 | 贾玉庆 | Quinazolinyl carboxylic ester compound and application thereof |
CN109721552B (en) * | 2017-10-30 | 2022-09-20 | 上海北卡医药技术有限公司 | Preparation method of gefitinib |
CN109721551B (en) * | 2017-10-30 | 2022-09-20 | 上海北卡医药技术有限公司 | Preparation method of 3, 4-dihydro-7-methoxy-4-oxoquinazolin-6-ol acetate |
EP3749310A4 (en) | 2018-02-08 | 2021-08-18 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN109438423A (en) * | 2018-09-12 | 2019-03-08 | 通化师范学院 | A kind of new method of the synthesis technology of lung cancer target compound AZD-3759 |
KR20210061371A (en) | 2018-09-14 | 2021-05-27 | 스펙트럼 파마슈티컬즈 인크 | Cancer treatment kits and methods |
CN110903283B (en) * | 2018-09-17 | 2021-01-01 | 南京雷正医药科技有限公司 | Substituted quinazoline compound, pharmaceutical composition containing compound and application of compound |
CN112996784B (en) * | 2018-09-18 | 2023-05-30 | 北京越之康泰生物医药科技有限公司 | Indole derivatives and their use in medicine |
CN111747950B (en) * | 2019-03-29 | 2024-01-23 | 深圳福沃药业有限公司 | Pyrimidine derivatives for the treatment of cancer |
CN113645976A (en) | 2019-03-29 | 2021-11-12 | 阿斯利康(瑞典)有限公司 | Hitinib for treating non-small cell lung cancer |
CN110590683B (en) * | 2019-10-11 | 2022-08-19 | 山东四环药业股份有限公司 | Preparation method of intermediate of targeting drug AZD3759 |
US20210161897A1 (en) | 2019-11-12 | 2021-06-03 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
US20230056604A1 (en) | 2020-01-20 | 2023-02-23 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
US20210369709A1 (en) | 2020-05-27 | 2021-12-02 | Astrazeneca Ab | EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER |
CN111662273A (en) * | 2020-06-22 | 2020-09-15 | 通化师范学院 | Preparation method of tyrosine kinase inhibitor AZD3759 |
CN111675700A (en) * | 2020-06-22 | 2020-09-18 | 通化师范学院 | Preparation method of novel anti-cancer drug AZD3759 |
CN111848584A (en) * | 2020-07-10 | 2020-10-30 | 江南大学 | Polysubstituted quinazoline compound and application thereof |
CN113943273A (en) * | 2020-07-17 | 2022-01-18 | 上海天慈国际药业有限公司 | Preparation method of lung cancer drug AZD3759 |
CN113135901A (en) * | 2021-04-12 | 2021-07-20 | 南京雷正医药科技有限公司 | Crystal form of deuterated quinazoline hydrochloride compound and preparation and application thereof |
WO2023187037A1 (en) | 2022-03-31 | 2023-10-05 | Astrazeneca Ab | Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer |
WO2023209084A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer |
WO2023209090A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their application in the treatment of cancer |
WO2023209086A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds for treating cancer |
WO2023209088A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their use in the treatment of cancer |
WO2024002938A1 (en) | 2022-06-27 | 2024-01-04 | Astrazeneca Ab | Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
CN115813927A (en) * | 2022-07-06 | 2023-03-21 | 江苏晨泰医药科技有限公司 | Combined medicine of receptor tyrosine kinase inhibitor and biphenyl cyclooctadiene diluted lignan and application thereof |
WO2024008929A1 (en) | 2022-07-08 | 2024-01-11 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors in combination with hgf-receptor inhibitors for the treatment of cancer |
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DK2699264T3 (en) | 2011-04-20 | 2018-06-25 | Medimmune Llc | ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 |
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CA2901269C (en) * | 2013-03-06 | 2022-01-18 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
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2014
- 2014-03-05 CA CA2901269A patent/CA2901269C/en active Active
- 2014-03-05 MY MYPI2015702970A patent/MY186126A/en unknown
- 2014-03-05 UA UAA201508063A patent/UA115686C2/en unknown
- 2014-03-05 ES ES14710620.7T patent/ES2642201T3/en active Active
- 2014-03-05 LT LTEP14710620.7T patent/LT2964638T/en unknown
- 2014-03-05 EP EP14710620.7A patent/EP2964638B1/en active Active
- 2014-03-05 AP AP2015008696A patent/AP2015008696A0/en unknown
- 2014-03-05 SI SI201430449T patent/SI2964638T1/en unknown
- 2014-03-05 PE PE2015001877A patent/PE20152000A1/en active IP Right Grant
- 2014-03-05 RS RS20171114A patent/RS56566B1/en unknown
- 2014-03-05 NO NO14710620A patent/NO2964638T3/no unknown
- 2014-03-05 EP EP17179729.3A patent/EP3342770B1/en active Active
- 2014-03-05 CN CN201480012092.3A patent/CN105209456B/en active Active
- 2014-03-05 MX MX2015011818A patent/MX362247B/en active IP Right Grant
- 2014-03-05 US US14/197,476 patent/US9066979B2/en active Active
- 2014-03-05 PL PL14710620T patent/PL2964638T3/en unknown
- 2014-03-05 KR KR1020147021415A patent/KR101645112B1/en active IP Right Grant
- 2014-03-05 PT PT147106207T patent/PT2964638T/en unknown
- 2014-03-05 RU RU2015139513A patent/RU2656597C2/en active
- 2014-03-05 JP JP2015548782A patent/JP5894714B1/en active Active
- 2014-03-05 WO PCT/GB2014/050655 patent/WO2014135876A1/en active Application Filing
- 2014-03-05 SG SG11201506487YA patent/SG11201506487YA/en unknown
- 2014-03-05 BR BR112015020787-1A patent/BR112015020787B1/en active IP Right Grant
- 2014-03-05 AU AU2014224382A patent/AU2014224382B2/en active Active
- 2014-03-05 DK DK14710620.7T patent/DK2964638T3/en active
- 2014-03-05 ME MEP-2017-259A patent/ME03041B/en unknown
- 2014-03-05 HU HUE14710620A patent/HUE034568T2/en unknown
- 2014-03-06 UY UY0001035369A patent/UY35369A/en not_active Application Discontinuation
- 2014-03-06 AR ARP140100737A patent/AR095039A1/en active IP Right Grant
- 2014-03-06 TW TW103107724A patent/TWI543977B/en active
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2015
- 2015-05-12 US US14/709,900 patent/US9375432B2/en active Active
- 2015-08-11 DO DO2015000189A patent/DOP2015000189A/en unknown
- 2015-08-13 IL IL240578A patent/IL240578B/en active IP Right Grant
- 2015-08-21 CL CL2015002361A patent/CL2015002361A1/en unknown
- 2015-08-27 CR CR20150450A patent/CR20150450A/en unknown
- 2015-08-28 TN TN2015000368A patent/TN2015000368A1/en unknown
- 2015-09-04 MA MA38380A patent/MA38380A1/en unknown
- 2015-09-04 PH PH12015501965A patent/PH12015501965A1/en unknown
- 2015-09-04 NI NI201500123A patent/NI201500123A/en unknown
- 2015-09-04 GT GT201500251A patent/GT201500251A/en unknown
- 2015-10-05 ZA ZA2015/07353A patent/ZA201507353B/en unknown
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2016
- 2016-04-15 HK HK16104323.2A patent/HK1216315A1/en unknown
- 2016-05-24 US US15/162,816 patent/US9718806B2/en active Active
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2017
- 2017-06-23 US US15/631,230 patent/US20180016259A1/en not_active Abandoned
- 2017-10-18 CY CY20171101087T patent/CY1119487T1/en unknown
- 2017-11-06 HR HRP20171689TT patent/HRP20171689T1/en unknown
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