BRPI0602275A -
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
- Google Patents
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
Info
Publication number
BRPI0602275A
BRPI0602275ABRPI0602275-8ABRPI0602275ABRPI0602275ABR PI0602275 ABRPI0602275 ABR PI0602275ABR PI0602275 ABRPI0602275 ABR PI0602275ABR PI0602275 ABRPI0602275 ABR PI0602275A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca AbfiledCriticalAstrazeneca Ab
Priority to BRPI0602275-8ApriorityCriticalpatent/BRPI0602275A/en
Publication of BRPI0602275ApublicationCriticalpatent/BRPI0602275A/en
DERIVADO DE QUINAZOLINA, COMPOSIçãO FARMACêUTICA, USO DE UM DERIVADO DE QUINAZOLINA, MéTODOS PARA PRODUZIR UM EFEITO ANTI-PROLIFERATIVO EM UM ANIMAL DE SANGUE QUENTE E PARA TRATAR UM CáNCER EM UM ANIMAL DE SANGUE QUENTE E PROCESSO PARA A PREPARAçãO DE UM DERIVADO DE QUINALIZONA A invenção refere-se a derivados de quinazolina de fórmula (I), em que cada um dentre R¬ 1¬, R¬ 3¬, R¬ 20¬, X¬ 1¬, X¬ 2¬, Z, W (a) e (q) tem qualquer um dos significados definidos na descrição; processos para sua preparação, composições farmacêuticas contendo os mesmos e seu uso na fabricação de um medicamento para uso como um agente antiproliferativo na prevenção ou tratamento de tumores que são sensíveis à inibição de receptor erbB tirosina quinases, particularmente EGFR tirosina quinase.QUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION, USE OF A QUINAZOLINE DERIVATIVE, METHODS TO PRODUCE AN ANTI-PROLIFERATIVE EFFECT ON A BLOOD ANIMAL AND TO TREAT A CANCER IN A HOT BLOOD ANIMAL FOR THE PREPARATION OF A QUINAZOLINE The invention relates to quinazoline derivatives of formula (I), wherein each of R¬ 1¬, R¬ 3¬, R¬ 20¬, X¬ 1¬, X¬ 2¬, Z, W (a) and (q) has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors that are sensitive to inhibition of erbB receptor tyrosine kinases, particularly EGFR tyrosine kinase.
BRPI0602275-8A2006-03-242006-03-24
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
BRPI0602275A
(en)
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal and for treating a cancer in a warm-blooded animal and process for preparing a quinalizone derivative
compound, process for preparing same, pharmaceutical composition, use of a compound, and method for producing an antiproliferative effect on a warm-blooded animal
quinazoline derivative, compound, process for preparing a quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, and method for producing an antiproliferative effect on a warm-blooded animal
quinazoline derivative, or a pharmaceutically acceptable salt, or a pharmaceutically acceptable ester thereof, of formula I, use and process for the preparation thereof, compound, pharmaceutical composition, and methods for producing an antiproliferative effect in an animal of warm blood, for the prevention or treatment of a tumor, to provide a selective egfr tyrosine kinase inhibitory effect, and to treat cancer in a warm-blooded animal
quinazoline derivative, compound, pharmaceutical composition, use of quinazoline derivative, method for producing an antiproliferative effect on a warm-blooded animal, and process for the preparation of a quinazoline derivative
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods to produce an anti-proliferative effect in a warm-blooded animal, to prevent or treat tumors in a warm-blooded aminal, to provide a tyrosine kinase inhibitory effect of selective egfr in a warm-blooded animal and to treat cancer in a warm-blooded animal and process for the preparation of a quinazoline derivative
quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods for producing an antiproliferative effect in a warm-blooded animal, for prevention or treatment of tumors in a warm sago aminal, to provide a tyrosine kinase inhibitory effect of egfr selective in a warm-blooded animal and to treat a cancer in a warm-blooded animal and, process for the preparation of a quinazoline derivative
Quinazoline derivative or a pharmaceutically acceptable salt thereof, process for preparing it, pharmaceutical composition, use of said derivative or salt thereof, method for producing an antiproliferative effect on a warm-blooded animal in need of such treatment, and , compound or a salt thereof.
quinazoline derivative or a pharmaceutically acceptable salt thereof, pharmaceutical composition, process for preparing a quinazoline derivative or a pharmaceutically acceptable salt thereof
compound, process for preparing same, pharmaceutical composition, use of a compound, and methods for producing an inhibitory effect of b-raf and an anticancer effect on a warm-blooded animal, and for treating a disease or condition
Quinazoline derivative or a pharmaceutically acceptable salt thereof, process for its preparation, pharmaceutical composition, and use of the derivative or pharmaceutically acceptable salt thereof
compound, process for preparing a compound, use of a compound, methods of inhibiting trk activity, treating or prophylaxis of cancer, and producing an antiproliferative effect on a warm-blooded animal and pharmaceutical composition
compound, process for the manufacture thereof, composition, process for the manufacture thereof, method of treating or preventing a protein kinase-mediated disorder in an individual, use of a compound, assay to determine the activity of the compounds, and method inhibiting the activity or function of a protein kinase
compound, process for preparing same, pharmaceutical composition, use of a compound, and methods for producing an inhibitory effect of b-raf, and an anticancer effect on a warm-blooded animal, and for treating a disease.
pyrimidine derivative compounds linked to oxygen, pharmaceutical composition that includes said compounds, method of synthesis of the compounds and therapeutic uses thereof
compound or a pharmaceutically acceptable salt thereof, methods of limiting cell proliferation in a human or animal, treating a human or animal suffering from cancer, treating cancer prophylaxis, treating a human or animal suffering from a disease treatment of a human or animal suffering from a proliferative cancer treatment disease, for the treatment of cancer-associated infections, for the prophylactic treatment of cancer-associated infections, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, method of inhibiting chk1 kinase, and process for preparing a compound or a pharmaceutically acceptable salt thereof
compound, process for the preparation thereof, pharmaceutical composition, use of a compound, and methods for producing a b-raf inhibiting effect, and an anticancer effect on a warm-blooded animal, and for treating a disease