SG11201505800RA - Recombinant yeast transformant and process for preparing immunoglobulin fc fragment employing the same - Google Patents
Recombinant yeast transformant and process for preparing immunoglobulin fc fragment employing the sameInfo
- Publication number
- SG11201505800RA SG11201505800RA SG11201505800RA SG11201505800RA SG11201505800RA SG 11201505800R A SG11201505800R A SG 11201505800RA SG 11201505800R A SG11201505800R A SG 11201505800RA SG 11201505800R A SG11201505800R A SG 11201505800RA SG 11201505800R A SG11201505800R A SG 11201505800RA
- Authority
- SG
- Singapore
- Prior art keywords
- same
- recombinant yeast
- yeast transformant
- preparing immunoglobulin
- fragment employing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130011471A KR102073748B1 (en) | 2013-01-31 | 2013-01-31 | Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same |
| PCT/KR2014/000901 WO2014119956A1 (en) | 2013-01-31 | 2014-02-03 | Recombinant yeast transformant and process for preparing immunoglobulin fc fragment employing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201505800RA true SG11201505800RA (en) | 2015-08-28 |
Family
ID=51262604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201505800RA SG11201505800RA (en) | 2013-01-31 | 2014-02-03 | Recombinant yeast transformant and process for preparing immunoglobulin fc fragment employing the same |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9394546B2 (en) |
| EP (1) | EP2951284B1 (en) |
| JP (1) | JP6473696B2 (en) |
| KR (1) | KR102073748B1 (en) |
| CN (1) | CN105073977B (en) |
| AR (1) | AR095117A1 (en) |
| AU (1) | AU2014213134B2 (en) |
| CA (1) | CA2899838C (en) |
| DK (1) | DK2951284T3 (en) |
| ES (1) | ES2865443T3 (en) |
| RU (1) | RU2664862C2 (en) |
| SG (1) | SG11201505800RA (en) |
| TW (1) | TWI628279B (en) |
| WO (1) | WO2014119956A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102073748B1 (en) * | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same |
| KR101895634B1 (en) * | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | IgG4 Fc fragment comprising modified hinge region |
| KR20170037247A (en) * | 2015-09-25 | 2017-04-04 | 한미약품 주식회사 | A method for the production of immunoglobulin Fc region comprising initial Methionine residue |
| WO2021010531A1 (en) * | 2019-07-18 | 2021-01-21 | 한미약품 주식회사 | Novel method for preparing protein conjugate |
| CN114945587A (en) | 2019-07-18 | 2022-08-26 | 韩美药品株式会社 | Novel process for preparing long-acting drug conjugates by preparing intermediates |
| BR112022023738A2 (en) * | 2020-05-22 | 2023-01-31 | Hanmi Pharm Ind Co Ltd | LIQUID FORMULATION |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8504099D0 (en) | 1985-02-18 | 1985-03-20 | Wellcome Found | Physiologically active substances |
| US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
| ATE309376T1 (en) | 1990-06-28 | 2005-11-15 | Hoechst Ag | FUSION PROTEINS WITH IMMUNGLOBULIN COMPONENTS, THEIR PRODUCTION AND USE |
| EP0533006A1 (en) | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| DE69731289D1 (en) | 1996-03-18 | 2004-11-25 | Univ Texas | IMMUNGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-VALUE TIMES |
| JPH11174A (en) * | 1997-06-13 | 1999-01-06 | Asahi Breweries Ltd | Production of antibody fab fragment using yeast |
| ES2265693T3 (en) | 1998-10-16 | 2007-02-16 | Biogen Idec Ma Inc. | FUSION PROTEINS WITH INTERFERON-BETA AND USES. |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1200124B1 (en) | 1999-07-13 | 2008-09-10 | Bolder Biotechnology, Inc. | Erythropoietin-immunoglobulin fusion proteins |
| DE10021731B4 (en) | 2000-05-04 | 2005-12-08 | Aventis Pharma Deutschland Gmbh | Cyclipostins, process for their preparation and pharmaceutical preparation thereof |
| US6797493B2 (en) * | 2001-10-01 | 2004-09-28 | Lee-Hwei K. Sun | Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities |
| EP1682584B1 (en) * | 2003-11-13 | 2013-04-17 | Hanmi Science Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
| KR20050098032A (en) | 2004-01-19 | 2005-10-11 | 타이완 오아시스 테크놀러지 컴퍼니 리미티드 | White-light led and method for regulating the generated light color of the white-light led |
| KR100594607B1 (en) * | 2004-11-03 | 2006-06-30 | 재단법인서울대학교산학협력재단 | Probiotic microorganisms producing human growth hormone fused with Fc fragment of human IgG for oral delivery system and a method for producing the same |
| JP5457671B2 (en) * | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | M-CSF specific monoclonal antibody and use thereof |
| CN101258164B (en) * | 2005-08-16 | 2013-05-01 | 韩美科学株式会社 | A method for the mass production of immunoglobulin fc region deleted initial methionine residues |
| CN1974601A (en) * | 2005-11-28 | 2007-06-06 | 上海新生源医药研究有限公司 | New-type Fc fusion protein and its production process |
| AU2008233196B2 (en) * | 2007-03-30 | 2011-10-13 | Abbvie Inc. | Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells |
| WO2008145138A1 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Recombinant fucose modified monovalent half-antibodies obtained by molecular engineering |
| KR100980411B1 (en) * | 2007-10-15 | 2010-09-07 | 서울대학교산학협력단 | A method of intestinal delivery of therapeutic proteins using conditional suicide of genetically modified microorganisms |
| CN101748145A (en) * | 2008-12-03 | 2010-06-23 | 中国人民解放军军事医学科学院生物工程研究所 | Recombinant yeast for expressing antibody or antibody analogue as well as construction method and application thereof |
| EP2275442A1 (en) * | 2009-07-06 | 2011-01-19 | Ludwig-Maximilians-Universität München | Detection and vizualization of the cell cycle in living cells |
| KR102073748B1 (en) * | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | Recombinant yeast transformant and process for preparing immunoglobulin Fc fragment employing the same |
-
2013
- 2013-01-31 KR KR1020130011471A patent/KR102073748B1/en active IP Right Grant
-
2014
- 2014-01-29 TW TW103103472A patent/TWI628279B/en active
- 2014-01-31 AR ARP140100336A patent/AR095117A1/en not_active Application Discontinuation
- 2014-02-03 CA CA2899838A patent/CA2899838C/en active Active
- 2014-02-03 EP EP14746164.4A patent/EP2951284B1/en active Active
- 2014-02-03 US US14/763,722 patent/US9394546B2/en active Active
- 2014-02-03 AU AU2014213134A patent/AU2014213134B2/en active Active
- 2014-02-03 DK DK14746164.4T patent/DK2951284T3/en active
- 2014-02-03 JP JP2015555915A patent/JP6473696B2/en active Active
- 2014-02-03 WO PCT/KR2014/000901 patent/WO2014119956A1/en active Application Filing
- 2014-02-03 ES ES14746164T patent/ES2865443T3/en active Active
- 2014-02-03 RU RU2015133452A patent/RU2664862C2/en active
- 2014-02-03 SG SG11201505800RA patent/SG11201505800RA/en unknown
- 2014-02-03 CN CN201480006990.8A patent/CN105073977B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2664862C2 (en) | 2018-08-23 |
| CA2899838C (en) | 2023-03-07 |
| JP6473696B2 (en) | 2019-02-20 |
| CN105073977A (en) | 2015-11-18 |
| TW201443234A (en) | 2014-11-16 |
| AU2014213134B2 (en) | 2020-01-23 |
| KR20140098607A (en) | 2014-08-08 |
| CN105073977B (en) | 2020-11-10 |
| EP2951284A1 (en) | 2015-12-09 |
| EP2951284B1 (en) | 2021-03-31 |
| BR112015018288A2 (en) | 2018-08-14 |
| NZ710448A (en) | 2021-01-29 |
| KR102073748B1 (en) | 2020-02-05 |
| JP2016505277A (en) | 2016-02-25 |
| TWI628279B (en) | 2018-07-01 |
| RU2015133452A (en) | 2017-03-07 |
| EP2951284A4 (en) | 2016-08-17 |
| CA2899838A1 (en) | 2014-08-07 |
| AR095117A1 (en) | 2015-09-30 |
| ES2865443T3 (en) | 2021-10-15 |
| WO2014119956A1 (en) | 2014-08-07 |
| US9394546B2 (en) | 2016-07-19 |
| AU2014213134A1 (en) | 2015-08-13 |
| US20150361437A1 (en) | 2015-12-17 |
| DK2951284T3 (en) | 2021-04-26 |
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