SG11201503718QA - Dimeric compounds - Google Patents

Dimeric compounds

Info

Publication number
SG11201503718QA
SG11201503718QA SG11201503718QA SG11201503718QA SG11201503718QA SG 11201503718Q A SG11201503718Q A SG 11201503718QA SG 11201503718Q A SG11201503718Q A SG 11201503718QA SG 11201503718Q A SG11201503718Q A SG 11201503718QA SG 11201503718Q A SG11201503718Q A SG 11201503718QA
Authority
SG
Singapore
Prior art keywords
dimeric compounds
dimeric
compounds
Prior art date
Application number
SG11201503718QA
Other languages
English (en)
Inventor
Steven Gregory Mischke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201503718QA publication Critical patent/SG11201503718QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/121,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
SG11201503718QA 2012-12-11 2013-12-09 Dimeric compounds SG11201503718QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261735684P 2012-12-11 2012-12-11
PCT/EP2013/075874 WO2014090709A1 (en) 2012-12-11 2013-12-09 Dimeric compounds

Publications (1)

Publication Number Publication Date
SG11201503718QA true SG11201503718QA (en) 2015-06-29

Family

ID=49726780

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201503718QA SG11201503718QA (en) 2012-12-11 2013-12-09 Dimeric compounds

Country Status (19)

Country Link
US (1) US9409888B2 (he)
EP (1) EP2931719B1 (he)
JP (1) JP6309536B2 (he)
KR (1) KR20150093228A (he)
CN (1) CN104854100B (he)
AU (1) AU2013357493A1 (he)
CA (1) CA2887497A1 (he)
CL (1) CL2015001374A1 (he)
CO (1) CO7350640A2 (he)
CR (1) CR20150211A (he)
EA (1) EA201591024A1 (he)
HK (1) HK1213543A1 (he)
IL (1) IL238968A0 (he)
MA (1) MA38240B1 (he)
MX (1) MX2015007053A (he)
PE (1) PE20151083A1 (he)
PH (1) PH12015501088A1 (he)
SG (1) SG11201503718QA (he)
WO (1) WO2014090709A1 (he)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲mPGES-1抑制劑之三唑酮化合物
JP6302912B2 (ja) * 2012-09-19 2018-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 2−オキソ−2,3,4,5−テトラヒドロ−1h−ベンゾ[b]ジアゼピン及びがんの治療におけるその使用
RU2016122563A (ru) * 2013-11-18 2017-12-25 Ф. Хоффманн-Ля Рош Аг Тетрагидробензодиазепиноны
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201506872D0 (en) 2015-04-22 2015-06-03 Ge Oil & Gas Uk Ltd Novel compounds
WO2017056501A1 (ja) * 2015-10-02 2017-04-06 日本ゼオン株式会社 酸ハライド溶液の製造方法、混合溶液、及びモノエステル化合物の製造方法
CA3020792A1 (en) 2016-04-20 2017-10-26 Glaxosmithkline Intellectual Property Development Limited Conjugates comprising ripk2 inhibitors
EP3458101B1 (en) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Protac antibody conjugates and methods of use
WO2023031801A1 (en) 2021-09-01 2023-03-09 Novartis Ag Bifunctional degraders comprising a tead binder
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201402124A (zh) * 2005-08-19 2014-01-16 Array Biopharma Inc 作為類鐸受體(toll-like receptor)調節劑之8-經取代苯并氮雜呯
CN101861319B (zh) * 2007-11-16 2013-12-11 宇部兴产株式会社 苯并氮杂*酮化合物
WO2009136290A1 (en) * 2008-05-05 2009-11-12 Aegera Therapeutics, Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
WO2011059763A2 (en) * 2009-10-28 2011-05-19 Joyant Pharmaceuticals, Inc. Dimeric smac mimetics
JP6302912B2 (ja) * 2012-09-19 2018-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 2−オキソ−2,3,4,5−テトラヒドロ−1h−ベンゾ[b]ジアゼピン及びがんの治療におけるその使用

Also Published As

Publication number Publication date
MA38240A1 (fr) 2018-02-28
JP6309536B2 (ja) 2018-04-11
PE20151083A1 (es) 2015-08-06
MA38240B1 (fr) 2018-09-28
CA2887497A1 (en) 2014-06-19
KR20150093228A (ko) 2015-08-17
CN104854100B (zh) 2017-05-24
PH12015501088A1 (en) 2015-08-03
HK1213543A1 (zh) 2016-07-08
CO7350640A2 (es) 2015-08-10
AU2013357493A1 (en) 2015-04-30
EP2931719B1 (en) 2017-01-25
IL238968A0 (he) 2015-07-30
EP2931719A1 (en) 2015-10-21
MX2015007053A (es) 2015-09-28
CN104854100A (zh) 2015-08-19
CR20150211A (es) 2015-05-29
JP2016502986A (ja) 2016-02-01
CL2015001374A1 (es) 2015-09-25
WO2014090709A1 (en) 2014-06-19
EA201591024A1 (ru) 2015-09-30
US20160024055A1 (en) 2016-01-28
US9409888B2 (en) 2016-08-09

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