SG11201407346WA - Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent - Google Patents

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/169194 A1 (51) International Patent Classification: A61K 31/727 (2006.01) A61P15/04 (2006.01) A61K 38/11 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/SE2013/050510 7 May 2013 (07.05.2013) English (30) Priority Data: 61/644,036 61/668,150 8 May 2012 (08.05.2012) 5 July 2012 (05.07.2012) English US US (71) Applicant: DILAFOR AB [SE/SE]; Karolinska Institutet Science Park, Retzius vag 8, S-171 65 Solna (SE). (72) Inventors: EKMAN-ORDEBERG, Gunvor; Ridvagen 18 A, S-182 39 Danderyd (SE). MALMSTROM, Anders; Published: Vapenkroken 19, S-226 47 Lund (SE). (74) Agent: BERGENSTRAHLE & LINDVALL AB; Box 17704, S-l 18 93 Stockholm (SE). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: TREATMENT OF POSTPARTUM HAEMORRHAGE WITH CHEMICALLY MODIFIED HEPARIN OR HEPARAN SULPHATE AND A UTEROTONIC AGENT Oxytocin 0.01 IE/ml DF01 & •t 0\ i-H 0\ i-H en Figure 1c Time (s| ® (57) Abstract: The present invention refers to the use of certain sulfated glycosaminoglycans for treatment or prevention of post- ^ partum haemorrhage. The sulfated glycosaminoglycans have a reduced anticoagulant activity and are administered in combination Q with at least one uterotonic agent capable of promoting myometrial contractions of the uterus and thereby compress the vessels and cease the bleeding.