SG11201407194XA - Trehalose-containing mammalian cell suspension for prevention of pulmonary embolism formation - Google Patents

Abstract

(i2) mwu ft iz s-5 iv x m £ titz s issaj n d9) mm IHMMi _ (41) SI5S4>!H B 2013# 11 fll4 0(14.11.2013) w ,p 0 |PCT (10) WO 2013/168403 A1 (51) C12N 5/0775 (2010.01) A61K35/12 (2006.01) (21) (22) (25) (26) @U8&M©Wi§: (30) fiBfcftf '— 1 £: 4#Jg| 2012-106866 2012 ^5^ 8 0 (08.05.2012) JP (71) ttiJiA: ^5e^ttAiIII^XJi(OTSUKA PHAR­ MACEUTICAL FACTORY, INC.) [JP/JP]; T 7728601 1 1 5 Tokushi­ ma (JP). (72) ±}it(WAI)A, Tamaki); T 7728601 JI 1 15 ttasstt X Jf ®i3PIX±1 fa Tokushima (JP). ±g (DOI, Masako); T 7728601 = JS1 1 5 ^i^aAilii^xilfa Tokushima (JP). 3§±fe ®jS(KIKUCHI, Takeshi); T 7728601 — J1 1 1 5 ttsSSftt A M- §k X ±§ fa Tokushima (JP). Al x # IB] (KOBAYASHI, Eiji); T 7728601 %. 4 R R# PI rfT tS# = nrag^ftjs 1 1 5 tt5££a*S!J[3ixiSfa Tokushima (JP). (74) ItiA: S H f£ (HIROTA, Masanori); T 1070052 2# 1 9-%T K UXt>6B Tokyo (JP). (81) ^T©ffi®a)@faffi IS ^ PJ ft ): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) *!£H (asrofci^isy > ±T(Dmm(Dfcm% 11^ nlfb): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), 3. — =j V 7 (AM, AZ, BY, KG, KZ, RU, TJ, TM), 3 — • V / ^ (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). - (&&£ 21 &(3)) A61P9/00 (2006.01) C12N 5/071 (2010.01) PCT/JP2013/002925 2013 ^5^ 2 0(02.05.2013) B*lg B*lg = (54) Title: TREHALOSE-CONTAINING MAMMALIAN CELL SUSPENSION FOR PREVENTION OF PULMONARY EM- BOLISM FORMATION g (54)#^a>«ffc : h (57) Abstract: This invention addresses the problem of providing: a mammalian cell suspension capable of preventing the formation of pulmonary embolisms when mammalian stem cells or other mammalian cells are administered intravenously; or a prophylactic agent against the formation of pulmonary embolisms when mammalian cells are administered intravenously. This invention is characterized by the suspension of mammalian stem cells or other mammalian cells in physiological aqueous a solution including as an effective component thereof trehalose, derivative a thereof, or a salt of either, and the preparation of a mammalian cell suspension for the prevention of pulmonary embolism formation when administering mammalian cells intravenously, said suspension containing as an effective component thereof: mammalian cells; and trehalose, derivative a thereof, or a salt of either. In addition to mammalian ^ stem cells, dendritic cells, natural killer cells, alpha-beta islet cells, T cells, gamma-delta T cells, and cytotoxic lymphocytes, T etc., can be used as the mammalian cells. Mammalian mesenchymal stem cells and mammalian pluripotent stem cells are suitable ex- ^ amples of mammalian stem cells. gg (57) sift: £2 HW\P-X^L< it n utttKBifls, 7)iz>7 • **>-7 • =f ±fBnS?LSJjtl^« t LTMIL®) Mailt