SG11201403335WA - 1,5-naphthyridine derivatives and melk inhibitors containing the same - Google Patents
1,5-naphthyridine derivatives and melk inhibitors containing the sameInfo
- Publication number
- SG11201403335WA SG11201403335WA SG11201403335WA SG11201403335WA SG11201403335WA SG 11201403335W A SG11201403335W A SG 11201403335WA SG 11201403335W A SG11201403335W A SG 11201403335WA SG 11201403335W A SG11201403335W A SG 11201403335WA SG 11201403335W A SG11201403335W A SG 11201403335WA
- Authority
- SG
- Singapore
- Prior art keywords
- same
- inhibitors containing
- naphthyridine derivatives
- melk inhibitors
- melk
- Prior art date
Links
- 150000005055 1,5-naphthyridines Chemical class 0.000 title 1
- 229940124787 MELK inhibitor Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261588496P | 2012-01-19 | 2012-01-19 | |
| PCT/US2012/071434 WO2013109388A2 (en) | 2012-01-19 | 2012-12-21 | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201403335WA true SG11201403335WA (en) | 2014-09-26 |
Family
ID=48799799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403335WA SG11201403335WA (en) | 2012-01-19 | 2012-12-21 | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9067937B2 (zh) |
| EP (1) | EP2753329B1 (zh) |
| JP (1) | JP6159948B2 (zh) |
| KR (1) | KR101920109B1 (zh) |
| CN (1) | CN104968345B (zh) |
| AU (1) | AU2012366148B2 (zh) |
| BR (1) | BR112014014877B1 (zh) |
| CA (1) | CA2857346C (zh) |
| DK (1) | DK2753329T3 (zh) |
| ES (1) | ES2642720T3 (zh) |
| IL (1) | IL233529A (zh) |
| MX (1) | MX366983B (zh) |
| RU (1) | RU2645339C1 (zh) |
| SG (1) | SG11201403335WA (zh) |
| TW (2) | TWI623537B (zh) |
| WO (1) | WO2013109388A2 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2582610C2 (ru) * | 2010-07-30 | 2016-04-27 | Онкотерапи Сайенс, Инк. | Производные хинолина и содержащие их ингибиторы melk |
| US10254283B2 (en) | 2013-11-12 | 2019-04-09 | Dana-Farber Cancer Institute, Inc. | Biomarker for MELK activity and methods of using same |
| WO2015073509A2 (en) * | 2013-11-12 | 2015-05-21 | Dana-Farber Cancer Institute, Inc. | Biomarker for melk activity and methods of using same |
| WO2016141296A1 (en) | 2015-03-04 | 2016-09-09 | Dana-Farber Caner Institute, Inc. | Tricyclic kinase inhibitors of melk and methods of use |
| US10729680B2 (en) * | 2016-01-14 | 2020-08-04 | Bayer Pharma Aktiengesellschaft | 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines |
| BR112019003408A2 (pt) | 2016-08-31 | 2019-06-25 | Oncotherapy Science Inc | anticorpo monoclonal contra a melk e utilização da mesma |
| NL2020004B1 (en) | 2016-12-09 | 2018-07-02 | Ary Flohil Jacob | Treatment of diffuse intrinsic pontine glioma |
| US10981896B2 (en) | 2017-03-02 | 2021-04-20 | Board Of Regents, The University Of Texas System | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase |
| CN111171020A (zh) * | 2018-11-13 | 2020-05-19 | 上海轶诺药业有限公司 | 一类六元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK273689A (da) * | 1988-06-06 | 1989-12-07 | Sanofi Sa | 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler |
| FR2632639B1 (fr) * | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| US5240916A (en) * | 1989-07-27 | 1993-08-31 | Dowelanco | Naphthyridine derivatives |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| TWI345568B (en) | 2004-04-02 | 2011-07-21 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same |
| ATE491044T1 (de) | 2004-08-10 | 2010-12-15 | Oncotherapy Science Inc | Gene und polypeptide in verbindung mit brustkrebserkrankungen |
| CN101175862A (zh) | 2005-02-10 | 2008-05-07 | 肿瘤疗法科学股份有限公司 | 诊断膀胱癌的方法 |
| EP1907581A2 (en) | 2005-07-27 | 2008-04-09 | Oncotherapy Science, Inc. | Method of diagnosing small cell lung cancer |
| AU2007238372A1 (en) * | 2006-04-14 | 2007-10-25 | Astrazeneca Ab | 4-anilinoquinoline-3-carboxamides as CSF-1R kinase inhibitors |
| WO2008023841A1 (en) | 2006-08-25 | 2008-02-28 | Oncotherapy Science, Inc. | Breast cancer-associated gene, melk, and its interactions with bcl-g |
| JP2010529031A (ja) * | 2007-05-29 | 2010-08-26 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｐｉ３キナーゼ阻害剤としてのナフチリジン誘導体 |
| GB0801416D0 (en) * | 2008-01-25 | 2008-03-05 | Piramed Ltd | Pharmaceutical compounds |
| WO2010038165A1 (en) * | 2008-09-30 | 2010-04-08 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
| EP2332939A1 (en) * | 2009-11-26 | 2011-06-15 | Æterna Zentaris GmbH | Novel Naphthyridine derivatives and the use thereof as kinase inhibitors |
| RU2582610C2 (ru) * | 2010-07-30 | 2016-04-27 | Онкотерапи Сайенс, Инк. | Производные хинолина и содержащие их ингибиторы melk |
-
2012
- 2012-12-21 WO PCT/US2012/071434 patent/WO2013109388A2/en active Application Filing
- 2012-12-21 BR BR112014014877-5A patent/BR112014014877B1/pt active IP Right Grant
- 2012-12-21 CA CA2857346A patent/CA2857346C/en active Active
- 2012-12-21 DK DK12865937.2T patent/DK2753329T3/en active
- 2012-12-21 TW TW106119610A patent/TWI623537B/zh active
- 2012-12-21 SG SG11201403335WA patent/SG11201403335WA/en unknown
- 2012-12-21 EP EP12865937.2A patent/EP2753329B1/en active Active
- 2012-12-21 TW TW101149239A patent/TWI623536B/zh active
- 2012-12-21 RU RU2014133865A patent/RU2645339C1/ru active
- 2012-12-21 US US14/371,375 patent/US9067937B2/en active Active
- 2012-12-21 MX MX2014008780A patent/MX366983B/es active IP Right Grant
- 2012-12-21 KR KR1020147023109A patent/KR101920109B1/ko active IP Right Grant
- 2012-12-21 JP JP2014553304A patent/JP6159948B2/ja active Active
- 2012-12-21 CN CN201280067581.XA patent/CN104968345B/zh active Active
- 2012-12-21 AU AU2012366148A patent/AU2012366148B2/en active Active
- 2012-12-21 ES ES12865937.2T patent/ES2642720T3/es active Active
-
2014
- 2014-07-06 IL IL233529A patent/IL233529A/en active IP Right Grant
-
2015
- 2015-05-21 US US14/719,075 patent/US9345709B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015513313A (ja) | 2015-05-07 |
| WO2013109388A3 (en) | 2015-02-05 |
| TW201734015A (zh) | 2017-10-01 |
| JP6159948B2 (ja) | 2017-07-12 |
| KR20140115356A (ko) | 2014-09-30 |
| US9067937B2 (en) | 2015-06-30 |
| EP2753329A2 (en) | 2014-07-16 |
| MX366983B (es) | 2019-08-01 |
| TW201333005A (zh) | 2013-08-16 |
| US20150005302A1 (en) | 2015-01-01 |
| US20150328225A1 (en) | 2015-11-19 |
| WO2013109388A2 (en) | 2013-07-25 |
| BR112014014877B1 (pt) | 2020-09-08 |
| TWI623537B (zh) | 2018-05-11 |
| IL233529A (en) | 2017-10-31 |
| CN104968345A (zh) | 2015-10-07 |
| EP2753329A4 (en) | 2015-11-25 |
| BR112014014877A2 (pt) | 2017-06-13 |
| MX2014008780A (es) | 2014-10-23 |
| US9345709B2 (en) | 2016-05-24 |
| KR101920109B1 (ko) | 2018-11-19 |
| AU2012366148B2 (en) | 2016-12-01 |
| ES2642720T3 (es) | 2017-11-17 |
| IL233529A0 (en) | 2014-08-31 |
| CA2857346A1 (en) | 2013-07-25 |
| CN104968345B (zh) | 2018-05-08 |
| TWI623536B (zh) | 2018-05-11 |
| EP2753329B1 (en) | 2017-08-09 |
| WO2013109388A8 (en) | 2013-09-26 |
| DK2753329T3 (en) | 2017-10-23 |
| CA2857346C (en) | 2019-06-04 |
| AU2012366148A1 (en) | 2014-06-05 |
| RU2645339C1 (ru) | 2018-02-21 |
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