SG11201402131TA - Neurotoxins exhibiting shortened biological activity - Google Patents

Neurotoxins exhibiting shortened biological activity

Info

Publication number
SG11201402131TA
SG11201402131TA SG11201402131TA SG11201402131TA SG11201402131TA SG 11201402131T A SG11201402131T A SG 11201402131TA SG 11201402131T A SG11201402131T A SG 11201402131TA SG 11201402131T A SG11201402131T A SG 11201402131TA SG 11201402131T A SG11201402131T A SG 11201402131TA
Authority
SG
Singapore
Prior art keywords
biological activity
neurotoxins exhibiting
shortened biological
neurotoxins
exhibiting shortened
Prior art date
Application number
SG11201402131TA
Inventor
Michael Schmidt
Jürgen FREVERT
Fred Hofmann
Gerhard Groer
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48288558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201402131T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of SG11201402131TA publication Critical patent/SG11201402131TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SG11201402131TA 2011-11-09 2012-11-08 Neurotoxins exhibiting shortened biological activity SG11201402131TA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161628911P 2011-11-09 2011-11-09
EP11188440 2011-11-09
US201261659137P 2012-06-13 2012-06-13
EP12171801 2012-06-13
PCT/EP2012/072158 WO2013068476A1 (en) 2011-11-09 2012-11-08 Neurotoxins exhibiting shortened biological activity

Publications (1)

Publication Number Publication Date
SG11201402131TA true SG11201402131TA (en) 2014-08-28

Family

ID=48288558

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201402131TA SG11201402131TA (en) 2011-11-09 2012-11-08 Neurotoxins exhibiting shortened biological activity

Country Status (18)

Country Link
US (1) US9809809B2 (en)
EP (1) EP2776457B1 (en)
JP (1) JP6162135B2 (en)
KR (1) KR20150000468A (en)
CN (1) CN103974973A (en)
AR (1) AR089655A1 (en)
AU (1) AU2012334080B2 (en)
BR (1) BR112014011137A2 (en)
CA (1) CA2855173A1 (en)
CL (1) CL2014001217A1 (en)
ES (1) ES2638333T3 (en)
HK (1) HK1199890A1 (en)
IL (1) IL232508B (en)
MX (1) MX351012B (en)
RU (1) RU2646110C2 (en)
SG (1) SG11201402131TA (en)
TW (1) TWI583792B (en)
WO (1) WO2013068476A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2793934B1 (en) * 2011-12-23 2017-08-23 Merz Pharma GmbH & Co. KGaA Novel method for the manufacturing of di-chain proteins for use in humans
KR20180077343A (en) 2012-11-21 2018-07-06 입센 바이오이노베이션 리미티드 Methods for the manufacture of proteolytically processed polypeptides
GB201312317D0 (en) * 2013-07-09 2013-08-21 Syntaxin Ltd Cationic neurotoxins
PL2952205T3 (en) 2014-06-06 2018-01-31 Kleiner Fisman Galit Botulinum toxin for use in the treatment of paratonia
US20170189500A1 (en) 2014-06-13 2017-07-06 Merz Pharma Gmbh & Co. Kgaa Use of recombinant clostridial neurotoxins for the treatment of patients having certain muscle-related disorders
EP3154635A1 (en) 2014-06-13 2017-04-19 Merz Pharma GmbH & Co. KGaA Novel uses of recombinant clostridial neurotoxins with decreased duration of effect
EP3154562A1 (en) * 2014-06-13 2017-04-19 Merz Pharma GmbH & Co. KGaA Novel uses of recombinant clostridial neurotoxins with decreased duration of effect
EP3154572A1 (en) * 2014-06-13 2017-04-19 Merz Pharma GmbH & Co. KGaA Novel uses of recombinant clostridial neurotoxins with decreased duration of effect
KR102514666B1 (en) * 2014-12-19 2023-03-27 메르츠 파마 게엠베하 운트 코. 카가아 Means and methods for the determination of the biological activity of bont/e in cells
US10549042B2 (en) 2014-12-23 2020-02-04 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin prefilled glass syringe
PT3242884T (en) * 2015-01-09 2021-04-22 Ipsen Bioinnovation Ltd Cationic neurotoxins
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
WO2017063743A1 (en) 2015-10-14 2017-04-20 Merz Pharma Gmbh & Co. Kgaa Improvements to ultrasound-based therapy of photoaged tissue
WO2017148915A1 (en) 2016-03-02 2017-09-08 Merz Pharma Gmbh & Co. Kgaa Composition comprising botulinum toxin
TWI737742B (en) 2016-06-22 2021-09-01 德商梅茲製藥有限兩合公司 Botulinum toxin prefilled syringe system, kit having the same and use thereof
EP3290437A1 (en) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Novel recombinant clostridial neurotoxins with decreased duration of effect
CN106432423B (en) * 2016-09-21 2019-05-10 北京大学深圳研究生院 A kind of alpha-helix polypeptide and application thereof
EP3312193A1 (en) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum neurotoxins with accelerated onset of effect
KR20190126894A (en) * 2017-03-22 2019-11-12 본티, 인크. Botulinum neurotoxin for use in therapy
EP3642222A1 (en) 2017-06-20 2020-04-29 Merz Pharma GmbH & Co. KGaA Novel recombinant botulinum toxin with increased duration of effect
ES2930237T3 (en) * 2017-07-06 2022-12-09 Merz Pharma Gmbh & Co Kgaa New recombinant botulinum neurotoxins with longer duration of effects
WO2019133179A2 (en) * 2017-12-01 2019-07-04 Massachusetts Institute Of Technology Solution-phase affinity selection of inhibitors from combinatorial peptide libraries
WO2019158745A1 (en) * 2018-02-16 2019-08-22 Bontana Therapies Gmbh Nucleic acid-based botulinum neurotoxin for therapeutic use
JP2021516682A (en) * 2018-03-13 2021-07-08 スミヴェット ビー．ブイ．Ｓｍｉｖｅｔ Ｂ．Ｖ． Single domain antibody that binds to tetanus neurotoxin
GB201815844D0 (en) * 2018-09-28 2018-11-14 Ipsen Biopharm Ltd Therapeutic & comestic uses of botulinum neurotoxin serotype e
CN109666683B (en) * 2019-02-27 2021-10-29 昆明理工大学 Acetyl coenzyme A acetyltransferase gene RKAcaT2 and application thereof
CN110721314B (en) * 2019-10-11 2022-11-29 江苏恒泰生物科技有限公司 Anti-tumor nano-drug and preparation method thereof
SE2050326A1 (en) * 2020-03-25 2021-06-29 Jonathan Davies Engineered botulinum neurotoxin serotype E
CN111763663B (en) * 2020-07-09 2022-04-15 昆明理工大学 Gastrodia elata glucosyltransferase gene and application thereof
CN112410321B (en) * 2020-11-26 2022-01-28 昆明理工大学 Beta-glucosidase Ttbgl3 and application thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998001467A2 (en) * 1996-07-05 1998-01-15 Novartis Ag Inhibitors of the interaction between p53 and mdm2
GB9708092D0 (en) * 1997-04-22 1997-06-11 Univ Dundee Materials and methods relating to inhibiting the interaction of p53 and mdm2
GB9708089D0 (en) 1997-04-22 1997-06-11 Univ Dundee Materials and methods relating to stabilising substances in cells
TW574036B (en) 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
US6903187B1 (en) * 2000-07-21 2005-06-07 Allergan, Inc. Leucine-based motif and clostridial neurotoxins
US6678651B2 (en) * 2000-09-15 2004-01-13 Mindspeed Technologies, Inc. Short-term enhancement in CELP speech coding
DE10333317A1 (en) 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulation for protein medicines without the addition of human serum albumin (HSA)
KR100852822B1 (en) 2004-07-26 2008-08-18 메르츠 파마 게엠베하 운트 코. 카가아 Therapeutic composition with a botulinum neurotoxin
WO2008106507A2 (en) * 2007-02-27 2008-09-04 University Of South Florida Mdm2/mdmx inhibitor peptide
CA2680741A1 (en) * 2007-03-22 2009-01-15 The Regents Of The University Of California Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
WO2008157374A1 (en) * 2007-06-13 2008-12-24 The United States Of America, As Represented By The Secretrary Of Agriculture High-affinity monoclonal antibodies for botulinum toxin type a
EP2178905B1 (en) * 2007-07-26 2013-11-06 Allergan, Inc. Methods of activiting clostridial toxins
FR2924721B1 (en) * 2007-12-10 2010-02-26 Cytomics Systems METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD
US20100278826A1 (en) * 2008-06-10 2010-11-04 Shoemaker Charles B Designer Ubiquitin Ligases For Regulation Of Intracellular Pathogenic Proteins
US8343743B2 (en) * 2008-06-10 2013-01-01 Synaptic Research, Llc Designer ubiquitin ligases having a non-cleavable SNAP25 domain and E3-ligase domain
KR101818895B1 (en) * 2009-07-02 2018-01-15 메르츠 파마 게엠베하 운트 코. 카가아 Neurotoxins exhibiting shortened biological activity

Also Published As

Publication number Publication date
TW201326390A (en) 2013-07-01
MX2014005544A (en) 2014-05-30
EP2776457B1 (en) 2017-08-02
CL2014001217A1 (en) 2014-10-10
MX351012B (en) 2017-09-28
WO2013068476A1 (en) 2013-05-16
HK1199890A1 (en) 2015-07-24
IL232508A0 (en) 2014-06-30
CN103974973A (en) 2014-08-06
RU2646110C2 (en) 2018-03-01
CA2855173A1 (en) 2013-05-16
ES2638333T3 (en) 2017-10-19
TWI583792B (en) 2017-05-21
JP6162135B2 (en) 2017-07-12
AU2012334080B2 (en) 2016-12-15
JP2014533945A (en) 2014-12-18
KR20150000468A (en) 2015-01-02
BR112014011137A2 (en) 2018-06-12
EP2776457A1 (en) 2014-09-17
AR089655A1 (en) 2014-09-10
IL232508B (en) 2018-06-28
US20140308267A1 (en) 2014-10-16
US9809809B2 (en) 2017-11-07
AU2012334080A1 (en) 2014-05-15
RU2014123060A (en) 2015-12-20

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