FR2924721B1 - METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD - Google Patents

METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD

Info

Publication number
FR2924721B1
FR2924721B1 FR0759695A FR0759695A FR2924721B1 FR 2924721 B1 FR2924721 B1 FR 2924721B1 FR 0759695 A FR0759695 A FR 0759695A FR 0759695 A FR0759695 A FR 0759695A FR 2924721 B1 FR2924721 B1 FR 2924721B1
Authority
FR
France
Prior art keywords
activity
carrying
ubiquitin ligase
screening agents
agents modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0759695A
Other languages
French (fr)
Other versions
FR2924721A1 (en
Inventor
Cecile Bougeret
Jean Francois Briand
Patrick Zarzov
Dominique Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytomics Systems
Original Assignee
Cytomics Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytomics Systems filed Critical Cytomics Systems
Priority to FR0759695A priority Critical patent/FR2924721B1/en
Priority to PCT/FR2008/052258 priority patent/WO2009080981A2/en
Publication of FR2924721A1 publication Critical patent/FR2924721A1/en
Application granted granted Critical
Publication of FR2924721B1 publication Critical patent/FR2924721B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR0759695A 2007-12-10 2007-12-10 METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD Expired - Fee Related FR2924721B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0759695A FR2924721B1 (en) 2007-12-10 2007-12-10 METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD
PCT/FR2008/052258 WO2009080981A2 (en) 2007-12-10 2008-12-09 Method for screening for agents that modulate the activity of the mdm2 ubiquitin ligase and means for implementing said method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0759695A FR2924721B1 (en) 2007-12-10 2007-12-10 METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD

Publications (2)

Publication Number Publication Date
FR2924721A1 FR2924721A1 (en) 2009-06-12
FR2924721B1 true FR2924721B1 (en) 2010-02-26

Family

ID=39361392

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0759695A Expired - Fee Related FR2924721B1 (en) 2007-12-10 2007-12-10 METHOD FOR SCREENING AGENTS MODULATING THE ACTIVITY OF UBIQUITIN LIGASE MDM2 AND MEANS FOR CARRYING OUT SAID METHOD

Country Status (2)

Country Link
FR (1) FR2924721B1 (en)
WO (1) WO2009080981A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855173A1 (en) * 2011-11-09 2013-05-16 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
JP6286439B2 (en) * 2013-09-19 2018-02-28 国立大学法人 東京大学 Polyrotaxane in which cyclic molecule has polymer chain and method for producing the same
EP3421484A4 (en) * 2016-02-26 2019-08-14 Hu, Zhuowei Polypeptide, derivatives thereof, and application thereof in preparation of drugs having resistance to pulmonary fibrosis
JP2022532216A (en) * 2019-05-15 2022-07-13 シンセックス， インコーポレイテッド Selective degradation of proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740495B1 (en) * 2000-04-03 2004-05-25 Rigel Pharmaceuticals, Inc. Ubiquitin ligase assay
WO2004073615A2 (en) * 2003-02-13 2004-09-02 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Deazaflavin compounds and methods of use thereof

Also Published As

Publication number Publication date
WO2009080981A3 (en) 2009-08-27
FR2924721A1 (en) 2009-06-12
WO2009080981A2 (en) 2009-07-02

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20120831