SG10202011388UA - Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma - Google Patents

Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma

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Publication number
SG10202011388UA
SG10202011388UA SG10202011388UA SG10202011388UA SG10202011388UA SG 10202011388U A SG10202011388U A SG 10202011388UA SG 10202011388U A SG10202011388U A SG 10202011388UA SG 10202011388U A SG10202011388U A SG 10202011388UA SG 10202011388U A SG10202011388U A SG 10202011388UA
Authority
SG
Singapore
Prior art keywords
treating
cell carcinoma
squamous cell
cutaneous squamous
diagnosing
Prior art date
Application number
SG10202011388UA
Other languages
English (en)
Inventor
Prabha Sampath
Sundaram Gopinath
Shan Quah
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG10202011388UA publication Critical patent/SG10202011388UA/en

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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
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  • Plant Pathology (AREA)
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SG10202011388UA 2016-06-14 2017-06-14 Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma SG10202011388UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201604845W 2016-06-14

Publications (1)

Publication Number Publication Date
SG10202011388UA true SG10202011388UA (en) 2020-12-30

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SG10202011388UA SG10202011388UA (en) 2016-06-14 2017-06-14 Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma
SG11201810670VA SG11201810670VA (en) 2016-06-14 2017-06-14 Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma

Family Applications After (1)

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SG11201810670VA SG11201810670VA (en) 2016-06-14 2017-06-14 Use of mi r-198 in treating and diagnosing cutaneous squamous cell carcinoma

Country Status (5)

Country Link
US (1) US11053496B2 (fr)
EP (1) EP3468565A4 (fr)
CN (1) CN109789156B (fr)
SG (2) SG10202011388UA (fr)
WO (1) WO2017217935A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110736840A (zh) * 2019-10-21 2020-01-31 浙江大学 Mmp7、ctse或lamc2蛋白在制备肝内胆管细胞癌诊断试剂中的应用
US11976331B2 (en) 2020-01-31 2024-05-07 Castle Biosciences, Inc. Methods of diagnosing and treating patients with cutaneous squamous cell carcinoma
US11976333B2 (en) 2020-01-31 2024-05-07 Castle Biosciences, Inc. Methods of diagnosing and treating patients with cutaneous squamous cell carcinoma
CN111793605A (zh) * 2020-07-31 2020-10-20 北京中卫医正肿瘤医学研究有限公司 一种皮肤鳞癌原代肿瘤细胞的分离提取方法
WO2022036245A1 (fr) * 2020-08-14 2022-02-17 Castle Biosciences, Inc. Procédés de diagnostic et méthodes de traitement de patients atteints d'un carcinome à cellules squameuses cutané
CN113235188B (zh) * 2021-05-10 2022-09-06 中国科学技术大学 一种检测miRNA-198的荧光壳聚糖纤维及其制备方法
CN114015775A (zh) * 2021-11-10 2022-02-08 张波 头颈鳞癌治疗分子探针及应用
WO2023225618A2 (fr) * 2022-05-18 2023-11-23 Yale University Méthode d'estimation d'un programme moléculaire dynamique d'une cellule

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5451077B2 (ja) 2006-01-05 2014-03-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 肺癌の診断、予後診断及び治療のためのマイクロｒｎａを基盤とした方法及び組成物
US20100310583A1 (en) * 2007-01-31 2010-12-09 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
US20090326053A1 (en) * 2008-05-30 2009-12-31 Trustees Of Boston University Diagnostic uses of follistatin-like 1
KR101192297B1 (ko) 2008-12-10 2012-10-17 한국생명공학연구원 간암에 대한 신규 바이오마커 및 그의 용도
WO2010093379A1 (fr) 2009-02-13 2010-08-19 Fred Hutchinson Cancer Research Center L'établissement de profils d'expression génétique permet d'identifier des gènes prédictifs d'un carcinome malpighien de la cavité buccale et son pronostic
CN102892898B (zh) 2009-12-24 2016-03-09 复旦大学 用于肝细胞癌诊断的含微rna生物标记的诊断试剂盒和方法
EP2524059A4 (fr) 2010-01-13 2013-11-20 Caris Life Sciences Luxembourg Holdings Détection d'affections gastro-intestinales
US8987224B2 (en) 2011-08-05 2015-03-24 Baylor College Of Medicine MicroRNA-198 as a tumor suppressor in pancreatic cancer
SG11201500615WA (en) * 2012-07-27 2015-04-29 Agency Science Tech & Res Method of promoting wound healing
CN103173450B (zh) * 2013-03-07 2015-02-18 新乡医学院第一附属医院 与食管癌术后早期复发及预后相关的miRNA标志物及其应用
CN105586390B (zh) * 2014-10-23 2019-01-22 王辉云 一种用于乳腺癌预后判断的试剂盒

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Publication number Publication date
CN109789156A (zh) 2019-05-21
US11053496B2 (en) 2021-07-06
US20190330625A1 (en) 2019-10-31
EP3468565A4 (fr) 2020-08-19
WO2017217935A1 (fr) 2017-12-21
CN109789156B (zh) 2022-06-07
SG11201810670VA (en) 2018-12-28
EP3468565A1 (fr) 2019-04-17

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