SG10201909060SA - Substituted 2-anilinopyrimidine derivatives as egfr modulators - Google Patents

Substituted 2-anilinopyrimidine derivatives as egfr modulators

Info

Publication number
SG10201909060SA
SG10201909060SA SG10201909060SA SG10201909060SA SG 10201909060S A SG10201909060S A SG 10201909060SA SG 10201909060S A SG10201909060S A SG 10201909060SA SG 10201909060S A SG10201909060S A SG 10201909060SA
Authority
SG
Singapore
Prior art keywords
substituted
anilinopyrimidine derivatives
egfr modulators
anilinopyrimidine
derivatives
Prior art date
Application number
Other languages
English (en)
Inventor
Jirong Peng
Michael Costanzo
Michael Greco
Michael Green
Victoria Wilde
Don Zhang
Original Assignee
Beta Pharma Inc
Beta Pharma Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beta Pharma Inc, Beta Pharma Shanghai Co Ltd filed Critical Beta Pharma Inc
Publication of SG10201909060SA publication Critical patent/SG10201909060SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201909060S 2014-12-11 2015-12-11 Substituted 2-anilinopyrimidine derivatives as egfr modulators SG10201909060SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462090869P 2014-12-11 2014-12-11
US201562166883P 2015-05-27 2015-05-27

Publications (1)

Publication Number Publication Date
SG10201909060SA true SG10201909060SA (en) 2019-11-28

Family

ID=56108380

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201909060S SG10201909060SA (en) 2014-12-11 2015-12-11 Substituted 2-anilinopyrimidine derivatives as egfr modulators
SG11201704685TA SG11201704685TA (en) 2014-12-11 2015-12-11 Substituted 2-anilinopyrimidine derivatives as egfr modulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201704685TA SG11201704685TA (en) 2014-12-11 2015-12-11 Substituted 2-anilinopyrimidine derivatives as egfr modulators

Country Status (17)

Country Link
US (2) US10590111B2 (zh)
EP (1) EP3229798A4 (zh)
JP (2) JP6709786B2 (zh)
KR (1) KR20170098865A (zh)
CN (3) CN112457298B (zh)
AU (1) AU2015360360B2 (zh)
BR (1) BR112017012272A2 (zh)
CA (1) CA2970185C (zh)
CO (1) CO2017006962A2 (zh)
EA (1) EA036453B1 (zh)
HK (1) HK1245634A1 (zh)
IL (1) IL252554A0 (zh)
MX (1) MX2017007664A (zh)
PH (1) PH12017501057A1 (zh)
SG (2) SG10201909060SA (zh)
TW (1) TWI618704B (zh)
WO (1) WO2016094821A2 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085489B (zh) 2014-11-05 2019-03-01 益方生物科技（上海）有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
CN112457298B (zh) * 2014-12-11 2024-05-07 贝达医药公司 取代的2-苯胺基嘧啶衍生物及其作为表皮生长因子受体调节剂
CA3023228A1 (en) 2016-05-11 2017-11-16 Beta Pharma, Inc. 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers
KR102444835B1 (ko) 2016-05-26 2022-09-19 리커리엄 아이피 홀딩스, 엘엘씨 Egfr 억제제 화합물
SG11201810976TA (en) * 2016-06-17 2019-01-30 Beta Pharma Inc Pharmaceutical salts of n-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and crystalline forms thereof
CN106243044A (zh) * 2016-06-30 2016-12-21 浙江大学 含卤代丙烯酰胺侧链的嘧啶类衍生物及制备和应用
EP3492462B1 (en) * 2016-07-26 2023-08-30 Shenzhen TargetRx, Inc. Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
CN110799191B (zh) * 2017-06-16 2023-05-26 贝塔制药有限公司 N-(2-(2-(二甲氨基)乙氧基)-4-甲氧基-5-((4-(1-甲基-1h-吲哚-3-基)嘧啶-2-基)氨基)苯基)丙烯酰胺及其盐的药物制剂
CN109503573A (zh) * 2017-09-14 2019-03-22 昆明圣加南生物科技有限公司 2-取代苯胺基嘧啶衍生物及其用途
CN107935995A (zh) * 2017-11-28 2018-04-20 中山大学 一种新型2‑苯胺基嘧啶衍生物及其在制备抗肿瘤药物中的应用
CN108017633A (zh) * 2018-01-30 2018-05-11 天津大学 N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-2-氟代丙烯酰胺衍生物及应用
US20210253688A1 (en) * 2018-06-18 2021-08-19 UCB Biopharma SRL Gremlin-1 antagonist for the prevention and treatment of cancer
AU2020352528A1 (en) * 2019-09-23 2022-04-21 Beta Pharma, Inc. Treatment of EGFR mutant-related cancers using a combination of EGFR and CDK4/6 inhibitors
US20210161897A1 (en) 2019-11-12 2021-06-03 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
US20230056604A1 (en) 2020-01-20 2023-02-23 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
US20210369709A1 (en) 2020-05-27 2021-12-02 Astrazeneca Ab EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER
WO2023287783A1 (en) * 2021-07-13 2023-01-19 ACEA Therapeutics, Inc. Heterocyclic compounds and uses thereof
WO2023187037A1 (en) 2022-03-31 2023-10-05 Astrazeneca Ab Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer
WO2023209088A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab Bicyclic heteroaromatic compounds and their use in the treatment of cancer
US20240116926A1 (en) 2022-04-28 2024-04-11 Astrazeneca Ab Heteroaromatic compounds
WO2023209084A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer
WO2023209090A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab Bicyclic heteroaromatic compounds and their application in the treatment of cancer
WO2024002938A1 (en) 2022-06-27 2024-01-04 Astrazeneca Ab Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer
WO2024008929A1 (en) 2022-07-08 2024-01-11 Astrazeneca Ab Epidermal growth factor receptor tyrosine kinase inhibitors in combination with hgf-receptor inhibitors for the treatment of cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2699568C (en) * 1999-12-24 2013-03-12 Aventis Pharma Limited Azaindoles
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
AU2007328981B2 (en) * 2006-12-08 2013-07-11 F. Hoffmann-La Roche Ag Substituted pyrimidines and their use as JNK modulators
WO2010059711A1 (en) * 2008-11-18 2010-05-27 Wisconsin Alumni Research Foundation Sigma-1 receptor ligands and methods of use
WO2010129053A2 (en) 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
CN103501612B (zh) * 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
ES2900230T3 (es) * 2011-07-27 2022-03-16 Astrazeneca Ab Compuestos de 2-(2,4,5-anilino sustituido)pirimidina
US20150166591A1 (en) * 2012-05-05 2015-06-18 Ariad Pharmaceuticals, Inc. Methods and compositions for raf kinase mediated diseases
CN104860941B (zh) 2014-02-25 2017-03-22 上海海雁医药科技有限公司 2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
DK3157916T3 (en) * 2014-06-19 2019-03-18 Ariad Pharma Inc HETEROARYL COMPOUNDS FOR CHINESE INHIBITION
WO2016029839A1 (zh) 2014-08-25 2016-03-03 四川海思科制药有限公司 一种（取代的苯基）（取代的嘧啶）胺基衍生物及其制备方法和药物用途
CN105461695B (zh) * 2014-09-29 2018-03-27 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
CN105085489B (zh) * 2014-11-05 2019-03-01 益方生物科技（上海）有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
CN112457298B (zh) * 2014-12-11 2024-05-07 贝达医药公司 取代的2-苯胺基嘧啶衍生物及其作为表皮生长因子受体调节剂

Also Published As

Publication number Publication date
JP2020143131A (ja) 2020-09-10
CN112457298B (zh) 2024-05-07
EA036453B1 (ru) 2020-11-12
HK1245634A1 (zh) 2018-08-31
PH12017501057A1 (en) 2018-03-05
EP3229798A4 (en) 2018-05-30
WO2016094821A2 (en) 2016-06-16
EA201790921A1 (ru) 2017-12-29
IL252554A0 (en) 2017-07-31
TWI618704B (zh) 2018-03-21
US20200216421A1 (en) 2020-07-09
MX2017007664A (es) 2018-01-23
AU2015360360A1 (en) 2017-06-08
JP7181558B2 (ja) 2022-12-01
BR112017012272A2 (pt) 2018-01-30
WO2016094821A3 (en) 2016-08-25
US20170362203A1 (en) 2017-12-21
CN108024993A (zh) 2018-05-11
US11414401B2 (en) 2022-08-16
CA2970185A1 (en) 2016-06-16
CN112457298A (zh) 2021-03-09
TW201632512A (zh) 2016-09-16
EP3229798A2 (en) 2017-10-18
CN112375067B (zh) 2024-03-15
SG11201704685TA (en) 2017-07-28
CO2017006962A2 (es) 2017-10-20
JP2017537114A (ja) 2017-12-14
CA2970185C (en) 2023-10-17
JP6709786B2 (ja) 2020-06-17
CN112375067A (zh) 2021-02-19
CN108024993B (zh) 2020-11-06
KR20170098865A (ko) 2017-08-30
AU2015360360B2 (en) 2020-06-25
US10590111B2 (en) 2020-03-17

Similar Documents

Publication Publication Date Title
PH12017501057A1 (en) Substituted 2-anilinopyrimidine derivatives as egfr modulators
NZ737399A (en) Ccr2 modulators
MY192927A (en) Fused bicyclic compounds for the treatment of disease
MY197698A (en) Oxysterols and methods of use thereof
MX369623B (es) Compuestos biciclicos fusionados para el tratamiento de enfermedades.
MA39956A (fr) Analogues du benzomorphane et leur utilisation
MX2018004664A (es) Antagonistas de ep4.
MX2016009663A (es) Derivados de icariina.
MX2016011105A (es) Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona para usarse en el tratamiento de trastornos metabolicos.
MX2018005987A (es) Compuestos heterociclicos para el tratamiento de enfermedades.
PH12016501483B1 (en) P-substituted asymmetric ureas and medical uses thereof
GEP20186893B (en) Pyrazines modulators of gpr6
MX2020005707A (es) Profarmacos de creatina, composiciones y metodos de uso de estos.
WO2018211324A8 (en) Prodrugs for the treatment of disease
MX2018015269A (es) Derivados de tailanstatina a, metodos de tratamiento y metodos de sintesis de los mismos.
PH12016502480A1 (en) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
PH12017501147A1 (en) Total synthesis of trioxacarcin dc-45-a2 and preparation of trioxacarcin analogs
PH12017501134A1 (en) Fumagillol derivatives
EP3256131A4 (en) 3,5-DIHYDROXYPENTANOATE ANALOGUES FOR BONE FORMATION
HRP20181123T1 (hr) Spojevi 3,4-diamino-6-kloropirazin-2-karboksamida za liječenje bolesti posredovanih s enac
MX2017005669A (es) Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos.