SG10201901242PA - Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia - Google Patents

Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Info

Publication number
SG10201901242PA
SG10201901242PA SG10201901242PA SG10201901242PA SG10201901242PA SG 10201901242P A SG10201901242P A SG 10201901242PA SG 10201901242P A SG10201901242P A SG 10201901242PA SG 10201901242P A SG10201901242P A SG 10201901242PA SG 10201901242P A SG10201901242P A SG 10201901242PA
Authority
SG
Singapore
Prior art keywords
dementia
agitation
quinidine
treatment
pharmaceutical compositions
Prior art date
Application number
SG10201901242PA
Other languages
English (en)
Inventor
Joao Siffert
Original Assignee
Avanir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Publication of SG10201901242PA publication Critical patent/SG10201901242PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SG10201901242PA 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia SG10201901242PA (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US201562217142P 2015-09-11 2015-09-11
US201562217470P 2015-09-11 2015-09-11

Publications (1)

Publication Number Publication Date
SG10201901242PA true SG10201901242PA (en) 2019-03-28

Family

ID=55459653

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201901242PA SG10201901242PA (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia
SG11201701645WA SG11201701645WA (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201701645WA SG11201701645WA (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia

Country Status (14)

Country Link
US (3) US20190111047A1 (ja)
EP (4) EP3932907A3 (ja)
JP (4) JP2017531033A (ja)
KR (1) KR20170052684A (ja)
CN (3) CN110664801A (ja)
AU (3) AU2015314710A1 (ja)
CA (1) CA2960031A1 (ja)
IL (2) IL250786A0 (ja)
MX (3) MX2017003066A (ja)
PH (1) PH12017500444A1 (ja)
RU (2) RU2020116666A (ja)
SG (2) SG10201901242PA (ja)
TW (3) TW201613591A (ja)
WO (1) WO2016040930A1 (ja)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
WO2017020002A1 (en) * 2015-07-30 2017-02-02 Concert Pharmaceuticals, Inc. Deuterated morphinan compounds for use in treating agitation
CA2994153A1 (en) * 2015-07-30 2017-02-02 Concert Pharmaceuticals, Inc. Deuterated morphinan compounds for use in treating agitation
US10730841B2 (en) * 2016-07-04 2020-08-04 Avanir Pharmaceuticals, Inc. Methods for the synthesis of deuterated dextromethorphan
US11478467B2 (en) 2017-05-04 2022-10-25 Sreenivasarao Vepachedu Targeted drug rescue with novel compositions, combinations, and methods thereof
US20220226278A1 (en) * 2018-05-18 2022-07-21 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
CA3126062C (en) * 2019-01-07 2024-02-06 Antecip Bioventures Ii Llc Combination of dextromethorphan and bupropion for treating depression
EP3941469A4 (en) * 2019-03-18 2022-05-18 Avanir Pharmaceuticals, Inc. METHODS OF TREATING NEGATIVE SYMPTOMS OF SCHIZOPHRENIA USING DEUTTERATED DEXTROMETHORPHANE AND QUINIDINE
JP2023523373A (ja) * 2020-04-27 2023-06-02 アバニア ファーマシューティカルズ， インコーポレイテッド アルツハイマー病に関連する激越を治療する方法
CN115245515A (zh) * 2021-04-27 2022-10-28 杭州剂泰医药科技有限责任公司 一种组合物的医药用途
CN115322150B (zh) * 2021-05-11 2024-05-28 深圳信立泰药业股份有限公司 氘代右美沙芬氢溴酸盐的固体及其制备方法和医药用途
CN113209042A (zh) * 2021-05-28 2021-08-06 珠海润都制药股份有限公司 一种氢溴酸右美沙芬硫酸奎尼丁胶囊及其制备方法
WO2023076414A1 (en) * 2021-10-27 2023-05-04 Avanir Pharmaceuticals, Inc. Methods of treating agitation associated with alzheimer's disease

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US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5166207A (en) 1991-06-17 1992-11-24 Neurotherapeutics, Inc. Method for enhancing the systemic delivery of dextromethorphan for the treatment of neurological disorders
US5350756A (en) 1991-06-17 1994-09-27 Smith Richard A Use of a cytochrome oxidase inhibitor to increase the cough-suppressing activity of dextromorphan
US5366980A (en) 1991-06-17 1994-11-22 Smith Richard A Use of dextromethorphan and an oxidase inhibitor to treat dermatitis
US5206248A (en) 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
TW264473B (ja) * 1993-01-06 1995-12-01 Hoffmann La Roche
EP1634597A1 (en) * 1994-09-22 2006-03-15 Richard Alan Smith Compositions comprising dextromethorphan and quinidine or quinine for the treatment of emotional lability
US5874443A (en) 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US5886210A (en) 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
US5922683A (en) 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
CA2310664C (en) 1997-11-21 2008-03-11 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
IL137974A0 (en) 1998-03-26 2001-10-31 Shionogi & Co Indole derivatives having antiviral activity
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
FR2784988B1 (fr) 1998-10-23 2002-09-20 Adir Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
AU2007212586A1 (en) * 2006-02-03 2007-08-16 Avanir Pharmaceuticals Pharmaceutical compositions for treating depression, anxiety and neurodegenerative disorders
JP2009529673A (ja) * 2006-03-07 2009-08-20 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インク． 服薬遵守モニターシステム
WO2008097924A2 (en) * 2007-02-05 2008-08-14 Avanir Pharmaceuticals Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders
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EP3981404A1 (en) * 2013-11-05 2022-04-13 Antecip Bioventures II LLC Compositions and methods comprising bupropion or related compounds and dextromethorphan

Also Published As

Publication number Publication date
EP4166141A1 (en) 2023-04-19
KR20170052684A (ko) 2017-05-12
CA2960031A1 (en) 2016-03-17
JP2023105265A (ja) 2023-07-28
AU2015314710A1 (en) 2017-04-20
JP2020019818A (ja) 2020-02-06
RU2020116666A (ru) 2020-07-31
EP3932907A2 (en) 2022-01-05
EP3708168A3 (en) 2020-12-09
JP2021080300A (ja) 2021-05-27
JP7360409B2 (ja) 2023-10-12
AU2020289733A1 (en) 2021-01-21
SG11201701645WA (en) 2017-04-27
MX2022008181A (es) 2022-08-10
MX2017003066A (es) 2017-09-12
US20190111047A1 (en) 2019-04-18
MX2021010696A (es) 2021-10-01
CN107072990A (zh) 2017-08-18
RU2017112747A3 (ja) 2019-04-29
JP2017531033A (ja) 2017-10-19
US20240082237A1 (en) 2024-03-14
AU2022283671A1 (en) 2023-02-02
TW201613591A (en) 2016-04-16
TW202231278A (zh) 2022-08-16
CN110664801A (zh) 2020-01-10
EP3932907A3 (en) 2022-03-30
EP3193872A4 (en) 2018-02-28
US20200289499A1 (en) 2020-09-17
TW202106301A (zh) 2021-02-16
RU2017112747A (ru) 2018-10-15
EP3708168A2 (en) 2020-09-16
IL274742A (en) 2020-07-30
PH12017500444A1 (en) 2017-07-31
CN117427077A (zh) 2024-01-23
WO2016040930A1 (en) 2016-03-17
EP3193872A1 (en) 2017-07-26
IL250786A0 (en) 2017-04-30

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