SG10201900661YA - Purification platform for bispecific antibodies - Google Patents

Purification platform for bispecific antibodies

Info

Publication number
SG10201900661YA
SG10201900661YA SG10201900661YA SG10201900661YA SG10201900661YA SG 10201900661Y A SG10201900661Y A SG 10201900661YA SG 10201900661Y A SG10201900661Y A SG 10201900661YA SG 10201900661Y A SG10201900661Y A SG 10201900661YA SG 10201900661Y A SG10201900661Y A SG 10201900661YA
Authority
SG
Singapore
Prior art keywords
protein
binding
domain
bispecific antibodies
ablating
Prior art date
Application number
SG10201900661YA
Other languages
English (en)
Inventor
Andrew Tustian
Christine Edicott
Benjamin Adams
John Mattila
Hanne Bak
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201900661YA publication Critical patent/SG10201900661YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3819—Affinity chromatography of the nucleic acid-nucleic acid binding protein type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201900661YA 2014-07-26 2015-07-24 Purification platform for bispecific antibodies SG10201900661YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462029463P 2014-07-26 2014-07-26

Publications (1)

Publication Number Publication Date
SG10201900661YA true SG10201900661YA (en) 2019-02-27

Family

ID=53836215

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201700157VA SG11201700157VA (en) 2014-07-26 2015-07-24 Purification platform for bispecific antibodies
SG10201900661YA SG10201900661YA (en) 2014-07-26 2015-07-24 Purification platform for bispecific antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201700157VA SG11201700157VA (en) 2014-07-26 2015-07-24 Purification platform for bispecific antibodies

Country Status (20)

Country Link
US (1) US10626142B2 (fr)
EP (2) EP3172221B1 (fr)
JP (1) JP6702967B2 (fr)
KR (1) KR102440737B1 (fr)
CN (1) CN107074906B (fr)
AR (1) AR101262A1 (fr)
AU (1) AU2015298156B2 (fr)
CA (1) CA2955618A1 (fr)
DK (2) DK3172221T3 (fr)
EA (1) EA036154B1 (fr)
ES (2) ES2942533T3 (fr)
FI (1) FI3912987T3 (fr)
IL (1) IL255198B (fr)
MX (1) MX2017001217A (fr)
MY (1) MY187051A (fr)
PL (2) PL3172221T3 (fr)
SG (2) SG11201700157VA (fr)
TW (1) TWI704155B (fr)
WO (1) WO2016018740A2 (fr)
ZA (1) ZA201700622B (fr)

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EP3279216A4 (fr) 2015-04-01 2019-06-19 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production d'un hétéro-oligomère polypeptidique
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EP3398965A4 (fr) * 2015-12-28 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour favoriser l'efficacité de purification d'un polypeptide contenant une région fc
CN109071613A (zh) 2016-05-11 2018-12-21 通用电气医疗集团生物工艺研发股份公司 分离基质
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3455240A1 (fr) 2016-05-11 2019-03-20 GE Healthcare BioProcess R&D AB Procédé de conservation d'une matrice de séparation
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
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JP2022550930A (ja) 2019-12-06 2022-12-06 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｖｅｇｆタンパク質組成物及びその製造方法
MX2022006972A (es) * 2019-12-26 2022-08-04 Abl Bio Inc Metodo para la purificacion de peptido biologicamente activo utilizando cromatografia de afinidad con proteina a.
KR20210084054A (ko) 2019-12-27 2021-07-07 케이에스광학주식회사 투명한 방탄 적층 구조물
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Also Published As

Publication number Publication date
KR102440737B1 (ko) 2022-09-06
ZA201700622B (en) 2020-05-27
EA036154B1 (ru) 2020-10-06
EP3172221A2 (fr) 2017-05-31
ES2942533T3 (es) 2023-06-02
DK3172221T3 (da) 2021-08-09
EP3912987B1 (fr) 2023-03-22
EP3912987B9 (fr) 2023-05-31
IL255198B (en) 2022-04-01
TW201617359A (zh) 2016-05-16
MX2017001217A (es) 2017-05-03
WO2016018740A3 (fr) 2016-03-17
JP6702967B2 (ja) 2020-06-03
EP3172221B1 (fr) 2021-07-07
FI3912987T3 (fi) 2023-06-19
BR112017001443A2 (pt) 2017-12-05
AU2015298156A1 (en) 2017-02-23
WO2016018740A8 (fr) 2021-06-10
WO2016018740A2 (fr) 2016-02-04
ES2881026T3 (es) 2021-11-26
US10626142B2 (en) 2020-04-21
MY187051A (en) 2021-08-27
SG11201700157VA (en) 2017-02-27
EA201790247A1 (ru) 2017-08-31
DK3912987T3 (da) 2023-05-01
CN107074906B (zh) 2021-05-14
EP3912987A1 (fr) 2021-11-24
US20160024147A1 (en) 2016-01-28
IL255198A0 (en) 2017-12-31
AU2015298156B2 (en) 2020-07-16
CA2955618A1 (fr) 2016-02-04
TWI704155B (zh) 2020-09-11
NZ728700A (en) 2023-09-29
JP2017524740A (ja) 2017-08-31
PL3912987T3 (pl) 2023-07-24
AR101262A1 (es) 2016-12-07
KR20170035941A (ko) 2017-03-31
CN107074906A (zh) 2017-08-18
PL3172221T3 (pl) 2021-12-27

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