SG10201703682YA - Inhibitors of histone demethylases - Google Patents

Inhibitors of histone demethylases

Info

Publication number
SG10201703682YA
SG10201703682YA SG10201703682YA SG10201703682YA SG10201703682YA SG 10201703682Y A SG10201703682Y A SG 10201703682YA SG 10201703682Y A SG10201703682Y A SG 10201703682YA SG 10201703682Y A SG10201703682Y A SG 10201703682YA SG 10201703682Y A SG10201703682Y A SG 10201703682YA
Authority
SG
Singapore
Prior art keywords
inhibitors
histone demethylases
demethylases
histone
Prior art date
Application number
SG10201703682YA
Inventor
Marc Labelle
Thomas Boesen
Mukund Mehrotra
Qasim Khan
Farman Ullah
Original Assignee
Epitherapeutics Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitherapeutics Aps filed Critical Epitherapeutics Aps
Publication of SG10201703682YA publication Critical patent/SG10201703682YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG10201703682YA 2012-10-02 2013-10-01 Inhibitors of histone demethylases SG10201703682YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261708806P 2012-10-02 2012-10-02
DKPA201200599 2012-10-02
US201361770050P 2013-02-27 2013-02-27
DKPA201370112 2013-02-27

Publications (1)

Publication Number Publication Date
SG10201703682YA true SG10201703682YA (en) 2017-06-29

Family

ID=52781382

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201502452RA SG11201502452RA (en) 2012-10-02 2013-10-01 Inhibitors of histone demethylases
SG10201703682YA SG10201703682YA (en) 2012-10-02 2013-10-01 Inhibitors of histone demethylases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201502452RA SG11201502452RA (en) 2012-10-02 2013-10-01 Inhibitors of histone demethylases

Country Status (33)

Country Link
US (3) US20150203453A1 (en)
EP (3) EP3023415B1 (en)
JP (2) JP6530313B2 (en)
KR (1) KR102160320B1 (en)
CN (2) CN107434803B (en)
AP (1) AP2015008389A0 (en)
AU (1) AU2018200876C1 (en)
BR (1) BR112015007083A2 (en)
CA (2) CA3095019C (en)
CL (1) CL2015000829A1 (en)
CR (1) CR20150217A (en)
CY (1) CY1118695T1 (en)
DK (1) DK2903968T3 (en)
EA (1) EA030698B1 (en)
ES (2) ES2617905T3 (en)
HK (3) HK1207373A1 (en)
HR (1) HRP20170358T1 (en)
HU (1) HUE033380T2 (en)
IL (2) IL237831A (en)
LT (1) LT2903968T (en)
MD (1) MD20150043A2 (en)
ME (1) ME02597B (en)
MX (1) MX2015003959A (en)
NZ (1) NZ706635A (en)
PE (1) PE20150998A1 (en)
PH (2) PH12015500730A1 (en)
PL (2) PL2903968T3 (en)
PT (2) PT3023415T (en)
RS (1) RS55764B1 (en)
SG (2) SG11201502452RA (en)
SI (2) SI2903968T1 (en)
SM (1) SMT201700109B (en)
WO (1) WO2014053491A1 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2903968T3 (en) 2012-10-02 2017-05-31 Gilead Sciences, Inc. Inhibitors of histone demethylases
JP6514117B2 (en) * 2013-02-27 2019-05-15 エピセラピューティクス アーペーエス Inhibitors of histone demethylase
EP3126345A1 (en) * 2014-03-31 2017-02-08 Gilead Sciences, Inc. Inhibitors of histone demethylases
KR20170040805A (en) 2014-08-27 2017-04-13 길리애드 사이언시즈, 인코포레이티드 Compounds and methods for inhibiting histone demethylases
BR112017005511A2 (en) 2014-09-17 2018-08-14 Celgene Quanticel Res Inc histone demethylase inhibitors.
US9758517B2 (en) * 2014-09-17 2017-09-12 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
US10030017B2 (en) 2014-09-17 2018-07-24 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
AU2015340215B2 (en) 2014-10-29 2018-11-15 Dong-A St Co., Ltd Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs)
US20190100769A1 (en) * 2014-10-31 2019-04-04 Massachusetts Institute Of Technology Massively parallel combinatorial genetics for crispr
WO2016168349A1 (en) * 2015-04-14 2016-10-20 Gilead Sciences, Inc. Methods of treating hepatitis b virus
US10206930B2 (en) * 2015-08-14 2019-02-19 New York University Methods for treating T-cell acute lymphoblastic leukemia
US11998540B2 (en) * 2015-12-11 2024-06-04 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
CN108698997A (en) 2015-12-28 2018-10-23 赛尔基因昆蒂赛尔研究公司 Histone demethylase inhibitors
ES2921009T3 (en) * 2016-03-15 2022-08-16 Celgene Quanticel Res Inc Histone demethylase inhibitors
WO2017198785A1 (en) * 2016-05-18 2017-11-23 Ieo - Istituto Europeo Di Oncologia S.R.L. Oxime derivatives useful as inhibitors of histone demethylase kdm4c
BR102017010009A2 (en) 2016-05-27 2017-12-12 Gilead Sciences, Inc. COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
US11738013B2 (en) 2016-05-27 2023-08-29 Gilead Sciences, Inc. Methods for treating hepatitis B virus infections using NS5A, NS5B or NS3 inhibitors
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
MA46093A (en) 2016-09-02 2021-05-19 Gilead Sciences Inc TOLL-TYPE RECEIVER MODULATING COMPOUNDS
DK3526323T5 (en) 2016-10-14 2024-09-02 Prec Biosciences Inc MODIFIED MEGANUCLEASES SPECIFIC FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME
AR110768A1 (en) 2017-01-31 2019-05-02 Gilead Sciences Inc CRYSTAL FORMS OF TENOFOVIR ALAFENAMIDA
JOP20180008A1 (en) 2017-02-02 2019-01-30 Gilead Sciences Inc Compounds for the treatment of hepatitis b virus infection
JOP20180040A1 (en) 2017-04-20 2019-01-30 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2019123340A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
CN111511754B (en) 2017-12-20 2023-09-12 捷克共和国有机化学与生物化学研究所 2'3' cyclic dinucleotides with phosphonate bonds of activated STING adaptor protein
PE20210640A1 (en) 2018-02-13 2021-03-23 Gilead Sciences Inc INHIBITORS PD-1 / PD-L1
JP7050165B2 (en) 2018-02-26 2022-04-07 ギリアード サイエンシーズ， インコーポレイテッド Substituted pyrrolidine compounds as HBV replication inhibitors
WO2019195181A1 (en) 2018-04-05 2019-10-10 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
CN108186643B (en) * 2018-04-09 2021-04-20 徐州维康生物科技有限公司 Pharmaceutical composition with synergistic osteosarcoma resistance effect and application thereof
CN108464984A (en) * 2018-04-09 2018-08-31 徐州维康生物科技有限公司 A kind of epigenetic drug for treating osteosarcoma
US11142750B2 (en) 2018-04-12 2021-10-12 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
TWI712412B (en) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd-1/pd-l1 inhibitors
US20190359645A1 (en) 2018-05-03 2019-11-28 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide
CN108530381B (en) * 2018-05-07 2021-09-21 上海科技大学 Method for preparing diamine derivative from amide ester
ES2962674T3 (en) 2018-07-13 2024-03-20 Gilead Sciences Inc PD-1/PD-L1 inhibitors
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
CA3106548A1 (en) * 2018-08-06 2020-02-13 Dana-Farber Cancer Institute, Inc. Histone demethylase 5 inhibitors and uses thereof
CN109234313A (en) * 2018-09-25 2019-01-18 上海交通大学医学院附属第九人民医院 Cotransfection carrier and its application in anti-bone and flesh tumor medicine
CN112955435B (en) 2018-10-24 2024-09-06 吉利德科学公司 PD-1/PD-L1 inhibitors
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
AU2019372046B2 (en) 2018-10-31 2022-05-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as HPK1 inhibitors
AU2020231201A1 (en) 2019-03-07 2021-08-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
JP7350872B2 (en) 2019-03-07 2023-09-26 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． 3'3'-cyclic dinucleotide and its prodrug
EP3935065A1 (en) 2019-03-07 2022-01-12 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
CA3142513A1 (en) 2019-06-25 2020-12-30 Gilead Sciences, Inc. Flt3l-fc fusion proteins and methods of use
WO2021011891A1 (en) 2019-07-18 2021-01-21 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
EP4017476A1 (en) 2019-08-19 2022-06-29 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
CN117843811A (en) 2019-09-30 2024-04-09 吉利德科学公司 HBV vaccine and method of treating HBV
CN110652589A (en) * 2019-10-12 2020-01-07 中国人民解放军陆军军医大学 Application of GASC1 inhibitor in preparation of medicine for treating liver cancer
CN116057068A (en) 2019-12-06 2023-05-02 精密生物科学公司 Optimized engineered meganucleases with specificity for recognition sequences in hepatitis b virus genomes
CN111073900B (en) * 2019-12-09 2023-05-02 温氏食品集团股份有限公司 Method for improving development efficiency of pig cloned embryo
AU2021237718B2 (en) 2020-03-20 2023-09-21 Gilead Sciences, Inc. Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
CN115551998A (en) 2020-05-26 2022-12-30 希里欧斯株式会社 Low immunogenic cells
WO2022031894A1 (en) 2020-08-07 2022-02-10 Gilead Sciences, Inc. Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
CN111905102A (en) * 2020-09-04 2020-11-10 福建医科大学附属第一医院 Use of EZH2 inhibitors for the treatment of gliomas
TWI815194B (en) 2020-10-22 2023-09-11 美商基利科學股份有限公司 INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE
WO2022241134A1 (en) 2021-05-13 2022-11-17 Gilead Sciences, Inc. COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240005901A (en) 2021-06-23 2024-01-12 길리애드 사이언시즈, 인코포레이티드 Diacylglycerol Kinase Modulating Compounds
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
US11976072B2 (en) 2021-06-23 2024-05-07 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
CN114907317B (en) * 2022-06-01 2023-06-13 郑州大学 Pyrazole-vinyl-isonicotinic acid derivative and preparation method and application thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
ATE28864T1 (en) 1982-07-23 1987-08-15 Ici Plc AMIDE DERIVATIVES.
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
GB8717374D0 (en) 1987-07-22 1987-08-26 Smith Kline French Lab Pharmaceutically active compounds
US5010099A (en) 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
JP2001500851A (en) 1996-08-30 2001-01-23 ノバルティス アクチエンゲゼルシャフト Process for producing epothilone and intermediate products obtained during the process
CA2264908C (en) 1996-09-06 2006-04-25 Obducat Ab Method for anisotropic etching of structures in conducting materials
US5874438A (en) 1996-10-11 1999-02-23 Bayer Aktiengesellschaft 2,2'-bridged bis-2,4-diaminoquinazolines
HU229833B1 (en) 1996-11-18 2014-09-29 Biotechnolog Forschung Gmbh Epothilone d production process, and its use as cytostatic as well as phytosanitary agents
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
NZ506742A (en) 1998-02-25 2003-09-26 Sloan Kettering Inst Cancer Synthesis of desoxyepothilones and hydroxy acid derivative intermediates
NZ511722A (en) 1998-11-20 2004-05-28 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
PE20020354A1 (en) 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
PL401637A1 (en) 2002-03-13 2013-05-27 Array Biopharma Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
EP1758895A1 (en) * 2004-06-17 2007-03-07 Wyeth a Corporation of the State of Delaware Gonadotropin releasing hormone receptor antagonists
WO2008002671A2 (en) 2006-06-29 2008-01-03 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors
JPWO2009119088A1 (en) * 2008-03-25 2011-07-21 武田薬品工業株式会社 Heterocyclic compounds
SA109300195B1 (en) 2008-03-28 2013-04-20 Astrazeneca Ab A Novel Anti-Cancer Pharmaceutical Composition
EP2350051A4 (en) * 2008-10-29 2012-05-30 Sirtris Pharmaceuticals Inc Pyridine, bicyclic pyridine and related analogs as sirtuin modulators
UA108618C2 (en) 2009-08-07 2015-05-25 APPLICATION OF C-MET-MODULATORS IN COMBINATION WITH THEMOSOLOMID AND / OR RADIATION THERAPY FOR CANCER TREATMENT
CA2770307A1 (en) 2009-08-07 2011-02-10 The Wistar Institute Compositions containing jarid1b inhibitors and methods for treating cancer
TWI643857B (en) 2010-03-10 2018-12-11 英塞特公司 Piperidin-4-yl azetidine derivatives as jak1 inhibitors
WO2011148888A1 (en) * 2010-05-27 2011-12-01 あすか製薬株式会社 Heterocyclic ring compound and h1 receptor antagonist
WO2012007007A1 (en) * 2010-07-15 2012-01-19 Epitherapeutics Aps Inhibitors of hdme
US20130303545A1 (en) 2010-09-30 2013-11-14 Tamara Maes Cyclopropylamine derivatives useful as lsd1 inhibitors
WO2012047156A1 (en) * 2010-10-04 2012-04-12 Astrazeneca Ab Isoxazol-3(2h)-one analogs as plasminogen inhibitors and their use in the treatment of fibrinolysis related diseases
WO2012071469A2 (en) 2010-11-23 2012-05-31 Nevada Cancer Institute Histone demethylase inhibitors and uses thereof for treatment o f cancer
PE20141322A1 (en) 2011-03-25 2014-10-05 Glaxosmithkline Intellectual Property (N 2) Limited CYCLOPROPYLAMINES AS INHIBITORS OF LYSINE-SPECIFIC DESMETILASE 1
CA2843609C (en) 2011-08-15 2020-12-08 University Of Utah Research Foundation Substituted (e)-n'-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
EA023955B1 (en) 2011-10-27 2016-07-29 Астеллас Фарма Инк. Aminoalkyl-substituted n-thienyl benzamide derivative
WO2013081091A1 (en) * 2011-12-01 2013-06-06 国立大学法人 千葉大学 Drug for producing radiolabeled polypeptide reducing non-specific renal accumulation
CN102585150B (en) * 2012-02-01 2013-09-04 嘉兴学院 Preparation method of anionic aqueous polyurethane dispersoid for fabric coating and decoration
WO2013123411A1 (en) 2012-02-17 2013-08-22 Board Of Regents, The University Of Texas System Methods for diagnosing and treating cancer
WO2013129435A1 (en) * 2012-02-28 2013-09-06 協和発酵キリン株式会社 Fused thiophene derivative
PL2903968T3 (en) 2012-10-02 2017-05-31 Gilead Sciences, Inc. Inhibitors of histone demethylases
MX2015007205A (en) 2012-12-06 2016-03-31 Quanticel Pharmaceuticals Inc Histone demethylase inhibitors.
US8969343B2 (en) 2012-12-19 2015-03-03 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
EA028774B1 (en) 2012-12-21 2017-12-29 Квонтисел Фармасьютикалс, Инк. Histone demethylase inhibitors
JP6514117B2 (en) 2013-02-27 2019-05-15 エピセラピューティクス アーペーエス Inhibitors of histone demethylase
WO2014151106A1 (en) 2013-03-15 2014-09-25 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
RU2016112568A (en) 2013-09-05 2017-10-06 Дженентек, Инк. ANTIPROLIFERATIVE COMPOUNDS
EP3126345A1 (en) 2014-03-31 2017-02-08 Gilead Sciences, Inc. Inhibitors of histone demethylases

Also Published As

Publication number Publication date
RS55764B1 (en) 2017-07-31
AU2018200876C1 (en) 2020-02-06
IL253259B (en) 2018-04-30
AP2015008389A0 (en) 2015-04-30
KR102160320B1 (en) 2020-09-28
CA3095019C (en) 2022-06-14
JP2018016661A (en) 2018-02-01
DK2903968T3 (en) 2017-01-30
CN107434803A (en) 2017-12-05
CR20150217A (en) 2015-06-11
HK1215710A1 (en) 2016-09-09
CY1118695T1 (en) 2017-07-12
CN104981458B (en) 2017-07-21
EP2903968A1 (en) 2015-08-12
MX2015003959A (en) 2015-11-16
CN104981458A (en) 2015-10-14
JP2015532295A (en) 2015-11-09
SI2903968T1 (en) 2017-03-31
EP3150582A1 (en) 2017-04-05
SMT201700109B (en) 2017-03-08
WO2014053491A1 (en) 2014-04-10
US10189787B2 (en) 2019-01-29
CN107434803B (en) 2020-05-05
BR112015007083A2 (en) 2017-07-04
US10221139B2 (en) 2019-03-05
JP6530313B2 (en) 2019-06-12
CA2885969C (en) 2021-04-06
PH12015500730A1 (en) 2015-06-01
US20170320827A1 (en) 2017-11-09
EA201500394A1 (en) 2015-11-30
PT2903968T (en) 2017-03-13
EP3023415A1 (en) 2016-05-25
PL3023415T3 (en) 2018-06-29
CL2015000829A1 (en) 2015-12-04
AU2018200876A1 (en) 2018-02-22
PH12017501306A1 (en) 2019-02-27
NZ706635A (en) 2018-08-31
CA3095019A1 (en) 2014-04-10
ES2617905T3 (en) 2017-06-20
ME02597B (en) 2017-06-20
AU2018200876B2 (en) 2019-09-19
IL253259A0 (en) 2017-08-31
ES2654143T3 (en) 2018-02-12
HRP20170358T1 (en) 2017-04-21
EA030698B1 (en) 2018-09-28
LT2903968T (en) 2017-02-27
SI3023415T1 (en) 2018-01-31
PT3023415T (en) 2018-02-27
HK1223612A1 (en) 2017-08-04
HK1207373A1 (en) 2016-01-29
MD20150043A2 (en) 2015-08-31
EP2903968B1 (en) 2016-12-07
EP3023415B1 (en) 2017-12-06
HUE033380T2 (en) 2017-11-28
PE20150998A1 (en) 2015-06-29
US20140371195A1 (en) 2014-12-18
KR20150063517A (en) 2015-06-09
US20150203453A1 (en) 2015-07-23
SG11201502452RA (en) 2015-05-28
PL2903968T3 (en) 2017-05-31
CA2885969A1 (en) 2014-04-10
IL237831A (en) 2017-10-31

Similar Documents

Publication Publication Date Title
IL253259B (en) Inhibitors of histone demethylases
HK1220460A1 (en) Inhibitors of histone demethylases
HK1210611A1 (en) Histone demethylase inhibitors
RS56821B1 (en) Histone demethylase inhibitors
EP2928471A4 (en) Histone demethylase inhibitors
AP4029A (en) Inhibitors of beta-secretase
IL236963A0 (en) Inhibitors of beta-secretase
HK1247920A1 (en) Inhibitors of histone demethylases
AU2013326554A1 (en) Inhibitors of histone demethylases
PT2961736T (en) Inhibitors of histone demethylases