SG10201406210PA - Novel heterocycles - Google Patents

Novel heterocycles

Info

Publication number
SG10201406210PA
SG10201406210PA SG10201406210PA SG10201406210PA SG10201406210PA SG 10201406210P A SG10201406210P A SG 10201406210PA SG 10201406210P A SG10201406210P A SG 10201406210PA SG 10201406210P A SG10201406210P A SG 10201406210PA SG 10201406210P A SG10201406210P A SG 10201406210PA
Authority
SG
Singapore
Prior art keywords
novel heterocycles
heterocycles
novel
Prior art date
Application number
SG10201406210PA
Other languages
English (en)
Inventor
Visweswara Akella Satya Surya Srinivas
Ravikumar Tadiparthi
Ganapavarapu Veera Raghava Sharma
Thirunavukkarasu Sappanimuthu
Durairaj Peter Bhakiaraj
Virendra Kachhadia
Kilambi Narasimhan
Sathya Narayana Thara
Sriram Rajagopal
Sukunath Narayanan
Venkatesan Parameswaran
Venkatesan Janarthanam
Maruthikumar Narayanam
Sathyanarayana Gadde
Uma Ramachandran
Gopalan Balasubramanian
Narayanan Surendran
Shridhar Narayanan
Lolaknath Santosh Vishwakarma
Sanjeev Saxena
Original Assignee
Orchid Res Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Res Lab Ltd filed Critical Orchid Res Lab Ltd
Publication of SG10201406210PA publication Critical patent/SG10201406210PA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
SG10201406210PA 2008-02-01 2009-01-30 Novel heterocycles SG10201406210PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN271CH2008 2008-02-01

Publications (1)

Publication Number Publication Date
SG10201406210PA true SG10201406210PA (en) 2014-11-27

Family

ID=40913343

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201406210PA SG10201406210PA (en) 2008-02-01 2009-01-30 Novel heterocycles

Country Status (15)

Country Link
US (2) US8420653B2 (ko)
EP (1) EP2245017A4 (ko)
JP (1) JP5704924B2 (ko)
KR (1) KR101595506B1 (ko)
CN (1) CN101965338B (ko)
AU (1) AU2009208712B2 (ko)
BR (1) BRPI0912029A2 (ko)
CA (1) CA2715069C (ko)
IL (1) IL207298A (ko)
MX (1) MX336946B (ko)
NZ (1) NZ587153A (ko)
RU (1) RU2572616C2 (ko)
SG (1) SG10201406210PA (ko)
WO (1) WO2009095773A2 (ko)
ZA (1) ZA201005986B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ305457B6 (cs) * 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
AR090880A1 (es) * 2012-04-30 2014-12-10 Janssen R & D Ireland Derivados de pirimidina
EP3328382A4 (en) 2015-09-17 2018-12-19 Marvin J. Miller Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2024119067A1 (en) 2022-12-02 2024-06-06 Neumora Therapeutics, Inc. Methods of treating neurological disorders

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US4698340A (en) * 1984-07-19 1987-10-06 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine derivatives, processes for preparation thereof and composition containing the same
US5166137A (en) 1991-03-27 1992-11-24 Nobipols Forskningsstiftelse Guluronic acid polymers and use of same for inhibition of cytokine production
AU683620B2 (en) 1992-09-28 1997-11-20 Pfizer Inc. Substituted pyrimidines for control of diabetic complications
US5622977A (en) 1992-12-23 1997-04-22 Celltech Therapeutics Limited Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
PT706513E (pt) 1993-07-02 2002-10-31 Byk Gulden Lomberg Chem Fab Benzimidazois substituidos por fluoralcoxi e sua utilizacao como inibidores de fosfodiesterase nucleotidica ciclica
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
US5527546A (en) 1994-08-10 1996-06-18 Bayer Corporation Human interleukin 6 inhibitor
DK0824588T3 (da) 1995-05-11 2004-08-16 Applied Research Systems Inhibitor af IL-6 aktivitet
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
NZ507022A (en) 1998-04-01 2002-06-28 Janssen Pharmaceutica Nv PDE IV inhibiting pyridine derivatives
US6410563B1 (en) 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
JPWO2002074298A1 (ja) 2001-03-21 2004-07-08 小野薬品工業株式会社 Ｉｌ−６産生阻害剤
US7101873B2 (en) * 2002-04-10 2006-09-05 Bexel Pharmaceuticals Inc. Pyrimidinedione derivatives
AU2003216585A1 (en) * 2002-04-10 2003-10-20 Orchid Chemicals And Pharmaceuticals Limited Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases
EP1542978B1 (en) * 2002-07-22 2011-04-13 Orchid Research Laboratories Limited Novel bio-active molecules
WO2004094379A2 (en) * 2003-04-16 2004-11-04 Amgen Inc. 3-phenyl-4- (pyrimidin-2-yl) -6- (piperidin-4-yl) derivatives and related compounds as tnf-alpha and il-1 inhibitors for the treatment of inflammations
TW200614993A (en) * 2004-06-11 2006-05-16 Akzo Nobel Nv 4-phenyl-pyrimidine-2-carbonitrile derivatives
ES2600804T3 (es) * 2006-01-19 2017-02-10 Orchid Pharma Limited Nuevos heterociclos
US7863446B2 (en) * 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles

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Publication number Publication date
RU2010136707A (ru) 2012-03-10
IL207298A (en) 2017-08-31
MX2010008414A (es) 2010-12-15
KR20100131443A (ko) 2010-12-15
NZ587153A (en) 2012-10-26
EP2245017A2 (en) 2010-11-03
AU2009208712A1 (en) 2009-08-06
WO2009095773A3 (en) 2010-04-22
EP2245017A4 (en) 2011-12-28
WO2009095773A2 (en) 2009-08-06
JP5704924B2 (ja) 2015-04-22
AU2009208712B2 (en) 2013-03-14
US20130172350A1 (en) 2013-07-04
ZA201005986B (en) 2011-04-28
CN101965338B (zh) 2014-09-17
IL207298A0 (en) 2010-12-30
WO2009095773A8 (en) 2010-01-07
BRPI0912029A2 (pt) 2020-06-30
KR101595506B1 (ko) 2016-02-18
RU2572616C2 (ru) 2016-01-20
CN101965338A (zh) 2011-02-02
CA2715069C (en) 2016-06-07
US8828999B2 (en) 2014-09-09
US8420653B2 (en) 2013-04-16
CA2715069A1 (en) 2009-08-06
US20100329998A1 (en) 2010-12-30
JP2011510967A (ja) 2011-04-07
MX336946B (es) 2016-02-08

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