SG10201402287TA - Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers - Google Patents

Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers

Info

Publication number
SG10201402287TA
SG10201402287TA SG10201402287TA SG10201402287TA SG10201402287TA SG 10201402287T A SG10201402287T A SG 10201402287TA SG 10201402287T A SG10201402287T A SG 10201402287TA SG 10201402287T A SG10201402287T A SG 10201402287TA SG 10201402287T A SG10201402287T A SG 10201402287TA
Authority
SG
Singapore
Prior art keywords
diagnosis
methods
metabolic disorders
intracellular molecules
environmental influencers
Prior art date
Application number
SG10201402287TA
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of SG10201402287TA publication Critical patent/SG10201402287TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
SG10201402287TA 2009-05-11 2010-05-11 Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers SG10201402287TA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17724409P 2009-05-11 2009-05-11
US17724309P 2009-05-11 2009-05-11
US17724509P 2009-05-11 2009-05-11
US17724609P 2009-05-11 2009-05-11
US17724109P 2009-05-11 2009-05-11

Publications (1)

Publication Number Publication Date
SG10201402287TA true SG10201402287TA (en) 2014-07-30

Family

ID=43085533

Family Applications (10)

Application Number Title Priority Date Filing Date
SG10201402289VA SG10201402289VA (en) 2009-05-11 2010-05-11 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
SG2011082898A SG175992A1 (en) 2009-05-11 2010-05-11 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
SG2011082930A SG175996A1 (en) 2009-05-11 2010-05-11 Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082880A SG175991A1 (en) 2009-05-11 2010-05-11 Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402288RA SG10201402288RA (en) 2009-05-11 2010-05-11 Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402293SA SG10201402293SA (en) 2009-05-11 2010-05-11 Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082914A SG175994A1 (en) 2009-05-11 2010-05-11 Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402287TA SG10201402287TA (en) 2009-05-11 2010-05-11 Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402291QA SG10201402291QA (en) 2009-05-11 2010-05-11 Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082906A SG175993A1 (en) 2009-05-11 2010-05-11 Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers

Family Applications Before (7)

Application Number Title Priority Date Filing Date
SG10201402289VA SG10201402289VA (en) 2009-05-11 2010-05-11 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
SG2011082898A SG175992A1 (en) 2009-05-11 2010-05-11 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
SG2011082930A SG175996A1 (en) 2009-05-11 2010-05-11 Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082880A SG175991A1 (en) 2009-05-11 2010-05-11 Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402288RA SG10201402288RA (en) 2009-05-11 2010-05-11 Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG10201402293SA SG10201402293SA (en) 2009-05-11 2010-05-11 Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082914A SG175994A1 (en) 2009-05-11 2010-05-11 Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201402291QA SG10201402291QA (en) 2009-05-11 2010-05-11 Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
SG2011082906A SG175993A1 (en) 2009-05-11 2010-05-11 Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers

Country Status (13)

Country Link
US (15) US20110027247A1 (en)
EP (5) EP2430455A4 (en)
JP (13) JP5903735B2 (en)
KR (7) KR20120034649A (en)
CN (7) CN102481269B (en)
AU (9) AU2010247761A1 (en)
BR (5) BRPI1010827A2 (en)
CA (5) CA2763325A1 (en)
EA (5) EA201101519A1 (en)
IL (5) IL216299A0 (en)
MX (6) MX357528B (en)
SG (10) SG10201402289VA (en)
WO (5) WO2010132440A2 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2680825C (en) * 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
KR20120034649A (en) * 2009-05-11 2012-04-12 버그 바이오시스템즈, 엘엘씨 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
NZ602057A (en) 2010-03-12 2015-06-26 Berg Pharma Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
AU2011273509A1 (en) * 2010-06-30 2013-06-13 Galderma Research & Development Use of alpha-adrenergic receptor agonist for preventing or treating skin tumor
SG182016A1 (en) * 2010-12-14 2012-07-30 Univ Singapore Method of detecting resistance to cancer therapy
US9783785B2 (en) 2010-12-20 2017-10-10 Cameron K. Tebbi Screening methods for detection of susceptibility to leukemia and lymphomas
CA2821673C (en) * 2010-12-20 2020-06-02 Cameron K. Tebbi Methods of detecting leukemia/ lymphoma and induction of the same
AU2012205337B2 (en) 2011-01-13 2017-04-13 Expression Pathology, Inc. Bcl-2-like protein 11 SRM/MRM assay
EP2670368A4 (en) * 2011-02-03 2015-04-15 Pharmedica Ltd New oral dissolving films for insulin administration, for treating diabetes
CN103501859B (en) 2011-03-02 2017-08-25 博格有限责任公司 Probing analysis and its application based on cell
RU2453849C1 (en) * 2011-03-11 2012-06-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" Method for detecting carbohydrate metabolites in biological tissues
ES2762451T3 (en) * 2011-04-04 2020-05-25 Berg Llc Treatment of tumors of the central nervous system with coenzyme Q10
US9464016B2 (en) 2011-06-14 2016-10-11 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
SG10201605008TA (en) 2011-06-17 2016-07-28 Berg Llc Inhalable pharmaceutical compositions
CN102453769A (en) * 2011-12-27 2012-05-16 芮屈生物技术（上海）有限公司 Kit for mRNA level in-site hybridization detection in leukemia precursor lesion, and detecting method and application thereof
MX365392B (en) 2012-03-06 2019-05-31 Univ Illinois Procaspase 3 activation by combination therapy.
KR20200105524A (en) 2012-04-02 2020-09-07 버그 엘엘씨 Interrogatory cell-based assays and uses thereof
JP6352905B2 (en) * 2012-06-01 2018-07-04 バーグ エルエルシー Treatment of solid tumors with coenzyme Q10
JP6059350B2 (en) * 2012-09-06 2017-01-11 日立化成株式会社 Methods for assessment of peptide-specific immunity
PL2897604T3 (en) 2012-09-19 2018-10-31 Grespo Ab Compositions for improvement of brain function
JP6189962B2 (en) 2012-10-09 2017-08-30 ザ プロクター アンド ギャンブル カンパニー How to identify synergistic cosmetic ingredient combinations
JP6194003B2 (en) 2012-10-09 2017-09-06 ザ プロクター アンド ギャンブル カンパニー Method for identifying or evaluating beneficial agent and composition containing the same
US9138393B2 (en) 2013-02-08 2015-09-22 The Procter & Gamble Company Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin
US9144538B2 (en) 2013-02-08 2015-09-29 The Procter & Gamble Company Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin
US20160022649A1 (en) * 2013-03-15 2016-01-28 The Board Of Regents Of The University Of Texas System Use of inhibitors of mtor to improve vascular functions in apoe4 carriers
EP2976002A1 (en) * 2013-03-19 2016-01-27 The Procter & Gamble Company Method of measuring the metabolic indicators of hair follicles
EA032775B1 (en) 2013-04-08 2019-07-31 Берг Ллк Methofs of treating cancer using coenzyme q10 combination therapies
WO2014181968A1 (en) * 2013-05-09 2014-11-13 가톨릭대학교 산학협력단 Composition for preventing or treating immune diseases, containing metformin and coenzyme q10 as active ingredients
WO2014210389A1 (en) * 2013-06-26 2014-12-31 Rett Syndrome Research Trust Rett syndrome and treatments therefore
JP6595478B2 (en) 2013-09-04 2019-10-23 バーグ エルエルシー Cancer treatment by continuous injection of coenzyme Q10
CN103585619A (en) * 2013-10-31 2014-02-19 浙江大学 Application of DJ-1 protein in preparation of product for diagnosis and therapy of osteosarcoma
CN105793253B (en) 2013-11-22 2019-08-23 法玛克亚公司 Autotaxin inhibitors compound
WO2015084862A1 (en) * 2013-12-02 2015-06-11 Fu-Shin Yu Compositions and methods to diagnose diabetes and/or to treat negative effects of diabetes
CA3206208A1 (en) 2013-12-31 2015-07-09 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
EP3094968B1 (en) * 2014-01-15 2020-12-09 The Regents of The University of California Metabolic screening for gestational diabetes
EP3129466B1 (en) * 2014-04-07 2020-08-05 Memorial Sloan Kettering Cancer Center Modulating cell proliferation and pluripotency
US11465989B2 (en) 2014-04-17 2022-10-11 ImmunoMet Therapeutics, Inc. Guanidine compounds and use thereof
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
EP3550306B1 (en) * 2014-08-26 2021-03-03 Keio University Anti-cancer agent sensitivity-determining marker
US10482385B2 (en) 2014-09-11 2019-11-19 Berg Llc Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
AU2016268250B2 (en) 2015-05-27 2020-08-27 Sabre Therapeutics Llc Autotaxin inhibitors and uses thereof
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
US20170168055A1 (en) * 2015-12-11 2017-06-15 Expression Pathology, Inc. SRM/MRM Assays
EP3544993A1 (en) * 2016-11-25 2019-10-02 Koninklijke Philips N.V. Method to distinguish tumor suppressive foxo activity from oxidative stress
US20210130291A1 (en) 2016-12-22 2021-05-06 The National Institute for Biotechnology in the Negev Ltd. Methods for treating diabetes using vdac1 inhibitors
EP3559209A4 (en) 2016-12-23 2021-03-10 Keio University Compositions and methods for the induction of cd8+ t-cells
AU2018269377A1 (en) 2017-05-17 2019-12-19 Berg Llc Use of coenzyme Q10 formulations in the treatment and prevention of epidermolysis bullosa
CN113684275B (en) * 2017-06-22 2024-02-27 北海康成（北京）医药科技有限公司 Methods and kits for predicting the response of esophageal cancer to anti-ERBB 3 antibody therapy
JP7209951B2 (en) * 2017-10-30 2023-01-23 日本メナード化粧品株式会社 White hair prevention and improvement agent
CA3082575A1 (en) 2017-11-17 2019-05-23 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual mek signaling
US11723934B2 (en) 2018-02-09 2023-08-15 Keio University Compositions and methods for the induction of CD8+ T-cells
US11802103B2 (en) 2018-09-25 2023-10-31 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
US11767526B2 (en) 2019-01-23 2023-09-26 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
JP2022523564A (en) 2019-03-04 2022-04-25 アイオーカレンツ， インコーポレイテッド Data compression and communication using machine learning
WO2021102356A1 (en) 2019-11-20 2021-05-27 Berg Llc Combination therapy of a coenzyme q10 compound and radiation therapy for treatment of glioma
CN112924681B (en) * 2019-12-05 2023-01-17 张曼 Application of urine KRT10 protein and polypeptide fragment thereof in normal pregnancy
KR102383788B1 (en) * 2020-06-12 2022-04-05 이화여자대학교 산학협력단 Method for evaluating physical stress level
CA3188646A1 (en) * 2020-07-02 2022-01-06 Ponce De Leon Health Designated Activity Company Compositions and methods for treating crp-mediated diseases
US11938152B2 (en) 2020-08-06 2024-03-26 Kedar N Prasad High-dose antioxidants in cancer treatment
KR20230124915A (en) 2020-12-23 2023-08-28 리제너론 파마슈티칼스 인코포레이티드 Treatment of liver disease with apoptosis-inducing DFFA-like effector B (CIDEB) inhibitors
AU2022226164A1 (en) 2021-02-26 2023-08-03 Regeneron Pharmaceuticals, Inc. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors
CN114306608B (en) * 2022-01-04 2024-01-16 上海科技大学 Tumor treatment target point adapting to hypoxia or anoxia microenvironment and application thereof
CN117347643B (en) * 2023-12-05 2024-02-06 成都泰莱生物科技有限公司 Metabolic marker combination for judging benign and malignant pulmonary nodule, screening method and application thereof

Family Cites Families (392)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525350A (en) 1975-02-20 1985-06-25 The New England Institute, Inc. Methods of stimulating host defense system with coenzymes Q4 to Q.sub.1
JPS5775916A (en) 1980-10-29 1982-05-12 Nippon Chemiphar Co Ltd Coenzyme q pharmaceutical and its preparation
JPS58113127A (en) 1981-12-28 1983-07-05 Ajinomoto Co Inc Aqueous solution containing ubidecarenone
IT1157269B (en) 1982-03-19 1987-02-11 Seuref Ag NEW PHARMACEUTICAL FORMULATIONS CONTAINING COENZYME Q10 SUITABLE FOR TOPICAL ADMINISTRATION
JPS58201711A (en) 1982-05-19 1983-11-24 Eisai Co Ltd Coated liposome containing ubidecarenone
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4833128A (en) 1984-12-28 1989-05-23 Neil Solomon Dietary supplement
US4824669A (en) 1985-04-11 1989-04-25 Board Of Regents, The University Of Texas System Formulations of coenzyme Q10 for intravenous use
US4895727A (en) 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
JPS62123113A (en) 1985-11-22 1987-06-04 Green Cross Corp:The Fatty emulsion containing ubidecarenone
US4843071A (en) 1986-12-05 1989-06-27 Serotonin Industries Of Charleston Method and composition for treating obesity, drug abuse, and narcolepsy
US5651991A (en) 1987-10-28 1997-07-29 Nippon Shinyaku Co. Ltd. Drug carriers
JP2600726B2 (en) 1987-11-30 1997-04-16 大正製薬株式会社 Fine particle fat emulsion
GB8811410D0 (en) 1988-05-13 1988-06-15 Unilever Plc Treatment of skin disorders
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
JP2828655B2 (en) 1989-04-14 1998-11-25 エーザイ株式会社 Fat-soluble drug-containing aqueous liquid
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5962243A (en) 1990-04-18 1999-10-05 Board Of Regents, The University Of Texas System Methods for the identification of farnesyltransferase inhibitors
ATE117665T1 (en) 1990-11-14 1995-02-15 Oreal AMPHIPHILES, NON-IONIC DERIVATIVES OF GLYCERIN AND THE CORRESPONDING INTERMEDIATE PRODUCTS, METHOD FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM.
SE502569C2 (en) * 1991-05-31 1995-11-13 British Tech Group Use of an immunologically inert matrix of a sterol and saponins which can form spherical nanoparticles of narrow size distribution such as drug carriers, particles, composition and kits
US5378461A (en) 1991-07-12 1995-01-03 Neigut; Stanley J. Composition for the topical treatment of skin damage
US5605930A (en) 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
US6461593B1 (en) 1992-02-19 2002-10-08 Biomedical And Clinical Research Therapy with coenzyme Q10 to reduce subgingival microorganisms in patients with periodontal disease
EP0627921B1 (en) 1992-02-24 2000-05-31 East Carolina University Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof
US6093706A (en) 1992-03-04 2000-07-25 Bioresponse, L.L.C. Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders
FR2697841B1 (en) 1992-11-12 1995-01-13 Rhone Poulenc Rorer Sa New taxane derivatives, their preparation and the pharmaceutical compositions containing them.
US5602184A (en) 1993-03-03 1997-02-11 The United States Of America As Represented By Department Of Health And Human Services Monoterpenes, sesquiterpenes and diterpenes as cancer therapy
WO1994020508A1 (en) 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives
DE59406065D1 (en) 1993-03-24 1998-07-02 Ciba Geigy Ag Process for the production of a liposome dispersion in the high pressure range
DE4327063A1 (en) 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenone particles with modified physicochemical properties
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE4410238A1 (en) * 1994-03-25 1995-09-28 Beiersdorf Ag Skin care products
US20020049422A1 (en) * 1994-03-31 2002-04-25 Brewitt Barbara A. Homeopathic preparations
AU4510596A (en) 1994-12-06 1996-06-26 National Research Council Of Canada Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
US6958150B2 (en) 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
US6005086A (en) 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
DE19537027A1 (en) 1995-10-05 1997-04-10 Beiersdorf Ag Skin care product for old skin
AU730969B2 (en) 1995-10-19 2001-03-22 University Of Washington Discrete-length polyethylene glycols
US5944012A (en) 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
DE19615577A1 (en) 1996-04-19 1997-10-23 Beiersdorf Ag Use of salicin as an anti-irritative agent in cosmetic and topical dermatological preparations
US5891465A (en) * 1996-05-14 1999-04-06 Biozone Laboratories, Inc. Delivery of biologically active material in a liposomal formulation for administration into the mouth
GB9625895D0 (en) 1996-12-13 1997-01-29 Riley Patrick A Novel compound useful as therapeutic agents and assay reagents
US20040228910A1 (en) 1997-02-11 2004-11-18 Mse Pharmazeutika Gmbh Transdermal, oral and intravenous formulations of 2, 3-dimethoxy-5-methyl-6-decaprenyl-1, 4-benzoquinone
ATE201988T1 (en) 1997-02-11 2001-06-15 Mse Pharmazeutika Gmbh TRANSDERMAL, ORAL AND INTRAVENOUS PREPARATIONS OF 2,3-DIMETHOXY-5-METHYL-6-DECAPRENYL-1,4-BENZOCINONE
WO1998035658A2 (en) 1997-02-12 1998-08-20 Mse Pharmazeutika Gmbh The use of 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone
IT1291113B1 (en) 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti NUTRITIONAL THERAPEUTIC COMPOSITION FOR SUBJECTS WITH DIABETES MELLITUS
US6599513B2 (en) 1997-05-27 2003-07-29 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
US6372234B1 (en) 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
AU9221698A (en) 1997-09-04 1999-03-22 Biozone Laboratories, Inc. Oral liposomal delivery system
JP4738592B2 (en) 1997-10-31 2011-08-03 アーチ・デヴェロップメント・コーポレイション Methods and compositions for modulating 5α-reductase activity
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
WO1999026657A1 (en) 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6372880B1 (en) * 1997-12-25 2002-04-16 Mitsui Chemicals, Inc. Copolymer and process for preparing the same
US6048846A (en) 1998-02-26 2000-04-11 Cochran; Timothy M. Compositions used in human treatment
WO1999051097A1 (en) 1998-04-02 1999-10-14 Avicena Group, Inc. Compositions containing a combination of a creatine compound and a second agent
WO1999053071A1 (en) 1998-04-14 1999-10-21 Kyowa Hakko Kogyo Co., Ltd. Process for producing isoprenoid compounds by using microorganisms and method for detecting compounds having antibacterial or herbicidal activity
US6503523B2 (en) 1998-05-07 2003-01-07 Gs Development A.B. Skin care agents containing combinations of active agents consisting of vitamin a derivatives and UBI- or plastoquinones
CA2335472C (en) 1998-06-19 2008-10-28 Rtp Pharma Inc. Processes to generate submicron particles of water-insoluble compounds
US6093743A (en) 1998-06-23 2000-07-25 Medinox Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
DE19828081C2 (en) 1998-06-24 2000-08-10 Cognis Deutschland Gmbh W / O emulsion bases
DE59905858D1 (en) 1998-07-16 2003-07-10 Cognis Deutschland Gmbh USE OF PIT EMULSIONS
DK1098641T3 (en) 1998-07-27 2016-08-15 St Jude Pharmaceuticals Inc Chemically induced intracellular hyperthermia
EP1100517A1 (en) 1998-08-04 2001-05-23 John V. Kosbab Nutrient and therapeutic compositions for the treatment of cancer
ATE466850T1 (en) * 1998-09-23 2010-05-15 Res Dev Foundation TOCOPHEROLES, TOCOTRIENOLS, OTHER CHROMENE AND SIDE CHAIN DERIVATIVES, AND THEIR USES
US6048886A (en) * 1998-10-05 2000-04-11 Neigut; Stanley Compositions and delivery systems for the topical treatment of psoriasis and other conditions of the skin
IT1304406B1 (en) 1998-10-21 2001-03-19 Danital Italia S R L PREPARATION FOR THE VEHICULATION OF ACTIVE INGREDIENTS BASED ON POLYUNSATURATED ACIDIGIDS OF THE OMEGA GROUP 3.
US20050123938A1 (en) * 1999-01-06 2005-06-09 Chondrogene Limited Method for the detection of osteoarthritis related gene transcripts in blood
US20050019268A1 (en) 1999-02-11 2005-01-27 Mse Pharmazeutika Gmbh Spray containing ubiquinone Qn
US20040034107A1 (en) * 1999-02-11 2004-02-19 Mse Pharmazeutika Gmbh Ubiquinone Qn for the treatment of pain
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030104048A1 (en) 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US6632443B2 (en) 2000-02-23 2003-10-14 National Research Council Of Canada Water-soluble compositions of bioactive lipophilic compounds
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6140067A (en) 1999-04-30 2000-10-31 Mitokor Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
US6803193B1 (en) 1999-06-23 2004-10-12 The Penn State Research Foundation Methods to identify modulators of the mevalonate pathway in sterol synthesis
US6242491B1 (en) 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
DE59912559D1 (en) * 1999-07-02 2005-10-20 Cognis Ip Man Gmbh Microcapsules - III
US20030104080A1 (en) 1999-09-07 2003-06-05 Singh Parashu Ram Topical urea composition
US6630160B1 (en) 1999-09-07 2003-10-07 Genetic Services Management, Inc. Process to modulate disease risk with doses of a nutraceutical
US7005274B1 (en) 1999-09-15 2006-02-28 Migenix Corp. Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass
EP1230926A4 (en) 1999-10-14 2006-03-15 Nisshin Oillio Ltd Skin-care agents, skin antiaging agents, whitening agents and external skin preparations
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
US20020049176A1 (en) 1999-11-10 2002-04-25 Anderson Christen M. Modulation of mitochondrial mass and function for the treatment of diseases and for target and drug discovery
US20030180352A1 (en) 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7250174B2 (en) 1999-12-07 2007-07-31 Schott Ag Cosmetic, personal care, cleaning agent, and nutritional supplement compositions and methods of making and using same
US7083780B2 (en) 1999-12-11 2006-08-01 Cognis Deutschland Gmbh & Co. Kg Cosmetic composition containing hydroxyethers
AU5440901A (en) 1999-12-20 2001-07-03 Cognis France, S.A. Cosmetic and/or pharmaceutical preparations
AUPQ515000A0 (en) 2000-01-19 2000-02-10 Grigg, Geoffrey Walter Treatment of uv induced immunosuppression
US7105572B2 (en) 2000-02-04 2006-09-12 Takeda Pharmaceutical Company Limited Stable emulsion compositions
NZ509803A (en) 2000-02-09 2001-08-31 Paul A Treatment of fibromyalgia with ubiquinone 10 and succinic acid
FR2804864B1 (en) 2000-02-11 2003-04-04 Serobiologiques Lab Sa EXTRACTS OF RESIDUES FROM THE MANUFACTURE OF WINE AND THEIR USE IN COSMETICS OR PHARMACOLOGY
US20020044913A1 (en) * 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
EP1127567B1 (en) 2000-02-17 2010-09-01 Basf Se Aqueous dispersions of water insoluble organic sunscreens
DE10007322A1 (en) * 2000-02-17 2001-08-23 Cognis Deutschland Gmbh Pearlescent agents
FR2805464B1 (en) 2000-02-25 2003-02-14 Serobiologiques Lab Sa COSMETIC PREPARATIONS CONTAINING EXTRACTS FROM THE PLANT MOURERA FLUVIAUS
DE10009996B4 (en) 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Solid granules with monodisperse particle size distribution, a process for their preparation and their use
US6664287B2 (en) 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
US6866864B2 (en) 2000-03-20 2005-03-15 Ahmed Mousa Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders
US6447760B2 (en) 2000-05-08 2002-09-10 Playtex Products, Inc. Sunless tanning compositions
TWI287995B (en) 2000-05-09 2007-10-11 Kaneka Corp Dermatological composition containing co-enzyme Q as active ingredient
US6468552B1 (en) 2000-06-02 2002-10-22 Neutrogena Corporation Stabilized compositions containing oxygen-labile active agents
SE0002189D0 (en) * 2000-06-09 2000-06-09 Metcon Medicin Ab New method and assay
DE10031703A1 (en) 2000-06-29 2002-01-10 Beiersdorf Ag Use of calcium-releasing or binding substances for targeted scavenging or strengthening of the barrier function of the skin
EP1170015A1 (en) 2000-07-06 2002-01-09 Laboratoires Serobiologiques(Societe Anonyme) Use of extracts of the fungus Grifola frondosa
DE10033022A1 (en) * 2000-07-07 2002-01-17 Cognis Deutschland Gmbh aerosols
US20030012825A1 (en) 2000-07-10 2003-01-16 Charles Kapper Metallized molecule therapies
US6465517B1 (en) 2000-07-11 2002-10-15 N.V. Nutricia Composition for the treatment of migraine
DE10034619A1 (en) * 2000-07-17 2002-01-31 Cognis Deutschland Gmbh Wax-based opacifier formulations, used in detergents, pharmaceutical formulations and especially cosmetics, contain emulsifier mixture of alk(en)yl-oligoglycoside and fatty acid partial glyceride
DE10036655A1 (en) 2000-07-26 2002-02-07 Basf Ag Cosmetic or dermatological preparations to prevent skin damage from peroxides
DE10036799A1 (en) 2000-07-28 2002-02-07 Beiersdorf Ag New treatment for hair and scalp
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20020045230A1 (en) 2000-08-14 2002-04-18 Rosen Craig A. Nucleic acids, proteins, and antibodies
US6441050B1 (en) 2000-08-29 2002-08-27 Raj K. Chopra Palatable oral coenzyme Q liquid
FR2813195B1 (en) 2000-08-29 2003-04-04 Serobiologiques Lab Sa USE OF CASSIA ALATA PLANT EXTRACTS IN CARE PRODUCTS
DE10048260A1 (en) 2000-09-29 2002-04-11 Beiersdorf Ag Cosmetic or dermatological composition for combating undesirable skin pigmentation, contains aminoguanidine or its derivatives
DE10053328A1 (en) 2000-10-27 2002-05-08 Cognis Deutschland Gmbh Cosmetic preparations
US6403116B1 (en) 2000-11-03 2002-06-11 Triarco Inductries, Inc. Coenzyme Q10 formulation
US6689385B2 (en) 2000-11-03 2004-02-10 Chronorx Llc Formulations for the treatment of insulin resistance and type 2 diabetes mellitus
IT1317938B1 (en) 2000-11-17 2003-07-15 Sigma Tau Healthscience Spa COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF ALTERATIONS OF LIPID METABOLISM, OF ALLERGIC FORMS AND TO ACTIVATE DEFENSES
US20070003536A1 (en) * 2000-11-21 2007-01-04 Zimmerman Amy C Topical skin compositions, their preparation, and their use
AUPR177300A0 (en) 2000-11-29 2000-12-21 Centre For Molecular Biology And Medicine Therapeutic methods
JP2004515508A (en) 2000-12-16 2004-05-27 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング COMPOUND HEALTH PROMOTING COMPOSITION
DE10064818A1 (en) 2000-12-22 2002-06-27 Basf Ag Use of chroman derivatives in cosmetic or dermatological preparations
US6806069B2 (en) 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
FR2819414A1 (en) 2001-01-15 2002-07-19 Cognis France Sa COSMETIC AND / OR PHARMACEUTICAL PREPARATIONS COMPRISING EXTRACTS FROM PLANTS RESOURCING
WO2002056823A2 (en) 2001-01-18 2002-07-25 Arnold Hoffman Redox therapy for tumors
KR20030071853A (en) 2001-01-25 2003-09-06 브리스톨-마이어스스퀴브컴파니 Parenteral Formulations Containing Epothilone Analogs
NL1017205C2 (en) 2001-01-26 2002-07-29 Adriaan Emanuel Hendricus Wiel Medicinal and cosmetic application of hops and coenzyme Q10.
ITRM20010044A1 (en) 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa SLIMMING FOOD SUPPLEMENT.
CA2444661A1 (en) 2001-01-31 2002-08-08 Idec Pharmaceutical Corporation Use of cd23 antagonists for the treatment of neoplastic disorders
ITMI20010204A1 (en) 2001-02-02 2002-08-02 Hunza Di Marazzita Maria Carme THERAPEUTIC SPECIALTIES EQUIPPED WITH ANTI-OXIDANT ACTIVITY AND ABLE TO CONTROL THE EXCESS OF THE BODY WEIGHT
FR2821624B1 (en) 2001-03-01 2004-01-02 Sod Conseils Rech Applic NEW POLYNUCLEOTIDE FOR USE IN MODULATING THE PROLIFERATION OF CANCER CELLS
BR0207948A (en) 2001-03-09 2004-07-27 Produits Nestel S A Soc D Composition that improves age-related physiological deficits and increases longevity
DE10113053A1 (en) 2001-03-15 2002-09-19 Beiersdorf Ag Self-foaming or foamed cosmetic or dermatological composition comprises a specified emulsifier system, a lipid phase, a gas, a gelling agent and a hydrocolloid
DE10113050A1 (en) 2001-03-15 2002-09-19 Beiersdorf Ag Self-foaming or foamed cosmetic or dermatological composition comprises a specified emulsifier system, a lipid phase, a gas and an organic hydrocolloid
DE10113046A1 (en) 2001-03-15 2002-09-26 Beiersdorf Ag Self-foaming product for dermatological and cosmetic products comprises an emulsifier system, a lipid phase, gas, organic hydrocolloid and a solid body
ATE327006T1 (en) 2001-03-23 2006-06-15 Oreal SKIN TREATMENT PRODUCTS CONTAINING FIBERS AND UBICHINONES
US20030031688A1 (en) * 2001-04-02 2003-02-13 Dipak Ghosh Cosmetic composition with improved skin moisturizing properties
US6727234B2 (en) * 2001-04-03 2004-04-27 University Of Iowa Research Foundation Isoprenoid analog compounds and methods of making and use thereof
US6469061B1 (en) 2001-04-04 2002-10-22 Ramot University Authority For Applied Research And Industrial Development Limited Jasmonate pharmaceutical composition for treatment of cancer
DE10118269A1 (en) 2001-04-12 2002-10-17 Cognis Deutschland Gmbh Production of polyetherurethane thickeners, useful in cosmetic compositions for, e.g. skin or hair, comprises reacting an ethoxylated fatty alcohol with an aliphatic di- or triisocyanate
US6686485B2 (en) * 2001-04-19 2004-02-03 Daniel David West Synthesis of coenzyme Q10, ubiquinone
AU2002303427A1 (en) 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
WO2002085308A2 (en) 2001-04-24 2002-10-31 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
US20040049022A1 (en) 2001-04-24 2004-03-11 Nyce Jonathan W. Composition & methods for treatment and screening
US6582723B2 (en) 2001-05-03 2003-06-24 Wayne F. Gorsek Cancer immune composition for prevention and treatment of individuals
JP3742602B2 (en) 2001-05-09 2006-02-08 株式会社カネカ Stable solution of reduced coenzyme Q
GB0111279D0 (en) 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes
JP4603192B2 (en) 2001-05-10 2010-12-22 株式会社カネカ Hair scalp composition
AU2002309038B2 (en) 2001-05-10 2007-05-17 Kaneka Corporation Compositions for transmucosal administration containing coenzyme Q as the active ingredient
DE10123771B4 (en) 2001-05-16 2019-01-10 Beiersdorf Ag Use of electrolytes to strengthen the barrier function of the skin
EP1260212A1 (en) 2001-05-21 2002-11-27 Cognis France S.A. Cosmetic composition
US20050118151A1 (en) * 2001-05-29 2005-06-02 Syddansk Universitet Proteins in diabetes proteome anlysis
CA2449199A1 (en) 2001-05-30 2002-12-05 Laxdale Limited Coenzyme q and eicosapentaenoic acid (epa)
US20030138792A1 (en) * 2001-05-31 2003-07-24 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer
EP1262167A1 (en) 2001-06-01 2002-12-04 Cognis France S.A. Cosmetic preparations containing an extract from germinating plants
US7091241B2 (en) 2001-06-01 2006-08-15 Summa Health System Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K3
US6506915B1 (en) 2001-06-14 2003-01-14 Daniel David West Synthesis of coenzyme Q10 ubiquinone
US6696060B2 (en) 2001-06-14 2004-02-24 Clearant, Inc. Methods for sterilizing preparations of monoclonal immunoglobulins
FR2826017B1 (en) 2001-06-15 2004-06-11 Cognis France Sa SURFACTANT MIXTURES
SE0102380D0 (en) 2001-07-02 2001-07-02 Macronova Ab Cream for the treatment of age changes in the skin of man
DE10133198A1 (en) 2001-07-07 2003-01-23 Beiersdorf Ag Use of topical compositions containing creatine and its precursors and derivatives e.g. to improve skin condition and to treat or prevent skin disorders
JP2003020495A (en) 2001-07-10 2003-01-24 Cognis Japan Ltd Oil and fat composition
EP2351765A3 (en) 2001-07-10 2012-02-22 Lakewood-Amedex, Inc Oligonucleotide-containing pharmacological compositions and their use
CH695085A5 (en) 2001-07-13 2005-12-15 Mibelle Ag Cosmetics Formulations for care of the skin after laser treatment and / or chemical peels, and use of formulations.
TWI235146B (en) 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
JP2004535202A (en) 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション Therapeutic agents containing pro-apoptotic proteins
FR2827603B1 (en) 2001-07-18 2003-10-17 Oreal COMPOUNDS DERIVED FROM DIAMINOPYRAZOLE SUBSTITUTED BY A HETEROAROMATIC RADICAL AND THEIR USE IN OXIDATION DYES OF KERATINIC FIBERS
ATE374032T1 (en) 2001-07-27 2007-10-15 Nutricia Nv ORAL COMPOSITION FOR PREVENTING OR TREATING SEPSIS
EP1281392A1 (en) 2001-08-02 2003-02-05 Cognis France S.A. Cosmetic or/and pharmaceutical compositions containing plant extracts
DE10139580A1 (en) 2001-08-10 2003-02-20 Beiersdorf Ag O/W emulsions useful e.g. cleansing, skin-care or anti-acne agents comprise a combination of steroids or fatty acids with optionally ethoxylated esters
US6503506B1 (en) 2001-08-10 2003-01-07 Millenium Biotechnologies, Inc. Nutrient therapy for immuno-compromised patients
DE10143964A1 (en) 2001-09-07 2003-03-27 Basf Ag Low-emulsifier or emulsifier-free systems of the oil-in-water type containing stabilizers and an amino-substituted hydroxybenzophenone
DE10143962A1 (en) 2001-09-07 2003-03-27 Basf Ag Cosmetic and dermatological preparations in the form of O / W emulsions containing an amino-substituted hydroxybenzophenone
DE10143963A1 (en) 2001-09-07 2003-03-27 Basf Ag Cosmetic and dermatological preparations in the form of W / O emulsions containing an amino-substituted hydroxybenzophenone
AU2002339555B2 (en) * 2001-09-18 2007-03-01 Ciba Specialty Chemicals Holding Inc. Use of guaiol for treating the skin
DE10150725A1 (en) * 2001-10-13 2003-04-17 Cognis Deutschland Gmbh Wax-based, anionic surfactant-free hazeing agent giving white non-lustrous haze in e.g. cosmetics contains an amphoteric surfactant, fatty acid partial glyceride, fatty acid polyglycol ester and optionally also a polyol
WO2003033662A2 (en) 2001-10-16 2003-04-24 Atherogenics, Inc. Protection against oxidative stress and inflammation by a cytoprotective response element
US7560123B2 (en) 2004-08-12 2009-07-14 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US6723527B2 (en) 2001-10-26 2004-04-20 Board Of Regents, The University Of Texas System Methods for determining toxicity reversing agents
ES2261760T3 (en) * 2001-10-26 2006-11-16 Cognis Ip Management Gmbh IMPREGNANT SOLUTION FOR COSMETIC TOWELS.
EP1444210B1 (en) 2001-11-03 2009-02-18 AstraZeneca AB Qunazoline derivatives as antitumor agents
US20030105027A1 (en) 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US7435725B2 (en) 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030118536A1 (en) 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US6753325B2 (en) 2001-11-06 2004-06-22 The Quigley Corporation Composition and method for prevention, reduction and treatment of radiation dermatitis
US20030105031A1 (en) 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
KR20040068545A (en) * 2001-11-09 2004-07-31 메드스타 리서치 인스티튜트 Method of using physiological markers to estimate cardiovascular risk
DE10155769A1 (en) 2001-11-14 2003-05-22 Cognis Deutschland Gmbh Cosmetic and / or pharmaceutical emulsions
DE10160682A1 (en) 2001-12-11 2003-06-18 Cognis Deutschland Gmbh Cosmetic and/or pharmaceutical preparations, e.g. for skin or body care, comprise 2-methyl-1,3-propanediol diesters as emollients, having both lipophilic and hydrophilic properties
US6652891B2 (en) 2001-12-12 2003-11-25 Herbasway Laboratories, Llc Co-enzyme Q10 dietary supplement
DE10162351A1 (en) * 2001-12-18 2003-07-03 Cognis Deutschland Gmbh Cosmetic and / or pharmaceutical emulsions
DE10162026A1 (en) 2001-12-18 2003-07-03 Cognis Deutschland Gmbh Highly concentrated flowable pearlescent concentrates
ITRM20010755A1 (en) 2001-12-20 2003-06-20 Simonelli Giuseppe USE OF Q10 QUINONE FOR THE TREATMENT OF EYE DISEASES.
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
US20030129253A1 (en) * 2002-01-03 2003-07-10 Milley Christopher J. Stable aqueous suspension
TW200302056A (en) 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
US20050118209A1 (en) 2002-01-18 2005-06-02 Basf Aktiengesellschaft Cosmetic or dermatological preparations for preventing damages to skin caused by peroxides
CN100473374C (en) 2002-01-31 2009-04-01 西巴特殊化学品控股有限公司 Micropigment mixtures
AU2003206825B8 (en) * 2002-02-12 2008-03-20 Dsm Ip Assets B.V. Sunscreen compositions as well as dihydropyridines and dihydropyranes
AU2003205738A1 (en) 2002-02-14 2003-09-04 Dsm Ip Assets B.V. Water-dispersible coenzyme q10 dry powders
EP1340486A1 (en) 2002-03-01 2003-09-03 Cognis France S.A. Use of sugar esters
US20030167556A1 (en) 2002-03-05 2003-09-11 Consumers Choice Systems, Inc. Methods and devices for transdermal delivery of anti-aging compounds for treatment and prevention of facial or neck skin aging
DE10254315A1 (en) 2002-03-15 2003-10-02 Cognis Deutschland Gmbh Cosmetic emulsion with aqueous phase(s) and water-insoluble oil phase, used for cosmetic and pharmaceutical purposes, preferably in body-care formulations, contains cyclohexylcyclohexane as oil body
CN1856708A (en) 2002-03-20 2006-11-01 普赖德普罗特奥米克斯公司 Human diabetes-mediating proteins
TW200304372A (en) * 2002-03-20 2003-10-01 Kanegafuchi Chemical Ind Compositions for diabetes
DE10212528A1 (en) * 2002-03-21 2003-10-02 Cognis Deutschland Gmbh Oil phases for cosmetic products
DE10213957A1 (en) * 2002-03-28 2003-10-09 Beiersdorf Ag Crosslinked cosmetic or pharmaceutical phospholipid-containing gels and emulsions based on ethylene oxide-containing or propylene oxide-containing emulsifiers
US7811594B2 (en) * 2002-03-28 2010-10-12 Beiersdorf Ag Crosslinked oil droplet-based cosmetic or pharmaceutical emulsions
AU2003223520A1 (en) 2002-04-12 2003-10-27 Mitokor Targets for therapeutic intervention identified in the mitochondrial proteome
DE10217474A1 (en) 2002-04-19 2003-11-06 Cognis Deutschland Gmbh Sun protection emulsion with foam dispenser
US20060193905A1 (en) 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
CA2486909A1 (en) 2002-05-23 2003-12-04 Umd, Inc. Compositions and method for transmucosal drug delivery and cryoprotection
DE10223486A1 (en) 2002-05-27 2003-12-11 Beiersdorf Ag Cosmetic and / or dermatological preparation with 2,3-dibenzylbutyrolactones
ATE334654T1 (en) 2002-06-03 2006-08-15 Ciba Sc Holding Ag COMPOSITIONS PROTECTIVE FROM UV RAYS
DE10226018A1 (en) * 2002-06-12 2003-12-24 Cognis Deutschland Gmbh Preparations with conjugated linoleic alcohol
US7182950B2 (en) 2002-06-12 2007-02-27 Nutralease Ltd. Nano-sized self-assembled liquid dilutable vehicles
US7147841B2 (en) 2002-06-17 2006-12-12 Ciba Specialty Chemicals Corporation Formulation of UV absorbers by incorporation in solid lipid nanoparticles
WO2004003564A2 (en) 2002-06-26 2004-01-08 Europroteome Ag Tumour marker and the use thereof for the diagnosis and treatment of tumour diseases
US7060733B2 (en) 2002-08-15 2006-06-13 The Regents Of The University Of California Methods for treating pancreatitis with curcumin compounds and inhibitors of reactive oxygen species
JP2006503852A (en) 2002-09-25 2006-02-02 ユニバーシティー オブ ロチェスター Caspase inhibitors as anticancer drugs
US6953786B2 (en) 2002-10-01 2005-10-11 The Regents Of The University Of California Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof
FR2845602B1 (en) 2002-10-11 2005-07-08 Servier Lab ASSOCIATION BETWEEN A LIGAND OF RECEPTORS ACTIVE BY PEROXISOME PROLIFIERS AND AN ANTIOXIDANT AGENT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7083813B2 (en) 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
EP1421929A3 (en) 2002-11-21 2004-11-24 Cognis Deutschland GmbH & Co. KG Emollients and cosmetic preparations
DE10256881A1 (en) 2002-12-05 2004-06-24 Beiersdorf Ag New topical use of bis-arylimidazo [1,2-a] thiolane derivatives
US20040110848A1 (en) 2002-12-10 2004-06-10 Peffley Dennis M Method and kit for treating cancer
CA2509832A1 (en) 2002-12-16 2004-07-01 Garvan Institute Of Medical Research Methods of treatment of feeding disorders or disorders of glucose uptake and for modifying metabolism and identifying therapeutic reagents therefor
AU2003302340B8 (en) 2002-12-24 2008-09-11 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US8557512B2 (en) * 2003-01-02 2013-10-15 HMI Medical Innovations, LLC Method of screening activators and/or inhibitors of insulin receptor substrate 2
US20090036516A1 (en) 2003-01-13 2009-02-05 Ctg Pharma S.R.L. Compounds for treating metabolic syndrome
CN1738592A (en) 2003-01-20 2006-02-22 西巴特殊化学品控股有限公司 Triazine derivatives as UV absorbers
JP2006514661A (en) * 2003-02-03 2006-05-11 デーエスエム アイピー アセッツ ベー． ヴェー． Novel stabilized cinnamate sunscreen composition
US7258876B2 (en) 2003-02-05 2007-08-21 Craig Bozzacco Topical composition for treating infectious conditions of skin and mucosa
CN1208052C (en) 2003-03-20 2005-06-29 上海家化联合股份有限公司 Coenzyme Q10 precursor liposome and preparation method
WO2004085412A2 (en) 2003-03-24 2004-10-07 Ciba Specialty Chemicals Holding Inc. Symmetrical triazine derivatives
US20040202740A1 (en) 2003-04-08 2004-10-14 Barrie Tan Annatto extract compositions, including geranyl geraniols and methods of use
US20050037102A1 (en) 2003-07-18 2005-02-17 Barrie Tan Annatto extract compositions including tocotrienols and tocopherols and methods of use
JP2004321171A (en) * 2003-04-11 2004-11-18 Fancl Corp Food and drink
EP1473043A1 (en) 2003-04-29 2004-11-03 Boehringer Ingelheim Pharma GmbH & Co.KG Pharmaceutical combination for the treatment of diseases involving cell proliferation, migration or apotosis of myeloma cells, or angiogenesis
JP2004345988A (en) 2003-05-21 2004-12-09 Eisai Co Ltd Medicine composition containing riboflavin-based compound
US7438903B2 (en) * 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
US20040253323A1 (en) 2003-06-11 2004-12-16 Giles Brian C. Ionic cancer therapy and methods for using same in the treatment of tumors and metastasis
US8003094B2 (en) 2003-06-25 2011-08-23 Charles Erwin Chemical combination and method for increasing delivery of Coenzyme Q10
US20050026848A1 (en) 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20070248693A1 (en) 2003-08-02 2007-10-25 Elizabeth Mazzio Nutraceutical composition and method of use for treatment / prevention of cancer
US8802161B2 (en) 2003-08-02 2014-08-12 Florida Agricultural And Mechanical University Herbal composition and method of use for the treatment of cancer
US20060035981A1 (en) * 2003-08-02 2006-02-16 Mazzio Elizabeth A Inhibition of anaerobic glucose metabolism and corresponding composition as a natural non-toxic approach to cancer treatment
US20080069779A1 (en) 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
US20050036976A1 (en) 2003-08-12 2005-02-17 Joel Rubin Topical skin care composition
US8741321B2 (en) * 2003-08-27 2014-06-03 Beiersdorf Ag Capsule whose envelope is separately imperceptible during the topical use thereof
US8105583B2 (en) 2003-09-29 2012-01-31 Soft Gel Technologies, Inc. Solubilized CoQ-10
US8124072B2 (en) * 2003-09-29 2012-02-28 Soft Gel Technologies, Inc. Solubilized CoQ-10
US7169385B2 (en) * 2003-09-29 2007-01-30 Ronald G. Udell Solubilized CoQ-10 and carnitine
WO2005030169A1 (en) 2003-10-02 2005-04-07 Sembiosys Genetics Inc. Methods for preparing oil bodies comprising active ingredients
DE10347218A1 (en) * 2003-10-10 2005-05-12 Cognis Deutschland Gmbh Sunscreens
CN1897950A (en) 2003-10-14 2007-01-17 惠氏公司 Fused-aryl and heteroaryl derivatives and methods of their use
DE10347940A1 (en) 2003-10-15 2005-05-19 Cognis Deutschland Gmbh & Co. Kg Self-emulsifying preparations
EP1681053B1 (en) 2003-10-31 2014-10-08 Kaneka Corporation Composition containing clathrated reduced coenzyme Q
EP1682228B1 (en) 2003-11-05 2009-12-02 DSM IP Assets B.V. Light protecting composition with reduced total amount of uv filter containing a polysiloxane-based uv filter
US20050100537A1 (en) 2003-11-10 2005-05-12 Evans Gregory S. Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals
WO2005048925A2 (en) 2003-11-14 2005-06-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating a neoplastic disease in a subject using inorganic selenium-containing compounds
DE20320413U1 (en) 2003-11-17 2004-08-26 Beiersdorf Ag Cosmetic with sensitive ingredients
US20050118235A1 (en) 2003-12-02 2005-06-02 Shiguang Yu Dietary non-essential amino acid tyrosine regulates the body weight of animals through regulating the animal appetite or food intake
JP2007514695A (en) 2003-12-18 2007-06-07 ネステク ソシエテ アノニム Composition for improving the health of skin, hair and skin containing flavanones
JP4742526B2 (en) * 2003-12-26 2011-08-10 シンフォニアテクノロジー株式会社 IC chip mounting body manufacturing method and manufacturing apparatus
KR101535395B1 (en) * 2004-01-22 2015-07-08 유니버시티 오브 마이애미 Topical co-enzyme q10 formulations and methodns of use
US20050226947A1 (en) * 2004-02-04 2005-10-13 Dale Kern Agents for sequestering serum aging factors and uses therefore
US20070149618A1 (en) 2004-02-17 2007-06-28 Action Medicines, S.L. Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis
WO2005079143A2 (en) * 2004-02-19 2005-09-01 Occell Inc. Topical formulations for the treatment of skin conditions
WO2005084452A1 (en) 2004-02-23 2005-09-15 The Texas A & M University System Antioxidant compositions and methods of use thereof
US7780873B2 (en) 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
US20050202521A1 (en) 2004-03-10 2005-09-15 Albert Crum Methods of assessing the need for and the effectiveness of therapy with antioxidants
DE102004014615A1 (en) 2004-03-23 2005-10-13 Beiersdorf Ag Taurine-containing preparations for improving the skin barrier
WO2005104213A2 (en) * 2004-04-06 2005-11-03 Basf Aktiengesellschaft COSMETIC FORMULATIONS COMPRISING ZnO NANOPARTICLES
US20050226858A1 (en) 2004-04-09 2005-10-13 Kaneka Corporation Compositions containing reduced coenzyme Q10 and carotenoid
US7723569B2 (en) * 2004-04-30 2010-05-25 National Institute Of Agrobiological Sciences Method for producing ubiquinone-10 in plant
US7351739B2 (en) 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
IL161899A0 (en) 2004-05-10 2005-11-20 Hoffman Arnold Kit for treatment of cancer
JP2005323573A (en) * 2004-05-17 2005-11-24 Sumitomo Pharmaceut Co Ltd Method for analyzing gene expression data and, method for screening disease marker gene and its utilization
US20070202090A1 (en) 2004-05-18 2007-08-30 Mirko Prosek Water Soluble Form Of Coenzyme Q10 In The Form Of An Inclusion Complex With Beta-Cyclodextrin, Process Of Preparing, And Use Thereof
MXPA06013458A (en) 2004-05-24 2007-03-01 Basf Ag Keratin-binding polypeptides.
KR20050112942A (en) 2004-05-28 2005-12-01 주식회사 뉴트렉스테크놀러지 Composition for obesity suppression
US20050288333A1 (en) 2004-06-08 2005-12-29 Kem William R Controlling angiogenesis with anabaseine analogs
US7906140B2 (en) 2004-06-17 2011-03-15 Virun, Inc. Compositions for mucosal delivery of agents
EP1761271B1 (en) * 2004-06-18 2008-12-03 Symrise GmbH & Co. KG Blackberry extract
JP2008503579A (en) * 2004-06-21 2008-02-07 ハッチソン メディファーマ エンタープライジズ リミテッド Cancer chemotherapy
ES2380940T3 (en) * 2004-06-28 2012-05-21 Dsm Ip Assets B.V. Cosmetic compositions containing protein hydrolysates
JP2008506667A (en) 2004-07-13 2008-03-06 オリディス・ビオメド・フォルシュングス−ウント・エントヴィックルングス・ゲーエムベーハー Mitochondrial targeted antioxidants in the treatment of liver disease and epithelial cancer
US20060069068A1 (en) 2004-07-15 2006-03-30 Nanobac Pharmaceuticals, Inc. Methods and compositions for the treatment of diseases characterized by pathological calcification
CA2574968C (en) 2004-07-28 2014-05-20 Raymond M. Pleva Emu oil and fruit composition
WO2006017494A2 (en) * 2004-08-02 2006-02-16 Elizabeth Mazzio Inhibition of anaerobic glucose metabolism
JP2006070016A (en) 2004-08-02 2006-03-16 Kaneka Corp Whitening composition containing reduced coenzyme q
EP1789031A2 (en) 2004-08-18 2007-05-30 Ace ApS Cosmetic and pharmaceutical compositions comprising ace inhibitors and/or angiotensin ii receptor antagonists
US20060041017A1 (en) 2004-08-20 2006-02-23 Chopra Raj K Synergistic conjugated linoleic acid (CLA) and carnitine combination
US20060051462A1 (en) * 2004-09-03 2006-03-09 Wang Jimmy X Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients
US7288263B2 (en) * 2004-09-13 2007-10-30 Evera Laboratories, Llc Compositions and methods for treatment of skin discoloration
ZA200703087B (en) 2004-09-17 2009-04-29 Inst Of Medicinal Biotechno Methods and compositions for the treatment of hyperlipidemia
US20060062755A1 (en) 2004-09-21 2006-03-23 Woodward John R Method of cancer screening; method of cancer treatment; and method of diabetes treatment
DE102004046235A1 (en) 2004-09-22 2006-03-30 Altana Pharma Ag drug preparation
JP5093998B2 (en) 2004-09-22 2012-12-12 大塚製薬株式会社 Pigmentation preventing or improving agent
US20080020018A1 (en) 2004-09-27 2008-01-24 Joey Moodley Combination Products
EP1809272A4 (en) 2004-10-18 2008-01-02 Maroon Biotech Corp Methods and compositions for treatment of free radical injury
US20060120997A1 (en) 2004-10-29 2006-06-08 Biomune, Inc. Cancer therapeutic compositions
CN101052659B (en) 2004-11-02 2011-11-23 帝斯曼知识产权资产管理有限公司 Additive for uv-sunscreen preparations
US8349359B2 (en) 2004-11-07 2013-01-08 Your Energy Systems, LLC Liposomal formulation for oral administration of glutathione (reduced)
GB0424891D0 (en) 2004-11-11 2004-12-15 Boots Co Plc Topical compositions
US8961958B2 (en) * 2004-11-16 2015-02-24 Bioavailability, Inc High concentration self-microemulsifying coenzyme Q10 preparations for nutritional use
US20060110415A1 (en) 2004-11-22 2006-05-25 Bioderm Research Topical Delivery System for Cosmetic and Pharmaceutical Agents
US20060127384A1 (en) 2004-12-09 2006-06-15 Sergio Capaccioli Coenzyme Q10 as antiapoptotic agent
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
CN101099084A (en) 2004-12-14 2008-01-02 弗·哈夫曼-拉罗切有限公司 CD99 as target/marker for insulin resistance
WO2006063402A1 (en) 2004-12-16 2006-06-22 Melvin Mackenzie Stewart Therapeutic compositions based on extracts of plants from the genus plumeria (frangipani)
NO20045674D0 (en) 2004-12-28 2004-12-28 Uni I Oslo Thin films prepared with gas phase deposition technique
US20060286046A1 (en) 2005-01-05 2006-12-21 Haber C Andrew Skin care compositions
US20060188492A1 (en) 2005-01-13 2006-08-24 Chronorx Llc, An Alaska Limited Liability Company Topical management of ocular and periocular conditions
DE102005007980A1 (en) 2005-02-22 2006-02-23 Clariant Gmbh Cosmetic, pharmaceutical or dermatological preparation, useful as decorative agents e.g. mascara, eyelid shade and eyeliner, comprises copolymer wax comprising e.g. heterocyclic compounds and optionally aryl compounds
JPWO2006103750A1 (en) 2005-03-29 2008-09-04 日本ハム株式会社 Composition for improving obesity, functional food and pharmaceutical composition
US20060251690A1 (en) 2005-04-01 2006-11-09 Zymes, Llc Skin enrichment using CoQ10 as the delivery system
CN1853507A (en) * 2005-04-28 2006-11-01 尚宝虎 Non-effect components for beverage or solid oral agent or food additive with weight-losing function
JP2007001922A (en) 2005-06-23 2007-01-11 Asahi Kasei Pharma Kk Renal disease ameliorating agent in dialysis patient or functional food
WO2007013556A1 (en) 2005-07-28 2007-02-01 Kaneka Corporation Composition for prevention of cancer
WO2007014392A2 (en) 2005-07-28 2007-02-01 Isp Investments Inc. Benzoquinones of enhanced bioavailability
US20070053985A1 (en) 2005-08-24 2007-03-08 Kaneka Corporation Coenzyme Q10-containing fine particle with excellent dispersibility
CN1928556A (en) 2005-09-05 2007-03-14 中国医学科学院基础医学研究所 Reagent kit for detecting 2-diabetes serum mark in Chinese people
US20070071779A1 (en) * 2005-09-26 2007-03-29 Leggit Ingenuity, Llc Compositions for delivering lipophilic agents to the intestinal mucosa and method of making thereof
EP1876448A1 (en) 2005-09-30 2008-01-09 DIGILAB BioVisioN GmbH Method and analytical reagents for identifying therapeutics using biomarkers responsive to thiazolidinediones.
US20070092469A1 (en) 2005-10-26 2007-04-26 Eric Jacobs Topically applied Glucosamine Sulfate and all its related, precursor, and derivative compounds significantly increases the skin's natural produciton of hyaluronic acid for the rejuvenation of healthier younger-looking skin; while PhosphatidylCholine is required to replace its deficiency caused by topical Dimethylaminoethanol (DMAE)
US8506956B2 (en) 2005-10-31 2013-08-13 Kaneka Corporation Method for stabilizing reduced coenzyme Q10
US9034316B2 (en) 2006-10-24 2015-05-19 Amorcyte, Llc Infarct area perfusion-improving compositions and methods of vascular injury repair
US9265792B2 (en) 2005-11-16 2016-02-23 Patricia A. Riley Integument cell regeneration formulation
EP1960551A2 (en) 2005-12-01 2008-08-27 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
AU2006339607A1 (en) 2005-12-02 2007-09-13 Sirtris Pharmaceuticals, Inc. Modulators of Cdc2-like kinases (Clks) and methods of use thereof
JP2007176804A (en) 2005-12-27 2007-07-12 Ｚｍｃ−Ｋｏｕｇｅｎ株式会社 Medicine or healthy food having slimming action
US20070172436A1 (en) 2006-01-23 2007-07-26 Jerry Zhang Nonaqueous ascorbic acid compositions and methods for preparing same
US20070184076A1 (en) 2006-02-07 2007-08-09 Unger Evan C Liquid-filled nanodroplets for anti-cancer therapy
US20070184041A1 (en) 2006-02-09 2007-08-09 Burja Adam M Methods and compositions related to production of coenzyme q10
EP1991701A4 (en) 2006-02-14 2010-03-17 Dana Farber Cancer Inst Inc Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
US8067152B2 (en) * 2006-02-27 2011-11-29 The Fred Hutchinson Cancer Research Center Liver cancer biomarkers
US20070203091A1 (en) 2006-02-28 2007-08-30 Eliezer Rapaport Methods and therapeutic compositions for improving liver, blood flow and skeletal muscle functions in advanced diseases and aging
EA026670B1 (en) 2006-03-10 2017-05-31 Лабосвисс Аг Method for solubilizing, dispersing, and stabilizing materials, products manufactured according to said method, and use thereof
US7335384B2 (en) 2006-03-17 2008-02-26 4K Nutripharma International Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
US8030013B2 (en) 2006-04-14 2011-10-04 Mount Sinai School Of Medicine Methods and compositions for the diagnosis for early hepatocellular carcinoma
US8021659B2 (en) 2006-04-28 2011-09-20 Naidu Lp Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof
ES2639567T3 (en) 2006-04-28 2017-10-27 Kaneka Corporation Method for stabilization of reduced coenzyme Q10
JPWO2007126086A1 (en) 2006-04-28 2009-09-10 株式会社カネカ Purification method of reduced coenzyme Q10
EP2073819B1 (en) * 2006-05-02 2016-12-28 University of Miami Topical co-enzyme q10 formulations and treatment of pain, fatigue and wounds
US20080020022A1 (en) * 2006-06-05 2008-01-24 Udell Ronald G Chewable co-enzyme q-10 capsule
WO2007142347A1 (en) 2006-06-05 2007-12-13 Shimadzu Corporation Tumor marker and method for determination of the occurrence of cancerous disease
US20080014187A1 (en) 2006-07-15 2008-01-17 Bryant Villeponteau Compositions and Methods for Treating Hypertension and Inflammation
US8894993B2 (en) 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
US7645616B2 (en) 2006-10-20 2010-01-12 The University Of Hong Kong Use of lipocalin-2 as a diagnostic marker and therapeutic target
JPWO2008069276A1 (en) 2006-12-06 2010-03-25 株式会社カネカ Cancer therapeutic agent and carcinogenesis inhibitor
CN101015524B (en) * 2007-02-15 2011-09-14 沈阳药科大学 Coenzyme Q10 oral emulsion and preparing process thereof
CA2680825C (en) * 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
US20090143279A1 (en) * 2007-06-15 2009-06-04 Vamsi Krishna Mootha Methods and compositions for treating metabolic disorders
US20090005398A1 (en) 2007-06-27 2009-01-01 Mohammed Dar Methods For The Treatment of Central Nervous System Tumors
US7989007B2 (en) 2007-07-03 2011-08-02 Vincent James Enterprises, Llc Weight loss composition
KR100849537B1 (en) 2007-07-04 2008-07-31 유효경 Nano-emulsion composition of coenzyme q10
AU2008279778B2 (en) 2007-07-17 2014-09-18 Metabolon, Inc. Method for Determining Insulin Sensitivity with Biomarkers
CN101091890A (en) 2007-07-26 2007-12-26 沈阳药科大学 Composite type emulsifier, and emulsion prepared by using the emulsifier, and preparation method
US7776894B2 (en) 2007-08-17 2010-08-17 Burnham Institute For Medical Research Compositions and methods for inhibiting growth and metastasis of melanoma
RU2345367C1 (en) 2007-08-22 2009-01-27 Государственное образовательное учреждение высшего профессионального образования Новосибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию (ГОУ ВПО НГМУ Росздрава) Prediction method for lymphoma clinical course severity and treatment efficiency
JP2009050168A (en) 2007-08-23 2009-03-12 Tsujido Kagaku Kk Food composition
JP2010540498A (en) 2007-09-28 2010-12-24 ウニヴェルズィテーツシュピタール バーゼル Immunoliposomes for the treatment of cancer
JP2009096757A (en) 2007-10-17 2009-05-07 Tsujido Kagaku Kk Fat metabolism suppressing agent
WO2009073843A1 (en) * 2007-12-06 2009-06-11 Cytotech Labs, Llc Inhalable compositions having enhanced bioavailability
EP2271325A4 (en) * 2008-04-11 2011-11-09 Cytotech Labs Llc Methods and use of inducing apoptosis in cancer cells
JP5945096B2 (en) 2008-07-04 2016-07-05 小野薬品工業株式会社 Use of a determination marker for optimizing the therapeutic effect of anti-human PD-1 antibody on cancer
DE102008060773A1 (en) 2008-12-05 2010-06-10 Sartorius Stedim Biotech Gmbh Closure for a container
US8247435B2 (en) 2009-02-19 2012-08-21 Thornthwaite Jerry T Formulations for treating human and animal diseases
KR20120034649A (en) 2009-05-11 2012-04-12 버그 바이오시스템즈, 엘엘씨 Methods for treatment of disease using an epimetabolic shifter (coenzyme q10)
WO2011031503A2 (en) 2009-08-25 2011-03-17 Cytotech Labs, Llc Methods for treatment of a sarcoma using an epimetabolic shifter (coenzyme q10)
US8506954B2 (en) 2009-12-01 2013-08-13 The Board Of Trustees Of The Leland Stanford Junior University Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy
NZ602057A (en) 2010-03-12 2015-06-26 Berg Pharma Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
EP2595633A4 (en) 2010-07-19 2014-01-22 Remedy Pharmaceuticals Inc Methods of intravenous administration of glyburide and other drugs
US9125835B2 (en) 2010-11-12 2015-09-08 Rutgers, The State University Of New Jersey Synergistic combinations to reduce particle dose for targeted treatment of cancer and its metastases
ES2762451T3 (en) * 2011-04-04 2020-05-25 Berg Llc Treatment of tumors of the central nervous system with coenzyme Q10
JP6352905B2 (en) 2012-06-01 2018-07-04 バーグ エルエルシー Treatment of solid tumors with coenzyme Q10
EA032775B1 (en) 2013-04-08 2019-07-31 Берг Ллк Methofs of treating cancer using coenzyme q10 combination therapies
JP6595478B2 (en) 2013-09-04 2019-10-23 バーグ エルエルシー Cancer treatment by continuous injection of coenzyme Q10
JP6398212B2 (en) 2014-02-12 2018-10-03 株式会社Ihi Bearing structure and turbocharger
JP2017530130A (en) 2014-10-03 2017-10-12 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Use of Annexin V as a method of inhibiting immunosuppression of tumor-induced innate immune responses
EP3209778B1 (en) 2014-10-24 2019-04-03 Astrazeneca AB Combination
WO2016094639A1 (en) 2014-12-10 2016-06-16 Wisconsin Alumni Research Foundation Mini-intronic plasmid dna vaccines in combination with lag3 blockade
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
WO2018018018A1 (en) 2016-07-21 2018-01-25 Berg Llc Methods for the treatment of cancer using coenzyme q10 in combination with immune checkpoint modulators

Also Published As

Publication number Publication date
EA201101519A1 (en) 2012-10-30
US20180334721A1 (en) 2018-11-22
US20210332439A1 (en) 2021-10-28
KR20140014390A (en) 2014-02-06
US20170137879A1 (en) 2017-05-18
CN102481269A (en) 2012-05-30
US10519504B2 (en) 2019-12-31
MX349796B (en) 2017-08-11
CN102482713B (en) 2017-06-30
US20200157630A1 (en) 2020-05-21
CN102481269B (en) 2015-10-07
SG175994A1 (en) 2011-12-29
MX2011011949A (en) 2012-02-13
JP2017214413A (en) 2017-12-07
KR20120060945A (en) 2012-06-12
EP2430194A4 (en) 2013-09-04
EP2430194A2 (en) 2012-03-21
US20160145693A1 (en) 2016-05-26
AU2016204621A1 (en) 2016-07-21
JP2012526824A (en) 2012-11-01
IL216296B (en) 2020-06-30
SG175993A1 (en) 2011-12-29
BRPI1010576A2 (en) 2016-03-15
BRPI1011025A2 (en) 2016-03-29
IL216295A0 (en) 2012-01-31
KR20120034649A (en) 2012-04-12
JP2012526829A (en) 2012-11-01
AU2010247734A1 (en) 2011-12-15
CA2763347C (en) 2021-11-23
BRPI1010827A2 (en) 2019-09-24
IL216296A0 (en) 2012-01-31
IL216297A0 (en) 2012-01-31
EA201101521A1 (en) 2012-09-28
AU2016269471A1 (en) 2016-12-22
WO2010132507A2 (en) 2010-11-18
JP2018048125A (en) 2018-03-29
WO2010132486A3 (en) 2011-03-03
EP2429513A2 (en) 2012-03-21
CN105287449A (en) 2016-02-03
KR101860294B1 (en) 2018-07-02
US11028446B2 (en) 2021-06-08
US20110020312A1 (en) 2011-01-27
EA201101522A1 (en) 2012-09-28
CA2763336A1 (en) 2010-11-18
US20110123987A1 (en) 2011-05-26
WO2010132486A2 (en) 2010-11-18
JP2015199746A (en) 2015-11-12
AU2010247750B2 (en) 2016-09-22
US20220081720A1 (en) 2022-03-17
US20110027247A1 (en) 2011-02-03
BRPI1010908A2 (en) 2016-03-15
JP2012526828A (en) 2012-11-01
US20180355435A1 (en) 2018-12-13
KR20180018833A (en) 2018-02-21
EP2429511A4 (en) 2013-08-28
JP2017074038A (en) 2017-04-20
AU2016222422A1 (en) 2016-09-22
CA2763336C (en) 2018-10-30
AU2010247755B2 (en) 2016-09-15
MX345044B (en) 2017-01-16
AU2010247800A1 (en) 2011-12-15
SG10201402291QA (en) 2014-07-30
EP2429512A4 (en) 2013-07-31
CN102483419A (en) 2012-05-30
JP6081195B2 (en) 2017-02-15
WO2010132479A3 (en) 2011-03-31
MX2011011940A (en) 2012-06-25
AU2010247750A1 (en) 2011-12-15
CN102481271A (en) 2012-05-30
US9205064B2 (en) 2015-12-08
CA2763325A1 (en) 2010-11-18
SG175991A1 (en) 2011-12-29
AU2016222515A1 (en) 2016-09-22
EP2429511A2 (en) 2012-03-21
JP2012526554A (en) 2012-11-01
KR20120088555A (en) 2012-08-08
WO2010132440A3 (en) 2011-04-07
JP6254979B2 (en) 2017-12-27
MX2011011958A (en) 2012-02-13
CA2762213A1 (en) 2010-11-18
KR20120034647A (en) 2012-04-12
KR101829201B1 (en) 2018-02-19
SG10201402293SA (en) 2014-08-28
SG10201402289VA (en) 2014-07-30
US9896731B2 (en) 2018-02-20
WO2010132507A3 (en) 2011-03-31
IL216299A0 (en) 2012-01-31
JP5903735B2 (en) 2016-04-13
JP2016023190A (en) 2016-02-08
EA201101520A1 (en) 2012-09-28
MX351083B (en) 2017-09-29
US20190010554A1 (en) 2019-01-10
SG10201402288RA (en) 2014-07-30
KR20180056816A (en) 2018-05-29
WO2010132479A2 (en) 2010-11-18
EP2429511B1 (en) 2019-02-20
US20110123986A1 (en) 2011-05-26
EP2429512A2 (en) 2012-03-21
AU2010247755A1 (en) 2011-12-15
EA201101523A1 (en) 2012-10-30
MX2011011947A (en) 2012-01-30
JP5903734B2 (en) 2016-04-13
CA2761717A1 (en) 2010-11-18
WO2010132502A3 (en) 2011-04-21
EA023913B1 (en) 2016-07-29
EP2430455A2 (en) 2012-03-21
WO2010132440A2 (en) 2010-11-18
US20150023940A1 (en) 2015-01-22
JP2018021064A (en) 2018-02-08
IL216298A0 (en) 2012-01-31
EP2429513A4 (en) 2013-08-14
AU2010247734B2 (en) 2016-04-14
BRPI1011025A8 (en) 2016-07-19
CN102481270A (en) 2012-05-30
WO2010132502A2 (en) 2010-11-18
AU2010247761A1 (en) 2011-12-15
EA034552B1 (en) 2020-02-19
EP2430455A4 (en) 2013-09-04
CN102482713A (en) 2012-05-30
MX2011011942A (en) 2011-12-06
SG175996A1 (en) 2011-12-29
US20110110914A1 (en) 2011-05-12
SG175992A1 (en) 2011-12-29
CN104825429A (en) 2015-08-12
JP2012526555A (en) 2012-11-01
US10351915B2 (en) 2019-07-16
JP2017018134A (en) 2017-01-26
CN102483419B (en) 2017-12-15
CA2763347A1 (en) 2010-11-18
BRPI1010648A2 (en) 2016-03-15
JP2016023189A (en) 2016-02-08
JP6169846B2 (en) 2017-07-26
MX357528B (en) 2018-07-13
US20210002725A1 (en) 2021-01-07

Similar Documents

Publication Publication Date Title
IL216299A0 (en) Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
HK1222210A1 (en) Spatially encoded biological assays
LT2424975T (en) Organisms for the production of 1,3-butanediol
PL2611761T3 (en) Continuous low-temperature process to produce trans-1-chloro-3,3,3-trifluoropropene
IL211176A0 (en) Methods for the production of ips cells
PL2630108T3 (en) Process for the preparation of 2,3,3,3 tetrafluoropropene
AP2012006167A0 (en) DLL4-binding molecules.
EP2557920A4 (en) Methods for treating glucose metabolic disorders
GB0817513D0 (en) Co-crystals
GB0817976D0 (en) Co-crystals
EP2326749A4 (en) Methods for the electrolytic production of xylo-pent-1,5-diose
Anderson Teaching Portfolios
GB0917199D0 (en) Metabolic disorders
GB201014118D0 (en) Assay molecules
GB201014117D0 (en) Assay molecules
AU2010900589A0 (en) Super health drug
AU2010900588A0 (en) Super health drug
AU2008903664A0 (en) Student online resource
AU2009900275A0 (en) Novel metabolic disease therapy
AU2011902777A0 (en) The hodge water saver
AU2008901099A0 (en) Treasure pounding the puffin etc training system
AU2008901359A0 (en) Movement Analysis
GB201018989D0 (en) Biological methods
GB201000171D0 (en) Biological methods
GB201006120D0 (en) The cast buster