SE9500998D0 - New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics - Google Patents

New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics

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Publication number
SE9500998D0
SE9500998D0 SE9500998A SE9500998A SE9500998D0 SE 9500998 D0 SE9500998 D0 SE 9500998D0 SE 9500998 A SE9500998 A SE 9500998A SE 9500998 A SE9500998 A SE 9500998A SE 9500998 D0 SE9500998 D0 SE 9500998D0
Authority
SE
Sweden
Prior art keywords
alkyl
clozapine
iso
related structures
cyclopropylalkyl
Prior art date
Application number
SE9500998A
Other languages
Swedish (sv)
Inventor
Haakan Vilhelm Wikstroem
Peter De Boer
Yi Liao
Original Assignee
Haakan Wilhelm Wikstroem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haakan Wilhelm Wikstroem filed Critical Haakan Wilhelm Wikstroem
Priority to SE9500998A priority Critical patent/SE9500998D0/en
Publication of SE9500998D0 publication Critical patent/SE9500998D0/en
Priority to PCT/SE1996/000344 priority patent/WO1996029316A1/en
Priority to AU51305/96A priority patent/AU5130596A/en

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein R1 is H, (C1-C8) alkyl or haloalkyl or hydroxyalkyl, alkenyl, alkynyl, cyclopropylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; R2 is H, (C1-C8) alkyl, alkenyl, alkynyl, cyclopropylalkyl or (C1-C8) haloalkyl, hydroxyalkyl, hydroxyalkyloxyalkyl or 1-(alkyl-2-imidazolidinone); X is NH, NR1, O, S, SO, SO2. The compounds of this invention possess affinity to one or several receptor systems, e.g. DA (D1-D4), alpha 1, muscarinic (M1-M4) and 5-HT (5-HT2A, 5-HT2C and 5-HT7). The central nervous system disorders to be treated with the compounds of the present invention include psychoses-schizophrenia, autism, Tourette's syndrome, restless legs, Huntington's chorea, motion sickness, nausea, vomiting and severe anxiety.
SE9500998A 1995-03-19 1995-03-19 New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics SE9500998D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9500998A SE9500998D0 (en) 1995-03-19 1995-03-19 New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics
PCT/SE1996/000344 WO1996029316A1 (en) 1995-03-19 1996-03-19 NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS
AU51305/96A AU5130596A (en) 1995-03-19 1996-03-19 New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9500998A SE9500998D0 (en) 1995-03-19 1995-03-19 New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics

Publications (1)

Publication Number Publication Date
SE9500998D0 true SE9500998D0 (en) 1995-03-19

Family

ID=20397615

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9500998A SE9500998D0 (en) 1995-03-19 1995-03-19 New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics

Country Status (3)

Country Link
AU (1) AU5130596A (en)
SE (1) SE9500998D0 (en)
WO (1) WO1996029316A1 (en)

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GB9615767D0 (en) * 1996-07-26 1996-09-04 Smithkline Beecham Plc Novel treatment
CZ301061B6 (en) * 1999-07-09 2009-10-29 Astrazeneca Uk Limited Process for preparing dibenzothiazepine derivatives
US6777407B2 (en) 2000-11-03 2004-08-17 Wyeth Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
US6759405B2 (en) 2000-11-03 2004-07-06 Wyeth Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031199A1 (en) 2000-11-03 2003-09-10 Wyeth Corp CICLOHEPTA / B // 1,4 / DIACEPINO / 6,7,1-HI / INDOLES AND DERIVATIVES
AR031196A1 (en) 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF CYCLOPENTA (B) (1,4) -DIAZEPINO (6,7,1-HI) INDOLES AND DERIVATIVES
DE60106641T2 (en) * 2000-11-03 2005-12-01 Wyeth CYCLOPENTA [B] [1,4] DIAZEPINO [6,7,1-HI] INDOLE AS 5HT2C ANTAGONISTS
AR031197A1 (en) 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1,2,3,4,8,9,10,10A-OCTAHIDRO-7BH-CICLOPENTA (B) DIAZEPINO (6,7,1-HI) INDOL
US6916922B2 (en) 2000-11-03 2005-07-12 Wyeth Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
WO2004087124A1 (en) * 2003-03-29 2004-10-14 Mitsubishi Pharma Corporation Compounds having serotonin 5-ht17 receptor antagonist activity and muscarinic m4 receptor agonist activity and their use in the treatment of psychotic disorders
CN1913900B (en) * 2003-12-22 2010-11-24 阿卡蒂亚药品公司 Amino bustituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
ATE426405T1 (en) * 2003-12-22 2009-04-15 Acadia Pharm Inc AMINO-SUBSTITUTED DIARYLAA,DUCYCLOHEPTENE ANALOGAS AS MUSCARINIC AGONISTS AND METHOD FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
GT200500317A (en) 2004-11-05 2006-10-27 PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM
WO2007004234A1 (en) * 2005-07-04 2007-01-11 Usv Limited A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE
AR054849A1 (en) 2005-07-26 2007-07-18 Wyeth Corp DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (en) * 1961-07-20 1966-10-31 Wander Ag Dr A Process for the preparation of 11-basic substituted dibenzo (b, f) (1,4) thiazepines
IL29571A (en) * 1967-03-13 1972-04-27 Wander Ag Dr A 11-substituted dibenzo(b,f)-1,4-oxazepines,dibenzo(b,f)-1,4-thiazepines and dibenzo(b,e)-1,4-diazepines and their preparation
DK72693D0 (en) * 1993-06-18 1993-06-18 Lundbeck & Co As H COMPOUNDS

Also Published As

Publication number Publication date
AU5130596A (en) 1996-10-08
WO1996029316A1 (en) 1996-09-26

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