SE9500998D0 - New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics - Google Patents
New sulfone ester analogues of iso-clozapine and related structures: atypical neurolepticsInfo
- Publication number
- SE9500998D0 SE9500998D0 SE9500998A SE9500998A SE9500998D0 SE 9500998 D0 SE9500998 D0 SE 9500998D0 SE 9500998 A SE9500998 A SE 9500998A SE 9500998 A SE9500998 A SE 9500998A SE 9500998 D0 SE9500998 D0 SE 9500998D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- clozapine
- iso
- related structures
- cyclopropylalkyl
- Prior art date
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A compound of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein R1 is H, (C1-C8) alkyl or haloalkyl or hydroxyalkyl, alkenyl, alkynyl, cyclopropylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; R2 is H, (C1-C8) alkyl, alkenyl, alkynyl, cyclopropylalkyl or (C1-C8) haloalkyl, hydroxyalkyl, hydroxyalkyloxyalkyl or 1-(alkyl-2-imidazolidinone); X is NH, NR1, O, S, SO, SO2. The compounds of this invention possess affinity to one or several receptor systems, e.g. DA (D1-D4), alpha 1, muscarinic (M1-M4) and 5-HT (5-HT2A, 5-HT2C and 5-HT7). The central nervous system disorders to be treated with the compounds of the present invention include psychoses-schizophrenia, autism, Tourette's syndrome, restless legs, Huntington's chorea, motion sickness, nausea, vomiting and severe anxiety.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500998A SE9500998D0 (en) | 1995-03-19 | 1995-03-19 | New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics |
PCT/SE1996/000344 WO1996029316A1 (en) | 1995-03-19 | 1996-03-19 | NEW SULFONE ESTER ANALOGUES OF iso-CLOZAPINE AND RELATED STRUCTURES: ATYPICAL NEUROLEPTICS |
AU51305/96A AU5130596A (en) | 1995-03-19 | 1996-03-19 | New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500998A SE9500998D0 (en) | 1995-03-19 | 1995-03-19 | New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9500998D0 true SE9500998D0 (en) | 1995-03-19 |
Family
ID=20397615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9500998A SE9500998D0 (en) | 1995-03-19 | 1995-03-19 | New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU5130596A (en) |
SE (1) | SE9500998D0 (en) |
WO (1) | WO1996029316A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9615767D0 (en) * | 1996-07-26 | 1996-09-04 | Smithkline Beecham Plc | Novel treatment |
CZ301061B6 (en) * | 1999-07-09 | 2009-10-29 | Astrazeneca Uk Limited | Process for preparing dibenzothiazepine derivatives |
US6777407B2 (en) | 2000-11-03 | 2004-08-17 | Wyeth | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6759405B2 (en) | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
AR031199A1 (en) | 2000-11-03 | 2003-09-10 | Wyeth Corp | CICLOHEPTA / B // 1,4 / DIACEPINO / 6,7,1-HI / INDOLES AND DERIVATIVES |
AR031196A1 (en) | 2000-11-03 | 2003-09-10 | Wyeth Corp | PROCEDURE FOR THE PREPARATION OF CYCLOPENTA (B) (1,4) -DIAZEPINO (6,7,1-HI) INDOLES AND DERIVATIVES |
DE60106641T2 (en) * | 2000-11-03 | 2005-12-01 | Wyeth | CYCLOPENTA [B] [1,4] DIAZEPINO [6,7,1-HI] INDOLE AS 5HT2C ANTAGONISTS |
AR031197A1 (en) | 2000-11-03 | 2003-09-10 | Wyeth Corp | PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1,2,3,4,8,9,10,10A-OCTAHIDRO-7BH-CICLOPENTA (B) DIAZEPINO (6,7,1-HI) INDOL |
US6916922B2 (en) | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
WO2004087124A1 (en) * | 2003-03-29 | 2004-10-14 | Mitsubishi Pharma Corporation | Compounds having serotonin 5-ht17 receptor antagonist activity and muscarinic m4 receptor agonist activity and their use in the treatment of psychotic disorders |
CN1913900B (en) * | 2003-12-22 | 2010-11-24 | 阿卡蒂亚药品公司 | Amino bustituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
ATE426405T1 (en) * | 2003-12-22 | 2009-04-15 | Acadia Pharm Inc | AMINO-SUBSTITUTED DIARYLAA,DUCYCLOHEPTENE ANALOGAS AS MUSCARINIC AGONISTS AND METHOD FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES |
GT200500317A (en) | 2004-11-05 | 2006-10-27 | PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM | |
WO2007004234A1 (en) * | 2005-07-04 | 2007-01-11 | Usv Limited | A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE |
AR054849A1 (en) | 2005-07-26 | 2007-07-18 | Wyeth Corp | DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM |
WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH422793A (en) * | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Process for the preparation of 11-basic substituted dibenzo (b, f) (1,4) thiazepines |
IL29571A (en) * | 1967-03-13 | 1972-04-27 | Wander Ag Dr A | 11-substituted dibenzo(b,f)-1,4-oxazepines,dibenzo(b,f)-1,4-thiazepines and dibenzo(b,e)-1,4-diazepines and their preparation |
DK72693D0 (en) * | 1993-06-18 | 1993-06-18 | Lundbeck & Co As H | COMPOUNDS |
-
1995
- 1995-03-19 SE SE9500998A patent/SE9500998D0/en unknown
-
1996
- 1996-03-19 WO PCT/SE1996/000344 patent/WO1996029316A1/en active Application Filing
- 1996-03-19 AU AU51305/96A patent/AU5130596A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5130596A (en) | 1996-10-08 |
WO1996029316A1 (en) | 1996-09-26 |
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