SE9000873D0 - PREPARATION PROCESS OF NEW THIENO-TRIAZOLO-DIAZEPINE - Google Patents

PREPARATION PROCESS OF NEW THIENO-TRIAZOLO-DIAZEPINE

Info

Publication number
SE9000873D0
SE9000873D0 SE9000873A SE9000873A SE9000873D0 SE 9000873 D0 SE9000873 D0 SE 9000873D0 SE 9000873 A SE9000873 A SE 9000873A SE 9000873 A SE9000873 A SE 9000873A SE 9000873 D0 SE9000873 D0 SE 9000873D0
Authority
SE
Sweden
Prior art keywords
substd
triazolo
alkyl
hrs
formula
Prior art date
Application number
SE9000873A
Other languages
Swedish (sv)
Other versions
SE9000873L (en
SE507189C3 (en
SE507189C2 (en
Inventor
M Braquet
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Priority to SE9000873A priority Critical patent/SE507189C3/en
Publication of SE9000873D0 publication Critical patent/SE9000873D0/en
Publication of SE9000873L publication Critical patent/SE9000873L/en
Publication of SE507189C2 publication Critical patent/SE507189C2/en
Publication of SE507189C3 publication Critical patent/SE507189C3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prepn. of thieno-triazolo derivs. of formula (I) comprises; (a) reacting a thieno-triazolo-diazepine (II) with a slight stoichiometric excess of (III) under N2 in a pretic solvent, and refluxing for 24 hrs.; (b) reacting the above prod. with a cpd. of formula (IV) under N2 with a slight stoichiometric excess of hydrazine hydrate at 0 deg.C to room temp. for 5 mins. to 1 hr.; and (c) cyclising under N2 in a protic solvent the above prod. with 4 stoichiometric equivs. of triethylorthoacetate at room temp. for 15 mins. to 3 hrs., and then uder reflux for 1/2 hr. to 5 hrs.. R2=2-5C straight chain alkenyl, 1-20C alkyl, 3-6C cycloalkyl, 1-5C straight chain alkyl substd. by (hetero) aryl opt. substd. by Me, phenyl opt. substd. by IZ, a condensed bycyclic gp. contg. a hetero atom or a sulphonyl substd. by phenyl, hetero aryl or by a condensed bicyclic gp.; Z=1-5C alkyl, 1-5C alkoxy, phenoxy, 1-5C alkyl sulphonyl, F, Cl or CF3; Y=O or S; Ar= a gp. of formula (a).
SE9000873A 1990-03-12 1990-03-12 Preparation process for new thieno-triazolo-diazepine compounds SE507189C3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE9000873A SE507189C3 (en) 1990-03-12 1990-03-12 Preparation process for new thieno-triazolo-diazepine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9000873A SE507189C3 (en) 1990-03-12 1990-03-12 Preparation process for new thieno-triazolo-diazepine compounds

Publications (4)

Publication Number Publication Date
SE9000873D0 true SE9000873D0 (en) 1990-03-12
SE9000873L SE9000873L (en) 1991-09-13
SE507189C2 SE507189C2 (en) 1998-04-20
SE507189C3 SE507189C3 (en) 1998-05-04

Family

ID=20378831

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9000873A SE507189C3 (en) 1990-03-12 1990-03-12 Preparation process for new thieno-triazolo-diazepine compounds

Country Status (1)

Country Link
SE (1) SE507189C3 (en)

Also Published As

Publication number Publication date
SE9000873L (en) 1991-09-13
SE507189C3 (en) 1998-05-04
SE507189C2 (en) 1998-04-20

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