SE8803931L - NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS - Google Patents

NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS

Info

Publication number
SE8803931L
SE8803931L SE8803931A SE8803931A SE8803931L SE 8803931 L SE8803931 L SE 8803931L SE 8803931 A SE8803931 A SE 8803931A SE 8803931 A SE8803931 A SE 8803931A SE 8803931 L SE8803931 L SE 8803931L
Authority
SE
Sweden
Prior art keywords
ginkgolides
alcoxide
derivatives
preparation
new
Prior art date
Application number
SE8803931A
Other languages
Swedish (sv)
Other versions
SE8803931D0 (en
Inventor
P Braquet
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Publication of SE8803931D0 publication Critical patent/SE8803931D0/en
Publication of SE8803931L publication Critical patent/SE8803931L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention relates to 1-alkoxy or 10-alkoxy substituted Ginkgolides or mixtures of the same, to a preparation process of these compounds consisting in reacting a dioxan solution of the selected Ginkgolide on a diethyl ether solution of diazoalkane in excess, at room temperature for 1 to 10 hours and to therapeutic compositions containing the same.
SE8803931A 1987-11-04 1988-10-31 NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS SE8803931L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878725871A GB8725871D0 (en) 1987-11-04 1987-11-04 Ginkgolide derivatives

Publications (2)

Publication Number Publication Date
SE8803931D0 SE8803931D0 (en) 1988-10-31
SE8803931L true SE8803931L (en) 1989-05-05

Family

ID=10626449

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8803931A SE8803931L (en) 1987-11-04 1988-10-31 NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS

Country Status (28)

Country Link
JP (1) JPH0686455B2 (en)
KR (1) KR970005536B1 (en)
AT (1) AT397097B (en)
AU (1) AU616367B2 (en)
BE (1) BE1003455A3 (en)
CA (1) CA1303619C (en)
CH (1) CH675583A5 (en)
DE (1) DE3837550A1 (en)
DK (1) DK612788A (en)
ES (1) ES2009364A6 (en)
FI (1) FI90081C (en)
FR (2) FR2622584B1 (en)
GB (2) GB8725871D0 (en)
GR (1) GR1000264B (en)
HK (1) HK53992A (en)
IE (1) IE61541B1 (en)
IN (1) IN173404B (en)
IT (1) IT1227456B (en)
MA (1) MA21423A1 (en)
MY (1) MY103446A (en)
NL (1) NL8802635A (en)
NO (1) NO167739C (en)
NZ (1) NZ226738A (en)
PT (1) PT88924B (en)
SE (1) SE8803931L (en)
SG (1) SG48292G (en)
TN (1) TNSN88118A1 (en)
ZA (1) ZA888184B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
DE69132379T2 (en) * 1990-06-06 2001-03-01 Ruth-Maria Korth Treatment of diseases with Paf antagonists and method for determining their effectiveness
ES2181665T3 (en) * 1991-11-04 2003-03-01 Ruth-Maria Korth TREATMENT AND PREVENTION OF MENTAL DISEASES, ACCOMPANIED BY ELEVATED LEVELS OF LISO PAF, WITH PAF ANTAGONISTS.
FR2763592B1 (en) * 1997-05-20 1999-07-16 Sod Conseils Rech Applic NOVEL GLYCOSYL DERIVATIVES OF GINKGOLIDES, THEIR APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2777280B1 (en) * 1998-04-10 2001-04-20 Centre Nat Rech Scient GINKGOLIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA3008698C (en) 2015-12-18 2020-12-15 Chengdu Baiyu Ginkgolide Pharmaceuticals Co., Ltd. Ginkgolide b derivative and preparation method and use thereof
CN108373474B (en) * 2017-12-25 2020-06-09 上海信谊百路达药业有限公司 A bilobalide compound extracted from folium Ginkgo and its preparation method
CN108383852B (en) * 2017-12-25 2019-11-22 上海信谊百路达药业有限公司 A kind of Ginkgolid extracted from ginkgo leaf and its preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418424D0 (en) * 1984-07-19 1984-08-22 Scras Inhibition of platelets aggregation
DE3710921C2 (en) * 1986-10-21 1996-09-26 Korth Ruth Use of Gingkolide BN 52020, BN 52021 and BN 52063 for the treatment of arteriosclerosis
DE3735525C2 (en) * 1987-10-20 1997-02-20 Korth Ruth Maria Method for determining the efficacy of paf-acether receptor antagonists

Also Published As

Publication number Publication date
FR2622584A1 (en) 1989-05-05
GB8824859D0 (en) 1988-11-30
PT88924B (en) 1993-01-29
ZA888184B (en) 1989-07-26
GR1000264B (en) 1992-05-12
FR2622584B1 (en) 1992-01-10
FR2622448A1 (en) 1989-05-05
NO884900L (en) 1989-05-05
SE8803931D0 (en) 1988-10-31
IE883315L (en) 1989-05-04
KR970005536B1 (en) 1997-04-17
GB8725871D0 (en) 1987-12-09
ES2009364A6 (en) 1989-09-16
IE61541B1 (en) 1994-11-16
KR890008156A (en) 1989-07-10
NL8802635A (en) 1989-06-01
DE3837550C2 (en) 1991-12-12
FI90081B (en) 1993-09-15
NO167739B (en) 1991-08-26
NO884900D0 (en) 1988-11-03
FI885046A (en) 1989-05-05
AU2464488A (en) 1989-05-25
DE3837550A1 (en) 1989-05-18
BE1003455A3 (en) 1992-03-31
SG48292G (en) 1992-06-12
ATA269688A (en) 1993-06-15
FR2622448B1 (en) 1992-01-10
IT1227456B (en) 1991-04-11
MY103446A (en) 1993-06-30
NZ226738A (en) 1990-05-28
HK53992A (en) 1992-07-30
AU616367B2 (en) 1991-10-24
CH675583A5 (en) 1990-10-15
GB2211841A (en) 1989-07-12
FI90081C (en) 1993-12-27
TNSN88118A1 (en) 1990-07-10
JPH0686455B2 (en) 1994-11-02
JPH01151583A (en) 1989-06-14
GB2211841B (en) 1991-01-16
DK612788A (en) 1989-05-05
CA1303619C (en) 1992-06-16
NO167739C (en) 1991-12-04
FI885046A0 (en) 1988-11-02
DK612788D0 (en) 1988-11-03
PT88924A (en) 1988-12-01
MA21423A1 (en) 1989-07-01
IT8822493A0 (en) 1988-11-04
IN173404B (en) 1994-04-30
AT397097B (en) 1994-01-25

Similar Documents

Publication Publication Date Title
GB8826066D0 (en) New use of 11 28-dioxa-4-azatricyclo(22 3 1 0 4.9)octacos-18-ene derivatives & pharmaceutical compositions
DE3382156D1 (en) USE OF COMPOSITIONS CONTAINING 8-SUBSTITUTED GUANOSINE DERIVATIVES FOR THE PRODUCTION OF MEDICINAL PRODUCTS.
PT84449A (en) Process for the preparation of 3,5-disubstituted pyrocatechole derivatives and of pharmaceutical compositions containing the same
IL67572A (en) Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them
MY103850A (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
IL81482A0 (en) 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups,their manufacture and pharmaceutical compositions containing them
HUT51138A (en) Process for production of medical composition against osteoporosis containing derivatives of imidasole /1,2-a/-piridasine or pirasine
CS405391A3 (en) N-aminobutyl-n-phenylarylamide derivatives, process of their preparationand pharmaceutical compositions containing said derivatives
NO883813D0 (en) PROCEDURE FOR THE PREPARATION OF HOMOPOLYAMIDES.
HUT47086A (en) Herbicide compositions containing sulfonamide derivatives and process for producing the sulfonamide derivatives
SE8803931L (en) NEW ALCOXIDE DERIVATIVES OF GINKGOLIDES, THEIR PREPARATION AND THERAPEUTIC CONTENTS
HU896190D0 (en) Process for the preparation of pharmaceutical compositions containing pyrazole derivatives
IL52227A (en) Process for the preparation of 10,19-dihydro-vitamin d derivatives and some novel 10,19-dihydro-1alpha-hydroxy and 1 alpha,25-dihydroxy-vitamin d3 compounds and pharmaceutical compositions containing them
IL88207A (en) Pharmaceutical compositions for the treatment of osteoporosis containing imidazole compounds
PT88682A (en) A PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS CONTAINING PIPERIDINOALKANOL-DECONGESTANT COMBINATION
IL57214A0 (en) Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepiens,process for the preparation thereof and pharmaceutical compositions containing them
GB2202145B (en) Compositions of nedocromil for dermatological use.
IL60025A (en) Process for the preparation of 1,3,7-tri substituted xanthines and certain new such xanthines and pharmaceutical compositions containing them
PT88681A (en) A PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS CONTAINING PIPERIDINOALKANOL DERIVATIVES
GR82568B (en) Process for the preparation of 1,3-dioxolanyl derivatives, use thereof, medicaments containing said compounds
PT87301A (en) PROCESS FOR THE PREPARATION OF 1,3-DIOXANES BY PRODUCTS AND OF PHARMACEUTICAL COMPOUNDS CONTAINING THEM
PT87031A (en) PROCESS FOR THE PREPARATION OF 4-PHENYLPIPERIDINE COMPOUNDS AN D OF PHARMACEUTICAL COMPOSITIONS THEREWITH
GB2020658B (en) Preparation of 1,5dimethyl bicyclo(3.2.1)octanol-8
ES8504166A1 (en) 6,11-Dihydro-11,-oxo-dibenz(b,e)-oxepin derivatives, methods for their preparation, pharmaceutical compositions containing the same and their use as medicaments.
PT86455A (en) Process for the preparation of pharmaceutical compositions containing pyranoquinoline derivatives

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8803931-8