SE8802480D0 - METHOD OF PREPARATION OF NUCLEIC ACID DERIVATIVES AND METHOD OF PREPARATION OF MEDICAL COMPOSITION CONTAINING THE SAME - Google Patents

METHOD OF PREPARATION OF NUCLEIC ACID DERIVATIVES AND METHOD OF PREPARATION OF MEDICAL COMPOSITION CONTAINING THE SAME

Info

Publication number
SE8802480D0
SE8802480D0 SE8802480A SE8802480A SE8802480D0 SE 8802480 D0 SE8802480 D0 SE 8802480D0 SE 8802480 A SE8802480 A SE 8802480A SE 8802480 A SE8802480 A SE 8802480A SE 8802480 D0 SE8802480 D0 SE 8802480D0
Authority
SE
Sweden
Prior art keywords
nucleic acid
preparation
acid derivatives
composition containing
same
Prior art date
Application number
SE8802480A
Other languages
Swedish (sv)
Other versions
SE8802480L (en
Inventor
J Yano
T Ohgi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of SE8802480D0 publication Critical patent/SE8802480D0/en
Publication of SE8802480L publication Critical patent/SE8802480L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of producing double-stranded nucleic acid derivatives having RNA as the parent body (the total molecular size distribution of which is from 4S to 13S expressed as sedimentation constant value of, alternatively, is such that the derivatives have base numbers in the range 50 to 10,000) including sizing nucleic acid polymers and subsequently combining them. Before combination the sized polymers may be subjected to ion-exchange treatment (to effect a size determination). Such treatment with ion-exchange will also serve to remove pyrogens from nucleic acid derivatives intended for administration by injection.
SE8802480A 1987-07-03 1988-07-01 PROCEDURES FOR PREPARING NUCLEIC ACID DERIVATIVES AND PROCEDURES FOR PREPARING MEDICAL COMPOSITION CONTAINING THEM SE8802480L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16743487 1987-07-03

Publications (2)

Publication Number Publication Date
SE8802480D0 true SE8802480D0 (en) 1988-07-01
SE8802480L SE8802480L (en) 1989-01-04

Family

ID=15849635

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802480A SE8802480L (en) 1987-07-03 1988-07-01 PROCEDURES FOR PREPARING NUCLEIC ACID DERIVATIVES AND PROCEDURES FOR PREPARING MEDICAL COMPOSITION CONTAINING THEM

Country Status (19)

Country Link
KR (1) KR890002226A (en)
CN (1) CN1024556C (en)
AT (1) AT397658B (en)
AU (1) AU1864488A (en)
CH (1) CH676123A5 (en)
DE (1) DE3822406A1 (en)
DK (1) DK369088A (en)
ES (1) ES2007252A6 (en)
FI (1) FI883163A (en)
FR (1) FR2617403B1 (en)
GB (1) GB2207138B (en)
HU (1) HU202250B (en)
IL (1) IL86884A0 (en)
IT (1) IT1224504B (en)
NL (1) NL8801664A (en)
NO (1) NO882922L (en)
PT (1) PT87903B (en)
SE (1) SE8802480L (en)
ZA (1) ZA884698B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963532A (en) * 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
RU2222334C2 (en) 1998-05-25 2004-01-27 Ниппон Синяку Ко., Лтд. Method for preparing nucleic acid-containing composite preparation
CN1194002C (en) * 1999-02-15 2005-03-23 日本新药株式会社 Shortened-chain polynucleotide and process for the preparation thereof
EP2930180B1 (en) * 2012-12-06 2021-11-10 Kyowa Hakko Bio Co., Ltd. Double-stranded ribonucleic acid for adjuvants
CN117517551A (en) * 2023-11-03 2024-02-06 成都迈科康生物科技有限公司 Method for detecting polyinosinic cell content by adopting high performance liquid chromatography

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194880A (en) * 1979-09-17 1983-07-15 Merck & Co Inc Interferon-inducing composition containing modified polyriboinosinic-polyribocytidylic acid

Also Published As

Publication number Publication date
GB2207138B (en) 1992-02-05
IL86884A0 (en) 1988-11-30
HU202250B (en) 1991-02-28
DK369088A (en) 1989-01-04
AU1864488A (en) 1989-04-27
AT397658B (en) 1994-06-27
GB8815262D0 (en) 1988-08-03
NO882922L (en) 1989-01-04
PT87903B (en) 1995-03-01
ATA169988A (en) 1993-10-15
KR890002226A (en) 1989-04-10
FI883163A (en) 1989-01-04
CH676123A5 (en) 1990-12-14
FI883163A0 (en) 1988-07-01
HUT48272A (en) 1989-05-29
IT1224504B (en) 1990-10-04
DK369088D0 (en) 1988-07-01
PT87903A (en) 1989-06-30
DE3822406A1 (en) 1989-01-12
CN1030424A (en) 1989-01-18
CN1024556C (en) 1994-05-18
SE8802480L (en) 1989-01-04
NO882922D0 (en) 1988-06-30
FR2617403A1 (en) 1989-01-06
NL8801664A (en) 1989-02-01
FR2617403B1 (en) 1993-05-07
IT8848147A0 (en) 1988-07-01
ES2007252A6 (en) 1989-06-01
GB2207138A (en) 1989-01-25
ZA884698B (en) 1989-03-29

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