SE8502286D0 - ESTARS FOR PREPARING A BETA-LACTAMA INHIBITOR - Google Patents

ESTARS FOR PREPARING A BETA-LACTAMA INHIBITOR

Info

Publication number
SE8502286D0
SE8502286D0 SE8502286A SE8502286A SE8502286D0 SE 8502286 D0 SE8502286 D0 SE 8502286D0 SE 8502286 A SE8502286 A SE 8502286A SE 8502286 A SE8502286 A SE 8502286A SE 8502286 D0 SE8502286 D0 SE 8502286D0
Authority
SE
Sweden
Prior art keywords
estars
lactama
beta
inhibitor
preparing
Prior art date
Application number
SE8502286A
Other languages
Swedish (sv)
Other versions
SE8502286L (en
SE466203B (en
Inventor
W J Gottstein
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/214,833 external-priority patent/US4340539A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8502286D0 publication Critical patent/SE8502286D0/en
Publication of SE8502286L publication Critical patent/SE8502286L/en
Publication of SE466203B publication Critical patent/SE466203B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

2???-Chloromethyl-2???- methylpenam-3???-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of ???-lactamases. The invention also includes a number of intermediate 6???-bromo analogues of esters of the aforementioned acid and of the sulfoxide and sulfone thereof.
SE8502286A 1980-01-21 1985-05-08 ESTRARS FOR PREPARING A BETA-LACTAMAS INHIBITOR SE466203B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11389480A 1980-01-21 1980-01-21
US21483180A 1980-12-11 1980-12-11
US06/214,833 US4340539A (en) 1980-01-21 1980-12-11 Derivatives of 6-bromo penicillanic acid

Publications (3)

Publication Number Publication Date
SE8502286D0 true SE8502286D0 (en) 1985-05-08
SE8502286L SE8502286L (en) 1985-05-08
SE466203B SE466203B (en) 1992-01-13

Family

ID=27381401

Family Applications (5)

Application Number Title Priority Date Filing Date
SE8100339A SE455702B (en) 1980-01-21 1981-01-21 2 BETA-CHLOROMETHYL-2ALFA-METHYLPENAM-3ALFA-CARBOXYLIC ACID SULPHONES ITS SALTS AND PHYSIOLOGY HYDRAULIC ESTABLES WITH BETALACTAMASHIN INHIBITIVE EFFECTS, PREPARATION FOR PREPARING THEREOF
SE8502286A SE466203B (en) 1980-01-21 1985-05-08 ESTRARS FOR PREPARING A BETA-LACTAMAS INHIBITOR
SE8502285A SE8502285D0 (en) 1980-01-21 1985-05-08 ANTIBACTERIAL COMPOSITION
SE9000189A SE9000189L (en) 1980-01-21 1990-01-19 ESTRARS FOR PREPARING A BETA LACTAMA INHIBITOR
SE9000190A SE9000190L (en) 1980-01-21 1990-01-19 ESTER FOR PREPARATION OF A BETA LACTAMA INHIBITOR

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8100339A SE455702B (en) 1980-01-21 1981-01-21 2 BETA-CHLOROMETHYL-2ALFA-METHYLPENAM-3ALFA-CARBOXYLIC ACID SULPHONES ITS SALTS AND PHYSIOLOGY HYDRAULIC ESTABLES WITH BETALACTAMASHIN INHIBITIVE EFFECTS, PREPARATION FOR PREPARING THEREOF

Family Applications After (3)

Application Number Title Priority Date Filing Date
SE8502285A SE8502285D0 (en) 1980-01-21 1985-05-08 ANTIBACTERIAL COMPOSITION
SE9000189A SE9000189L (en) 1980-01-21 1990-01-19 ESTRARS FOR PREPARING A BETA LACTAMA INHIBITOR
SE9000190A SE9000190L (en) 1980-01-21 1990-01-19 ESTER FOR PREPARATION OF A BETA LACTAMA INHIBITOR

Country Status (12)

Country Link
KR (1) KR850001066B1 (en)
CA (1) CA1175807A (en)
CH (2) CH651571A5 (en)
DE (1) DE3101527A1 (en)
DK (3) DK162717C (en)
GB (1) GB2070592B (en)
HU (2) HU188606B (en)
IL (1) IL61880A (en)
NL (1) NL8100209A (en)
NO (5) NO160298C (en)
OA (1) OA06748A (en)
SE (5) SE455702B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
ATE27772T1 (en) * 1983-09-15 1987-07-15 Bristol Myers Co PHARMACEUTICAL COMPOSITIONS TO COMBAT THE RESISTANCE OF BACTERIAL ANAEROBIA.
GB2157286B (en) * 1984-04-12 1987-12-31 Leo Pharm Prod Ltd B-lactam antibiotic potentiators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2912511C2 (en) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmaceutical composition containing penicillanic acid
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
NO164300B (en) 1990-06-11
IL61880A (en) 1984-11-30
DK164938B (en) 1992-09-14
NO861946L (en) 1981-07-22
DK162769C (en) 1992-04-27
SE9000190L (en) 1991-07-20
DK285890D0 (en) 1990-11-30
HU188606B (en) 1986-04-28
GB2070592B (en) 1983-05-11
DK162769B (en) 1991-12-09
NO160298C (en) 1989-04-05
SE8502285L (en) 1985-05-08
CH649087A5 (en) 1985-04-30
NO861945L (en) 1981-07-22
NO164300C (en) 1990-09-19
CH651571A5 (en) 1985-09-30
DK162717B (en) 1991-12-02
NO853450L (en) 1981-07-22
NO161677B (en) 1989-06-05
SE455702B (en) 1988-08-01
SE9000190D0 (en) 1990-01-19
DK162717C (en) 1992-04-21
NO810166L (en) 1981-07-22
DK21881A (en) 1981-07-22
SE9000189L (en) 1991-07-20
OA06748A (en) 1982-06-30
SE8502286L (en) 1985-05-08
NO160298B (en) 1988-12-27
HU184380B (en) 1984-08-28
KR850001066B1 (en) 1985-07-25
KR850001465A (en) 1985-03-18
NL8100209A (en) 1981-08-17
SE8502285D0 (en) 1985-05-08
GB2070592A (en) 1981-09-09
NO164298B (en) 1990-06-11
NO861944L (en) 1981-07-22
DK285790D0 (en) 1990-11-30
CA1175807A (en) 1984-10-09
SE9000189D0 (en) 1990-01-19
DK164938C (en) 1993-02-01
NO164299B (en) 1990-06-11
SE8100339L (en) 1981-09-01
SE466203B (en) 1992-01-13
NO164298C (en) 1990-09-19
DE3101527A1 (en) 1982-02-18
NO161677C (en) 1989-09-13
NO164299C (en) 1990-09-19
DK285890A (en) 1990-11-30
DK285790A (en) 1990-11-30

Similar Documents

Publication Publication Date Title
NO794010L (en) PROCEDURE FOR THE PREPARATION OF AMINO ACID DERIVATIVES
DK389480A (en) DERIVATIVES OF 6BETA-HYDROXYALKYL PENICILLANIC ACIDS FOR USE AS BETA-LACTAMSE INHIBITORS
RO86355A (en) PROCESS FOR THE PREPARATION OF (S) -EPEMER OF THE ACID ESTER 7-BETA-MALONAMIDE-7-ALFA-METHO-3-TETRAZOLYL-TOMETHYL-1-DETHALYL-
AR219077A1 (en) PROCEDURE FOR THE ELABORATION OF 1-AMINO-ALKYL (C1-C6) -PHOSPHONIC ACIDS
ES546625A0 (en) PROCEDURE FOR THE SYNTHESIS OF OMEGA-AMINATED ACID DERIVATIVES
SE8502286D0 (en) ESTARS FOR PREPARING A BETA-LACTAMA INHIBITOR
PT88545A (en) PROCESS FOR THE MANUFACTURE OF BENZIMIDAZOLINE-2-OXO-1-CARBOXYLIC ACID DERIVATIVE COMPOUNDS
IT1150046B (en) PROCEDURE FOR THE PRODUCTION OF SULFUR THEATRAFLUORIDE
IT1192308B (en) PROCEDURE FOR THE MANUFACTURE OF A SEAL NUT
AR214791A1 (en) PROCEDURE FOR THE ELABORATION OF ACID 7-B (D-2-AMINO-2- (3-METHYLSULFONYLAMINOPHENIL)) - ACETYLAMINO-3-CHLORINE OR 3-METOXI-CEFEM-4-CARBOXILICOS
NO151619C (en) PROCEDURE FOR THE PREPARATION OF CYCLOPROPAN-CARBOXYLIC ACID ESTER DERIVATIVES
JPS5536484A (en) Novel 1*44dihydropyridazinee33carboxylic acid derivative
IT7949838A0 (en) PROCEDURE FOR DEODORIZATION OF WORKSHOP GAS
DK159272C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ALFA-SUBSTITUTED UREIDOBENZYLPENICILLANIC ACID
NO791293L (en) PROCEDURE FOR THE PREPARATION OF SULFUR-CONTAINING N-BENZYLAMINO ACIDS
AT373914B (en) METHOD FOR THE STEREO-SPECIFIC PRODUCTION OF D-CARBAMYL DERIVATIVES FROM ALPHA HYDROXYSAEURS
AR226118A1 (en) PROCEDURE FOR THE PRODUCTION OF 3-ACIL-AZOPROPIONIC ACID ESTERS
FI811409L (en) IMIDAZOLYL INDENOTIOFENER FOERFARANDE FOER DERAS FRAMSTAELLNING SAMT ANVAENDNING SOM LAEKEMEDEL
NO158416C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PENTANDIC ACID DERIVATIVES.
DK534383A (en) METHOD OF PREPARING ACETYLSALICYLIC ACID DERIVATIVES
AR221864A1 (en) A PROCEDURE FOR THE MANUFACTURE OF DERIVATIVES OF 1- (INDANIL OR TETRAHIDRONAFTIL) OXI-3-ALQUILAMINO-ALCAN-2-OL
NO158217C (en) ANALOGUE PROCEDURE FOR PREPARING PHARMASOYYTIC ACTIVE ESTER DERIVATIVES OF ACETYLSALICYLIC ACID.
DK554079A (en) PROCEDURE FOR THE PREPARATION OF CITRIC ACID DERIVATIVES
IT7948358A0 (en) PROCEDURE FOR THE PRODUCTION OF CYANOCARBOXYLIC ACIDS
IT1057937B (en) PROCEDURE FOR THE MANUFACTURE OF ESTER PHOSPHORODITIOATE

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8502286-1

Effective date: 19940810

Format of ref document f/p: F