SE8405514L - FURYL DERIVATIVES OF 16-SUBSTITUTED PROSTAGLANDINES AND PROCEDURES FOR THEIR PREPARATION - Google Patents

FURYL DERIVATIVES OF 16-SUBSTITUTED PROSTAGLANDINES AND PROCEDURES FOR THEIR PREPARATION

Info

Publication number
SE8405514L
SE8405514L SE8405514A SE8405514A SE8405514L SE 8405514 L SE8405514 L SE 8405514L SE 8405514 A SE8405514 A SE 8405514A SE 8405514 A SE8405514 A SE 8405514A SE 8405514 L SE8405514 L SE 8405514L
Authority
SE
Sweden
Prior art keywords
alkyl
group
hydrogen
furyl
pentatomic
Prior art date
Application number
SE8405514A
Other languages
Swedish (sv)
Other versions
SE8405514D0 (en
Inventor
F Faustini
A Panzeri
F Orzi
Salle E Di
R Ceserani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8405514D0 publication Critical patent/SE8405514D0/en
Publication of SE8405514L publication Critical patent/SE8405514L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

The present invention relates to new furyl derivatives of 16-substituted prostaglandins, to a process for their preparation and to pharmaceutical and veterinary compositions containing them. The new compounds of the invention are optically active or racemic prostaglandins of the following formula (I) <IMAGE> (I) wherein R is (1) -OH or -OR' wherein R' is C1-C6 alkyl optionally substituted by phenyl or by a monocycloalkyl group or by a pentatomic or hexatomic heteromonocyclic ring containing at least one heteroatom chosen from O, S and N; (2) <IMAGE> wherein each of R'' and R''', is independently, hydrogen; C1-C6 alkyl; phenyl; or a pentatomic or hexatomic heteromonocyclic ring containing at least one heteroatom chosen from O, S and N; or R'' and R''', together with the nitrogen atom to which they are linked, form a pentatomic or hexatomic heteromonocyclic ring optionally containing a further heteroatom chosen from O, S and N; (3) -W-(CH2)n-X wherein W is -O- or -NH-, n is an integer of 1 to 4 and X represents a group -OR' or a group <IMAGE> wherein R', R'' and R''' are as defined above; one of R1 and R2 is hydrogen and the other is hydroxy or R1 and R2, taken together, form an oxo group; one of R3 and R4 is hydrogen and the other is hydroxy; one of R5 and R6 is hydroxy and the other is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, or phenyl; one of R7 and R8 is hydrogen and the other is a C1-C4 alkyl or tri-halo-C1-C4 alkyl group; m is an integer of 1 to 3; R9 is a 2-furyl or 3-furyl group, optionally substituted by one or more substituents chosen from C1-C4 alkyl, C1-C4 alkoxy, tri-halo-C1-C4 alkyl and halogen; and the symbol represents a single bond or a cis double bond.
SE8405514A 1983-11-04 1984-11-02 FURYL DERIVATIVES OF 16-SUBSTITUTED PROSTAGLANDINES AND PROCEDURES FOR THEIR PREPARATION SE8405514L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838329559A GB8329559D0 (en) 1983-11-04 1983-11-04 Furyl derivatives of 16-substituted prostaglandins preparations

Publications (2)

Publication Number Publication Date
SE8405514D0 SE8405514D0 (en) 1984-11-02
SE8405514L true SE8405514L (en) 1985-05-05

Family

ID=10551287

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8405514A SE8405514L (en) 1983-11-04 1984-11-02 FURYL DERIVATIVES OF 16-SUBSTITUTED PROSTAGLANDINES AND PROCEDURES FOR THEIR PREPARATION

Country Status (18)

Country Link
US (1) US4585791A (en)
JP (1) JPS60112782A (en)
AU (1) AU563999B2 (en)
BE (1) BE900959A (en)
CH (1) CH663413A5 (en)
DE (1) DE3439863A1 (en)
DK (1) DK524484A (en)
FI (1) FI844273L (en)
FR (1) FR2554448B1 (en)
GB (2) GB8329559D0 (en)
GR (1) GR80822B (en)
HU (1) HU193708B (en)
IL (1) IL73395A0 (en)
IT (1) IT1177095B (en)
NL (1) NL8403307A (en)
SE (1) SE8405514L (en)
SU (1) SU1489582A3 (en)
ZA (1) ZA848551B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5741810A (en) 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
US8063033B2 (en) * 2008-01-18 2011-11-22 Allergan, Inc. Therapeutic beta-lactams
US7960378B2 (en) * 2008-03-18 2011-06-14 Allergan, Inc. Therapeutic compounds
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
CA2731279A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Therapeutic compounds
US8569349B2 (en) 2008-05-09 2013-10-29 Allergan, Inc. Therapeutic compounds
EP2300439A1 (en) * 2008-05-09 2011-03-30 Allergan, Inc. Therapeutic substituted hydantoins, and related compounds
AU2009244513B2 (en) * 2008-05-09 2014-04-10 Allergan, Inc. Therapeutic cyclopentane derivatives
WO2009137411A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
WO2014015246A1 (en) * 2012-07-19 2014-01-23 Cayman Chemical Company, Inc. Difluorolactam compositions for ep4-mediated osteo related diseases and conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1386146A (en) * 1972-05-03 1975-03-05 Ici Ltd Cyclopentane derivatives
ES416865A1 (en) * 1972-07-13 1976-03-01 Pfizer 15-substituted-omega-pentanorprostaglandins
US3956284A (en) * 1972-07-13 1976-05-11 Pfizer Inc. Heterocyclic 15-substituted-ω-pentanorprostoglandins
US4404372A (en) * 1977-06-13 1983-09-13 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandin derivatives
IT1088966B (en) * 1977-11-15 1985-06-10 Erba Carlo Spa 13,14-didehydro-prostaglandins
US4543353A (en) * 1981-11-27 1985-09-24 Farmitalia Carlo Erba S.P.A. Ester and amide derivatives of 13,14-didehydro prostaglandins

Also Published As

Publication number Publication date
FI844273L (en) 1985-05-05
AU3494584A (en) 1985-05-09
JPS60112782A (en) 1985-06-19
GB8329559D0 (en) 1983-12-07
DK524484D0 (en) 1984-11-02
IT8423390A0 (en) 1984-10-30
IT1177095B (en) 1987-08-26
BE900959A (en) 1985-05-02
FR2554448A1 (en) 1985-05-10
GB2149788A (en) 1985-06-19
NL8403307A (en) 1985-06-03
FI844273A0 (en) 1984-10-31
CH663413A5 (en) 1987-12-15
GB2149788B (en) 1987-04-08
IT8423390A1 (en) 1986-04-30
ZA848551B (en) 1985-06-26
US4585791A (en) 1986-04-29
GR80822B (en) 1985-03-04
DE3439863A1 (en) 1985-05-23
AU563999B2 (en) 1987-07-30
SE8405514D0 (en) 1984-11-02
GB8427678D0 (en) 1984-12-05
FR2554448B1 (en) 1987-07-24
SU1489582A3 (en) 1989-06-23
HU193708B (en) 1987-11-30
HUT35637A (en) 1985-07-29
DK524484A (en) 1985-05-05
IL73395A0 (en) 1985-02-28

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