SE8403268L - 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE - Google Patents

1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE

Info

Publication number
SE8403268L
SE8403268L SE8403268A SE8403268A SE8403268L SE 8403268 L SE8403268 L SE 8403268L SE 8403268 A SE8403268 A SE 8403268A SE 8403268 A SE8403268 A SE 8403268A SE 8403268 L SE8403268 L SE 8403268L
Authority
SE
Sweden
Prior art keywords
atoms
carbon
alkyl
pharmaceutical preparations
preparations containing
Prior art date
Application number
SE8403268A
Other languages
Swedish (sv)
Other versions
SE8403268D0 (en
Inventor
A Vogel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8403268D0 publication Critical patent/SE8403268D0/en
Publication of SE8403268L publication Critical patent/SE8403268L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

1,4-dihydropyridine-3,5-dicarbonic acid esters having the formula (I), wherein R1 is hydrogen, a cyclo-alkyl comprising from 3 to 7 atoms of carbon or optionally a substituted alkyl comprising from 1 to 6 atoms of carbon; R2 and R5 represent independently from each other a hydrogen or an alkyl comprising from 1 to 6 atoms of carbon; R3 is an alkyl comprising from 1 to 12 atoms of carbon or independently -AR4 described hereunder, proportion included; R4 is a hydroxy, an alkoxy comprising from 1 to 12 atoms of carbon, -OCOR6, -NR7R8 or -NB; A is an alkylene comprising from 2 to 14 atoms of carbon; Q is an annulate fully unsaturated ring system, comprising at least 2 different ring hetero atoms, and having an aromatic character. Production thereof and pharmaceutical preparations containing them.
SE8403268A 1983-06-21 1984-06-19 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE SE8403268L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH339483 1983-06-21

Publications (2)

Publication Number Publication Date
SE8403268D0 SE8403268D0 (en) 1984-06-19
SE8403268L true SE8403268L (en) 1984-12-22

Family

ID=4255028

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8403268A SE8403268L (en) 1983-06-21 1984-06-19 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE

Country Status (15)

Country Link
JP (1) JPS6013789A (en)
AU (1) AU2956484A (en)
BE (1) BE899937A (en)
CH (1) CH663616A5 (en)
DE (1) DE3421992A1 (en)
DK (1) DK299784A (en)
FR (1) FR2549058B1 (en)
GB (1) GB2142021B (en)
IL (1) IL72152A0 (en)
IT (1) IT1199143B (en)
LU (1) LU85423A1 (en)
NL (1) NL8401932A (en)
SE (1) SE8403268L (en)
WO (1) WO1985000169A1 (en)
ZA (1) ZA844725B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755512A (en) * 1984-04-11 1988-07-05 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities
HUT39179A (en) * 1984-12-10 1986-08-28 Sandoz Ag Process for production of derivatives of 1,4-dihydro-piridin
EP0191724A3 (en) * 1985-01-15 1986-12-03 Sandoz Ag 1,4-dihydropyridine derivatives, their preparation and pharmaceutical compositions containing them
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
EP0222702A3 (en) * 1985-11-06 1988-01-07 Ciba-Geigy Ag Basic carbonyl derivatives
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
EP0343193A1 (en) * 1987-03-27 1989-11-29 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydropyridine enantiomers
AU1541188A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh New optically active compounds
JPH03500647A (en) * 1987-10-27 1991-02-14 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング New pyrrolidine
JPH10205466A (en) * 1997-01-23 1998-08-04 Mitsubishi Heavy Ind Ltd Scroll type fluid machine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2949464A1 (en) * 1978-12-18 1980-06-26 Sandoz Ag BENZOXADIAZOLES AND BENZOTHIADIAZOLES, THEIR PRODUCTION AND USE
DE3022030A1 (en) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-THIAZOLE or 4-IMIDAZOLE-SUBSTITUTED, 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM
JPS57175165A (en) * 1981-04-21 1982-10-28 Tokyo Tanabe Co Ltd Novel 1,4-dihydropyridine-3,5-dicarboxylic diester derivative and its salt
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
EP0094159B1 (en) * 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives, their production and use

Also Published As

Publication number Publication date
GB2142021A (en) 1985-01-09
DK299784A (en) 1984-12-22
IT8448415A0 (en) 1984-06-19
IL72152A0 (en) 1984-10-31
NL8401932A (en) 1985-01-16
AU2956484A (en) 1985-01-03
GB8415523D0 (en) 1984-07-25
JPS6013789A (en) 1985-01-24
DK299784D0 (en) 1984-06-19
CH663616A5 (en) 1987-12-31
FR2549058B1 (en) 1988-02-19
FR2549058A1 (en) 1985-01-18
ZA844725B (en) 1986-02-26
DE3421992A1 (en) 1985-01-03
GB2142021B (en) 1987-07-15
LU85423A1 (en) 1985-03-26
WO1985000169A1 (en) 1985-01-17
BE899937A (en) 1984-12-18
SE8403268D0 (en) 1984-06-19
IT1199143B (en) 1988-12-30

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Effective date: 19890101