BE899937A - NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS. - Google Patents

NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.

Info

Publication number
BE899937A
BE899937A BE1/011042A BE1011042A BE899937A BE 899937 A BE899937 A BE 899937A BE 1/011042 A BE1/011042 A BE 1/011042A BE 1011042 A BE1011042 A BE 1011042A BE 899937 A BE899937 A BE 899937A
Authority
BE
Belgium
Prior art keywords
medicaments
alkyl
novel
preparation
dihydropyridine derivatives
Prior art date
Application number
BE1/011042A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE899937A publication Critical patent/BE899937A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne les 1,4-dihydropyridines de formule (I) dans laquelle R1 est l'hydrogène, cycloalkyle ou alkyle, R2 et R'2 sont hydrogène ou alkyle, R3 est alkyle, -AR4 est hydroxy, alcoxy, acyloxy, amino substitué ou une amine cyclique, A est alkylène et Q un système cyclique condensé insaturé contenant au moins 2 hétéro-atomes différents, et les sels d'ammonium des composés dans lesquels R4 est un groupe amino tertiaire. Ces composés peuvent etre utilisés comme médicaments, notamment comme antagonistes du calcium.The invention relates to 1,4-dihydropyridines of formula (I) in which R1 is hydrogen, cycloalkyl or alkyl, R2 and R'2 are hydrogen or alkyl, R3 is alkyl, -AR4 is hydroxy, alkoxy, acyloxy, substituted amino or a cyclic amine, A is alkylene and Q is an unsaturated condensed ring system containing at least 2 different hetero atoms, and the ammonium salts of the compounds in which R4 is a tertiary amino group. These compounds can be used as medicaments, in particular as calcium antagonists.

BE1/011042A 1983-06-21 1984-06-18 NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS. BE899937A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH339483 1983-06-21

Publications (1)

Publication Number Publication Date
BE899937A true BE899937A (en) 1984-12-18

Family

ID=4255028

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011042A BE899937A (en) 1983-06-21 1984-06-18 NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.

Country Status (15)

Country Link
JP (1) JPS6013789A (en)
AU (1) AU2956484A (en)
BE (1) BE899937A (en)
CH (1) CH663616A5 (en)
DE (1) DE3421992A1 (en)
DK (1) DK299784A (en)
FR (1) FR2549058B1 (en)
GB (1) GB2142021B (en)
IL (1) IL72152A0 (en)
IT (1) IT1199143B (en)
LU (1) LU85423A1 (en)
NL (1) NL8401932A (en)
SE (1) SE8403268L (en)
WO (1) WO1985000169A1 (en)
ZA (1) ZA844725B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755512A (en) * 1984-04-11 1988-07-05 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities
NL8503262A (en) * 1984-12-10 1986-07-01 Sandoz Ag 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THESE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
EP0191724A3 (en) * 1985-01-15 1986-12-03 Sandoz Ag 1,4-dihydropyridine derivatives, their preparation and pharmaceutical compositions containing them
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
EP0222702A3 (en) * 1985-11-06 1988-01-07 Ciba-Geigy Ag Basic carbonyl derivatives
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
AU1541188A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh New optically active compounds
JP2625190B2 (en) * 1987-03-27 1997-07-02 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 1,4-dihydropyridine-enantiomer and process for producing the same
AU2614288A (en) * 1987-10-27 1989-05-23 Byk Gulden Lomberg Chemische Fabrik Gmbh New pyrrolidines
JPH10205466A (en) * 1997-01-23 1998-08-04 Mitsubishi Heavy Ind Ltd Scroll type fluid machine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2949464A1 (en) * 1978-12-18 1980-06-26 Sandoz Ag BENZOXADIAZOLES AND BENZOTHIADIAZOLES, THEIR PRODUCTION AND USE
DE3022030A1 (en) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-THIAZOLE or 4-IMIDAZOLE-SUBSTITUTED, 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM
JPS57175165A (en) * 1981-04-21 1982-10-28 Tokyo Tanabe Co Ltd Novel 1,4-dihydropyridine-3,5-dicarboxylic diester derivative and its salt
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
ATE50987T1 (en) * 1982-05-10 1990-03-15 Takeda Chemical Industries Ltd DIHYDROPYRIDE DERIVATIVES, THEIR PREPARATION AND USE.

Also Published As

Publication number Publication date
IT1199143B (en) 1988-12-30
DK299784D0 (en) 1984-06-19
JPS6013789A (en) 1985-01-24
CH663616A5 (en) 1987-12-31
LU85423A1 (en) 1985-03-26
GB8415523D0 (en) 1984-07-25
GB2142021A (en) 1985-01-09
IT8448415A0 (en) 1984-06-19
ZA844725B (en) 1986-02-26
DK299784A (en) 1984-12-22
FR2549058B1 (en) 1988-02-19
AU2956484A (en) 1985-01-03
IL72152A0 (en) 1984-10-31
GB2142021B (en) 1987-07-15
SE8403268L (en) 1984-12-22
NL8401932A (en) 1985-01-16
DE3421992A1 (en) 1985-01-03
WO1985000169A1 (en) 1985-01-17
FR2549058A1 (en) 1985-01-18
SE8403268D0 (en) 1984-06-19

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19880630