SE8402305D0 - SETTLE TO DETERMINE KATEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES, AND SUITABLE COMPOUNDS - Google Patents
SETTLE TO DETERMINE KATEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES, AND SUITABLE COMPOUNDSInfo
- Publication number
- SE8402305D0 SE8402305D0 SE8402305A SE8402305A SE8402305D0 SE 8402305 D0 SE8402305 D0 SE 8402305D0 SE 8402305 A SE8402305 A SE 8402305A SE 8402305 A SE8402305 A SE 8402305A SE 8402305 D0 SE8402305 D0 SE 8402305D0
- Authority
- SE
- Sweden
- Prior art keywords
- katepsin
- settle
- proteolytic enzymes
- suitable compounds
- cathepsin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/20—Coumarin derivatives
- C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/20—Coumarin derivatives
- C12Q2337/24—7-Amino-4-trifluoromethylcoumarin, i.e. AFC
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
Abstract
A method of selectively assaying for the activity of cathepsin B in mammalian fluids and tissues which may also contain trypsin and trypsin-like enzymes using novel substrates. The substrates are of the general formula: Z - R2 - R1 - X wherein X is an indicator moiety cleavable by cathepsin B, R1 is an amino acid group which is not positively charged, R2 is a hydrophobic amino group, and Z is an amino blocking group.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48965183A | 1983-04-28 | 1983-04-28 | |
US59833184A | 1984-04-12 | 1984-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8402305D0 true SE8402305D0 (en) | 1984-04-27 |
SE8402305L SE8402305L (en) | 1984-10-29 |
Family
ID=27049779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8402305A SE8402305L (en) | 1983-04-28 | 1984-04-27 | SETTLE TO DETERMINE KATEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES, AND SUITABLE COMPOUNDS |
Country Status (12)
Country | Link |
---|---|
KR (1) | KR850002289A (en) |
AU (1) | AU2743284A (en) |
BR (1) | BR8401996A (en) |
DE (1) | DE3415636A1 (en) |
DK (1) | DK201084A (en) |
ES (1) | ES8604691A1 (en) |
FI (1) | FI841686A (en) |
FR (1) | FR2545503A1 (en) |
GB (1) | GB2140423A (en) |
IT (1) | IT1182706B (en) |
NL (1) | NL8401375A (en) |
SE (1) | SE8402305L (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4803162A (en) * | 1984-05-15 | 1989-02-07 | Fluorodiagnostic Limited Partners | Composition, article and process for detecting a microorganism |
US4908309A (en) * | 1986-03-11 | 1990-03-13 | Prototek, Inc. | Method of detecting cysteine proteases |
DE3783966T2 (en) * | 1986-07-29 | 1993-05-27 | Sunstar Inc | REAGENTS FOR THE EXAMINATION OF PERIODENTAL DISEASES. |
AR042064A1 (en) * | 2002-11-19 | 2005-06-08 | Takeda Pharmaceutical | AMINA COMPOUNDS WITH INHIBITING ACTIVITY OF THE UNION TO THE SOMASTOTINE RECEIVER |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE407405B (en) * | 1975-07-11 | 1979-03-26 | Kabi Ab | NEW CHROMOGENATE THROMBIN SUBSTRATE |
SE407571B (en) * | 1975-07-11 | 1979-04-02 | Kabi Ab | NEW CHROMOGENA ENZYME SUBSTRATE FOR SERINE PROTEASES |
JPS5255593A (en) * | 1975-10-30 | 1977-05-07 | Ajinomoto Kk | Measuring method of enzyme activity |
CH634662A5 (en) * | 1976-05-28 | 1983-02-15 | Pentapharm Ag | USE OF TRIPEPTIDE DERIVATIVES FOR THE QUANTITATIVE DETERMINATION OF PLASMINOGEN ACTIVATORS. |
JPS5524147A (en) * | 1978-08-10 | 1980-02-21 | Ajinomoto Co Inc | Peptide derivative |
CA1161431A (en) * | 1979-05-11 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives |
WO1982000641A1 (en) * | 1980-08-25 | 1982-03-04 | Ab Kabivitrum | Peptide substrates for determination of protease activity |
JPS5753446A (en) * | 1980-09-16 | 1982-03-30 | Torii Yakuhin Kk | Peptide derivative |
JPS5863399A (en) * | 1981-10-14 | 1983-04-15 | Nitto Boseki Co Ltd | Novel substrate for measuring plasmin |
-
1984
- 1984-04-18 DK DK201084A patent/DK201084A/en not_active Application Discontinuation
- 1984-04-26 DE DE3415636A patent/DE3415636A1/en not_active Withdrawn
- 1984-04-27 FI FI841686A patent/FI841686A/en not_active Application Discontinuation
- 1984-04-27 FR FR8406694A patent/FR2545503A1/en not_active Withdrawn
- 1984-04-27 KR KR1019840002250A patent/KR850002289A/en not_active Application Discontinuation
- 1984-04-27 SE SE8402305A patent/SE8402305L/en not_active Application Discontinuation
- 1984-04-27 GB GB08410841A patent/GB2140423A/en not_active Withdrawn
- 1984-04-27 BR BR8401996A patent/BR8401996A/en unknown
- 1984-04-27 ES ES531962A patent/ES8604691A1/en not_active Expired
- 1984-04-27 AU AU27432/84A patent/AU2743284A/en not_active Abandoned
- 1984-04-30 IT IT48107/84A patent/IT1182706B/en active
- 1984-05-01 NL NL8401375A patent/NL8401375A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB2140423A (en) | 1984-11-28 |
DK201084A (en) | 1984-10-29 |
FR2545503A1 (en) | 1984-11-09 |
IT8448107A0 (en) | 1984-04-30 |
GB8410841D0 (en) | 1984-06-06 |
ES531962A0 (en) | 1986-02-01 |
IT1182706B (en) | 1987-10-05 |
NL8401375A (en) | 1984-11-16 |
BR8401996A (en) | 1984-12-04 |
FI841686A (en) | 1984-10-29 |
ES8604691A1 (en) | 1986-02-01 |
DK201084D0 (en) | 1984-04-18 |
SE8402305L (en) | 1984-10-29 |
KR850002289A (en) | 1985-05-10 |
AU2743284A (en) | 1984-11-01 |
FI841686A0 (en) | 1984-04-27 |
DE3415636A1 (en) | 1984-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAV | Patent application has lapsed |
Ref document number: 8402305-0 Effective date: 19861101 |