NL7601983A - 12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium - Google Patents

12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium

Info

Publication number
NL7601983A
NL7601983A NL7601983A NL7601983A NL7601983A NL 7601983 A NL7601983 A NL 7601983A NL 7601983 A NL7601983 A NL 7601983A NL 7601983 A NL7601983 A NL 7601983A NL 7601983 A NL7601983 A NL 7601983A
Authority
NL
Netherlands
Prior art keywords
enzyme
clostridium
dehydrodroxylase
deriv
bifidobacterium
Prior art date
Application number
NL7601983A
Other languages
Dutch (nl)
Original Assignee
Intellectual Property Dev Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellectual Property Dev Corp filed Critical Intellectual Property Dev Corp
Priority to NL7601983A priority Critical patent/NL7601983A/en
Publication of NL7601983A publication Critical patent/NL7601983A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Dehydroxylation of 12, dihydroxysteroids (II) to (I) consists of using 12-dehydroxylase enzyme. (where X = H, OH, acyloxy, alkoxy or oxo; R = OH, acyloxy, alkoxy, taurine or glycine). The enzyme may be produced by cultivation of clostridium perfringens. Some (I) have hypolipidaemic activity.
NL7601983A 1976-02-26 1976-02-26 12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium NL7601983A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7601983A NL7601983A (en) 1976-02-26 1976-02-26 12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7601983A NL7601983A (en) 1976-02-26 1976-02-26 12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium

Publications (1)

Publication Number Publication Date
NL7601983A true NL7601983A (en) 1977-08-30

Family

ID=19825700

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7601983A NL7601983A (en) 1976-02-26 1976-02-26 12Dehydroxylation of 12-hydroxycholanic acid or deriv - with 12-dehydrodroxylase enzyme from clostridium or bifidobacterium

Country Status (1)

Country Link
NL (1) NL7601983A (en)

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