SE8303862L - NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES - Google Patents

NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES

Info

Publication number
SE8303862L
SE8303862L SE8303862A SE8303862A SE8303862L SE 8303862 L SE8303862 L SE 8303862L SE 8303862 A SE8303862 A SE 8303862A SE 8303862 A SE8303862 A SE 8303862A SE 8303862 L SE8303862 L SE 8303862L
Authority
SE
Sweden
Prior art keywords
substance
dimethylphenyl
acetamide
hexahydroazepine
pharmaceutical compositions
Prior art date
Application number
SE8303862A
Other languages
Swedish (sv)
Other versions
SE8303862D0 (en
Inventor
Del Corral A S Diez
A G Ramos
Original Assignee
Medichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa filed Critical Medichem Sa
Publication of SE8303862D0 publication Critical patent/SE8303862D0/en
Publication of SE8303862L publication Critical patent/SE8303862L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New compounds, 2-(hexahydroazepino)- N-(2,6-dimethylphenyl)- acetamide, and its acid addition salts, especially the hydrochloride thereof, and pharmaceutical compositions containing them are prepared by reacting 2,6-dimethylaniline with chloracetyl chloride to give 2-chloro- N-(2,6-dimethylphenyl)-acetamide which is reacted in turn with hexahydroazepine. The new compound and the derivatives thereof have local anaesthetic activity and anti- arrhythmic activity.
SE8303862A 1982-07-14 1983-07-06 NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES SE8303862L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES513980A ES8305724A1 (en) 1982-07-14 1982-07-14 Substituted acetamides, a process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
SE8303862D0 SE8303862D0 (en) 1983-07-06
SE8303862L true SE8303862L (en) 1984-01-15

Family

ID=8484458

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8303862A SE8303862L (en) 1982-07-14 1983-07-06 NEW COMPOUND 2- (HEXAHYDROAZEPINE) -N- (2,6-DIMETHYLPHENYL) ACETAMIDE, THE CHLORETTE OF THIS SUBSTANCE, PROCEDURE FOR PREPARING THE SUBSTANCE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SUBSTANCES

Country Status (10)

Country Link
JP (1) JPS5951272A (en)
BE (1) BE897281A (en)
CA (1) CA1215048A (en)
DE (1) DE3325004A1 (en)
ES (1) ES8305724A1 (en)
FR (1) FR2530244B1 (en)
GB (1) GB2124223B (en)
IT (1) IT1169538B (en)
NL (1) NL8302507A (en)
SE (1) SE8303862L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8900685D0 (en) * 1989-02-28 1989-02-28 Astra Ab NEW COMPOUNDS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR907128A (en) * 1943-07-15 1946-03-01 Astra Ab Process for preparing local anesthesia products
DE963427C (en) * 1952-12-17 1957-05-09 Cassella Farbwerke Mainkur Ag Process for the production of new anesthetically acting aminocarboxamides
HU183721B (en) * 1981-11-06 1984-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new cyclic imine derivatives

Also Published As

Publication number Publication date
GB8319108D0 (en) 1983-08-17
ES513980A0 (en) 1983-04-16
IT8322053A1 (en) 1985-01-13
JPS5951272A (en) 1984-03-24
IT8322053A0 (en) 1983-07-13
ES8305724A1 (en) 1983-04-16
FR2530244B1 (en) 1986-10-31
BE897281A (en) 1983-11-03
IT1169538B (en) 1987-06-03
CA1215048A (en) 1986-12-09
GB2124223A (en) 1984-02-15
FR2530244A1 (en) 1984-01-20
NL8302507A (en) 1984-02-01
GB2124223B (en) 1985-09-04
DE3325004A1 (en) 1984-01-19
SE8303862D0 (en) 1983-07-06

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